EOG8616K8 GO:0016021 29/137 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8616K8 GO:0055085 28/137 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8616K8 GO:0015293 1/137 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG8616K8 GO:0006816 1/137 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8616K8 GO:0008273 1/137 calcium, potassium:sodium antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] EOG8616K8 GO:0035725 1/137 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8616K8 GO:0006814 1/137 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8616K8 GO:0048749 1/137 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8616K8 GO:0048812 1/137 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8NGK3G GO:0005215 1/30 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8NGK3G GO:0055085 1/30 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8NGK3G GO:0005795 1/30 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG8NGK3G GO:0008378 1/30 galactosyltransferase activity molecular_function "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] EOG8NGK3G GO:0016020 1/30 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG822D04 GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8J9QF2 GO:0006351 1/21 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8J9QF2 GO:0003677 1/21 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8J9QF2 GO:0003899 1/21 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8DV82Q GO:0006879 32/93 cellular iron ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah] EOG8DV82Q GO:0006826 32/93 iron ion transport biological_process "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8DV82Q GO:0008199 32/93 ferric iron binding molecular_function "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai] EOG8DV82Q GO:0016491 2/93 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8DV82Q GO:0004322 2/93 ferroxidase activity molecular_function "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] EOG8DV82Q GO:0010106 1/93 cellular response to iron ion starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg] EOG8DV82Q GO:0046427 1/93 positive regulation of JAK-STAT cascade biological_process "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8XKXMQ GO:0016459 23/92 myosin complex cellular_component "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] EOG8XKXMQ GO:0003774 23/92 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG8XKXMQ GO:0005524 23/92 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XKXMQ GO:0007605 3/92 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8XKXMQ GO:0048800 3/92 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG8XKXMQ GO:0008407 3/92 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8XKXMQ GO:0006200 3/92 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8XKXMQ GO:0030898 3/92 actin-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah] EOG8XKXMQ GO:0030048 3/92 actin filament-based movement biological_process "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] EOG8XKXMQ GO:0005737 3/92 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XKXMQ GO:0035317 3/92 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG8XKXMQ GO:0032027 3/92 myosin light chain binding molecular_function "Interacting selectively and non-covalently with a light chain of a myosin complex." [GOC:mah] EOG8XKXMQ GO:0031477 1/92 myosin VII complex cellular_component "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8XKXMQ GO:0008586 1/92 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8XKXMQ GO:0003779 1/92 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8XKXMQ GO:0007423 1/92 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8XKXMQ GO:0008152 1/92 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8XKXMQ GO:0005856 1/92 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8XKXMQ GO:0016461 1/92 unconventional myosin complex cellular_component "A portmanteau term for myosins other than myosin II." [GOC:ma] EOG8XKXMQ GO:0007015 1/92 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8XKXMQ GO:0042623 1/92 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8XKXMQ GO:0035293 1/92 chitin-based larval cuticle pattern formation biological_process "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8XKXMQ GO:0005902 1/92 microvillus cellular_component "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194] EOG8XKXMQ GO:0045179 1/92 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8XKXMQ GO:0007469 1/92 antennal development biological_process "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] EOG8XKXMR GO:0008017 1/89 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8XKXMR GO:0007098 1/89 centrosome cycle biological_process "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] EOG8XKXMR GO:0007422 1/89 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8XKXMR GO:0007067 1/89 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8XKXMR GO:0007279 1/89 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG8XKXMR GO:0007494 1/89 midgut development biological_process "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] EOG8XKXMR GO:0005813 1/89 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8XKXMR GO:0055059 1/89 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8XKXMR GO:0005929 1/89 cilium cellular_component "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684] EOG8XKXMR GO:0008356 1/89 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG8XKXMR GO:0005515 1/89 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XKXMR GO:0000242 1/89 pericentriolar material cellular_component "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] EOG8XKXMR GO:0005875 1/89 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8XKXMR GO:0000922 1/89 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8XKXMR GO:0007099 1/89 centriole replication biological_process "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] EOG8XKXMR GO:0008594 1/89 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8XKXMR GO:0051297 1/89 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8XKXMR GO:0016321 1/89 female meiosis chromosome segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] EOG8XKXMR GO:0007017 1/89 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8XKXMR GO:0005814 1/89 centriole cellular_component "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] EOG8XKXMR GO:0040016 1/89 embryonic cleavage biological_process "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] EOG8XKXMR GO:0030997 1/89 regulation of centriole-centriole cohesion biological_process "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968] EOG8XKXMR GO:0007052 1/89 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8XKXMR GO:0007417 1/89 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8M3CPK GO:0003678 9/67 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8M3CPK GO:0000723 9/67 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG8M3CPK GO:0006281 9/67 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8M3CPK GO:0004386 3/67 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8M3CPK GO:0005524 3/67 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M3CPK GO:0003676 1/67 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8M3CPK GO:0006511 1/67 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8XKXMX GO:0046872 22/110 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XKXMX GO:0016491 17/110 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8XKXMX GO:0005739 4/110 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8XKXMX GO:0047988 4/110 hydroxyacid-oxoacid transhydrogenase activity molecular_function "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN] EOG8XKXMX GO:0015993 4/110 molecular hydrogen transport biological_process "The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] EOG8XKXMX GO:0050093 1/110 methanol dehydrogenase activity molecular_function "Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH." [EC:1.1.1.244, RHEA:19404] EOG84BDH7 GO:0004022 74/125 alcohol dehydrogenase (NAD) activity molecular_function "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] EOG84BDH7 GO:0006066 22/125 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG84BDH7 GO:0016491 17/125 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG84BDH7 GO:0046164 4/125 alcohol catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, GOC:ai] EOG84BDH7 GO:0045735 2/125 nutrient reservoir activity molecular_function "Functions in the storage of nutritious substrates." [GOC:ai] EOG84BDH7 GO:0005811 2/125 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG84BDH7 GO:0048149 1/125 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG84BDH7 GO:0005829 1/125 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG84BDH7 GO:0042572 1/125 retinol metabolic process biological_process "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] EOG84BDH7 GO:0042574 1/125 retinal metabolic process biological_process "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [CHEBI:15035, GOC:curators, ISBN:0198506732] EOG84BDH7 GO:0048812 1/125 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG84BDH7 GO:0004745 1/125 retinol dehydrogenase activity molecular_function "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105] EOG84BDH7 GO:0042803 1/125 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG84BDH7 GO:0016404 1/125 15-hydroxyprostaglandin dehydrogenase (NAD+) activity molecular_function "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141] EOG84BDH7 GO:0005875 1/125 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG84BDH7 GO:0006909 1/125 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG84BDH7 GO:0043234 1/125 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8PG8M1 GO:0003964 1/12 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8PG8M1 GO:0003723 1/12 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8WWTZC GO:0000166 6/79 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8WWTZC GO:0003676 5/79 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8WWTZC GO:0046872 3/79 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WWTZC GO:0003677 1/79 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NCPT6 GO:0005509 23/97 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8NP9J8 GO:0046872 23/203 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NP9J8 GO:0008270 11/203 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NP9J8 GO:0003676 6/203 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NP9J8 GO:0015074 1/203 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8NP9J8 GO:0005634 1/203 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NP9J8 GO:0003723 1/203 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NP9J8 GO:0003964 1/203 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8WWTZX GO:0005044 1/84 scavenger receptor activity molecular_function "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] EOG8WWTZX GO:0035556 1/84 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8WWTZX GO:0035073 1/84 pupariation biological_process "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] EOG8WWTZX GO:0004721 1/84 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8WWTZX GO:0016020 1/84 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8WWTZX GO:0035075 1/84 response to ecdysone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] EOG841SSB GO:0031418 27/127 L-ascorbic acid binding molecular_function "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] EOG841SSB GO:0005506 27/127 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG841SSB GO:0016706 26/127 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG841SSB GO:0005634 10/127 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG841SSB GO:0006355 9/127 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG841SSB GO:0046872 4/127 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG841SSB GO:0031543 1/127 peptidyl-proline dioxygenase activity molecular_function "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462] EOG841SSB GO:0030307 1/127 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG841SSB GO:0019511 1/127 peptidyl-proline hydroxylation biological_process "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah] EOG841SSB GO:0060439 1/127 trachea morphogenesis biological_process "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] EOG841SSB GO:0001666 1/127 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG841SSB GO:0000124 1/127 SAGA complex cellular_component "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012] EOG841SSB GO:0005654 1/127 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG841SSB GO:0008104 1/127 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG841SSB GO:0007430 1/127 terminal branching, open tracheal system biological_process "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] EOG841SSB GO:0071456 1/127 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG841SSB GO:0043970 1/127 histone H3-K9 acetylation biological_process "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl] EOG841SSB GO:0006974 1/127 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG841SSB GO:0006611 1/127 protein export from nucleus biological_process "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] EOG80GG63 GO:0005254 42/136 chloride channel activity molecular_function "Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG80GG63 GO:0034707 42/136 chloride channel complex cellular_component "An ion channel complex through which chloride ions pass." [GOC:mah] EOG80GG63 GO:1902476 2/136 chloride transmembrane transport biological_process "The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw] EOG80GG63 GO:0005886 2/136 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80GG63 GO:0016319 1/136 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG80GG63 GO:0016021 1/136 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80GG63 GO:0006909 1/136 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG80GG63 GO:0002121 1/136 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8S1WMX GO:0016772 29/143 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8Q2GXT GO:0007623 1/55 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8Q2GXT GO:0007444 1/55 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG8Q2GXT GO:0042302 1/55 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8X3KGK GO:0003964 5/28 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8X3KGK GO:0003723 5/28 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8X3KGK GO:0046872 1/28 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DBWWX GO:0033971 17/89 hydroxyisourate hydrolase activity molecular_function "Catalysis of the reaction: 5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)." [EC:3.5.2.17, RHEA:23739] EOG8DBWWX GO:0006144 17/89 purine nucleobase metabolic process biological_process "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators] EOG8DBWWX GO:0006810 17/89 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8WWTZ8 GO:0030178 37/110 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG8WWTZ8 GO:0016055 31/110 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8WWTZ8 GO:0007405 2/110 neuroblast proliferation biological_process "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] EOG8WWTZ8 GO:0005515 2/110 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WWTZ8 GO:0030951 2/110 establishment or maintenance of microtubule cytoskeleton polarity biological_process "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] EOG8WWTZ8 GO:0007017 2/110 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8WWTZ8 GO:0007447 2/110 imaginal disc pattern formation biological_process "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid] EOG8WWTZ8 GO:0008258 2/110 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8WWTZ8 GO:0007420 2/110 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8WWTZ8 GO:0005875 2/110 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8WWTZ8 GO:0008017 2/110 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8WWTZ8 GO:0016337 2/110 single organismal cell-cell adhesion biological_process "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb] EOG8WWTZ8 GO:0035293 2/110 chitin-based larval cuticle pattern formation biological_process "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8WWTZ8 GO:0021550 2/110 medulla oblongata development biological_process "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] EOG8WWTZ8 GO:0005737 2/110 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WWTZ8 GO:0030720 2/110 oocyte localization involved in germarium-derived egg chamber formation biological_process "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] EOG8WWTZ8 GO:0030111 2/110 regulation of Wnt signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] EOG8WWTZ8 GO:0007411 2/110 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8WWTZ8 GO:0035190 1/110 syncytial nuclear migration biological_process "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839] EOG8WWTZ8 GO:0045179 1/110 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8WWTZ8 GO:0008362 1/110 chitin-based embryonic cuticle biosynthetic process biological_process "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] EOG8WWTZ8 GO:0008013 1/110 beta-catenin binding molecular_function "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf] EOG8WWTZ8 GO:0045732 1/110 positive regulation of protein catabolic process biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] EOG8WWTZ8 GO:0030424 1/110 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8WWTZ8 GO:0045177 1/110 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG8WWTZ8 GO:0030877 1/110 beta-catenin destruction complex cellular_component "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] EOG8WWTZ8 GO:0040001 1/110 establishment of mitotic spindle localization biological_process "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai] EOG8WWTZ8 GO:0005938 1/110 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8WWTZ8 GO:0043025 1/110 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8WWTZ8 GO:0007155 1/110 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8WWTZ8 GO:0030589 1/110 pseudocleavage involved in syncytial blastoderm formation biological_process "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8WWTZ8 GO:0045862 1/110 positive regulation of proteolysis biological_process "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] EOG8WWTZ8 GO:0030425 1/110 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8WWTZ8 GO:0005912 1/110 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8WWTZ8 GO:0030866 1/110 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8WWTZ8 GO:0046673 1/110 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8WWTZ8 GO:0043234 1/110 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8WWTZ8 GO:0005634 1/110 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WWTZ8 GO:0045892 1/110 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8WWTZ8 GO:0016327 1/110 apicolateral plasma membrane cellular_component "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] EOG8WWTZ8 GO:0032154 1/110 cleavage furrow cellular_component "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] EOG8WWTZ8 GO:0031334 1/110 positive regulation of protein complex assembly biological_process "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] EOG8WWTZ8 GO:0006886 1/110 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8DJN9V GO:0016020 62/202 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DJN9V GO:0005524 60/202 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DJN9V GO:0016887 58/202 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8DJN9V GO:0006810 29/202 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8DJN9V GO:0016021 4/202 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DJN9V GO:0031409 3/202 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG8DJN9V GO:0006727 2/202 ommochrome biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] EOG8DJN9V GO:0006856 2/202 eye pigment precursor transport biological_process "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8DJN9V GO:0048072 1/202 compound eye pigmentation biological_process "Establishment of a pattern of pigment in the compound eye." [GOC:jid] EOG8DJN9V GO:0031410 1/202 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG8DJN9V GO:0042401 1/202 cellular biogenic amine biosynthetic process biological_process "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] EOG8DJN9V GO:0004888 1/202 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8DJN9V GO:0008049 1/202 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8DJN9V GO:0007165 1/202 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8DJN9V GO:0007613 1/202 memory biological_process "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] EOG8DJN9V GO:0042441 1/202 eye pigment metabolic process biological_process "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] EOG8DJN9V GO:0070731 1/202 cGMP transport biological_process "The directed movement of cyclic GMP (cGMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732] EOG8DJN9V GO:0015416 1/202 organic phosphonate transmembrane-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28] EOG8DJN9V GO:0042332 1/202 gravitaxis biological_process "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] EOG8DJN9V GO:0015417 1/202 polyamine-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31] EOG88WFGX GO:0015299 2/3 solute:proton antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] EOG88WFGX GO:0016021 2/3 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RR8XC GO:0005604 1/94 basement membrane cellular_component "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684] EOG8RR8XC GO:0016020 1/94 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RR8XC GO:0007155 1/94 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8RR8XC GO:0006914 1/94 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG8RR8XC GO:0004871 1/94 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG85TG39 GO:0046579 1/94 positive regulation of Ras protein signal transduction biological_process "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] EOG8G1PZR GO:0008270 1/293 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8G1PZR GO:0008237 1/293 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8B5RJW GO:0003777 4/33 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8B5RJW GO:0007018 4/33 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8B5RJW GO:0030286 3/33 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG8B5RJW GO:0005524 3/33 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8B5RJW GO:0016887 2/33 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8J9QFZ GO:0019028 86/300 viral capsid cellular_component "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] EOG8XPSZJ GO:0004129 51/145 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8XPSZJ GO:0005751 51/145 mitochondrial respiratory chain complex IV cellular_component "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] EOG8XPSZJ GO:0008340 1/145 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8XPSZJ GO:0005811 1/145 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8XPSZJ GO:0006123 1/145 mitochondrial electron transport, cytochrome c to oxygen biological_process "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363] EOG8XPSZJ GO:0050790 1/145 regulation of catalytic activity biological_process "Any process that modulates the activity of an enzyme." [GOC:ai] EOG8XPSZJ GO:1902600 1/145 hydrogen ion transmembrane transport biological_process "The directed movement of hydrogen ion (proton) across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] EOG8XPSZJ GO:0030234 1/145 enzyme regulator activity molecular_function "Binds to and modulates the activity of an enzyme." [GOC:mah] EOG815JTJ GO:0008177 1/5 succinate dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13716] EOG815JTJ GO:0022900 1/5 electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] EOG815JTJ GO:0050660 1/5 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG815JTJ GO:0006099 1/5 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG84BDHG GO:0016021 20/81 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84BDHG GO:0055085 19/81 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG84BDHG GO:0006810 1/81 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG83N9VW GO:0005634 95/339 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83N9VW GO:0003700 95/339 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG83N9VW GO:0043565 89/339 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG83N9VW GO:0019101 1/339 female somatic sex determination biological_process "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah] EOG83N9VW GO:0000398 1/339 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG83N9VW GO:0003677 1/339 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG83N9VW GO:0007548 1/339 sex differentiation biological_process "The establishment of the sex of an organism by physical differentiation." [GOC:ai] EOG83N9VW GO:0045497 1/339 female analia development biological_process "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] EOG83N9VW GO:0001078 1/339 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG83N9VW GO:0008049 1/339 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG83N9VW GO:0045892 1/339 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0046661 1/339 male sex differentiation biological_process "The establishment of the sex of a male organism by physical differentiation." [GOC:bf] EOG83N9VW GO:0048086 1/339 negative regulation of developmental pigmentation biological_process "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] EOG83N9VW GO:0045433 1/339 male courtship behavior, veined wing generated song production biological_process "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] EOG83N9VW GO:0018993 1/339 somatic sex determination biological_process "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems] EOG83N9VW GO:0006355 1/339 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0042803 1/339 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG83N9VW GO:0045893 1/339 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0048071 1/339 sex-specific pigmentation biological_process "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid] EOG83N9VW GO:0045496 1/339 male analia development biological_process "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] EOG83N9VW GO:0007619 1/339 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG83N9VW GO:0007283 1/339 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG83N9VW GO:0007417 1/339 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG83N9VW GO:0016199 1/339 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG83N9VW GO:0035215 1/339 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG83N9VW GO:0045944 1/339 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0046872 1/339 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83N9VW GO:0003729 1/339 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG83N9VW GO:0045498 1/339 sex comb development biological_process "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] EOG83N9VW GO:0005515 1/339 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG83N9VW GO:0000122 1/339 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0007483 1/339 genital disc morphogenesis biological_process "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] EOG83N9VW GO:0001077 1/339 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH] EOG83N9VW GO:0007530 1/339 sex determination biological_process "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] EOG83N9VW GO:0007486 1/339 imaginal disc-derived female genitalia development biological_process "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG83N9VW GO:0006357 1/339 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG83N9VW GO:0019102 1/339 male somatic sex determination biological_process "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah] EOG83N9VW GO:0007485 1/339 imaginal disc-derived male genitalia development biological_process "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG83N9VW GO:0035263 1/339 genital disc sexually dimorphic development biological_process "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] EOG83N9VW GO:0046660 1/339 female sex differentiation biological_process "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] EOG83N9VW GO:0045570 1/339 regulation of imaginal disc growth biological_process "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] EOG8N8TJV GO:0006749 3/39 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG8N8TJV GO:0003840 3/39 gamma-glutamyltransferase activity molecular_function "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] EOG8D2951 GO:0003677 20/68 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8D2951 GO:0003682 19/68 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8D2951 GO:0008270 6/68 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D2951 GO:0016573 1/68 histone acetylation biological_process "The modification of a histone by the addition of an acetyl group." [GOC:ai] EOG8D2951 GO:0043967 1/68 histone H4 acetylation biological_process "The modification of histone H4 by the addition of an acetyl group." [GOC:jl] EOG8D2951 GO:0000123 1/68 histone acetyltransferase complex cellular_component "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] EOG8D2951 GO:0006338 1/68 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG8D2951 GO:0004402 1/68 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8D2951 GO:0043966 1/68 histone H3 acetylation biological_process "The modification of histone H3 by the addition of an acetyl group." [GOC:jl] EOG83N9VG GO:0019441 13/94 tryptophan catabolic process to kynurenine biological_process "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators] EOG83N9VG GO:0004061 13/94 arylformamidase activity molecular_function "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9] EOG83N9VG GO:0016787 10/94 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8TTK16 GO:0003676 1/14 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TTK16 GO:0008270 1/14 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RV55R GO:0008270 21/75 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RV55R GO:0000381 1/75 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8RV55R GO:0005634 1/75 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZKN13 GO:0031532 25/103 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG8ZKN13 GO:0004674 23/103 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8ZKN13 GO:0005524 23/103 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZKN13 GO:0035556 21/103 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8ZKN13 GO:0046872 21/103 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZKN13 GO:0005083 20/103 GTPase regulator activity molecular_function "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] EOG8ZKN13 GO:0004697 2/103 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8ZKN13 GO:0030424 1/103 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8ZKN13 GO:0008154 1/103 actin polymerization or depolymerization biological_process "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] EOG8ZKN13 GO:0008039 1/103 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8ZKN13 GO:0006468 1/103 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8ZKN13 GO:0005515 1/103 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8ZKN13 GO:0030426 1/103 growth cone cellular_component "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] EOG8ZKN13 GO:0032440 1/103 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8ZKN13 GO:0004672 1/103 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8ZKN13 GO:0030833 1/103 regulation of actin filament polymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG82VBX8 GO:0005215 5/52 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG82VBX8 GO:0005622 5/52 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG81ZHQV GO:0030178 2/47 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG81ZHQV GO:0016055 2/47 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG81ZHQV GO:0046872 1/47 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81ZHQW GO:0016021 3/79 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81ZHQW GO:0016787 1/79 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG81ZHQW GO:0005634 1/79 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81ZHQW GO:0000245 1/79 spliceosomal complex assembly biological_process "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] EOG81ZHQW GO:0055085 1/79 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8ZW7SF GO:0008519 7/19 ammonium transmembrane transporter activity molecular_function "Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [GOC:go_curators, ISBN:0198506732] EOG8ZW7SF GO:0016021 7/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RV55D GO:0060361 1/91 flight biological_process "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] EOG8RV55D GO:0008328 1/91 ionotropic glutamate receptor complex cellular_component "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] EOG8RV55D GO:0097106 1/91 postsynaptic density organization biological_process "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273] EOG8RV55D GO:0007528 1/91 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8RV55D GO:0007274 1/91 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8RV55D GO:0097482 1/91 muscle cell postsynaptic density cellular_component "A postsynaptic density that is part of a muscle cell." [GOC:pr] EOG8RV55D GO:0035187 1/91 hatching behavior biological_process "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051] EOG8RV55D GO:0046331 1/91 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8RV55D GO:0051726 1/91 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8RV55D GO:0043113 1/91 receptor clustering biological_process "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460] EOG8RV55D GO:0040011 1/91 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8RV55D GO:0031594 1/91 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG81ZHQN GO:0003777 54/190 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG81ZHQN GO:0007018 54/190 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG81ZHQN GO:0030286 48/190 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG81ZHQN GO:0005524 48/190 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG81ZHQN GO:0016887 45/190 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG81ZHQN GO:0005875 2/190 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG81ZHQN GO:0006200 2/190 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG81ZHQN GO:0042623 2/190 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG81ZHQN GO:0007605 1/190 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG82JR5H GO:0016020 86/342 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82JR5H GO:0008236 85/342 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG82JR5H GO:0006508 7/342 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG82JR5H GO:0008239 2/342 dipeptidyl-peptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG82JR5H GO:0016491 1/342 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG82JR5H GO:0005576 1/342 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8T1M35 GO:0005783 31/91 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8T1M35 GO:0005811 1/91 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8T1M35 GO:0045169 1/91 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG8323FR GO:0003677 7/32 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8N5Z9W GO:0031011 25/90 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG83R61V GO:0020037 24/59 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG83R61V GO:0005506 24/59 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG83R61V GO:0016705 23/59 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG83R61V GO:0004497 22/59 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG83R61V GO:0070330 1/59 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG870WZW GO:0006950 6/101 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG870WZW GO:0030018 1/101 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG8BS026 GO:0007156 1/35 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8BS026 GO:0005509 1/35 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8BS026 GO:0005886 1/35 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8SR09K GO:0016301 3/106 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8SR09K GO:0005737 1/106 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SR09K GO:0017112 1/106 Rab guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8SR09K GO:0016192 1/106 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8SR09K GO:1902041 1/106 regulation of extrinsic apoptotic signaling pathway via death domain receptors biological_process "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429] EOG8SR09K GO:0004819 1/106 glutamine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18] EOG8SR09K GO:0016021 1/106 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SR09K GO:0006425 1/106 glutaminyl-tRNA aminoacylation biological_process "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8SR09K GO:0006915 1/106 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8SR09K GO:0032313 1/106 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8SR09K GO:0051726 1/106 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8SR09K GO:0008021 1/106 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8SR09K GO:0000187 1/106 activation of MAPK activity biological_process "The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267] EOG8SR09K GO:0007269 1/106 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8SR09K GO:0005524 1/106 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG879HMX GO:0003887 25/104 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG879HMX GO:0000166 23/104 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG879HMX GO:0003677 23/104 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG879HMX GO:0003676 3/104 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG879HMX GO:0005694 1/104 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG879HMX GO:0006261 1/104 DNA-dependent DNA replication biological_process "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] EOG879HMX GO:0000724 1/104 double-strand break repair via homologous recombination biological_process "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] EOG879HMX GO:0019985 1/104 translesion synthesis biological_process "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, PMID:10535901] EOG879HMX GO:0005634 1/104 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG879HMX GO:0016035 1/104 zeta DNA polymerase complex cellular_component "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464] EOG87DCWX GO:0016787 125/753 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG87DCWX GO:0003990 29/753 acetylcholinesterase activity molecular_function "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] EOG87DCWX GO:0052689 10/753 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG87DCWX GO:0004104 5/753 cholinesterase activity molecular_function "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] EOG87DCWX GO:0005576 3/753 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG87DCWX GO:0005524 1/753 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87DCWX GO:0006730 1/753 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG87DCWX GO:0004013 1/753 adenosylhomocysteinase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] EOG87DCWX GO:0003677 1/753 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG87DCWX GO:0016021 1/753 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87DCWX GO:0006260 1/753 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8RJJGP GO:0008097 21/87 5S rRNA binding molecular_function "Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382] EOG8RJJGP GO:0003735 21/87 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8RJJGP GO:0005840 21/87 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8RJJGP GO:0006412 21/87 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8RJJGP GO:0003723 1/87 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RJJGP GO:0000027 1/87 ribosomal large subunit assembly biological_process "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl] EOG8RJJGP GO:0022625 1/87 cytosolic large ribosomal subunit cellular_component "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] EOG8RJJGP GO:0005515 1/87 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QNQ9H GO:0003951 39/105 NAD+ kinase activity molecular_function "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632] EOG8QNQ9H GO:0007205 36/105 protein kinase C-activating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling] EOG8QNQ9H GO:0004143 36/105 diacylglycerol kinase activity molecular_function "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh] EOG8QNQ9H GO:0017050 2/105 D-erythro-sphingosine kinase activity molecular_function "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [MetaCyc:RXN3DJ-11417] EOG8QNQ9H GO:0016310 2/105 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8QNQ9H GO:0006665 2/105 sphingolipid metabolic process biological_process "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] EOG8QNQ9H GO:0001729 2/105 ceramide kinase activity molecular_function "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138] EOG8QNQ9H GO:0007629 1/105 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8QNQ9H GO:0018991 1/105 oviposition biological_process "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems] EOG8TMTJJ GO:0004252 1/5 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG81VNJ4 GO:0003735 25/96 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG81VNJ4 GO:0015935 25/96 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG81VNJ4 GO:0003723 25/96 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG81VNJ4 GO:0006412 24/96 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG81VNJ4 GO:0006974 1/96 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG81VNJ4 GO:0043524 1/96 negative regulation of neuron apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] EOG81VNJ4 GO:0000737 1/96 DNA catabolic process, endonucleolytic biological_process "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] EOG81VNJ4 GO:0006281 1/96 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG81VNJ4 GO:0003906 1/96 DNA-(apurinic or apyrimidinic site) lyase activity molecular_function "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18] EOG81VNJ4 GO:0005840 1/96 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG81VNJ4 GO:0006810 1/96 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG81VNJ4 GO:0032088 1/96 negative regulation of NF-kappaB transcription factor activity biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb] EOG81VNJ4 GO:0007067 1/96 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG81VNJ4 GO:0002181 1/96 cytoplasmic translation biological_process "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] EOG81VNJ4 GO:0016021 1/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81VNJ4 GO:0005875 1/96 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG81VNJ4 GO:0008534 1/96 oxidized purine nucleobase lesion DNA N-glycosylase activity molecular_function "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296] EOG81VNJ4 GO:0005634 1/96 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81VNJ4 GO:0016363 1/96 nuclear matrix cellular_component "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] EOG8GTNT7 GO:0005524 1/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GTNT7 GO:0005737 1/7 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GTNT7 GO:0006431 1/7 methionyl-tRNA aminoacylation biological_process "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8GTNT7 GO:0004825 1/7 methionine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10] EOG8RJJGZ GO:0008168 6/10 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG812PM2 GO:0005634 17/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG812PM2 GO:0005737 17/95 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG812PM2 GO:0070328 1/95 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG812PM2 GO:0009744 1/95 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG812PM2 GO:0006897 1/95 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG812PM2 GO:0016028 1/95 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG812PM2 GO:0016059 1/95 deactivation of rhodopsin mediated signaling biological_process "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] EOG812PM2 GO:0042593 1/95 glucose homeostasis biological_process "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] EOG8PP0WX GO:0005524 55/227 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8PP0WX GO:0004692 45/227 cGMP-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah] EOG8PP0WX GO:0030553 14/227 cGMP binding molecular_function "Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai] EOG8PP0WX GO:0004674 11/227 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8PP0WX GO:0005952 7/227 cAMP-dependent protein kinase complex cellular_component "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732] EOG8PP0WX GO:0008603 7/227 cAMP-dependent protein kinase regulator activity molecular_function "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] EOG8PP0WX GO:0006468 2/227 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8PP0WX GO:0032095 1/227 regulation of response to food biological_process "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] EOG8PP0WX GO:0005886 1/227 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PP0WX GO:0007526 1/227 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8PP0WX GO:0008345 1/227 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8PP0WX GO:0007616 1/227 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8PP0WX GO:0046959 1/227 habituation biological_process "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089] EOG8PP0WX GO:0009744 1/227 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG8PP0WX GO:0016301 1/227 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8PP0WX GO:0030536 1/227 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8PP0WX GO:0007631 1/227 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8PP0WX GO:0004672 1/227 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8PP0WX GO:0004690 1/227 cyclic nucleotide-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah] EOG8PP0WX GO:0008016 1/227 regulation of heart contraction biological_process "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] EOG8PP0WX GO:0007614 1/227 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8XD66J GO:0016021 27/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XD66J GO:0055085 26/91 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8XD66J GO:0005743 6/91 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8XD66J GO:0006810 1/91 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8XD66J GO:0050829 1/91 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8XD66J GO:0045089 1/91 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8TMTJ9 GO:0005576 16/44 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8TMTJ9 GO:0009416 15/44 response to light stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] EOG8TMTJ9 GO:0043153 1/44 entrainment of circadian clock by photoperiod biological_process "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl] EOG8TMTJ9 GO:0045475 1/44 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8TMTJ9 GO:0005184 1/44 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG8TMTJ9 GO:0010579 1/44 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway biological_process "Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb] EOG8TMTJ9 GO:0007617 1/44 mating behavior biological_process "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] EOG8TMTJ9 GO:0005615 1/44 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8TMTJ9 GO:0007218 1/44 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8TMTJ9 GO:0005102 1/44 receptor binding molecular_function "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] EOG8TMTJ9 GO:0008062 1/44 eclosion rhythm biological_process "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] EOG8TMTJ9 GO:0042745 1/44 circadian sleep/wake cycle biological_process "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com] EOG8TMTJ9 GO:0042749 1/44 regulation of circadian sleep/wake cycle biological_process "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl] EOG8TMTJ9 GO:0007623 1/44 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG8TMTJ9 GO:0042332 1/44 gravitaxis biological_process "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] EOG84TRNW GO:0003950 23/103 NAD+ ADP-ribosyltransferase activity molecular_function "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] EOG84TRNW GO:0006471 23/103 protein ADP-ribosylation biological_process "The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295] EOG84TRNW GO:0003677 21/103 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84TRNW GO:0008270 21/103 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG84TRNW GO:0051287 20/103 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG84TRNW GO:0005634 20/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84TRNW GO:0042393 1/103 histone binding molecular_function "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] EOG84TRNW GO:0035080 1/103 heat shock-mediated polytene chromosome puffing biological_process "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962] EOG84TRNW GO:0007000 1/103 nucleolus organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] EOG84TRNW GO:0048812 1/103 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG84TRNW GO:0005700 1/103 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG84TRNW GO:0030576 1/103 Cajal body organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] EOG84TRNW GO:0043484 1/103 regulation of RNA splicing biological_process "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] EOG84TRNW GO:0035363 1/103 histone locus body cellular_component "A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235] EOG84TRNW GO:0005719 1/103 nuclear euchromatin cellular_component "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732] EOG84TRNW GO:0016568 1/103 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG84TRNW GO:0051457 1/103 maintenance of protein location in nucleus biological_process "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] EOG84TRNW GO:0006963 1/103 positive regulation of antibacterial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] EOG84TRNW GO:0005703 1/103 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG84TRNW GO:0035079 1/103 polytene chromosome puffing biological_process "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals." [GOC:bf, PMID:12543962] EOG84TRNW GO:0015030 1/103 Cajal body cellular_component "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] EOG84TRNW GO:0009303 1/103 rRNA transcription biological_process "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732] EOG84TRNW GO:0006355 1/103 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG84TRNW GO:0005730 1/103 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG84TRNW GO:0045087 1/103 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG84TRNW GO:0007552 1/103 metamorphosis biological_process "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] EOG84TRNW GO:0051276 1/103 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG84TRNW GO:0005694 1/103 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8KH58C GO:0046872 10/75 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KH58C GO:0003676 10/75 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG87H867 GO:0003723 6/322 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG87H867 GO:0003964 6/322 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG82Z746 GO:0005634 4/62 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82Z746 GO:0008270 4/62 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82Z746 GO:0003677 3/62 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG82Z746 GO:0003676 3/62 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82Z746 GO:0046872 2/62 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8S7N43 GO:0008270 25/133 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S7N43 GO:0006351 25/133 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8S7N43 GO:0016817 22/133 hydrolase activity, acting on acid anhydrides molecular_function "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] EOG8S7N43 GO:0003676 3/133 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8S7N43 GO:0005634 2/133 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S7N43 GO:0000381 1/133 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8S7N43 GO:0005515 1/133 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8S7N47 GO:0046872 1/5 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8S7N47 GO:0003723 1/5 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8S7N47 GO:0016788 1/5 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG8XH2F3 GO:0030529 2/89 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8XH2F3 GO:0019013 2/89 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8XH2F3 GO:0019843 1/89 rRNA binding molecular_function "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] EOG8XH2F3 GO:0006364 1/89 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG8XH2F3 GO:0005730 1/89 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8XH2F3 GO:0003723 1/89 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8VMHWV GO:0005576 7/70 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG83XXJ5 GO:0006511 23/108 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG83XXJ5 GO:0008234 16/108 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG83XXJ5 GO:0004221 2/108 obsolete ubiquitin thiolesterase activity molecular_function "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] EOG83XXJ5 GO:0045880 1/108 positive regulation of smoothened signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG83XXJ5 GO:0016579 1/108 protein deubiquitination biological_process "The removal of one or more ubiquitin groups from a protein." [GOC:ai] EOG83XXJ5 GO:0008587 1/108 imaginal disc-derived wing margin morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG83XXJ5 GO:0090263 1/108 positive regulation of canonical Wnt signaling pathway biological_process "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] EOG83XXJ5 GO:0005737 1/108 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83XXJ5 GO:0004843 1/108 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709] EOG8RV557 GO:0016021 22/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RV557 GO:0005524 22/91 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8RV557 GO:0042626 21/91 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8RV557 GO:0005774 1/91 vacuolar membrane cellular_component "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] EOG8RV557 GO:0008559 1/91 xenobiotic-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] EOG8RV557 GO:0071585 1/91 detoxification of cadmium ion biological_process "Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion." [GOC:BHF, GOC:kmv, PMID:16741752] EOG8RV557 GO:0046686 1/91 response to cadmium ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai] EOG8RV553 GO:0005634 1/98 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RV553 GO:0051536 1/98 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8RV553 GO:0008233 1/98 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8RV553 GO:0005198 1/98 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8RV553 GO:0016226 1/98 iron-sulfur cluster assembly biological_process "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] EOG8ZKN1X GO:0006807 72/199 nitrogen compound metabolic process biological_process "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732] EOG8ZKN1X GO:0016811 72/199 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] EOG8ZKN1X GO:0004435 2/199 phosphatidylinositol phospholipase C activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] EOG8ZKN1X GO:0035556 2/199 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8ZKN1X GO:0006629 2/199 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8ZKN1X GO:0071110 1/199 histone biotinylation biological_process "The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041] EOG8ZKN1X GO:0019898 1/199 extrinsic component of membrane cellular_component "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] EOG8ZKN1X GO:0016787 1/199 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8ZKN1X GO:0009408 1/199 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8ZKN1X GO:0017159 1/199 pantetheine hydrolase activity molecular_function "Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448] EOG8ZKN1X GO:0018054 1/199 peptidyl-lysine biotinylation biological_process "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117] EOG8QFZZ1 GO:0003824 1/4 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG86HJR2 GO:0070681 1/5 glutaminyl-tRNAGln biosynthesis via transamidation biological_process "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921] EOG86HJR2 GO:0005739 1/5 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG86HJR2 GO:0032543 1/5 mitochondrial translation biological_process "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] EOG86HJR2 GO:0016740 1/5 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG86HJR2 GO:0030956 1/5 glutamyl-tRNA(Gln) amidotransferase complex cellular_component "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] EOG86HJR2 GO:0016787 1/5 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG86HJR2 GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86HJR2 GO:0050567 1/5 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] EOG8KWN8W GO:0031409 4/7 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG8KWN8W GO:0005576 2/7 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8KWN8W GO:0036094 1/7 small molecule binding molecular_function "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] EOG8QNQ9D GO:0003676 25/172 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QNQ9D GO:0008270 25/172 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QNQ9D GO:0044262 11/172 cellular carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] EOG8QNQ9D GO:0030060 10/172 L-malate dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37] EOG8QNQ9D GO:0006108 10/172 malate metabolic process biological_process "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] EOG8QNQ9D GO:0006099 5/172 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8QNQ9D GO:0071011 1/172 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8QNQ9D GO:0016616 1/172 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG8QNQ9D GO:0006909 1/172 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8QNQ9D GO:0071013 1/172 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8QNQ9D GO:0000398 1/172 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG808QP2 GO:0020037 41/103 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG808QP2 GO:0004383 41/103 guanylate cyclase activity molecular_function "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] EOG808QP2 GO:0035556 37/103 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG808QP2 GO:0000166 26/103 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG808QP2 GO:0008074 2/103 guanylate cyclase complex, soluble cellular_component "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah] EOG808QP2 GO:0046982 2/103 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG808QP2 GO:0046872 2/103 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG808QP2 GO:0001666 2/103 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG808QP2 GO:0005525 2/103 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG808QP2 GO:0006184 2/103 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG808QP2 GO:0000302 2/103 response to reactive oxygen species biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] EOG808QP2 GO:0006182 2/103 cGMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732] EOG808QP2 GO:0055093 1/103 response to hyperoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv] EOG844P0C GO:0008270 24/87 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG844P0C GO:0004181 24/87 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG88GZH5 GO:0016021 33/129 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88GZH5 GO:0004930 32/129 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG88GZH5 GO:0005886 28/129 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88GZH5 GO:0008343 1/129 adult feeding behavior biological_process "Feeding behavior in a fully developed and mature organism." [GOC:mah] EOG88GZH5 GO:0003676 1/129 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88GZH5 GO:0030425 1/129 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG88GZH5 GO:0005887 1/129 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88GZH5 GO:0007200 1/129 phospholipase C-activating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] EOG88GZH5 GO:0017085 1/129 response to insecticide biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] EOG88GZH5 GO:0051966 1/129 regulation of synaptic transmission, glutamatergic biological_process "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] EOG8CG2PK GO:0016020 14/85 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CG2PK GO:0008021 14/85 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8CG2PK GO:0005215 14/85 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8CG2PK GO:0016079 1/85 synaptic vesicle exocytosis biological_process "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] EOG8CG2PK GO:0035005 1/85 1-phosphatidylinositol-4-phosphate 3-kinase activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376] EOG8V45NG GO:0016021 2/124 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V45NG GO:0016301 1/124 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8Z0DKG GO:0000139 2/123 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8Z0DKG GO:0009967 2/123 positive regulation of signal transduction biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] EOG8Z0DKG GO:0019901 2/123 protein kinase binding molecular_function "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] EOG8Z0DKG GO:0005078 2/123 MAP-kinase scaffold activity molecular_function "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336] EOG8Z0DKG GO:0008088 2/123 axon cargo transport biological_process "The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194] EOG8Z0DKG GO:0046328 2/123 regulation of JNK cascade biological_process "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8Z0DKG GO:0016192 2/123 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8Z0DKG GO:0019894 2/123 kinesin binding molecular_function "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779] EOG8Z0DKG GO:0030140 2/123 trans-Golgi network transport vesicle cellular_component "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] EOG8Z0DKG GO:0016301 1/123 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8XPSVP GO:0005524 26/106 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XPSVP GO:0004525 25/106 ribonuclease III activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] EOG8XPSVP GO:0006396 24/106 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8XPSVP GO:0003723 24/106 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8XPSVP GO:0008026 23/106 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8XPSVP GO:0004386 4/106 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8XPSVP GO:0003677 3/106 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8XPSVP GO:0016075 3/106 rRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai] EOG8XPSVP GO:0003676 2/106 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XPSVP GO:0016891 2/106 endoribonuclease activity, producing 5'-phosphomonoesters molecular_function "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] EOG8XPSVP GO:0002230 1/106 positive regulation of defense response to virus by host biological_process "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] EOG8XPSVP GO:0016442 1/106 RISC complex cellular_component "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] EOG8XPSVP GO:0005515 1/106 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XPSVP GO:0005634 1/106 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XPSVP GO:0070868 1/106 heterochromatin organization involved in chromatin silencing biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah] EOG8XPSVP GO:0006342 1/106 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG8XPSVP GO:0035087 1/106 siRNA loading onto RISC involved in RNA interference biological_process "The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631] EOG8XPSVP GO:0030422 1/106 production of siRNA involved in RNA interference biological_process "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] EOG8XPSVP GO:0016887 1/106 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8XPSVP GO:0006200 1/106 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8XPSVP GO:0033227 1/106 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8XPSVP GO:0051607 1/106 defense response to virus biological_process "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] EOG8XPSVP GO:0005737 1/106 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XPSVP GO:0009047 1/106 dosage compensation by hyperactivation of X chromosome biological_process "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577] EOG8XPSVP GO:0030423 1/106 targeting of mRNA for destruction involved in RNA interference biological_process "The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674] EOG8XPSVP GO:0035197 1/106 siRNA binding molecular_function "Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283] EOG8XPSVP GO:0006379 1/106 mRNA cleavage biological_process "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] EOG8XPSVP GO:0007626 1/106 locomotory behavior biological_process "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] EOG8XPSVP GO:0003725 1/106 double-stranded RNA binding molecular_function "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl] EOG8XPSVP GO:0016246 1/106 RNA interference biological_process "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] EOG8XPSVP GO:0009597 1/106 detection of virus biological_process "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb] EOG84J4Z2 GO:0008270 20/123 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG84J4Z2 GO:0008237 20/123 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG84J4Z2 GO:0005578 20/123 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG84J4Z2 GO:0008233 4/123 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8C2KTR GO:0003964 6/27 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8C2KTR GO:0003723 6/27 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8V45NS GO:0035091 23/90 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG8V45NS GO:0038032 22/90 termination of G-protein coupled receptor signaling pathway biological_process "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] EOG8V45NS GO:0008340 1/90 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8ZGRTM GO:0050839 1/154 cell adhesion molecule binding molecular_function "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai] EOG8ZGRTM GO:0031362 1/154 anchored component of external side of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG8CVJQH GO:0006457 1/4 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8CVJQH GO:0005737 1/4 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8ZGRTF GO:0008270 25/98 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZGRTF GO:0006355 25/98 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8ZGRTF GO:0005634 25/98 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QJV4H GO:0005524 35/64 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QJV4H GO:0004674 31/64 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8QJV4H GO:0004713 2/64 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8QJV4H GO:0004672 2/64 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8QJV4H GO:0003676 1/64 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QJV4H GO:0016887 1/64 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG86X1Q7 GO:0046872 68/241 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG86X1Q7 GO:0003676 66/241 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86X1Q7 GO:0007366 3/241 periodic partitioning by pair rule gene biological_process "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG86X1Q7 GO:0045893 3/241 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0045944 3/241 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0016348 3/241 imaginal disc-derived leg joint morphogenesis biological_process "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG86X1Q7 GO:0000122 3/241 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0005634 3/241 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86X1Q7 GO:0045892 3/241 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0003677 2/241 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86X1Q7 GO:0007350 2/241 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG86X1Q7 GO:0000981 2/241 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG86X1Q7 GO:0006366 2/241 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG86X1Q7 GO:0009880 1/241 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG86X1Q7 GO:0006351 1/241 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG86X1Q7 GO:0007480 1/241 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG86X1Q7 GO:0007443 1/241 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG86X1Q7 GO:0046331 1/241 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG86X1Q7 GO:0035220 1/241 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG86X1Q7 GO:0048619 1/241 embryonic hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] EOG86X1Q7 GO:0007442 1/241 hindgut morphogenesis biological_process "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] EOG86X1Q7 GO:0006909 1/241 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG86X1Q7 GO:0003700 1/241 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86X1Q7 GO:0048617 1/241 embryonic foregut morphogenesis biological_process "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] EOG86X1Q7 GO:0007362 1/241 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG86X1Q7 GO:0006357 1/241 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86X1Q7 GO:0006355 1/241 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG85XBB9 GO:0030036 3/25 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG88PQ10 GO:0003677 8/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88PQ10 GO:0003676 2/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89CSNX GO:0006869 21/86 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG89CSNX GO:0016787 1/86 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG896273 GO:0008270 42/71 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8N5ZBC GO:0016021 3/100 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8N5ZBC GO:0007420 1/100 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG83BQ2Z GO:0006744 2/52 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG8T1M23 GO:0003682 13/63 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8T1M23 GO:0005634 13/63 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8T1M23 GO:0003677 13/63 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG886BVG GO:0003700 1/6 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG886BVG GO:0003677 1/6 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG89CSNM GO:0022008 1/89 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG89CSNM GO:0034472 1/89 snRNA 3'-end processing biological_process "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah] EOG89CSNM GO:0016180 1/89 snRNA processing biological_process "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl] EOG8X6FP2 GO:0005615 1/111 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8X6FP2 GO:0035556 1/111 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8X6FP2 GO:0016021 1/111 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8X6FP2 GO:0005875 1/111 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8X6FP2 GO:0005787 1/111 signal peptidase complex cellular_component "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509] EOG8X6FP2 GO:0008233 1/111 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8X6FP2 GO:0006465 1/111 signal peptide processing biological_process "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194] EOG8D55C2 GO:0005622 25/109 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8D55C2 GO:0007264 24/109 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8D55C2 GO:0005085 24/109 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8D55C2 GO:0051056 22/109 regulation of small GTPase mediated signal transduction biological_process "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] EOG8D55C2 GO:0005088 1/109 Ras guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8D55C2 GO:0016203 1/109 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8D55C2 GO:0007265 1/109 Ras protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] EOG8D55C2 GO:0032317 1/109 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8D55C2 GO:0007525 1/109 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG8D55C2 GO:0032854 1/109 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8D55C2 GO:0045214 1/109 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8D55C2 GO:0017034 1/109 Rap guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG87SVTX GO:0004252 1/8 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG85XB95 GO:0003677 26/91 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG85XB95 GO:0003682 25/91 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG85XB95 GO:0019185 1/91 snRNA-activating protein complex cellular_component "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788] EOG85XB95 GO:0043565 1/91 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG85XB95 GO:0042796 1/91 snRNA transcription from RNA polymerase III promoter biological_process "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] EOG85XB95 GO:0046331 1/91 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG85XB95 GO:0003681 1/91 bent DNA binding molecular_function "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977] EOG85XB95 GO:0065004 1/91 protein-DNA complex assembly biological_process "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] EOG85XB95 GO:0042795 1/91 snRNA transcription from RNA polymerase II promoter biological_process "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382] EOG85XB95 GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG80VZ6J GO:0003676 1/13 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80VZ6J GO:0008270 1/13 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RBT1M GO:0005634 84/201 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RBT1M GO:0006351 83/201 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8RBT1M GO:0003677 79/201 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RBT1M GO:0006355 79/201 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8RBT1M GO:0003700 5/201 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8RBT1M GO:0048749 5/201 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8RBT1M GO:0043565 5/201 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8RBT1M GO:0007219 4/201 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8RBT1M GO:0000122 4/201 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8RBT1M GO:0005515 2/201 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8RBT1M GO:0008134 2/201 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8RBT1M GO:0030154 2/201 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8RBT1M GO:0007399 2/201 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8RBT1M GO:0048666 1/201 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8RBT1M GO:0002052 1/201 positive regulation of neuroblast proliferation biological_process "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] EOG8RBT1M GO:2001020 1/201 regulation of response to DNA damage stimulus biological_process "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] EOG8RBT1M GO:0001964 1/201 startle response biological_process "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] EOG8RBT1M GO:0048190 1/201 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8RBT1M GO:0045466 1/201 R7 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] EOG8RBT1M GO:0001078 1/201 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG8RBT1M GO:0048813 1/201 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8RBT1M GO:0048052 1/201 R1/R6 cell differentiation biological_process "The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] EOG8RBT1M GO:0031987 1/201 locomotion involved in locomotory behavior biological_process "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] EOG8RBT1M GO:0048854 1/201 brain morphogenesis biological_process "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] EOG879HMZ GO:0016772 69/190 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG879HMZ GO:0016301 11/190 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG879HMZ GO:0017022 1/190 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG879HMZ GO:0022008 1/190 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8284FS GO:0005524 15/48 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8284FS GO:0003676 14/48 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8284FS GO:0008026 11/48 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8284FS GO:0004386 4/48 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8284FS GO:0006351 1/48 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8284FS GO:0003677 1/48 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8284FS GO:0003899 1/48 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8284FP GO:0005328 49/189 neurotransmitter:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] EOG8284FP GO:0016021 45/189 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8284FP GO:0005887 4/189 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8284FP GO:0006836 2/189 neurotransmitter transport biological_process "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] EOG8284FP GO:0005326 2/189 neurotransmitter transporter activity molecular_function "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732] EOG8284FP GO:0005886 1/189 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8284FQ GO:0008352 24/98 katanin complex cellular_component "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766] EOG8284FQ GO:0051013 24/98 microtubule severing biological_process "The process in which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234] EOG8284FQ GO:0005874 18/98 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8284FQ GO:0005813 18/98 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8284FQ GO:0007067 18/98 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8284FQ GO:0000922 18/98 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG8284FQ GO:0046843 1/98 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8284FQ GO:0008017 1/98 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8284FQ GO:0016740 1/98 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8284FQ GO:0007017 1/98 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8JHFW3 GO:0016491 83/244 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8JHFW3 GO:0046592 2/244 polyamine oxidase activity molecular_function "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380] EOG8JHFW3 GO:0046872 1/244 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8JHFW3 GO:0050232 1/244 putrescine oxidase activity molecular_function "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN] EOG8JHFW3 GO:0005615 1/244 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8JHFW3 GO:0003676 1/244 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG81G5MZ GO:0016021 2/13 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81G5MZ GO:0004930 2/13 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG86DPJH GO:0032440 2/12 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8B2WC0 GO:0000242 1/85 pericentriolar material cellular_component "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] EOG8B2WC0 GO:0007099 1/85 centriole replication biological_process "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] EOG8VDSCH GO:0005524 25/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VDSCH GO:0004672 24/90 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8VDSCH GO:0016772 1/90 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8VDSCH GO:0032504 1/90 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8QJV46 GO:0008270 3/10 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QJV46 GO:0003676 1/10 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QJV46 GO:0046872 1/10 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84F8RV GO:0003723 2/4 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG84F8RV GO:0004809 2/4 tRNA (guanine-N2-)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32] EOG8CVJQ4 GO:0030314 1/110 junctional membrane complex cellular_component "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622] EOG84J4ZS GO:0031965 2/82 nuclear membrane cellular_component "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] EOG84J4ZS GO:0005643 2/82 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG84J4ZS GO:0015031 2/82 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG84J4ZS GO:0051028 2/82 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG84J4ZS GO:0022008 1/82 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8VDSCD GO:0005524 26/105 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VDSCD GO:0003677 25/105 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VDSCD GO:0004386 24/105 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8VDSCD GO:0016740 1/105 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8VDSCD GO:0042742 1/105 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8VDSCD GO:0032508 1/105 DNA duplex unwinding biological_process "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] EOG8VDSCD GO:0006963 1/105 positive regulation of antibacterial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] EOG8VDSCD GO:0008063 1/105 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8VDSCD GO:0003676 1/105 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VDSCD GO:0019730 1/105 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG8VDSCD GO:0004003 1/105 ATP-dependent DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] EOG8VDSCD GO:0045087 1/105 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG87M4F5 GO:0005506 1/39 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG87M4F5 GO:0016705 1/39 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG87M4F5 GO:0020037 1/39 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG84TRQQ GO:0046872 19/62 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG84TRQQ GO:0022008 1/62 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8ZPH87 GO:0005524 26/109 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZPH87 GO:0008026 26/109 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8ZPH87 GO:0003676 26/109 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZPH87 GO:0046872 15/109 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZPH87 GO:0007283 14/109 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8ZPH87 GO:0007126 14/109 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8ZPH87 GO:0005737 14/109 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8ZPH87 GO:0007275 13/109 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8ZPH87 GO:0031047 13/109 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG8ZPH87 GO:0048477 11/109 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8ZPH87 GO:0030154 3/109 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8ZPH87 GO:0004386 2/109 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8ZPH87 GO:0006403 1/109 RNA localization biological_process "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] EOG8ZPH87 GO:0016246 1/109 RNA interference biological_process "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] EOG8ZPH87 GO:0008186 1/109 RNA-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] EOG8ZPH87 GO:0006342 1/109 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG8ZPH87 GO:0009994 1/109 oocyte differentiation biological_process "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] EOG8ZPH87 GO:0045451 1/109 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8ZPH87 GO:0009951 1/109 polarity specification of dorsal/ventral axis biological_process "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] EOG8ZPH87 GO:0046843 1/109 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8ZPH87 GO:0003724 1/109 RNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah] EOG8ZPH87 GO:0030423 1/109 targeting of mRNA for destruction involved in RNA interference biological_process "The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674] EOG8ZPH87 GO:0009949 1/109 polarity specification of anterior/posterior axis biological_process "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators] EOG8ZPH87 GO:0060213 1/109 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening biological_process "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] EOG8ZPH87 GO:0030720 1/109 oocyte localization involved in germarium-derived egg chamber formation biological_process "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] EOG8ZPH87 GO:0043186 1/109 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG8ZPH87 GO:0030717 1/109 karyosome formation biological_process "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] EOG8ZPH87 GO:0007294 1/109 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8ZPH87 GO:0006200 1/109 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8ZPH87 GO:0008298 1/109 intracellular mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] EOG8ZPH87 GO:0007076 1/109 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8ZPH87 GO:0001556 1/109 oocyte maturation biological_process "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu] EOG8ZPH87 GO:0010529 1/109 negative regulation of transposition biological_process "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] EOG8ZPH87 GO:0005634 1/109 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZPH87 GO:0007315 1/109 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8ZPH87 GO:0007317 1/109 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG8DJNB6 GO:0004190 45/113 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8DJNB6 GO:0005764 2/113 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG8DJNB6 GO:0006915 1/113 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8DJNB6 GO:0050829 1/113 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8DJNB6 GO:0035071 1/113 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8DJNB6 GO:0048102 1/113 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8DJNB6 GO:0045476 1/113 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG8DJNB6 GO:0005875 1/113 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8DJNB6 GO:0005576 1/113 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG88GZHJ GO:0046872 26/118 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG88GZHJ GO:0003676 26/118 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SJ7TK GO:0034088 9/94 maintenance of mitotic sister chromatid cohesion biological_process "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah] EOG8SJ7TK GO:0032116 9/94 SMC loading complex cellular_component "A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved." [GOC:curators, GOC:vw, PMID:10882066] EOG8SJ7TK GO:0070193 1/94 synaptonemal complex organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis." [GOC:mah] EOG8SJ7TK GO:0035327 1/94 transcriptionally active chromatin cellular_component "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] EOG8SJ7TK GO:0045893 1/94 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8SJ7TK GO:0006351 1/94 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8SJ7TK GO:0005700 1/94 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8SJ7TK GO:0007064 1/94 mitotic sister chromatid cohesion biological_process "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] EOG8SJ7TK GO:0016787 1/94 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8SJ7TK GO:0005634 1/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SJ7TK GO:0071733 1/94 transcriptional activation by promoter-enhancer looping biological_process "The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:mah, PMID:15060134, PMID:19923429] EOG8SJ7TK GO:0005515 1/94 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SJ7TK GO:0043234 1/94 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8SJ7TK GO:0006355 1/94 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8SJ7TK GO:0005654 1/94 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG8SJ7TK GO:0010628 1/94 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8QC3PM GO:0071203 3/5 WASH complex cellular_component "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875] EOG800400 GO:0046331 2/92 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG800400 GO:0006816 2/92 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG800400 GO:0005262 2/92 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG800400 GO:0005764 2/92 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG800400 GO:0044130 2/92 negative regulation of growth of symbiont in host biological_process "Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] EOG800400 GO:0006914 2/92 autophagy biological_process "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] EOG800400 GO:0006874 2/92 cellular calcium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] EOG800400 GO:0032008 2/92 positive regulation of TOR signaling biological_process "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah] EOG800400 GO:0070588 2/92 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG800400 GO:0005765 2/92 lysosomal membrane cellular_component "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] EOG800400 GO:0000046 2/92 autophagosome maturation biological_process "The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139] EOG800400 GO:0031902 2/92 late endosome membrane cellular_component "The lipid bilayer surrounding a late endosome." [GOC:pz] EOG8W6RBZ GO:0005829 1/87 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8W6RBZ GO:0007030 1/87 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8W6RBZ GO:0005794 1/87 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8W6RBZ GO:0009306 1/87 protein secretion biological_process "The controlled release of proteins from a cell." [GOC:ai] EOG8Z0DPX GO:0006952 31/85 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8Z0DPX GO:0042742 3/85 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8Z0DPX GO:0045087 3/85 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8Z0DPX GO:0005576 2/85 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z0DPX GO:0019731 1/85 antibacterial humoral response biological_process "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8Z0DPX GO:0050830 1/85 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8Z0DPX GO:0009617 1/85 response to bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] EOG8Z0DPX GO:0005615 1/85 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8Z0DPX GO:0006959 1/85 humoral immune response biological_process "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] EOG8SXQV3 GO:0016787 4/102 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8SXQV3 GO:0008477 2/102 purine nucleosidase activity molecular_function "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1] EOG8HB13F GO:0003676 3/25 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HB13F GO:0015074 2/25 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8HB13F GO:0008270 1/25 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8HB13F GO:0003964 1/25 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8GF5W3 GO:0008270 25/108 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GF5W3 GO:0005634 24/108 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GF5W3 GO:0003700 23/108 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8GF5W3 GO:0043565 23/108 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8GF5W3 GO:0016740 2/108 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8GF5W3 GO:0007391 1/108 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8GF5W3 GO:0007411 1/108 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8GF5W3 GO:0043433 1/108 negative regulation of sequence-specific DNA binding transcription factor activity biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl] EOG8GF5W3 GO:0008045 1/108 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8GF5W3 GO:0008293 1/108 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8GF5W3 GO:0070983 1/108 dendrite guidance biological_process "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] EOG8GF5W3 GO:0007507 1/108 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8GF5W3 GO:0007521 1/108 muscle cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators] EOG8GF5W3 GO:0008407 1/108 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8GF5W3 GO:0046665 1/108 amnioserosa maintenance biological_process "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf] EOG8GF5W3 GO:0045944 1/108 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8GF5W3 GO:0001102 1/108 RNA polymerase II activating transcription factor binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH] EOG8GF5W3 GO:0048542 1/108 lymph gland development biological_process "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] EOG8GF5W3 GO:0022416 1/108 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8GF5W3 GO:0008258 1/108 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8GF5W3 GO:0010468 1/108 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8GF5W3 GO:0035310 1/108 notum cell fate specification biological_process "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999] EOG8GF5W3 GO:0005515 1/108 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8GF5W3 GO:0000980 1/108 RNA polymerase II distal enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] EOG8GF5W3 GO:0007390 1/108 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG8GF5W3 GO:0006366 1/108 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8GF5W3 GO:0003705 1/108 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8GF5W3 GO:0007362 1/108 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8GF5W3 GO:0000977 1/108 RNA polymerase II regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] EOG8JDKNM GO:0050790 38/89 regulation of catalytic activity biological_process "Any process that modulates the activity of an enzyme." [GOC:ai] EOG8JDKNM GO:0004197 38/89 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8JDKNM GO:0035071 1/89 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8JDKNM GO:0008234 1/89 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8JDKNM GO:0048102 1/89 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8V19FP GO:0016021 24/98 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V19FP GO:0005216 23/98 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8V19FP GO:0070588 1/98 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8V19FP GO:0001964 1/98 startle response biological_process "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] EOG8V19FP GO:0048148 1/98 behavioral response to cocaine biological_process "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] EOG8V19FP GO:0040040 1/98 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG8V19FP GO:0007605 1/98 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8V19FP GO:0010996 1/98 response to auditory stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb] EOG8V19FP GO:0043052 1/98 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG8V19FP GO:0007608 1/98 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8V19FP GO:0007629 1/98 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8V19FP GO:0009408 1/98 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8V19FP GO:0048060 1/98 negative gravitaxis biological_process "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid] EOG8V19FP GO:0006816 1/98 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8V19FP GO:0005262 1/98 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8CJXX0 GO:0005083 25/115 GTPase regulator activity molecular_function "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] EOG8CJXX0 GO:0005524 24/115 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CJXX0 GO:0004674 13/115 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8CJXX0 GO:0004672 11/115 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8CJXX0 GO:0046330 1/115 positive regulation of JNK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8CJXX0 GO:0032006 1/115 regulation of TOR signaling biological_process "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah] EOG8CJXX0 GO:0007254 1/115 JNK cascade biological_process "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] EOG8CJXX0 GO:0070328 1/115 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG8CJXX0 GO:0016301 1/115 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8CJXX0 GO:0006468 1/115 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8CJXX0 GO:0007030 1/115 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8CJXX0 GO:0006915 1/115 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8CJXX0 GO:0031931 1/115 TORC1 complex cellular_component "A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787] EOG8CJXX0 GO:0046626 1/115 regulation of insulin receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8CJXX0 GO:0004702 1/115 receptor signaling protein serine/threonine kinase activity molecular_function "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] EOG8CJXX0 GO:0040009 1/115 regulation of growth rate biological_process "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah] EOG8CJXX0 GO:0043065 1/115 positive regulation of apoptotic process biological_process "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8CJXX0 GO:0005737 1/115 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8CJXX0 GO:0032008 1/115 positive regulation of TOR signaling biological_process "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah] EOG8CJXX0 GO:0008361 1/115 regulation of cell size biological_process "Any process that modulates the size of a cell." [GOC:go_curators] EOG8CJXX0 GO:0048149 1/115 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8CJXX0 GO:0042059 1/115 negative regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8V19FT GO:0005615 1/22 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG83R64D GO:0004792 1/5 thiosulfate sulfurtransferase activity molecular_function "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884] EOG8GB9M7 GO:0031463 1/174 Cul3-RING ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] EOG8GB9M7 GO:0006919 1/174 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG8GB9M7 GO:0007291 1/174 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8GB9M7 GO:0016567 1/174 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG8GB9M6 GO:0003676 17/52 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GB9M6 GO:0046872 17/52 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GB9M6 GO:0005634 2/52 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GB9M6 GO:0003677 1/52 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GB9M6 GO:0006351 1/52 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8GB9M6 GO:0006355 1/52 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8GB9M6 GO:0007275 1/52 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8GB9M6 GO:0008270 1/52 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8XKXN9 GO:0003677 21/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8XKXN9 GO:0006351 21/102 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8XKXN9 GO:0005634 21/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XKXN9 GO:0046872 14/102 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XKXN9 GO:0006909 1/102 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8XKXN9 GO:0008157 1/102 protein phosphatase 1 binding molecular_function "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] EOG870WX7 GO:0005634 28/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG870WX7 GO:0003677 28/103 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG870WX7 GO:0006355 3/103 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG870WX7 GO:0008587 3/103 imaginal disc-derived wing margin morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG870WX7 GO:0007379 3/103 segment specification biological_process "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG870WX7 GO:0016055 3/103 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG870WX7 GO:0046530 3/103 photoreceptor cell differentiation biological_process "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732] EOG870WX7 GO:0016568 3/103 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG870WX7 GO:0006351 3/103 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG870WX7 GO:0042058 1/103 regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG870WX7 GO:0005515 1/103 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG870WX7 GO:0014017 1/103 neuroblast fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] EOG870WX7 GO:0022008 1/103 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG870WX7 GO:0007476 1/103 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG870WX7 GO:0007480 1/103 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG870WX7 GO:0008586 1/103 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG870WX7 GO:0035060 1/103 brahma complex cellular_component "A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982] EOG870WX7 GO:0048190 1/103 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG870WX7 GO:0045893 1/103 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8TQPS1 GO:0008270 1/11 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TQPS1 GO:0002100 1/11 tRNA wobble adenosine to inosine editing biological_process "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X] EOG8TQPS1 GO:0008251 1/11 tRNA-specific adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] EOG8C5G2Q GO:0046872 27/45 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8C5G2Q GO:0055065 2/45 metal ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] EOG8C5G2Q GO:0010038 2/45 response to metal ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] EOG8C5G2Q GO:0005507 1/45 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8C5G2Q GO:0005515 1/45 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8W3W2J GO:0000166 28/119 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8W3W2J GO:0003676 27/119 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W3W2J GO:0003729 1/119 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8H48M4 GO:0016021 1/3 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8H48M4 GO:0005524 1/3 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8H48M4 GO:0004222 1/3 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8H48M4 GO:0008270 1/3 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82NMFB GO:0016020 9/123 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82NMFB GO:0007157 1/123 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] EOG8F4VSW GO:0016021 252/803 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F4VSW GO:0006633 246/803 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8F4VSW GO:0016740 246/803 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8F4VSW GO:0009922 7/803 fatty acid elongase activity molecular_function "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] EOG8F4VSW GO:0030497 7/803 fatty acid elongation biological_process "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094] EOG8F4VSW GO:0022008 1/803 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8F4VSW GO:0051225 1/803 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG8F4VSW GO:0007112 1/803 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG8F4VSW GO:0042761 1/803 very long-chain fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators] EOG8F4VSW GO:0007110 1/803 meiosis I cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8F4VSW GO:0000915 1/803 actomyosin contractile ring assembly biological_process "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] EOG8F4VSW GO:0007111 1/803 meiosis II cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8F4VSW GO:0030176 1/803 integral component of endoplasmic reticulum membrane cellular_component "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] EOG8F4VSW GO:0000212 1/803 meiotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] EOG8P2SH4 GO:0008234 43/140 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8P2SH4 GO:0035071 1/140 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8P2SH4 GO:0005764 1/140 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG8P2SH4 GO:0045169 1/140 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG8P2SH4 GO:0005524 1/140 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8P2SH4 GO:0007586 1/140 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG8P2SH4 GO:0048102 1/140 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8P2SH4 GO:0016021 1/140 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8P2SH4 GO:0042626 1/140 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8ZKN28 GO:0008168 24/162 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8ZKN28 GO:0030798 11/162 trans-aconitate 2-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972] EOG837TW7 GO:0005887 1/69 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8THZ7J GO:0016021 25/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8THZ7J GO:0005337 25/88 nucleoside transmembrane transporter activity molecular_function "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] EOG84QWFC GO:0004725 25/101 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG84QWFC GO:0005856 24/101 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG84QWFC GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84QWFC GO:0035331 1/101 negative regulation of hippo signaling biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf] EOG84QWFC GO:0006470 1/101 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG84QWFC GO:0005938 1/101 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG84QWFC GO:0008092 1/101 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG84QWFC GO:0019898 1/101 extrinsic component of membrane cellular_component "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] EOG84QWFC GO:2000647 1/101 negative regulation of stem cell proliferation biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph] EOG84QWFC GO:0045177 1/101 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG84QWFC GO:0050254 1/101 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG84QWFC GO:0035335 1/101 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG8M680T GO:0016021 1/15 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M680T GO:0004930 1/15 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8WHC0J GO:0006606 22/109 protein import into nucleus biological_process "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] EOG8WHC0J GO:0005643 22/109 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG8WHC0J GO:0003712 1/109 transcription cofactor activity molecular_function "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8WHC0J GO:0031490 1/109 chromatin DNA binding molecular_function "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah] EOG8WHC0J GO:0007346 1/109 regulation of mitotic cell cycle biological_process "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8WHC0J GO:0005652 1/109 nuclear lamina cellular_component "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363] EOG8WHC0J GO:0007094 1/109 mitotic spindle assembly checkpoint biological_process "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190] EOG8WHC0J GO:0045944 1/109 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8WHC0J GO:0006338 1/109 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG8WHC0J GO:0051028 1/109 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8WHC0J GO:0090235 1/109 regulation of metaphase plate congression biological_process "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8WHC0J GO:0005719 1/109 nuclear euchromatin cellular_component "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732] EOG8WHC0J GO:0090316 1/109 positive regulation of intracellular protein transport biological_process "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] EOG8WHC0J GO:0016363 1/109 nuclear matrix cellular_component "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] EOG8WHC0J GO:0005515 1/109 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WHC0J GO:0005819 1/109 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8WHC0J GO:0008270 1/109 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WHC0J GO:0051225 1/109 spindle assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] EOG8WHC0J GO:1990047 1/109 spindle matrix cellular_component "A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis." [GOC:ans, PMID:19273613, PMID:22855526] EOG8WHC0J GO:0030496 1/109 midbody cellular_component "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] EOG8WHC0J GO:0005737 1/109 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WHC0J GO:0072686 1/109 mitotic spindle cellular_component "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] EOG8WHC0J GO:0051781 1/109 positive regulation of cell division biological_process "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] EOG8WHC0J GO:0045840 1/109 positive regulation of mitotic nuclear division biological_process "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] EOG8WHC0J GO:0000022 1/109 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG8WHC0J GO:0006351 1/109 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8WHC0J GO:0034401 1/109 chromatin organization involved in regulation of transcription biological_process "Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators] EOG8WHC0J GO:0034399 1/109 nuclear periphery cellular_component "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] EOG8WHC0J GO:0090267 1/109 positive regulation of mitotic cell cycle spindle assembly checkpoint biological_process "Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw] EOG8WHC0J GO:0010965 1/109 regulation of mitotic sister chromatid separation biological_process "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb] EOG8WHC0J GO:0000775 1/109 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG8WHC0J GO:0060236 1/109 regulation of mitotic spindle organization biological_process "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8WHC0J GO:0031965 1/109 nuclear membrane cellular_component "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] EOG8WHC0J GO:0009408 1/109 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8WHC0J GO:0051233 1/109 spindle midzone cellular_component "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] EOG8WHC0J GO:0070090 1/109 metaphase plate cellular_component "The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division." [GOC:mah] EOG8WHC0J GO:0005634 1/109 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WHC0J GO:0042405 1/109 nuclear inclusion body cellular_component "An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl] EOG8WHC0J GO:0007067 1/109 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8WHC0J GO:0005635 1/109 nuclear envelope cellular_component "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] EOG8WHC0J GO:0004402 1/109 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8WHC0J GO:1901673 1/109 regulation of mitotic spindle assembly biological_process "Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie] EOG8WHC0J GO:0006355 1/109 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8WHC0J GO:0005730 1/109 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8P2SH7 GO:0003677 28/115 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8P2SH7 GO:0003887 28/115 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8P2SH7 GO:0005634 1/115 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8P2SH7 GO:0006974 1/115 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8P2SH7 GO:0007052 1/115 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8P2SH7 GO:0005875 1/115 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8HQH0K GO:0004047 24/87 aminomethyltransferase activity molecular_function "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] EOG8HQH0K GO:0005737 24/87 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HQH0K GO:0006546 24/87 glycine catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] EOG8HQH0K GO:0008483 24/87 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG8HQH0K GO:0005811 1/87 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG805VG6 GO:0005622 4/10 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG805VG6 GO:0004198 4/10 calcium-dependent cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] EOG805VG7 GO:0005506 679/2000 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG805VG7 GO:0020037 679/2000 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG805VG7 GO:0016705 629/2000 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG805VG7 GO:0004497 607/2000 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG805VG7 GO:0070330 31/2000 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG805VG7 GO:0005789 25/2000 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG805VG7 GO:0050591 15/2000 quinine 3-monooxygenase activity molecular_function "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152] EOG805VG7 GO:0004796 4/2000 thromboxane-A synthase activity molecular_function "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140] EOG805VG7 GO:0031000 2/2000 response to caffeine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] EOG805VG7 GO:0009055 2/2000 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG805VG7 GO:0016712 2/2000 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] EOG805VG7 GO:0017085 2/2000 response to insecticide biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] EOG805VG7 GO:0006697 1/2000 ecdysone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] EOG805VG7 GO:0050829 1/2000 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG805VG7 GO:0030178 1/2000 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG805VG7 GO:0017143 1/2000 insecticide metabolic process biological_process "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai] EOG805VG7 GO:0046701 1/2000 insecticide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai] EOG805VG7 GO:0022416 1/2000 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG805VG7 GO:0042742 1/2000 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG805VG7 GO:0048252 1/2000 lauric acid metabolic process biological_process "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid] EOG805VG7 GO:0016020 1/2000 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG805VG7 GO:1901563 1/2000 response to camptothecin biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie] EOG805VG7 GO:0018685 1/2000 alkane 1-monooxygenase activity molecular_function "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] EOG805VG7 GO:0033777 1/2000 lithocholate 6beta-hydroxylase activity molecular_function "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860] EOG805VG7 GO:0002118 1/2000 aggressive behavior biological_process "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] EOG805VG7 GO:0046683 1/2000 response to organophosphorus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544] EOG805VG7 GO:0035220 1/2000 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG805VG7 GO:0048638 1/2000 regulation of developmental growth biological_process "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] EOG805VG7 GO:0040040 1/2000 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG805VG7 GO:0046680 1/2000 response to DDT biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544] EOG805VG7 GO:0046689 1/2000 response to mercury ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai] EOG808QT9 GO:0005975 1/6 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG808QT9 GO:0009253 1/6 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG808QT9 GO:0003796 1/6 lysozyme activity molecular_function "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] EOG808QT9 GO:0016998 1/6 cell wall macromolecule catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] EOG8M945N GO:0003676 11/63 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8M945N GO:0046872 11/63 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M945C GO:0044267 23/106 cellular protein metabolic process biological_process "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] EOG8M945C GO:0005524 23/106 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M945C GO:0016307 20/106 phosphatidylinositol phosphate kinase activity molecular_function "Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495] EOG8M945C GO:0046872 19/106 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M945C GO:0035556 18/106 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8M945C GO:0000285 3/106 1-phosphatidylinositol-3-phosphate 5-kinase activity molecular_function "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612] EOG8M945C GO:0005768 1/106 endosome cellular_component "A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] EOG8M945C GO:0000046 1/106 autophagosome maturation biological_process "The process in which autophagosomes, double-membraned vacuoles containing cytoplasmic material fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [GOC:autophagy, GOC:lf, PMID:11099404, PMID:16874026, PMID:17534139] EOG8M945C GO:0016308 1/106 1-phosphatidylinositol-4-phosphate 5-kinase activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14428] EOG8M945C GO:0010008 1/106 endosome membrane cellular_component "The lipid bilayer surrounding an endosome." [GOC:mah] EOG8M945C GO:0008333 1/106 endosome to lysosome transport biological_process "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] EOG8M945C GO:0046854 1/106 phosphatidylinositol phosphorylation biological_process "The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732] EOG8M945C GO:0016310 1/106 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8M945C GO:0008270 1/106 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M945C GO:0012506 1/106 vesicle membrane cellular_component "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah] EOG8F20HF GO:0003677 1/114 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8S4RX5 GO:0004252 53/134 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8S4RX5 GO:0005576 2/134 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8S4RX5 GO:0003824 1/134 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8S4RX5 GO:0006508 1/134 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8GJ22Z GO:0046872 15/127 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GJ22Z GO:0006886 15/127 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8GJ22Z GO:0070073 1/127 clustering of voltage-gated calcium channels biological_process "The process in which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:18385325] EOG8GJ22Z GO:0048786 1/127 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG8GJ22Z GO:0007269 1/127 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8GJ22Z GO:0008021 1/127 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8GJ22Z GO:0048167 1/127 regulation of synaptic plasticity biological_process "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290] EOG8GJ22Z GO:0016079 1/127 synaptic vesicle exocytosis biological_process "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] EOG8GJ22Z GO:0007274 1/127 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8GJ22Z GO:0016192 1/127 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8T4G91 GO:0005737 23/89 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T4G91 GO:0004177 23/89 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8T4G91 GO:0008235 23/89 metalloexopeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] EOG8T4G91 GO:0030145 23/89 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG8T4G91 GO:0008240 1/89 tripeptidyl-peptidase activity molecular_function "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah] EOG8T4G91 GO:0006508 1/89 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8T4G91 GO:0008239 1/89 dipeptidyl-peptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG87DD05 GO:0003676 5/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG87DD05 GO:0003677 1/18 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8V71X1 GO:0004185 56/160 serine-type carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8V71X1 GO:0005576 1/160 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8V71X1 GO:0033227 1/160 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8GQSK1 GO:0006511 26/93 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8GQSK1 GO:0004843 24/93 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709] EOG8GQSK1 GO:0008270 11/93 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GQSK1 GO:0008234 2/93 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8GQSK1 GO:0007399 1/93 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8GQSK1 GO:0016579 1/93 protein deubiquitination biological_process "The removal of one or more ubiquitin groups from a protein." [GOC:ai] EOG8M945T GO:0016021 82/190 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M945T GO:0022857 58/190 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8M945T GO:0055085 24/190 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8M945T GO:0005215 10/190 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG80S2X7 GO:0003677 4/29 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80S2X7 GO:0004518 4/29 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG80S2X7 GO:0008270 2/29 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S1WNT GO:0016021 13/53 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S1WNT GO:0005230 7/53 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8S1WNT GO:0030054 6/53 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8S1WNT GO:0045211 6/53 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8S1WNT GO:0004889 6/53 acetylcholine-activated cation-selective channel activity molecular_function "Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967] EOG8C8B6G GO:0008270 21/106 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8C8B6G GO:0005634 21/106 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8C8B6G GO:0003677 20/106 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8C8B6G GO:0046872 3/106 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8C8B6G GO:0006355 1/106 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8C8B6G GO:0005705 1/106 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG8C8B6G GO:0045944 1/106 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8C8B6G GO:0022008 1/106 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8C8B6G GO:0044545 1/106 NSL complex cellular_component "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852] EOG8C8B6G GO:0003676 1/106 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8C8B6G GO:0007095 1/106 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8C8B6G GO:0035327 1/106 transcriptionally active chromatin cellular_component "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] EOG89KJ63 GO:0005615 4/10 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG89KJ63 GO:0008233 1/10 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG89CSP0 GO:0030170 24/89 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG89CSP0 GO:0019752 21/89 carboxylic acid metabolic process biological_process "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] EOG89CSP0 GO:0016831 20/89 carboxy-lyase activity molecular_function "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/] EOG89CSP0 GO:0003824 3/89 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG89CSP0 GO:0004837 1/89 tyrosine decarboxylase activity molecular_function "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25] EOG8HQH1R GO:0016020 1/50 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HQH1R GO:0016192 1/50 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8HHRG7 GO:0005083 4/51 GTPase regulator activity molecular_function "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] EOG8HHRG7 GO:0046872 4/51 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HHRG7 GO:0035556 4/51 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8HHRG7 GO:0004674 4/51 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8HHRG7 GO:0005524 4/51 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VHNMB GO:0016021 3/11 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VHNMB GO:0005216 3/11 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8V71WJ GO:0016491 25/79 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8V71WJ GO:0006546 24/79 glycine catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] EOG8V71WJ GO:0005737 24/79 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8V71WJ GO:0004047 24/79 aminomethyltransferase activity molecular_function "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] EOG8V71WJ GO:0016787 1/79 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8MKQXZ GO:0004930 2/4 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8MKQXZ GO:0016021 2/4 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MKQXZ GO:0004715 1/4 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8B5RKS GO:0004185 64/157 serine-type carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8KD91M GO:0004402 2/94 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8KD91M GO:0009405 1/94 pathogenesis biological_process "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] EOG8KD91M GO:0005576 1/94 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8KD91M GO:0051297 1/94 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8KD91M GO:0008200 1/94 ion channel inhibitor activity molecular_function "Stops, prevents, or reduces the activity of an ion channel." [GOC:mah] EOG8JWXVH GO:0003968 9/121 RNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] EOG8JWXVH GO:0008080 5/121 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8G4K4R GO:0016534 28/115 cyclin-dependent protein kinase 5 activator activity molecular_function "Binds to and increases the activity of cyclin-dependent protein kinase 5." [GOC:mah] EOG8G4K4R GO:0016533 28/115 cyclin-dependent protein kinase 5 holoenzyme complex cellular_component "A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [PMID:15689152] EOG8G4K4R GO:0016301 6/115 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8G4K4R GO:0007409 1/115 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8G4K4R GO:0004693 1/115 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG8G4K4R GO:0043025 1/115 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8G4K4R GO:0035011 1/115 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG8G4K4R GO:0030426 1/115 growth cone cellular_component "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] EOG8G4K4R GO:0030424 1/115 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8G4K4R GO:0030425 1/115 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8G4K4R GO:0070059 1/115 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708] EOG8G4K4R GO:0008045 1/115 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8G4K4R GO:0008344 1/115 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8G4K4R GO:0071902 1/115 positive regulation of protein serine/threonine kinase activity biological_process "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] EOG8G4K4R GO:0008340 1/115 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8Q2GW6 GO:0003995 76/231 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG8Q2GW6 GO:0050660 74/231 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8Q2GW6 GO:0048813 1/231 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8Q2GW6 GO:0006367 1/231 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8Q2GW6 GO:0005739 1/231 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8Q2GW6 GO:0001104 1/231 RNA polymerase II transcription cofactor activity molecular_function "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8Q2GW6 GO:0006357 1/231 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8Q2GW6 GO:0016592 1/231 mediator complex cellular_component "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] EOG8Q2GW6 GO:0043958 1/231 acryloyl-CoA reductase activity molecular_function "Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323] EOG8FBM8G GO:0046872 24/133 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FBM8G GO:0007476 1/133 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8FBM8G GO:0009790 1/133 embryo development biological_process "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] EOG8FBM8G GO:0000381 1/133 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8FBM8G GO:0003676 1/133 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FBM8G GO:0003677 1/133 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FBM8G GO:0001751 1/133 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG8FBM8G GO:0007601 1/133 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8FBM8G GO:0007525 1/133 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG8FBM8G GO:0048471 1/133 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8FBM8G GO:0046716 1/133 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG8FBM8G GO:0005737 1/133 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8FBM8G GO:0042052 1/133 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8FBM8G GO:0007422 1/133 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8FBM8G GO:0006915 1/133 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8FBM8G GO:0007517 1/133 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8FBM8G GO:0045924 1/133 regulation of female receptivity biological_process "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb] EOG8FBM8G GO:0005634 1/133 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FBM8G GO:0010468 1/133 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8MKQXF GO:0003676 7/27 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG81K1SR GO:0008270 44/198 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81K1SR GO:0043154 1/198 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG81K1SR GO:0007423 1/198 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG81K1SR GO:0004842 1/198 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG81K1SR GO:0003677 1/198 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81K1SR GO:0007289 1/198 spermatid nucleus differentiation biological_process "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] EOG81K1SR GO:0007283 1/198 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG81K1SR GO:0019788 1/198 NEDD8 transferase activity molecular_function "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah] EOG81K1SR GO:0005737 1/198 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG81K1SR GO:0007298 1/198 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG81K1SR GO:0051865 1/198 protein autoubiquitination biological_process "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai] EOG81K1SR GO:0006352 1/198 DNA-templated transcription, initiation biological_process "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] EOG81K1SR GO:0008407 1/198 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG81K1SR GO:0009987 1/198 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG81K1SR GO:0007275 1/198 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG81K1SR GO:0008354 1/198 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG81K1SR GO:0045035 1/198 sensory organ precursor cell division biological_process "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] EOG81K1SR GO:0048800 1/198 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG81K1SR GO:1990001 1/198 inhibition of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process." [GOC:mtg_apoptosis, PMID:11943137] EOG81K1SR GO:0005634 1/198 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81K1SR GO:0005515 1/198 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG81K1SR GO:0046673 1/198 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG81K1SR GO:0031398 1/198 positive regulation of protein ubiquitination biological_process "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] EOG81K1SR GO:0016055 1/198 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG81K1SR GO:0097340 1/198 inhibition of cysteine-type endopeptidase activity biological_process "Any process that prevents the activation of an inactive cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:20383739] EOG81K1SR GO:0019899 1/198 enzyme binding molecular_function "Interacting selectively and non-covalently with any enzyme." [GOC:jl] EOG81K1SR GO:0090263 1/198 positive regulation of canonical Wnt signaling pathway biological_process "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] EOG81K1SR GO:0043066 1/198 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG81K1SR GO:0042787 1/198 protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological_process "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] EOG81K1SR GO:0006915 1/198 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG81K1SR GO:0004869 1/198 cysteine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb] EOG81K1SS GO:0007476 1/91 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG81K1SS GO:0048149 1/91 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG81K1SS GO:0048865 1/91 stem cell fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete] EOG81K1SS GO:0007601 1/91 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG81K1SS GO:0042461 1/91 photoreceptor cell development biological_process "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] EOG81K1SS GO:0001751 1/91 compound eye photoreceptor cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] EOG81K1SS GO:0097038 1/91 perinuclear endoplasmic reticulum cellular_component "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] EOG81K1SS GO:0007421 1/91 stomatogastric nervous system development biological_process "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid] EOG81K1SS GO:0005794 1/91 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG81K1SS GO:0007173 1/91 epidermal growth factor receptor signaling pathway biological_process "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] EOG81K1SS GO:0005789 1/91 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG81K1SS GO:0005886 1/91 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG81K1SS GO:0035225 1/91 determination of genital disc primordium biological_process "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318] EOG81K1SS GO:0000139 1/91 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG81K1SS GO:0042058 1/91 regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG81K1SS GO:0048477 1/91 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG81K1SS GO:0061331 1/91 epithelial cell proliferation involved in Malpighian tubule morphogenesis biological_process "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] EOG81K1SS GO:0016318 1/91 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG81K1SS GO:0046667 1/91 compound eye retinal cell programmed cell death biological_process "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] EOG81K1SS GO:0000042 1/91 protein targeting to Golgi biological_process "The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah] EOG81K1SS GO:0007422 1/91 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG81K1SS GO:0007498 1/91 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG81K1SS GO:0038004 1/91 epidermal growth factor receptor ligand maturation biological_process "Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor." [GOC:signaling, PMID:11672524] EOG81K1SS GO:0016021 1/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81K1SS GO:0016020 1/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG81K1SS GO:0005783 1/91 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG81K1SS GO:0046845 1/91 branched duct epithelial cell fate determination, open tracheal system biological_process "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581] EOG8KM1H5 GO:0051539 24/91 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8KM1H5 GO:0009451 24/91 RNA modification biological_process "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337] EOG8KM1H5 GO:0016740 23/91 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8KM1H5 GO:0032440 2/91 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8KM1H5 GO:0003824 2/91 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8KM1H5 GO:0000079 1/91 regulation of cyclin-dependent protein serine/threonine kinase activity biological_process "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] EOG8KM1H5 GO:0046872 1/91 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KM1H5 GO:0051536 1/91 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8Q87BP GO:0051287 44/136 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8Q87BP GO:0048038 44/136 quinone binding molecular_function "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732] EOG8Q87BP GO:0016651 40/136 oxidoreductase activity, acting on NAD(P)H molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8Q87BP GO:0003954 2/136 NADH dehydrogenase activity molecular_function "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] EOG8Q87BP GO:0008137 2/136 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8Q87BP GO:0005739 1/136 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8Q87BP GO:0048812 1/136 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8Q87BP GO:0046331 1/136 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8DBWVS GO:0052726 11/51 inositol-1,3,4-trisphosphate 5-kinase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134] EOG8DBWVS GO:0047325 11/51 inositol tetrakisphosphate 1-kinase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN] EOG8DBWVS GO:0032957 11/51 inositol trisphosphate metabolic process biological_process "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [CHEBI:24540, CHEBI:24848, GOC:mah] EOG8DBWVS GO:0052725 11/51 inositol-1,3,4-trisphosphate 6-kinase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134] EOG8DBWVS GO:0000287 11/51 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8DBWVS GO:0005524 11/51 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DBWVS GO:0005622 11/51 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8DBWVR GO:0004850 58/135 uridine phosphorylase activity molecular_function "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3] EOG8DBWVR GO:0005737 56/135 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8DBWVR GO:0009166 56/135 nucleotide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] EOG8DBWVR GO:0009116 44/135 nucleoside metabolic process biological_process "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] EOG8DBWVR GO:0044206 15/135 UMP salvage biological_process "Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496] EOG8DBWVR GO:0016763 1/135 transferase activity, transferring pentosyl groups molecular_function "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8DBWVR GO:0000123 1/135 histone acetyltransferase complex cellular_component "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] EOG8DBWVR GO:0042332 1/135 gravitaxis biological_process "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] EOG8Q87BX GO:0004748 1/8 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor molecular_function "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1] EOG8Q87BX GO:0006260 1/8 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8P8J1V GO:0003677 1/7 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8P8J1V GO:0016740 1/7 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8P8J1V GO:0008270 1/7 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83JFJJ GO:0035556 82/275 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG83JFJJ GO:0016021 78/275 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83JFJJ GO:0000166 76/275 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG83JFJJ GO:0004016 72/275 adenylate cyclase activity molecular_function "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] EOG83JFJJ GO:0009190 12/275 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG83JFJJ GO:0016849 11/275 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG83JFJJ GO:0006171 3/275 cAMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] EOG83JFJJ GO:0007611 1/275 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG83JFJJ GO:0007186 1/275 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG83JFJJ GO:0001582 1/275 detection of chemical stimulus involved in sensory perception of sweet taste biological_process "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] EOG83JFJJ GO:0046872 1/275 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83JFJJ GO:0007614 1/275 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG83JFJJ GO:0007619 1/275 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG83JFJJ GO:0007617 1/275 mating behavior biological_process "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] EOG83JFJJ GO:0001661 1/275 conditioned taste aversion biological_process "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] EOG83JFJJ GO:0007591 1/275 molting cycle, chitin-based cuticle biological_process "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] EOG83JFJJ GO:0005524 1/275 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83JFJJ GO:0007612 1/275 learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] EOG83JFJJ GO:0007268 1/275 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG83JFJJ GO:0004383 1/275 guanylate cyclase activity molecular_function "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] EOG83JFJJ GO:0008306 1/275 associative learning biological_process "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] EOG83JFJJ GO:0042302 1/275 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG83JFJJ GO:0009744 1/275 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG83JFJJ GO:0008340 1/275 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG83JFJJ GO:0016020 1/275 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG83JFJJ GO:0010353 1/275 response to trehalose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512] EOG83JFJJ GO:0048149 1/275 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG83JFJJ GO:0008294 1/275 calcium- and calmodulin-responsive adenylate cyclase activity molecular_function "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah] EOG83JFJJ GO:0009408 1/275 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG83JFJJ GO:0007625 1/275 grooming behavior biological_process "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr] EOG83JFJJ GO:0007613 1/275 memory biological_process "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] EOG83JFJJ GO:0003676 1/275 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83JFJJ GO:0010738 1/275 regulation of protein kinase A signaling biological_process "Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] EOG83JFJJ GO:0019933 1/275 cAMP-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] EOG83JFJJ GO:0031000 1/275 response to caffeine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] EOG83JFJJ GO:0090328 1/275 regulation of olfactory learning biological_process "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb] EOG83JFJJ GO:0030431 1/275 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG83JFJJ GO:0048675 1/275 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG83JFJJ GO:0004930 1/275 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG83JFJJ GO:0008355 1/275 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG83JFJJ GO:0007274 1/275 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG83JFJJ GO:0007528 1/275 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG83JFJJ GO:0006979 1/275 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8KD915 GO:0004634 1/6 phosphopyruvate hydratase activity molecular_function "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732] EOG8KD915 GO:0000015 1/6 phosphopyruvate hydratase complex cellular_component "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732] EOG8KD915 GO:0006096 1/6 glycolytic process biological_process "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] EOG8KD915 GO:0000287 1/6 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8KD915 GO:0003924 1/6 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8KD915 GO:0005525 1/6 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8RFP7N GO:0030246 26/95 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8QVFV7 GO:0007229 4/28 integrin-mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] EOG8QVFV7 GO:0016021 3/28 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QVFV7 GO:0007155 3/28 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG85QKT4 GO:0005319 22/91 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG85QKT4 GO:0042157 1/91 lipoprotein metabolic process biological_process "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732] EOG85QKT4 GO:0015914 1/91 phospholipid transport biological_process "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai] EOG85QKT4 GO:0035149 1/91 lumen formation, open tracheal system biological_process "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] EOG85QKT4 GO:0048813 1/91 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG85QKT4 GO:0008525 1/91 phosphatidylcholine transporter activity molecular_function "Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732] EOG85QKT4 GO:0005811 1/91 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG85QKT4 GO:0008039 1/91 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG84BDG9 GO:0006869 4/29 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG84BDG9 GO:0008270 1/29 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG84BDG9 GO:0004222 1/29 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG81K1S7 GO:0003834 3/101 beta-carotene 15,15'-monooxygenase activity molecular_function "Catalysis of the reaction: beta-carotene + O(2) = 2 retinal." [EC:1.14.99.36, RHEA:10407] EOG81K1S7 GO:0004497 2/101 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG81K1S7 GO:0007602 1/101 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG81K1S7 GO:0009110 1/101 vitamin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732] EOG81K1S7 GO:0046872 1/101 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81K1S7 GO:0010436 1/101 carotenoid dioxygenase activity molecular_function "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333] EOG81K1S7 GO:0016119 1/101 carotene metabolic process biological_process "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684] EOG81K1S7 GO:0004744 1/101 retinal isomerase activity molecular_function "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [RHEA:24127] EOG81K1S7 GO:0035238 1/101 vitamin A biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606] EOG81K1S7 GO:0042574 1/101 retinal metabolic process biological_process "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [CHEBI:15035, GOC:curators, ISBN:0198506732] EOG81K1S7 GO:0016063 1/101 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG81K1S7 GO:0042572 1/101 retinol metabolic process biological_process "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] EOG8CVJMV GO:0000166 3/103 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8CVJMV GO:0003676 3/103 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CVJMV GO:0051301 3/103 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8CVJMV GO:0045842 1/103 positive regulation of mitotic metaphase/anaphase transition biological_process "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] EOG8CVJMV GO:0000398 1/103 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8CVJMV GO:0005634 1/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CVJMV GO:0008054 1/103 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation biological_process "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions via the negative regulation of a cyclin-dependent kinase." [GOC:mah, PMID:15840442] EOG8CVJMV GO:0090302 1/103 APC-Cdc20 complex activity molecular_function "A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] EOG8CVJMV GO:0009987 1/103 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8CVJMV GO:0005680 1/103 anaphase-promoting complex cellular_component "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] EOG8CVJMV GO:0071011 1/103 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8CVJMV GO:0000278 1/103 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8CVJMV GO:0022008 1/103 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CVJMV GO:0007067 1/103 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8KD918 GO:0016021 1/99 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KD918 GO:0000166 1/99 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8KD918 GO:0002121 1/99 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8KD918 GO:0019829 1/99 cation-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] EOG8KD918 GO:0016363 1/99 nuclear matrix cellular_component "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] EOG8KD918 GO:0008586 1/99 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8KD918 GO:0046872 1/99 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG89S8R9 GO:0016614 1/2 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG82C0RN GO:0006030 16/42 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG82C0RN GO:0008061 16/42 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG82C0RN GO:0005576 16/42 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80VZ4V GO:0004514 30/115 nicotinate-nucleotide diphosphorylase (carboxylating) activity molecular_function "Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [EC:2.4.2.19, RHEA:12736] EOG80VZ4V GO:0009435 30/115 NAD biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] EOG80VZ4V GO:0004516 22/115 nicotinate phosphoribosyltransferase activity molecular_function "Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [EC:2.4.2.11, RHEA:13396] EOG80VZ4V GO:0019358 22/115 nicotinate nucleotide salvage biological_process "The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators] EOG80VZ4V GO:0016763 1/115 transferase activity, transferring pentosyl groups molecular_function "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG80VZ4V GO:0005829 1/115 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG80VZ4V GO:0006979 1/115 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG80VZ4V GO:0016874 1/115 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG89KJ6R GO:0009890 1/18 negative regulation of biosynthetic process biological_process "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] EOG80P6ND GO:0016021 230/726 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80P6ND GO:0022891 177/726 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG80P6ND GO:0022857 38/726 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG80P6ND GO:0008643 18/726 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG80P6ND GO:0005886 18/726 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80P6ND GO:0015771 15/726 trehalose transport biological_process "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai] EOG80P6ND GO:0015574 15/726 trehalose transmembrane transporter activity molecular_function "Enables the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] EOG80P6ND GO:0032440 8/726 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG80P6ND GO:0016020 2/726 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG80P6ND GO:0046427 1/726 positive regulation of JAK-STAT cascade biological_process "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] EOG8MD0DB GO:0016020 1/6 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8MD0DB GO:0008137 1/6 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8MD0DB GO:0042773 1/6 ATP synthesis coupled electron transport biological_process "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] EOG8MD0DB GO:0051536 1/6 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8MD0DB GO:0009055 1/6 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8ZKN42 GO:0004222 10/58 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8ZKN42 GO:0008270 10/58 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8ZKN42 GO:0031012 10/58 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8ZKN42 GO:0003676 1/58 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8ZKN42 GO:0003887 1/58 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8ZKN42 GO:0046872 1/58 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZKN42 GO:0008408 1/58 3'-5' exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] EOG8ZKN42 GO:0000166 1/58 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8ZKN42 GO:0003677 1/58 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG87H83S GO:0005694 27/103 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG87H83S GO:0005524 26/103 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG87H83S GO:0051276 26/103 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG87H83S GO:0006281 21/103 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG87H83S GO:0005634 21/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG87H83S GO:0006310 21/103 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG87H83S GO:0007052 1/103 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG87H83S GO:0003677 1/103 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG87H83S GO:0005737 1/103 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG87H83S GO:0016491 1/103 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG87H83S GO:0000070 1/103 mitotic sister chromatid segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] EOG87H83S GO:0000166 1/103 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG87H83S GO:0000819 1/103 sister chromatid segregation biological_process "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] EOG87H83S GO:0000785 1/103 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG87H83S GO:0007076 1/103 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG87H83S GO:0007422 1/103 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG87H83S GO:0007067 1/103 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG87H83S GO:0000796 1/103 condensin complex cellular_component "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] EOG8X3KF3 GO:0006353 7/151 DNA-templated transcription, termination biological_process "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161] EOG8X3KF3 GO:0003887 1/151 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8X3KF3 GO:0008408 1/151 3'-5' exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] EOG8X3KF3 GO:0003676 1/151 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8X3KF3 GO:0006298 1/151 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG8X3KF3 GO:0000166 1/151 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8X3KF3 GO:0004519 1/151 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8X3KF3 GO:0003677 1/151 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8MD0DH GO:0016021 29/104 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MD0DH GO:0055085 28/104 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8MD0DH GO:0005215 28/104 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8MD0DH GO:0015293 1/104 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG8MD0DH GO:0015171 1/104 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8MD0DH GO:0006814 1/104 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8MD0DH GO:0015220 1/104 choline transmembrane transporter activity molecular_function "Enables the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] EOG8MD0DH GO:0015871 1/104 choline transport biological_process "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] EOG8MD0DH GO:0003333 1/104 amino acid transmembrane transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] EOG8MD0DH GO:0008292 1/104 acetylcholine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] EOG8J6V58 GO:0004450 1/8 isocitrate dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42] EOG8J6V58 GO:0000287 1/8 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8J6V58 GO:0051287 1/8 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8J6V58 GO:0006099 1/8 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8J6V58 GO:0006097 1/8 glyoxylate cycle biological_process "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732] EOG8FXTNJ GO:0046856 12/78 phosphatidylinositol dephosphorylation biological_process "The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732] EOG8FXTNJ GO:0004439 2/78 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767] EOG8FXTNJ GO:0046030 1/78 inositol trisphosphate phosphatase activity molecular_function "Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf] EOG8FXTNJ GO:0016311 1/78 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG81G5KF GO:0030170 3/9 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG81G5KF GO:0003824 2/9 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG81G5KF GO:0031071 1/9 cysteine desulfurase activity molecular_function "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7] EOG8FN6Z0 GO:0004385 2/125 guanylate kinase activity molecular_function "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] EOG8FN6Z0 GO:0008105 1/125 asymmetric protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma] EOG8FN6Z0 GO:0042332 1/125 gravitaxis biological_process "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] EOG8FN6Z0 GO:0004871 1/125 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8FN6Z0 GO:0016336 1/125 establishment or maintenance of polarity of larval imaginal disc epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah] EOG8FN6Z0 GO:0030710 1/125 regulation of border follicle cell delamination biological_process "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261] EOG8FN6Z0 GO:0051124 1/125 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8FN6Z0 GO:0007617 1/125 mating behavior biological_process "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] EOG8FN6Z0 GO:0016334 1/125 establishment or maintenance of polarity of follicular epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah] EOG8FN6Z0 GO:0045211 1/125 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8FN6Z0 GO:0008104 1/125 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8FN6Z0 GO:0045167 1/125 asymmetric protein localization involved in cell fate determination biological_process "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai] EOG8FN6Z0 GO:0005886 1/125 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FN6Z0 GO:0060581 1/125 cell fate commitment involved in pattern specification biological_process "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph] EOG8FN6Z0 GO:0005938 1/125 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8FN6Z0 GO:0016332 1/125 establishment or maintenance of polarity of embryonic epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah] EOG8FN6Z0 GO:0005198 1/125 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8FN6Z0 GO:0051726 1/125 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8FN6Z0 GO:0016020 1/125 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FN6Z0 GO:0008285 1/125 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8FN6Z0 GO:0002009 1/125 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8FN6Z0 GO:0061176 1/125 type Ib terminal bouton cellular_component "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc] EOG8FN6Z0 GO:0016333 1/125 morphogenesis of follicular epithelium biological_process "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl] EOG8FN6Z0 GO:0005918 1/125 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG8FN6Z0 GO:0042058 1/125 regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8FN6Z0 GO:0046956 1/125 positive phototaxis biological_process "The directed movement of a cell or organism towards a source of light." [GOC:ai] EOG8FN6Z0 GO:0008049 1/125 male courtship behavior biological_process "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] EOG8FN6Z0 GO:0016327 1/125 apicolateral plasma membrane cellular_component "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] EOG8FN6Z0 GO:0000132 1/125 establishment of mitotic spindle orientation biological_process "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] EOG8FN6Z0 GO:0001708 1/125 cell fate specification biological_process "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] EOG8FN6Z0 GO:0030707 1/125 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8FN6Z0 GO:0001738 1/125 morphogenesis of a polarized epithelium biological_process "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] EOG8FN6Z0 GO:0046939 1/125 nucleotide phosphorylation biological_process "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai] EOG8FN6Z0 GO:0051294 1/125 establishment of spindle orientation biological_process "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai] EOG8FN6Z0 GO:0043195 1/125 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG8FN6Z0 GO:0007155 1/125 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8FN6Z0 GO:0005154 1/125 epidermal growth factor receptor binding molecular_function "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai] EOG8FN6Z0 GO:0016328 1/125 lateral plasma membrane cellular_component "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] EOG8FN6Z0 GO:0016323 1/125 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8FN6Z0 GO:0016335 1/125 morphogenesis of larval imaginal disc epithelium biological_process "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl] EOG8FN6Z0 GO:0007268 1/125 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8FN6Z0 GO:0000122 1/125 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8FN6Z0 GO:0045196 1/125 establishment or maintenance of neuroblast polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083] EOG8FN6Z0 GO:0005515 1/125 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FN6Z0 GO:0045179 1/125 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8FN6Z0 GO:0007318 1/125 pole plasm protein localization biological_process "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG8FN6Z0 GO:0008593 1/125 regulation of Notch signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8FN6Z0 GO:0005920 1/125 smooth septate junction cellular_component "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] EOG8FN6Z0 GO:0030714 1/125 anterior/posterior axis specification, follicular epithelium biological_process "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf] EOG8FN6Z0 GO:0007391 1/125 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8FN6Z0 GO:0045175 1/125 basal protein localization biological_process "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf] EOG8FN6Z0 GO:0008283 1/125 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8FN6Z0 GO:0048471 1/125 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8FN6Z0 GO:0046425 1/125 regulation of JAK-STAT cascade biological_process "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf] EOG8FN6Z0 GO:0045197 1/125 establishment or maintenance of epithelial cell apical/basal polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] EOG8FN6Z0 GO:0031594 1/125 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8FN6Z0 GO:0007399 1/125 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8FN6Z0 GO:0005856 1/125 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8FN6Z0 GO:0045202 1/125 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8FN6Z0 GO:0045475 1/125 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8FN6Z0 GO:0045887 1/125 positive regulation of synaptic growth at neuromuscular junction biological_process "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8FN6Z0 GO:0042127 1/125 regulation of cell proliferation biological_process "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] EOG8FN6Z0 GO:0019991 1/125 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG8FN6Z0 GO:0007010 1/125 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8FN6Z1 GO:0033554 25/92 cellular response to stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8FN6Z1 GO:0005741 25/92 mitochondrial outer membrane cellular_component "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] EOG8CRPCZ GO:0005097 26/91 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG83XXH8 GO:0017112 1/79 Rab guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG83XXH8 GO:0032313 1/79 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG83XXH8 GO:0035011 1/79 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG83XXH8 GO:0032483 1/79 regulation of Rab protein signal transduction biological_process "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah] EOG8FBM7F GO:0005524 1/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FBM7F GO:0006424 1/7 glutamyl-tRNA aminoacylation biological_process "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8FBM7F GO:0004818 1/7 glutamate-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] EOG8FBM7F GO:0005737 1/7 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8PRW4X GO:0030170 26/89 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8PRW4X GO:0030151 25/89 molybdenum ion binding molecular_function "Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai] EOG8PRW4X GO:0016829 20/89 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8PRW4X GO:0008265 20/89 Mo-molybdopterin cofactor sulfurase activity molecular_function "Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764] EOG8PRW4X GO:0016740 20/89 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8PRW4X GO:0006777 20/89 Mo-molybdopterin cofactor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] EOG8PRW4X GO:0043545 16/89 molybdopterin cofactor metabolic process biological_process "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] EOG8PRW4X GO:0003824 6/89 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8PRW4X GO:0006727 1/89 ommochrome biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] EOG8PCD89 GO:0003723 2/9 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8PCD89 GO:0003964 2/9 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8PCD89 GO:0004519 1/9 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8DV813 GO:0005509 1/31 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8DV813 GO:0007156 1/31 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8DV813 GO:0016021 1/31 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D293S GO:0005524 64/214 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8D293S GO:0035556 57/214 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8D293S GO:0004697 55/214 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG8D293S GO:0008270 34/214 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D293S GO:0046872 24/214 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D293S GO:0004674 11/214 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8D293S GO:0006468 3/214 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8D293S GO:0045471 2/214 response to ethanol biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] EOG8D293S GO:0006928 1/214 movement of cell or subcellular component biological_process "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] EOG8D293S GO:0008585 1/214 female gonad development biological_process "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb] EOG8D293S GO:0048812 1/214 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8D293S GO:0035206 1/214 regulation of hemocyte proliferation biological_process "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8D293S GO:0007252 1/214 I-kappaB phosphorylation biological_process "The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:21772278, PMID:7594468] EOG8D293S GO:0019722 1/214 calcium-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] EOG8D293S GO:0016059 1/214 deactivation of rhodopsin mediated signaling biological_process "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] EOG8D293S GO:0050962 1/214 detection of light stimulus involved in sensory perception biological_process "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos] EOG8D293S GO:0005515 1/214 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8D293S GO:0007030 1/214 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8D293S GO:0005886 1/214 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8D293S GO:0016062 1/214 adaptation of rhodopsin mediated signaling biological_process "The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207] EOG8D293S GO:0007601 1/214 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8D293S GO:0004672 1/214 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8D293S GO:0034389 1/214 lipid particle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] EOG8D293S GO:0008285 1/214 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8D293S GO:0009416 1/214 response to light stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] EOG8D293S GO:0016027 1/214 inaD signaling complex cellular_component "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] EOG8D293S GO:0016301 1/214 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8D293S GO:0007616 1/214 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8D293S GO:0006909 1/214 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8D293S GO:0030845 1/214 phospholipase C-inhibiting G-protein coupled receptor signaling pathway biological_process "A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098] EOG8D293S GO:0016028 1/214 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8D293S GO:0007602 1/214 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG8D293S GO:0009950 1/214 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG876NG4 GO:0046872 5/16 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG876NG4 GO:0003676 2/16 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG876NG4 GO:0008270 1/16 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG876NG4 GO:0043565 1/16 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG876NG4 GO:0003700 1/16 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG876NG4 GO:0005634 1/16 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG876NG4 GO:0016021 1/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG876NG4 GO:0003677 1/16 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8R269Q GO:0005524 1/9 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8R269Q GO:0006298 1/9 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG8R269Q GO:0030983 1/9 mismatched DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] EOG8T1M2C GO:0005737 24/90 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T1M2C GO:0008033 23/90 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8T1M2C GO:0016783 22/90 sulfurtransferase activity molecular_function "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544] EOG8T1M2C GO:0008168 3/90 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8T1M2C GO:0004808 2/90 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61, GOC:imk] EOG8T1M2C GO:0000049 1/90 tRNA binding molecular_function "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] EOG8T1M2C GO:0016740 1/90 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8T1M2C GO:0005739 1/90 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8T1M2C GO:0005524 1/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80306F GO:0005509 24/91 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG80306F GO:0006898 22/91 receptor-mediated endocytosis biological_process "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] EOG80306F GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8M3CPF GO:0003924 27/110 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8M3CPF GO:0005525 27/110 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8M3CPF GO:0090148 1/110 membrane fission biological_process "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8M3CPF GO:0008355 1/110 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8M3CPF GO:0034334 1/110 adherens junction maintenance biological_process "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] EOG8M3CPF GO:0030866 1/110 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8M3CPF GO:0007349 1/110 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8M3CPF GO:0000281 1/110 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8M3CPF GO:0045202 1/110 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8M3CPF GO:0008017 1/110 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8M3CPF GO:0045747 1/110 positive regulation of Notch signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8M3CPF GO:0007298 1/110 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8M3CPF GO:0007435 1/110 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8M3CPF GO:0005737 1/110 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8M3CPF GO:0048499 1/110 synaptic vesicle membrane organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806] EOG8M3CPF GO:0046843 1/110 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8M3CPF GO:0048489 1/110 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG8M3CPF GO:0006898 1/110 receptor-mediated endocytosis biological_process "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] EOG8M3CPF GO:0007613 1/110 memory biological_process "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] EOG8M3CPF GO:0032970 1/110 regulation of actin filament-based process biological_process "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] EOG8M3CPF GO:0009408 1/110 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8M3CPF GO:0006897 1/110 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8M3CPF GO:0030536 1/110 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8M3CPF GO:0007612 1/110 learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] EOG8M3CPF GO:0016185 1/110 synaptic vesicle budding from presynaptic membrane biological_process "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709] EOG8M3CPF GO:0046667 1/110 compound eye retinal cell programmed cell death biological_process "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] EOG8M3CPF GO:0007427 1/110 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8M3CPF GO:0050803 1/110 regulation of synapse structure or activity biological_process "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] EOG8M3CPF GO:0048488 1/110 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8M3CPF GO:0006184 1/110 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8M3CPF GO:0005886 1/110 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8M3CPF GO:0007637 1/110 proboscis extension reflex biological_process "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid] EOG8M3CPF GO:0001661 1/110 conditioned taste aversion biological_process "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] EOG8M3CPF GO:0032956 1/110 regulation of actin cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] EOG8M3CPF GO:0040008 1/110 regulation of growth biological_process "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] EOG8M3CPF GO:0003779 1/110 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8M3CPF GO:0007614 1/110 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8M3CPF GO:0072583 1/110 clathrin-mediated endocytosis biological_process "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965] EOG8M3CPF GO:0001738 1/110 morphogenesis of a polarized epithelium biological_process "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] EOG8M3CPF GO:0070864 1/110 sperm individualization complex cellular_component "A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716] EOG8M3CPF GO:0035152 1/110 regulation of tube architecture, open tracheal system biological_process "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584] EOG8M3CPF GO:0007291 1/110 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8M3CPF GO:0007424 1/110 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8M3CPF GO:0030198 1/110 extracellular matrix organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] EOG8M3CPF GO:0005874 1/110 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8M3CPF GO:0048172 1/110 regulation of short-term neuronal synaptic plasticity biological_process "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] EOG85QKXQ GO:0005507 2/3 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG85QKXQ GO:0016491 2/3 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8SJ7WG GO:0008270 5/91 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SJ7WG GO:0048786 1/91 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG8SJ7WG GO:0001956 1/91 positive regulation of neurotransmitter secretion biological_process "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] EOG8SJ7WG GO:2000809 1/91 positive regulation of synaptic vesicle clustering biological_process "Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708] EOG81VNJJ GO:0016021 20/74 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81VNJJ GO:0004930 19/74 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8MD0GP GO:0005576 6/31 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8MD0GP GO:0030414 6/31 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG80306V GO:0008270 329/890 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80306V GO:0004181 329/890 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG80306V GO:0005319 8/890 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG80306V GO:0005615 3/890 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG80306V GO:0007586 1/890 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG80306V GO:0022008 1/890 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG80306V GO:0031982 1/890 vesicle cellular_component "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] EOG80306V GO:0004180 1/890 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG80306V GO:0005515 1/890 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG80306V GO:0005576 1/890 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80306V GO:0016021 1/890 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80306V GO:0004930 1/890 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8D295N GO:0004519 7/42 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8D295N GO:0003964 7/42 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8D295N GO:0003723 6/42 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8D295N GO:0046872 1/42 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DV81R GO:0016192 2/15 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8DV81R GO:0016021 2/15 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QJV1Z GO:0007155 24/111 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8QJV1Z GO:0006030 20/111 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8QJV1Z GO:0005576 20/111 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8QJV1Z GO:0008061 20/111 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8QJV1Z GO:0042060 1/111 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8QJV1Z GO:0047712 1/111 Cypridina-luciferin 2-monooxygenase activity molecular_function "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN] EOG8QJV1Z GO:0042381 1/111 hemolymph coagulation biological_process "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] EOG8QJV1Z GO:0042803 1/111 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8QJV1Z GO:0003676 1/111 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QJV1Z GO:0007599 1/111 hemostasis biological_process "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732] EOG8QJV1Z GO:0008270 1/111 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8HMMS1 GO:0005634 1/15 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HMMS1 GO:0003700 1/15 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8DZ49Z GO:0003676 6/41 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8N8TK7 GO:0016021 26/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8N8TK7 GO:0004190 25/91 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8N8TK7 GO:0006465 1/91 signal peptide processing biological_process "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194] EOG8N8TK7 GO:0006508 1/91 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8N8TK7 GO:0016020 1/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8N8TK7 GO:0005783 1/91 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8N8TK7 GO:0042500 1/91 aspartic endopeptidase activity, intramembrane cleaving molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732] EOG8N8TK7 GO:0034620 1/91 cellular response to unfolded protein biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] EOG8GF5XB GO:0003676 4/39 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GF5XB GO:0046872 4/39 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DV81C GO:0016740 2/140 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG85F05D GO:0004364 32/318 glutathione transferase activity molecular_function "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] EOG85F05D GO:0016740 19/318 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG85F05D GO:0004667 6/318 prostaglandin-D synthase activity molecular_function "Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10603] EOG85F05D GO:0008152 1/318 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG85F05D GO:0006749 1/318 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG85F05D GO:0055114 1/318 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG85F05D GO:0004602 1/318 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG8N5ZBF GO:0006541 33/106 glutamine metabolic process biological_process "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] EOG8N5ZBF GO:0008242 32/106 omega peptidase activity molecular_function "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] EOG8N5ZBF GO:0034722 1/106 gamma-glutamyl-peptidase activity molecular_function "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26] EOG803065 GO:0005525 26/90 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG803065 GO:0003924 26/90 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG803065 GO:0005739 12/90 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG803065 GO:0032543 12/90 mitochondrial translation biological_process "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] EOG803065 GO:0032790 12/90 ribosome disassembly biological_process "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] EOG803065 GO:0006184 12/90 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG803065 GO:0003746 3/90 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG803064 GO:0016787 26/103 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG803064 GO:0008033 24/103 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG803064 GO:0048477 1/103 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG803064 GO:0090502 1/103 RNA phosphodiester bond hydrolysis, endonucleolytic biological_process "The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] EOG803064 GO:0005739 1/103 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG803064 GO:0006388 1/103 tRNA splicing, via endonucleolytic cleavage and ligation biological_process "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290] EOG803064 GO:0006409 1/103 tRNA export from nucleus biological_process "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma] EOG803064 GO:0030307 1/103 positive regulation of cell growth biological_process "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG803064 GO:0042780 1/103 tRNA 3'-end processing biological_process "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators] EOG803064 GO:0005634 1/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG803064 GO:0036093 1/103 germ cell proliferation biological_process "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv] EOG803064 GO:0001558 1/103 regulation of cell growth biological_process "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] EOG803064 GO:0022008 1/103 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG803064 GO:0016891 1/103 endoribonuclease activity, producing 5'-phosphomonoesters molecular_function "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] EOG803064 GO:0046872 1/103 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG803064 GO:0045727 1/103 positive regulation of translation biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] EOG803064 GO:0046331 1/103 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG81NX2Z GO:0016021 1/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81NX2Z GO:0005328 1/6 neurotransmitter:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] EOG8TTJZV GO:0004842 24/91 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8TTJZV GO:0005634 24/91 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TTJZV GO:0006511 24/91 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8TTJZV GO:0008270 24/91 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TTJZV GO:0007275 20/91 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8TTJZV GO:0005737 4/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8TTJZV GO:0007601 4/91 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8TTJZV GO:0050896 4/91 response to stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] EOG8TTJZV GO:0007423 4/91 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8TTJZV GO:0045676 4/91 regulation of R7 cell differentiation biological_process "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] EOG8TTJZV GO:0016874 3/91 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8TTJZV GO:0010498 1/91 proteasomal protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] EOG8TTJZV GO:0000151 1/91 ubiquitin ligase complex cellular_component "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] EOG8TTJZV GO:0042802 1/91 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG8TTJZV GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8TTJZV GO:0007465 1/91 R7 cell fate commitment biological_process "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] EOG8TTJZV GO:0043621 1/91 protein self-association molecular_function "Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl] EOG8TTJZV GO:0006508 1/91 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8J3ZZX GO:0048102 1/92 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8J3ZZX GO:0046692 1/92 sperm competition biological_process "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514] EOG8J3ZZX GO:0035071 1/92 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG89361X GO:0016787 1/21 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG80GG52 GO:0016021 24/95 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80GG52 GO:0006810 24/95 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG80GG52 GO:0005739 4/95 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8WM77S GO:0016197 1/97 endosomal transport biological_process "The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732] EOG8WM77S GO:0008333 1/97 endosome to lysosome transport biological_process "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] EOG8WM77S GO:0016021 1/97 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RNDQ5 GO:0008270 2/29 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RNDQ5 GO:0003676 2/29 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8RNDQ5 GO:0006511 1/29 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8Q5C4Z GO:0008270 29/245 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Q5C4Z GO:0003676 26/245 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Q5C4Z GO:0003964 4/245 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8Q5C4Z GO:0003723 4/245 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8Z91CZ GO:0005328 1/5 neurotransmitter:sodium symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] EOG8Z91CZ GO:0016021 1/5 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8N3339 GO:0007264 13/95 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8N3339 GO:0005622 13/95 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8N3339 GO:0005089 10/95 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8N3339 GO:0005085 3/95 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8N3339 GO:0051056 2/95 regulation of small GTPase mediated signal transduction biological_process "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] EOG8N3339 GO:0016740 1/95 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8PVRDN GO:0005634 27/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PVRDN GO:0003700 27/90 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8PVRDN GO:0043565 27/90 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8PVRDN GO:0008270 27/90 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PVRDN GO:0016740 2/90 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8PVRDN GO:0008045 1/90 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8PVRDN GO:0051726 1/90 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8PVRDN GO:0007399 1/90 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8MKQWT GO:0008270 26/95 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MKQWT GO:0004842 1/95 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8MKQWT GO:0031648 1/95 protein destabilization biological_process "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah] EOG8FBM7S GO:0016021 21/80 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BP3RP GO:0007165 8/65 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8BP3RP GO:0005622 8/65 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8HDW7B GO:0045475 1/146 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8HDW7B GO:0072347 1/146 response to anesthetic biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart] EOG8Z91CK GO:0007155 1/11 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8Z91CK GO:0016021 1/11 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HDW7F GO:0030983 1/5 mismatched DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] EOG8HDW7F GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HDW7F GO:0006298 1/5 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG8G4K4B GO:0005615 7/55 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8G4K4B GO:0004866 7/55 endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] EOG85MQK7 GO:0040011 1/91 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG85MQK7 GO:0007099 1/91 centriole replication biological_process "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] EOG85MQK7 GO:0007140 1/91 male meiosis biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] EOG85MQK7 GO:0051298 1/91 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG85MQK7 GO:0051297 1/91 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG85MQK7 GO:0008356 1/91 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG85MQK7 GO:0005814 1/91 centriole cellular_component "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] EOG85MQK7 GO:0042384 1/91 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG85MQK7 GO:0007052 1/91 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG85MQK7 GO:0035186 1/91 syncytial blastoderm mitotic cell cycle biological_process "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] EOG85MQK7 GO:0000242 1/91 pericentriolar material cellular_component "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] EOG8RZ1D3 GO:0005089 8/80 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8RZ1D3 GO:0035556 6/80 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8RZ1D3 GO:0016740 2/80 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8RZ1D3 GO:0004725 1/80 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8PCD9M GO:0016787 1/2 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG81RS89 GO:0055085 250/817 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG81RS89 GO:0005215 250/817 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG81RS89 GO:0016021 249/817 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81RS89 GO:0016020 2/817 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG81RS89 GO:0006814 1/817 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG81RS89 GO:0051780 1/817 behavioral response to nutrient biological_process "Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai] EOG81RS89 GO:0008343 1/817 adult feeding behavior biological_process "Feeding behavior in a fully developed and mature organism." [GOC:mah] EOG81RS89 GO:0016323 1/817 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG81RS89 GO:0015293 1/817 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG81RS89 GO:0007156 1/817 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG81RS89 GO:0005509 1/817 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8S1WQM GO:0005634 12/62 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S1WQM GO:0003700 12/62 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8642SS GO:0005234 1/19 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8642SS GO:0004970 1/19 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8642SS GO:0016021 1/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BP3WK GO:0005622 1/2 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8BP3WK GO:0005215 1/2 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8PG8FN GO:0016884 30/131 carbon-nitrogen ligase activity, with glutamine as amido-N-donor molecular_function "Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532] EOG8PG8FN GO:0050567 1/131 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] EOG86Q982 GO:0008375 26/98 acetylglucosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] EOG86Q982 GO:0030158 26/98 protein xylosyltransferase activity molecular_function "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26] EOG86Q982 GO:0016020 24/98 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG86Q982 GO:0006024 24/98 glycosaminoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] EOG86Q982 GO:0042732 2/98 D-xylose metabolic process biological_process "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732] EOG86Q982 GO:0030206 2/98 chondroitin sulfate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] EOG86Q982 GO:0005789 2/98 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG86Q982 GO:0000139 2/98 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG86Q982 GO:0015012 2/98 heparan sulfate proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210] EOG86Q982 GO:0016021 2/98 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q982 GO:0050650 2/98 chondroitin sulfate proteoglycan biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] EOG86Q982 GO:0016740 1/98 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG84F8QF GO:0007299 1/102 ovarian follicle cell-cell adhesion biological_process "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496] EOG84F8QF GO:0007259 1/102 JAK-STAT cascade biological_process "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028] EOG84F8QF GO:0046843 1/102 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG84F8QF GO:0007010 1/102 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG84F8QF GO:0007162 1/102 negative regulation of cell adhesion biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] EOG84F8QF GO:0016020 1/102 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG84F8QF GO:0005737 1/102 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84F8QF GO:0060250 1/102 germ-line stem-cell niche homeostasis biological_process "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph] EOG84F8QF GO:0005634 1/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84F8QF GO:0030536 1/102 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8B2WBV GO:0003824 5/146 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8B2WBV GO:0016787 2/146 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8B2WBV GO:0005789 1/146 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8B2WBV GO:0030433 1/146 ER-associated ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858] EOG8B2WBV GO:0006950 1/146 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8B2WBV GO:0033961 1/146 cis-stilbene-oxide hydrolase activity molecular_function "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] EOG8B2WBV GO:0008233 1/146 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8B2WBV GO:0016021 1/146 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8B2WBV GO:0006515 1/146 misfolded or incompletely synthesized protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl] EOG8F7R09 GO:0002028 2/137 regulation of sodium ion transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] EOG8F7R09 GO:0017080 2/137 sodium channel regulator activity molecular_function "Modulates the activity of a sodium channel." [GOC:mah] EOG8F7R09 GO:0016021 2/137 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R7XS0 GO:0016787 23/63 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG88973M GO:0005874 1/80 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG88973M GO:0005525 1/80 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG88973M GO:0004930 1/80 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG88973M GO:0007017 1/80 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG88973M GO:0016020 1/80 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG818F4N GO:0035556 2/9 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8H74S9 GO:0016020 26/100 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8H74S9 GO:0008654 24/100 phospholipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] EOG8H74S9 GO:0016780 23/100 phosphotransferase activity, for other substituted phosphate groups molecular_function "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] EOG8H74S9 GO:0004142 2/100 diacylglycerol cholinephosphotransferase activity molecular_function "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2] EOG8H74S9 GO:0004307 1/100 ethanolaminephosphotransferase activity molecular_function "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1] EOG8H74S9 GO:0016740 1/100 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8XSP3R GO:0046872 13/72 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XSP3R GO:0003824 12/72 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8XSP3R GO:0016020 1/72 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XSP3R GO:0008236 1/72 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8RV581 GO:0016021 6/66 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RV581 GO:0005789 6/66 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8RV581 GO:0033116 6/66 endoplasmic reticulum-Golgi intermediate compartment membrane cellular_component "The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system." [GOC:mah, GOC:pr, PMID:16723730] EOG8RV581 GO:0012507 6/66 ER to Golgi transport vesicle membrane cellular_component "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] EOG808QQS GO:0003676 7/236 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG808QQS GO:0008270 3/236 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG847J95 GO:0000166 25/85 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG847J95 GO:0003676 24/85 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG847J95 GO:0005634 1/85 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG847J95 GO:0071013 1/85 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG847J95 GO:0007095 1/85 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG847J95 GO:0000398 1/85 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG847J95 GO:0005515 1/85 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG847J95 GO:0003729 1/85 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG847J95 GO:0022008 1/85 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG847J95 GO:0071011 1/85 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG847J95 GO:0006376 1/85 mRNA splice site selection biological_process "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] EOG81ZHRC GO:0016021 26/80 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81ZHRC GO:0015171 1/80 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG81ZHRC GO:0003333 1/80 amino acid transmembrane transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] EOG8F7R0Z GO:0003676 1/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HB10Z GO:0016740 2/151 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8HB10Z GO:0010378 1/151 temperature compensation of the circadian clock biological_process "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099] EOG8HB10Z GO:0031514 1/151 motile cilium cellular_component "A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG8HB10Z GO:0060285 1/151 cilium-dependent cell motility biological_process "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013] EOG8HB10Z GO:0005737 1/151 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8HB10Z GO:0045433 1/151 male courtship behavior, veined wing generated song production biological_process "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] EOG8HB10Z GO:0035082 1/151 axoneme assembly biological_process "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] EOG8HB10Z GO:0030425 1/151 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8HB10Z GO:0007605 1/151 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8C5FZN GO:0004672 1/95 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8C5FZN GO:0005524 1/95 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Z91C8 GO:0090175 1/71 regulation of establishment of planar polarity biological_process "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8QC3M4 GO:0008270 27/93 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QC3M4 GO:0006355 26/93 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8QC3M4 GO:0006352 26/93 DNA-templated transcription, initiation biological_process "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] EOG8QC3M4 GO:0003743 3/93 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8QC3M4 GO:0005634 2/93 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QC3M4 GO:0001174 1/93 transcriptional start site selection at RNA polymerase II promoter biological_process "Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104] EOG8QC3M4 GO:0006357 1/93 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8QC3M4 GO:0051101 1/93 regulation of DNA binding biological_process "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb] EOG8QC3M4 GO:0006367 1/93 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8QC3M4 GO:0005667 1/93 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8QC3M4 GO:0008134 1/93 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8QC3M4 GO:0005515 1/93 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8RJJFM GO:0016020 23/90 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RJJFM GO:0055085 22/90 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8RJJFM GO:0003333 1/90 amino acid transmembrane transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] EOG8RJJFM GO:0015171 1/90 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8RR8ZT GO:0051539 23/91 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8RR8ZT GO:0016020 23/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RR8ZT GO:0016651 21/91 oxidoreductase activity, acting on NAD(P)H molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8RR8ZT GO:0003954 2/91 NADH dehydrogenase activity molecular_function "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] EOG8RR8ZT GO:0005739 1/91 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8RJJFP GO:0005234 64/194 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8RJJFP GO:0016020 63/194 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8RJJFP GO:0004970 63/194 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8RJJFP GO:0034220 3/194 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8RJJFP GO:0036081 3/194 extracellular ammonia-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] EOG8RJJFP GO:0016021 3/194 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RJJFP GO:0015276 2/194 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8RJJFP GO:0050907 1/194 detection of chemical stimulus involved in sensory perception biological_process "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] EOG8RJJFP GO:0005215 1/194 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8RJJFP GO:0009593 1/194 detection of chemical stimulus biological_process "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] EOG8RJJFP GO:0050911 1/194 detection of chemical stimulus involved in sensory perception of smell biological_process "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai] EOG8QRKKS GO:0006520 47/148 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG8QRKKS GO:0016639 26/148 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] EOG8QRKKS GO:0016491 20/148 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8QRKKS GO:0004353 2/148 glutamate dehydrogenase [NAD(P)+] activity molecular_function "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3] EOG8QRKKS GO:0006116 1/148 NADH oxidation biological_process "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD." [GOC:ai] EOG8QRKKS GO:0005524 1/148 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QRKKS GO:0005525 1/148 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8QRKKS GO:0006536 1/148 glutamate metabolic process biological_process "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] EOG8QRKKS GO:0005739 1/148 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8QRKKS GO:0004352 1/148 glutamate dehydrogenase (NAD+) activity molecular_function "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2] EOG8QRKKS GO:0005759 1/148 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8QRKKS GO:0042802 1/148 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG8RJJFT GO:0016021 16/63 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RJJFT GO:0022891 15/63 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG8RJJFT GO:0008643 5/63 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8RJJFT GO:0003964 1/63 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8RJJFT GO:0046872 1/63 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RJJFT GO:0003723 1/63 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RJJFT GO:0022857 1/63 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8RBT05 GO:0005230 61/226 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8RBT05 GO:0016021 61/226 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RBT05 GO:0004890 52/226 GABA-A receptor activity molecular_function "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333] EOG8RBT05 GO:0005886 51/226 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8RBT05 GO:0030054 47/226 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8RBT05 GO:0045202 44/226 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8RBT05 GO:0006811 4/226 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8RBT05 GO:0045211 3/226 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8RBT05 GO:0034707 3/226 chloride channel complex cellular_component "An ion channel complex through which chloride ions pass." [GOC:mah] EOG8RBT05 GO:0005254 3/226 chloride channel activity molecular_function "Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8RBT05 GO:0030594 2/226 neurotransmitter receptor activity molecular_function "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling] EOG8RBT05 GO:0007165 2/226 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8RBT05 GO:0007268 2/226 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG8RBT05 GO:0042493 1/226 response to drug biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl] EOG8RBT05 GO:0030425 1/226 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8RBT05 GO:0042749 1/226 regulation of circadian sleep/wake cycle biological_process "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl] EOG8RBT05 GO:0050805 1/226 negative regulation of synaptic transmission biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] EOG8RBT05 GO:0030424 1/226 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8RBT05 GO:0030431 1/226 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8RBT05 GO:0090328 1/226 regulation of olfactory learning biological_process "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb] EOG8RBT05 GO:0009612 1/226 response to mechanical stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] EOG8WSZRS GO:0004197 68/247 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8WSZRS GO:0006915 68/247 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8WSZRS GO:0010623 2/247 developmental programmed cell death biological_process "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb] EOG8WSZRS GO:0016322 2/247 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8WSZRS GO:0045476 2/247 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG8WSZRS GO:0005737 2/247 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8WSZRS GO:0012501 2/247 programmed cell death biological_process "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] EOG8WSZRS GO:0005515 2/247 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8WSZRS GO:0046672 1/247 positive regulation of compound eye retinal cell programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8WSZRS GO:0009267 1/247 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG8WSZRS GO:0035103 1/247 sterol regulatory element binding protein cleavage biological_process "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, GOC:vw, PMID:12923525] EOG8WSZRS GO:0010165 1/247 response to X-ray biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] EOG8WSZRS GO:0007275 1/247 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8WSZRS GO:0030036 1/247 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8WSZRS GO:0048515 1/247 spermatid differentiation biological_process "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] EOG8WSZRS GO:0007300 1/247 ovarian nurse cell to oocyte transport biological_process "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8WSZRS GO:0048477 1/247 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8WSZRS GO:0097194 1/247 execution phase of apoptosis biological_process "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] EOG8WSZRS GO:0007015 1/247 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8WSZRS GO:0035071 1/247 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8WSZRS GO:0046668 1/247 regulation of retinal cell programmed cell death biological_process "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] EOG8WSZRS GO:0016239 1/247 positive regulation of macroautophagy biological_process "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] EOG8WSZRS GO:0010508 1/247 positive regulation of autophagy biological_process "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8WSZRS GO:0035070 1/247 salivary gland histolysis biological_process "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] EOG8WSZRS GO:1900074 1/247 negative regulation of neuromuscular synaptic transmission biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] EOG8WSZRS GO:0007303 1/247 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG8WSZRS GO:0097200 1/247 cysteine-type endopeptidase activity involved in execution phase of apoptosis molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Caspase] EOG8WSZRS GO:0048102 1/247 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG866Z30 GO:0034587 1/86 piRNA metabolic process biological_process "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] EOG866Z30 GO:0046331 1/86 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG866Z30 GO:0005739 1/86 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8TF30F GO:0006541 1/6 glutamine metabolic process biological_process "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] EOG8TF30F GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TF30F GO:0003883 1/6 CTP synthase activity molecular_function "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] EOG8TF30F GO:0044210 1/6 'de novo' CTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components." [GOC:ecd, GOC:jl, PMID:11912132, PMID:18439916] EOG8G1PX8 GO:0004747 35/98 ribokinase activity molecular_function "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15] EOG8G1PX8 GO:0006014 35/98 D-ribose metabolic process biological_process "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732] EOG8G1PX8 GO:0003676 1/98 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8G1PX8 GO:0016829 1/98 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8G1PX8 GO:0055085 1/98 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8G1PX8 GO:0016021 1/98 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G1PX8 GO:0000166 1/98 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8QJV2D GO:0009253 22/121 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8QJV2D GO:0008745 22/121 N-acetylmuramoyl-L-alanine amidase activity molecular_function "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28] EOG8QJV2D GO:0046872 1/121 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WDGTH GO:0042302 31/105 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8WDGTH GO:0031012 1/105 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8WDGTH GO:0008010 1/105 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8WDGTH GO:0040003 1/105 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8NKFB8 GO:0004089 104/367 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8NKFB8 GO:0006730 100/367 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8NKFB8 GO:0008270 99/367 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NKFB8 GO:0031233 1/367 intrinsic component of external side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah] EOG8QJV2W GO:0008484 1/9 sulfuric ester hydrolase activity molecular_function "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] EOG8QJV2V GO:0008146 160/572 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8QJV2V GO:0004027 62/572 alcohol sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] EOG8QJV2V GO:0004304 10/572 estrone sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] EOG8QJV2V GO:0005829 3/572 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8QJV2V GO:0051923 3/572 sulfation biological_process "The addition of a sulfate group to a molecule." [http://www.onelook.com] EOG8QJV2V GO:0006805 2/572 xenobiotic metabolic process biological_process "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] EOG8QJV2V GO:0004062 1/572 aryl sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] EOG8XKXPH GO:0016020 142/797 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XKXPH GO:0005515 4/797 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8XKXPH GO:0015031 1/797 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8XKXPH GO:0046331 1/797 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8XKXPH GO:0005789 1/797 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8XKXPH GO:0016021 1/797 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QJV2Z GO:0007606 16/1207 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8QJV2Z GO:0005515 9/1207 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QJV2Z GO:0016021 3/1207 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QJV2Z GO:0008039 1/1207 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8QJV2Z GO:0050914 1/1207 sensory perception of salty taste biological_process "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8QJV2Z GO:0002115 1/1207 store-operated calcium entry biological_process "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] EOG8QJV2Z GO:0035199 1/1207 salt aversion biological_process "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf] EOG8QJV2Z GO:0048149 1/1207 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG8QJV2Z GO:0005886 1/1207 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8NKFB5 GO:0005509 25/70 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8NKFB5 GO:0016787 2/70 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8NKFB5 GO:0004198 1/70 calcium-dependent cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] EOG8NKFB5 GO:0006508 1/70 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8NKFB5 GO:0005737 1/70 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NKFB5 GO:0046330 1/70 positive regulation of JNK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG841SVR GO:0015074 1/70 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG841SVR GO:0003676 1/70 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8F4VRK GO:0032777 31/95 Piccolo NuA4 histone acetyltransferase complex cellular_component "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [GOC:rb, PMID:12782659, PMID:15964809] EOG8F4VRK GO:0006351 25/95 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8F4VRK GO:0006355 25/95 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8F4VRK GO:0005700 1/95 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8F4VRK GO:0005725 1/95 intercalary heterochromatin cellular_component "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] EOG8F4VRK GO:0005634 1/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8F4VRK GO:0043486 1/95 histone exchange biological_process "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277] EOG8F4VRK GO:0000123 1/95 histone acetyltransferase complex cellular_component "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] EOG8F4VRK GO:0035267 1/95 NuA4 histone acetyltransferase complex cellular_component "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] EOG8F4VRK GO:0070983 1/95 dendrite guidance biological_process "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] EOG8F4VRK GO:0016573 1/95 histone acetylation biological_process "The modification of a histone by the addition of an acetyl group." [GOC:ai] EOG8F4VRK GO:0006325 1/95 chromatin organization biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah] EOG86T5GX GO:0008137 44/138 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG86T5GX GO:0048038 43/138 quinone binding molecular_function "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732] EOG86T5GX GO:0051539 43/138 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG86T5GX GO:0046872 43/138 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG86T5GX GO:0032981 1/138 mitochondrial respiratory chain complex I assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph] EOG86T5GX GO:0051536 1/138 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG86T5GX GO:0000302 1/138 response to reactive oxygen species biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] EOG86T5GX GO:0008340 1/138 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG880MBX GO:0046872 3/27 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8RV55H GO:0005089 26/99 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8RV55H GO:0035556 7/99 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8RV55H GO:0046872 6/99 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8DNHJ5 GO:0006511 13/93 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8DNHJ5 GO:0004221 2/93 obsolete ubiquitin thiolesterase activity molecular_function "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] EOG8DNHJ5 GO:0046666 1/93 retinal cell programmed cell death biological_process "Programmed cell death that occurs in the developing retina." [GOC:bf] EOG8DNHJ5 GO:0016318 1/93 ommatidial rotation biological_process "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] EOG8DNHJ5 GO:0046667 1/93 compound eye retinal cell programmed cell death biological_process "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] EOG8DNHJ5 GO:0008157 1/93 protein phosphatase 1 binding molecular_function "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] EOG8DNHJ5 GO:0046672 1/93 positive regulation of compound eye retinal cell programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8GF5VP GO:0005737 1/6 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GF5VP GO:0004808 1/6 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61, GOC:imk] EOG8GF5VP GO:0016783 1/6 sulfurtransferase activity molecular_function "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544] EOG8DFS4R GO:0005856 1/7 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8DFS4R GO:0005198 1/7 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG854CHN GO:0004190 1/2 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG89S8Q2 GO:0008270 13/25 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8J3ZWS GO:0000166 25/102 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8J3ZWS GO:0003676 24/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8J3ZWS GO:0003729 1/102 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8J3ZWS GO:0016021 1/102 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GF5VV GO:0016772 5/67 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8GF5VV GO:0016887 1/67 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8SFCKZ GO:0006188 30/121 IMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732] EOG8SFCKZ GO:0003876 30/121 AMP deaminase activity molecular_function "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] EOG8SFCKZ GO:0005515 1/121 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG89PDGC GO:0008270 4/28 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PZMMG GO:0008270 25/88 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PZMMG GO:0003677 3/88 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8PZMMG GO:0018024 2/88 histone-lysine N-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] EOG8PZMMG GO:0004402 2/88 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8PZMMG GO:0033563 1/88 dorsal/ventral axon guidance biological_process "The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:kmv, GOC:tb] EOG8X9B0Z GO:0003964 1/17 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8X9B0Z GO:0003723 1/17 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8577P8 GO:0016881 37/106 acid-amino acid ligase activity molecular_function "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] EOG8577P8 GO:0004842 7/106 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8577P8 GO:0005524 1/106 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8577P8 GO:0005515 1/106 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8577P8 GO:0022008 1/106 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CJZ12 GO:0015074 3/41 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8CJZ12 GO:0003676 3/41 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CJZ12 GO:0003964 2/41 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8CJZ12 GO:0004190 1/41 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8CJZ12 GO:0003723 1/41 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8GXJ2W GO:0007165 18/74 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8GXJ2W GO:0045089 1/74 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8GXJ2W GO:0005622 1/74 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8GXJ2W GO:0019730 1/74 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG8GXJ2W GO:0006959 1/74 humoral immune response biological_process "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] EOG8GXJ2W GO:0006963 1/74 positive regulation of antibacterial peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] EOG8GXJ2W GO:0070513 1/74 death domain binding molecular_function "Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531] EOG8GXJ2W GO:0019731 1/74 antibacterial humoral response biological_process "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8GXJ2W GO:0006964 1/74 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] EOG8GXJ2W GO:0061057 1/74 peptidoglycan recognition protein signaling pathway biological_process "A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] EOG8GXJ2W GO:0005515 1/74 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8GXJ2W GO:0042742 1/74 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8GXJ2W GO:0002230 1/74 positive regulation of defense response to virus by host biological_process "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] EOG8GXJ2W GO:0050829 1/74 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8GXJ2W GO:0045087 1/74 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8GXJ2W GO:0006952 1/74 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8GXJ2W GO:0009617 1/74 response to bacterium biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] EOG8GXJ2W GO:0006955 1/74 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8GXJ2W GO:0035556 1/74 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8GXJ2W GO:0007399 1/74 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG81K1TZ GO:0016740 9/88 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81K1TZ GO:0006633 9/88 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG81K1TZ GO:0016021 9/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GF5V5 GO:0022900 35/131 electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] EOG8GF5V5 GO:0006099 35/131 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8GF5V5 GO:0050660 35/131 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8GF5V5 GO:0016627 31/131 oxidoreductase activity, acting on the CH-CH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8GF5V5 GO:0016491 5/131 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8GF5V5 GO:0008177 4/131 succinate dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13716] EOG8GF5V5 GO:0005743 1/131 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8GF5V5 GO:0005739 1/131 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG89S8QV GO:0030554 1/2 adenyl nucleotide binding molecular_function "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] EOG8VT8BB GO:0005509 16/83 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8VT8BB GO:0016301 3/83 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8VT8BB GO:0007596 1/83 blood coagulation biological_process "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732] EOG8VT8BB GO:0004888 1/83 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8VT8BB GO:0016787 1/83 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8VT8BB GO:0016020 1/83 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8C5FZF GO:0006364 1/103 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG8C5FZF GO:0005730 1/103 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8C5FZF GO:0030529 1/103 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8C5FZF GO:0022008 1/103 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8GJ237 GO:0016021 48/257 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GJ237 GO:0003917 24/257 DNA topoisomerase type I activity molecular_function "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] EOG8GJ237 GO:0003677 24/257 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GJ237 GO:0006265 24/257 DNA topological change biological_process "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] EOG8GJ237 GO:0005694 23/257 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8GJ237 GO:0008270 22/257 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GJ237 GO:0042246 1/257 tissue regeneration biological_process "The regrowth of lost or destroyed tissues." [GOC:curators] EOG8GJ237 GO:0006909 1/257 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8GJ237 GO:0005739 1/257 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8GJ237 GO:0005634 1/257 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GJ237 GO:0003916 1/257 DNA topoisomerase activity molecular_function "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] EOG8GJ237 GO:0005524 1/257 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GJ237 GO:0050829 1/257 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8GJ237 GO:0004185 1/257 serine-type carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8GJ237 GO:0000002 1/257 mitochondrial genome maintenance biological_process "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] EOG8GJ237 GO:0048589 1/257 developmental growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] EOG8GJ237 GO:0005215 1/257 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8GJ237 GO:0035010 1/257 encapsulation of foreign target biological_process "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920] EOG8GJ237 GO:0000724 1/257 double-strand break repair via homologous recombination biological_process "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] EOG8QNQDD GO:0005249 2/7 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8QNQDD GO:0008076 2/7 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8VT8F4 GO:0001895 1/60 retina homeostasis biological_process "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178] EOG8VT8F4 GO:0007603 1/60 phototransduction, visible light biological_process "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG8VT8F4 GO:0072321 1/60 chaperone-mediated protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins." [GOC:mah, PMID:20378773] EOG8VT8F4 GO:0090314 1/60 positive regulation of protein targeting to membrane biological_process "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] EOG8VT8F4 GO:0016063 1/60 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG8VT8F4 GO:0071482 1/60 cellular response to light stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah] EOG8VT8F4 GO:0097038 1/60 perinuclear endoplasmic reticulum cellular_component "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] EOG8F4VR7 GO:0016787 5/18 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8F4VR7 GO:0005509 5/18 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8F4VR7 GO:0004721 4/18 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG876ND9 GO:0003676 2/78 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG876ND9 GO:0015074 2/78 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8J9QDG GO:0016020 20/108 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8J9QDG GO:0005886 1/108 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8J9QDG GO:0008039 1/108 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8FFGHB GO:0006950 26/583 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8FFGHB GO:0005212 9/583 structural constituent of eye lens molecular_function "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] EOG8FFGHB GO:0008340 3/583 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8FFGHB GO:0005875 3/583 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8FFGHB GO:0010998 2/583 regulation of translational initiation by eIF2 alpha phosphorylation biological_process "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb] EOG8FFGHB GO:0009631 2/583 cold acclimation biological_process "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] EOG8FFGHB GO:0005515 2/583 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FFGHB GO:0007275 1/583 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8FFGHB GO:0017022 1/583 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8FFGHB GO:0042595 1/583 behavioral response to starvation biological_process "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] EOG8FFGHB GO:0009408 1/583 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8FFGHB GO:0007476 1/583 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8FFGHB GO:0010506 1/583 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8FFGHB GO:0003779 1/583 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8FFGHB GO:0006497 1/583 protein lipidation biological_process "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl] EOG8FFGHB GO:0001666 1/583 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG8FFGHB GO:0006979 1/583 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8FFGHB GO:0031427 1/583 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG8FFGHB GO:0050832 1/583 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8FFGHB GO:0042742 1/583 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG80CKWZ GO:0031418 25/105 L-ascorbic acid binding molecular_function "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] EOG80CKWZ GO:0005506 25/105 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG80CKWZ GO:0016706 23/105 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG80CKWZ GO:0008475 2/105 procollagen-lysine 5-dioxygenase activity molecular_function "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4] EOG80CKWZ GO:0005581 2/105 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG80CKWZ GO:0005615 1/105 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG80CKWZ GO:0007295 1/105 growth of a germarium-derived egg chamber biological_process "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG80CKWZ GO:0005783 1/105 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG80CKWZ GO:0048471 1/105 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8DRCVB GO:0007525 1/66 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG8DRCVB GO:0000981 1/66 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG8DRCVB GO:0005634 1/66 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8DRCVB GO:0007498 1/66 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8DRCVB GO:0043425 1/66 bHLH transcription factor binding molecular_function "Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] EOG8DRCVB GO:0003677 1/66 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8DRCVB GO:0007474 1/66 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8DRCVB GO:0046982 1/66 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8DRCVB GO:0016203 1/66 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8DRCVB GO:0033627 1/66 cell adhesion mediated by integrin biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] EOG8DRCVB GO:0006355 1/66 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8DRCVB GO:0006357 1/66 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8DRCVB GO:0006366 1/66 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8X99XM GO:0016021 24/72 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TMTFX GO:0046872 20/75 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TMTFX GO:0005524 12/75 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TMTFX GO:0017111 12/75 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8TMTFX GO:0004386 2/75 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8SN45G GO:0003682 14/229 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8SN45G GO:0006915 3/229 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8SN45G GO:0005634 3/229 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SN45G GO:0003677 3/229 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SN45G GO:0008270 1/229 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SN45J GO:0005856 2/19 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8SN45J GO:0005737 1/19 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SN45J GO:0019898 1/19 extrinsic component of membrane cellular_component "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] EOG8JHFVP GO:0003924 29/92 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8JHFVP GO:0005525 29/92 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8JHFVP GO:0030382 1/92 sperm mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] EOG8JHFVP GO:0005875 1/92 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8JHFVP GO:0000281 1/92 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8JHFVP GO:0016185 1/92 synaptic vesicle budding from presynaptic membrane biological_process "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709] EOG8JHFVP GO:0090141 1/92 positive regulation of mitochondrial fission biological_process "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8JHFVP GO:0007005 1/92 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG8JHFVP GO:0051646 1/92 mitochondrion localization biological_process "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG8C2KR7 GO:0004831 1/6 tyrosine-tRNA ligase activity molecular_function "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10223] EOG8C2KR7 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8C2KR7 GO:0006437 1/6 tyrosyl-tRNA aminoacylation biological_process "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8C2KR7 GO:0005737 1/6 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JHFVS GO:0005634 25/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8JHFVS GO:0006260 25/90 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8JHFVS GO:0005515 1/90 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8JHFVS GO:0070868 1/90 heterochromatin organization involved in chromatin silencing biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah] EOG8JHFVS GO:0016321 1/90 female meiosis chromosome segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] EOG8JHFVS GO:1901693 1/90 negative regulation of compound eye retinal cell apoptotic process biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] EOG8JHFVS GO:0045678 1/90 positive regulation of R7 cell differentiation biological_process "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] EOG8JHFVS GO:0042023 1/90 DNA endoreduplication biological_process "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] EOG8JHFVS GO:0035214 1/90 eye-antennal disc development biological_process "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8JHFVS GO:0030261 1/90 chromosome condensation biological_process "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8JHFVS GO:0045931 1/90 positive regulation of mitotic cell cycle biological_process "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8JHFVS GO:0046872 1/90 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8QFZTJ GO:0008234 32/101 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8QFZTJ GO:0005215 2/101 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8QFZTJ GO:0005576 2/101 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8QFZTJ GO:0005875 1/101 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8QFZTJ GO:0005811 1/101 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8CVJNC GO:0000156 1/3 phosphorelay response regulator activity molecular_function "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] EOG8CVJNC GO:0009190 1/3 cyclic nucleotide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] EOG8CVJNC GO:0016849 1/3 phosphorus-oxygen lyase activity molecular_function "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8STVJG GO:0071203 28/94 WASH complex cellular_component "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875] EOG8G7FCZ GO:0005634 28/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8G7FCZ GO:0003707 28/94 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG8G7FCZ GO:0006351 27/94 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8G7FCZ GO:0003700 27/94 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8G7FCZ GO:0008270 26/94 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8G7FCZ GO:0043565 24/94 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8G7FCZ GO:0003677 4/94 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8G7FCZ GO:0016042 1/94 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG8G7FCZ GO:0030522 1/94 intracellular receptor signaling pathway biological_process "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] EOG8G7FCZ GO:0004879 1/94 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding molecular_function "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] EOG8G7FCZ GO:0034440 1/94 lipid oxidation biological_process "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GOC:BHF, GOC:mah] EOG8N8TN3 GO:0003678 2/3 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG8N8TN3 GO:0005524 2/3 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8N8TN3 GO:0006260 2/3 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8WSZQB GO:0016021 3/137 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WSZQB GO:0004721 2/137 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8WSZQB GO:0000166 1/137 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8WSZQB GO:0003676 1/137 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8WSZQD GO:0008203 24/104 cholesterol metabolic process biological_process "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732] EOG8WSZQD GO:0016042 24/104 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG8WSZQD GO:0016298 23/104 lipase activity molecular_function "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] EOG8WSZQD GO:0016787 10/104 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8WSZQD GO:0033878 3/104 hormone-sensitive lipase activity molecular_function "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79] EOG8WSZQD GO:0005811 1/104 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8WSZQD GO:0016021 1/104 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WSZQD GO:0006642 1/104 triglyceride mobilization biological_process "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625] EOG8WSZQD GO:0004930 1/104 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8WSZQD GO:0005829 1/104 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8WSZQD GO:0004806 1/104 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG844P1B GO:0008270 22/103 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG844P1B GO:0031213 1/103 RSF complex cellular_component "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179] EOG844P1B GO:0005705 1/103 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG844P1B GO:0004970 1/103 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG844P1B GO:0003677 1/103 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG844P1B GO:0070868 1/103 heterochromatin organization involved in chromatin silencing biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah] EOG844P1B GO:0005634 1/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG844P1B GO:0005700 1/103 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG844P1B GO:0016020 1/103 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG844P1B GO:0005234 1/103 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG82JR7B GO:0006281 24/83 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG82JR7B GO:0030915 24/83 Smc5-Smc6 complex cellular_component "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739] EOG82JR7B GO:0008270 16/83 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82JR7B GO:0035556 15/83 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG82JR7B GO:0016567 1/83 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG82JR7B GO:0004842 1/83 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG82JR7B GO:0005634 1/83 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82JR7B GO:0006310 1/83 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG82JR7B GO:0046872 1/83 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82JR7B GO:2001022 1/83 positive regulation of response to DNA damage stimulus biological_process "Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] EOG83R657 GO:0046872 1/2 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83R657 GO:0003676 1/2 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BK7KG GO:0007165 1/4 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG82RGN3 GO:0006537 28/124 glutamate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] EOG82RGN3 GO:0051536 24/124 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG82RGN3 GO:0050660 23/124 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG82RGN3 GO:0005506 22/124 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG82RGN3 GO:0010181 22/124 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG82RGN3 GO:0016040 22/124 glutamate synthase (NADH) activity molecular_function "Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH." [EC:1.4.1.14, RHEA:13756] EOG82RGN3 GO:0015930 5/124 glutamate synthase activity molecular_function "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-] EOG82RGN3 GO:0016639 2/124 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] EOG82RGN3 GO:0006807 1/124 nitrogen compound metabolic process biological_process "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732] EOG82RGN3 GO:0017113 1/124 dihydropyrimidine dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2] EOG82RGN3 GO:0004355 1/124 glutamate synthase (NADPH) activity molecular_function "Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13, RHEA:15504] EOG82RGN3 GO:0008152 1/124 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG8W10VF GO:0004871 2/90 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8W10VF GO:0005886 2/90 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8W10VF GO:0005070 2/90 SH3/SH2 adaptor activity molecular_function "Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so] EOG8W10VF GO:0038202 1/90 TORC1 signaling biological_process "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] EOG8W10VF GO:0008360 1/90 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8W10VF GO:0009967 1/90 positive regulation of signal transduction biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] EOG8W10VF GO:0007175 1/90 negative regulation of epidermal growth factor-activated receptor activity biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators] EOG8W10VF GO:0007476 1/90 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8W10VF GO:0008595 1/90 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8W10VF GO:0007256 1/90 activation of JNKK activity biological_process "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] EOG8W10VF GO:0008293 1/90 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8W10VF GO:0007614 1/90 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8W10VF GO:0043410 1/90 positive regulation of MAPK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] EOG8W10VF GO:0005118 1/90 sevenless binding molecular_function "Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:3151175] EOG8W10VF GO:0007265 1/90 Ras protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] EOG8W10VF GO:0007015 1/90 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8W10VF GO:0045678 1/90 positive regulation of R7 cell differentiation biological_process "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] EOG8W10VF GO:0001700 1/90 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8W10VF GO:0008355 1/90 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8W10VF GO:0005515 1/90 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8W10VF GO:0008306 1/90 associative learning biological_process "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] EOG8W10VF GO:0045500 1/90 sevenless signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:10771085] EOG87SVW1 GO:0003012 1/97 muscle system process biological_process "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] EOG8S4RZ0 GO:0016021 116/397 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S4RZ0 GO:0005215 113/397 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8S4RZ0 GO:0055085 6/397 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8S4RZ0 GO:0015267 5/397 channel activity molecular_function "Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-] EOG8S4RZ0 GO:0003014 3/397 renal system process biological_process "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] EOG8S4RZ0 GO:0016020 3/397 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8S4RZ0 GO:0015250 1/397 water channel activity molecular_function "Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] EOG8S4RZ0 GO:0046662 1/397 regulation of oviposition biological_process "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai] EOG8S4RZ0 GO:0006833 1/397 water transport biological_process "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8S4RZ0 GO:0030104 1/397 water homeostasis biological_process "Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb] EOG89GNWT GO:0016779 1/11 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG89GNWT GO:0003924 1/11 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG89GNWT GO:0005525 1/11 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG89GNWT GO:0005622 1/11 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG89GNWT GO:0003746 1/11 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG869T85 GO:0005524 27/97 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG869T85 GO:0004674 25/97 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG869T85 GO:0008353 2/97 RNA polymerase II carboxy-terminal domain kinase activity molecular_function "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] EOG869T85 GO:0045880 1/97 positive regulation of smoothened signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG869T85 GO:0007623 1/97 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG869T85 GO:0046331 1/97 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG869T85 GO:0031397 1/97 negative regulation of protein ubiquitination biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] EOG869T85 GO:0005737 1/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG869T85 GO:0004672 1/97 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG869T85 GO:0007411 1/97 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG869T85 GO:0005829 1/97 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG869T85 GO:0005956 1/97 protein kinase CK2 complex cellular_component "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779] EOG869T85 GO:0007067 1/97 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG869T85 GO:0031647 1/97 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG869T85 GO:0030177 1/97 positive regulation of Wnt signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] EOG869T85 GO:0048749 1/97 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG869T85 GO:0045475 1/97 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG869T85 GO:0016055 1/97 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG869T85 GO:0022416 1/97 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG869T85 GO:0005634 1/97 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG869T85 GO:0005515 1/97 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG869T85 GO:0007228 1/97 positive regulation of hh target transcription factor activity biological_process "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936] EOG869T85 GO:0006468 1/97 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8BK7KW GO:0046872 1/11 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GTNV8 GO:0003676 34/211 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GTNV8 GO:0008270 27/211 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GTNV8 GO:0015074 11/211 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8GTNV8 GO:0003723 6/211 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8GTNV8 GO:0005198 6/211 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8GTNV8 GO:0005882 6/211 intermediate filament cellular_component "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] EOG8GTNV8 GO:0003964 6/211 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8GTNV8 GO:0005524 1/211 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GTNV8 GO:0005737 1/211 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GTNV8 GO:0004190 1/211 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8GTNV8 GO:0006457 1/211 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8W6RC4 GO:0005198 1/3 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8W6RC4 GO:0016226 1/3 iron-sulfur cluster assembly biological_process "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] EOG8W6RC4 GO:0051536 1/3 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8R7XR3 GO:0055085 46/146 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8R7XR3 GO:0016021 46/146 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8H48HM GO:0004190 2/90 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8H48HM GO:0032440 1/90 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8ZSCJF GO:0005634 45/168 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8ZSCJF GO:0003700 44/168 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8ZSCJF GO:0007275 41/168 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8ZSCJF GO:0000976 35/168 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8ZSCJF GO:0043565 10/168 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8ZSCJF GO:0007367 3/168 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG8ZSCJF GO:0048100 2/168 wing disc anterior/posterior pattern formation biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531] EOG8ZSCJF GO:0007386 2/168 compartment pattern specification biological_process "The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8ZSCJF GO:0007474 2/168 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8ZSCJF GO:0007400 2/168 neuroblast fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] EOG8ZSCJF GO:0003677 2/168 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8ZSCJF GO:0007388 1/168 posterior compartment specification biological_process "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8ZSCJF GO:0000122 1/168 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8ZSCJF GO:0048099 1/168 anterior/posterior lineage restriction, imaginal disc biological_process "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jid, PMID:10625531, PMID:9374402] EOG8ZSCJF GO:0007487 1/168 analia development biological_process "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu] EOG8ZSCJF GO:0007485 1/168 imaginal disc-derived male genitalia development biological_process "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG8ZSCJF GO:0010629 1/168 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8ZSCJF GO:0035288 1/168 anterior head segmentation biological_process "Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136] EOG8ZSCJF GO:0007486 1/168 imaginal disc-derived female genitalia development biological_process "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG8ZSCJF GO:0035289 1/168 posterior head segmentation biological_process "Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136] EOG8ZSCJF GO:0007447 1/168 imaginal disc pattern formation biological_process "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid] EOG8ZSCJF GO:0045944 1/168 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8ZSCJF GO:0016787 1/168 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8ZSCJF GO:0035215 1/168 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG8ZSCJF GO:0007476 1/168 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8ZSCJF GO:0035277 1/168 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG8ZSCJF GO:0050832 1/168 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8ZSCJF GO:0000980 1/168 RNA polymerase II distal enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] EOG8ZSCJF GO:0007418 1/168 ventral midline development biological_process "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] EOG8ZSCJF GO:0045892 1/168 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8ZSCJF GO:0010468 1/168 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8ZSCJF GO:0008406 1/168 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8ZSCJF GO:0035290 1/168 trunk segmentation biological_process "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402] EOG8ZSCJF GO:0007411 1/168 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8ZSCJF GO:0006351 1/168 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8ZSCJF GO:0007448 1/168 anterior/posterior pattern specification, imaginal disc biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238] EOG8ZSCJF GO:0001158 1/168 enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH] EOG8ZSCJF GO:0021960 1/168 anterior commissure morphogenesis biological_process "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] EOG8ZSCJF GO:0001078 1/168 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] EOG8ZSCJF GO:0035224 1/168 genital disc anterior/posterior pattern formation biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318] EOG8KWN97 GO:0046872 2/23 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8KWN97 GO:0003676 2/23 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89GNWC GO:0007018 21/92 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG89GNWC GO:0005930 21/92 axoneme cellular_component "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] EOG89GNWC GO:0003777 21/92 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG89GNWC GO:0030286 19/92 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG89GNWC GO:0005524 16/92 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89GNWC GO:0016887 8/92 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG89GNWC GO:0003676 1/92 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89GNWC GO:0000166 1/92 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG89GNWC GO:0042623 1/92 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG89GNWC GO:0038032 1/92 termination of G-protein coupled receptor signaling pathway biological_process "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] EOG89GNWC GO:0006200 1/92 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG89GNWC GO:0005875 1/92 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8G7FCB GO:0016021 42/190 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G7FCB GO:0008271 30/190 secondary active sulfate transmembrane transporter activity molecular_function "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] EOG8G7FCB GO:0015116 13/190 sulfate transmembrane transporter activity molecular_function "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] EOG8G7FCB GO:0005452 1/190 inorganic anion exchanger activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah] EOG8G7FCB GO:1902358 1/190 sulfate transmembrane transport biological_process "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073] EOG8G7FCB GO:0015106 1/190 bicarbonate transmembrane transporter activity molecular_function "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] EOG8G7FCB GO:0008272 1/190 sulfate transport biological_process "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8G7FCB GO:0019532 1/190 oxalate transport biological_process "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] EOG8G7FCB GO:0015724 1/190 formate transport biological_process "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8G7FCB GO:0015085 1/190 calcium ion transmembrane transporter activity molecular_function "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf] EOG8G7FCB GO:0070588 1/190 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8G7FCB GO:0015499 1/190 formate transmembrane transporter activity molecular_function "Enables the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai] EOG8G7FCB GO:0019531 1/190 oxalate transmembrane transporter activity molecular_function "Enables the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] EOG8G7FCB GO:0015701 1/190 bicarbonate transport biological_process "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG8CC6HC GO:0005634 2/3 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CC6HC GO:0003677 2/3 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CC6HC GO:0003700 2/3 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8CRPDD GO:0005234 23/81 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8CRPDD GO:0004970 22/81 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8CRPDD GO:0016020 19/81 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CRPDD GO:0016021 4/81 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CRPDD GO:0015276 1/81 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8CRPDD GO:0009593 1/81 detection of chemical stimulus biological_process "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] EOG8CRPDD GO:0036081 1/81 extracellular ammonia-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] EOG8CRPDD GO:0034220 1/81 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8JQ6C0 GO:0004197 36/130 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8X6FPC GO:0003677 17/79 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NW20V GO:0016021 19/118 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW20V GO:0004930 16/118 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8NW20V GO:0005887 14/118 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW20V GO:0004952 12/118 dopamine neurotransmitter receptor activity molecular_function "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282] EOG8NW20V GO:0004715 3/118 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8NW20V GO:0016907 2/118 G-protein coupled acetylcholine receptor activity molecular_function "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] EOG8NW20V GO:0004993 2/118 serotonin receptor activity molecular_function "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai] EOG8NW20V GO:0060180 1/118 female mating behavior biological_process "The specific behavior of a female organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] EOG8NW20V GO:0016543 1/118 male courtship behavior, orientation prior to leg tapping and wing vibration biological_process "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster." [GOC:sensu, PMID:11092827] EOG8NW20V GO:0005886 1/118 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8NW20V GO:0008227 1/118 G-protein coupled amine receptor activity molecular_function "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] EOG8NW20V GO:0007210 1/118 serotonin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] EOG8NW20V GO:0007619 1/118 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8NW20V GO:0007192 1/118 adenylate cyclase-activating serotonin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] EOG8NW20V GO:0016546 1/118 male courtship behavior, proboscis-mediated licking biological_process "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] EOG8NW20V GO:0060179 1/118 male mating behavior biological_process "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] EOG8NW20V GO:0004935 1/118 adrenergic receptor activity molecular_function "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274] EOG8NW20V GO:0016545 1/118 male courtship behavior, veined wing vibration biological_process "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] EOG812PKC GO:0035058 1/94 nonmotile primary cilium assembly biological_process "The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kmv, PMID:14521833, PMID:14521834] EOG812PKC GO:0031513 1/94 nonmotile primary cilium cellular_component "A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998] EOG812PKC GO:0042384 1/94 cilium assembly biological_process "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732] EOG812PKC GO:0035721 1/94 intraciliary retrograde transport biological_process "The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia] EOG870WX3 GO:0007035 1/120 vacuolar acidification biological_process "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid] EOG870WX3 GO:0008593 1/120 regulation of Notch signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8BS00S GO:0006281 28/109 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8BS00S GO:0006629 1/109 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8BS00S GO:0007095 1/109 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8WWV1P GO:0003824 3/6 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8WWV1P GO:0004619 1/6 phosphoglycerate mutase activity molecular_function "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] EOG8TTJXW GO:0042578 30/105 phosphoric ester hydrolase activity molecular_function "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] EOG87H841 GO:0007165 8/19 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG87H841 GO:0004114 8/19 3',5'-cyclic-nucleotide phosphodiesterase activity molecular_function "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] EOG87H841 GO:0046872 6/19 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8X6FPP GO:0004657 30/95 proline dehydrogenase activity molecular_function "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] EOG8X6FPP GO:0006562 30/95 proline catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] EOG8X6FPP GO:0006537 29/95 glutamate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] EOG8X6FPP GO:0007626 1/95 locomotory behavior biological_process "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] EOG8X6FPP GO:0005759 1/95 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8X6FPP GO:0042331 1/95 phototaxis biological_process "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] EOG8X6FPP GO:0010133 1/95 proline catabolic process to glutamate biological_process "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz] EOG8X6FPP GO:0005739 1/95 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8X6FPP GO:0071949 1/95 FAD binding molecular_function "Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] EOG8STVMC GO:0004725 28/118 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8STVMC GO:0015074 1/118 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8STVMC GO:0003677 1/118 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8STVMC GO:0006909 1/118 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8STVMC GO:0004803 1/118 transposase activity molecular_function "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] EOG8STVMC GO:0006313 1/118 transposition, DNA-mediated biological_process "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] EOG8STVMC GO:0006470 1/118 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8STVMC GO:0022008 1/118 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8STVMC GO:0035335 1/118 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG8STVMC GO:0050254 1/118 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG82JR79 GO:0003700 24/73 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG82JR79 GO:0043565 24/73 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82JR79 GO:0005634 22/73 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82JR79 GO:0007275 14/73 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG82JR79 GO:0001748 1/73 optic lobe placode development biological_process "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] EOG82JR79 GO:0004000 1/73 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG82VBZX GO:0004930 3/34 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG82VBZX GO:0016021 3/34 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S7N3W GO:0016021 27/114 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S7N3W GO:0008026 1/114 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8S7N3W GO:0005524 1/114 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8S7N3W GO:0003676 1/114 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89W4WF GO:0000242 1/59 pericentriolar material cellular_component "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] EOG89W4WF GO:0051297 1/59 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8C2KRT GO:0003993 96/479 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG8C2KRT GO:0006909 1/479 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8P8J07 GO:0008270 2/94 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8P8J07 GO:0003676 2/94 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83JFK0 GO:0004075 4/19 biotin carboxylase activity molecular_function "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] EOG83JFK0 GO:0046872 4/19 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83JFK0 GO:0005524 4/19 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83JFK0 GO:0004658 1/19 propionyl-CoA carboxylase activity molecular_function "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3] EOG8F7QZS GO:0007010 22/93 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8PK4RD GO:0016012 30/113 sarcoglycan complex cellular_component "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609] EOG8PK4RD GO:0016021 30/113 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PK4RD GO:0060047 1/113 heart contraction biological_process "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] EOG8PK4RD GO:0043034 1/113 costamere cellular_component "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378] EOG8PK4RD GO:0045214 1/113 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8PK4RD GO:0007498 1/113 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8PK4RD GO:0007016 1/113 cytoskeletal anchoring at plasma membrane biological_process "A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] EOG805VDW GO:0016020 82/211 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG805VDW GO:0005215 82/211 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG805VDW GO:0031427 1/211 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG8FR35V GO:0016021 33/136 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FR35V GO:0015299 32/136 solute:proton antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] EOG8FR35V GO:0000166 1/136 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8FR35V GO:0035725 1/136 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8FR35V GO:0015385 1/136 sodium:proton antiporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] EOG8FR35V GO:0003676 1/136 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FR35V GO:0003096 1/136 renal sodium ion transport biological_process "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio] EOG8FR35V GO:0005903 1/136 brush border cellular_component "Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] EOG8SN43R GO:0016021 2/63 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8616M6 GO:0008270 4/65 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8616M6 GO:0003676 3/65 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8616M6 GO:0003723 1/65 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8616M6 GO:0003964 1/65 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG82587J GO:0016021 30/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82587J GO:0055085 24/96 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG82587J GO:0006810 4/96 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG82587J GO:0006839 2/96 mitochondrial transport biological_process "Transport of substances into, out of or within a mitochondrion." [GOC:ai] EOG82587J GO:0031966 2/96 mitochondrial membrane cellular_component "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] EOG80P6PC GO:0004030 37/289 aldehyde dehydrogenase [NAD(P)+] activity molecular_function "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5] EOG80P6PC GO:0006081 36/289 cellular aldehyde metabolic process biological_process "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732] EOG80P6PC GO:0005975 28/289 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG80P6PC GO:0005840 26/289 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG80P6PC GO:0006412 26/289 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG80P6PC GO:0003735 26/289 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG80P6PC GO:0016773 26/289 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG80P6PC GO:0016301 22/289 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG80P6PC GO:0004370 2/289 glycerol kinase activity molecular_function "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647] EOG80P6PC GO:0005811 1/289 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG80P6PC GO:0000022 1/289 mitotic spindle elongation biological_process "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] EOG80P6PC GO:0007052 1/289 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG80P6PC GO:0007264 1/289 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG80P6PC GO:0016491 1/289 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG80P6PC GO:0005525 1/289 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG80P6PC GO:0005622 1/289 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG80P6PC GO:0016020 1/289 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8PG8HS GO:0030414 1/14 peptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] EOG8PG8HS GO:0008233 1/14 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8DNHMH GO:0003755 24/89 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8DNHMH GO:0006457 24/89 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8DNHMH GO:0000412 18/89 histone peptidyl-prolyl isomerization biological_process "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc] EOG8DNHMH GO:0005730 18/89 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8DNHMH GO:0005528 18/89 FK506 binding molecular_function "Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl] EOG8DNHMH GO:0018208 1/89 peptidyl-proline modification biological_process "The modification of peptidyl-proline." [GOC:go_curators] EOG8DNHMH GO:0035626 1/89 juvenile hormone mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart] EOG8DNHMH GO:0070594 1/89 juvenile hormone response element binding molecular_function "Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872] EOG8DNHMH GO:0005515 1/89 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8DNHMH GO:0016242 1/89 negative regulation of macroautophagy biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] EOG8DNHMH GO:0005875 1/89 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8DNHMH GO:0010507 1/89 negative regulation of autophagy biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8DNHMH GO:0016020 1/89 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8K0T38 GO:0007476 1/59 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8K0T38 GO:0050995 1/59 negative regulation of lipid catabolic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] EOG8K0T38 GO:0030730 1/59 sequestering of triglyceride biological_process "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732] EOG8K0T38 GO:0019915 1/59 lipid storage biological_process "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] EOG8K0T38 GO:0051049 1/59 regulation of transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8K0T38 GO:0005515 1/59 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8K0T38 GO:0005875 1/59 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8K0T38 GO:0006629 1/59 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8K0T38 GO:0006869 1/59 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG8K0T38 GO:0005737 1/59 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K0T38 GO:0005811 1/59 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8K0T38 GO:0031887 1/59 lipid particle transport along microtubule biological_process "The directed movement of a lipid particle along a microtubule, mediated by motor proteins." [PMID:9491895] EOG851H4X GO:0016021 117/291 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG851H4X GO:0007155 117/291 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG851H4X GO:0048102 2/291 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG851H4X GO:0005044 2/291 scavenger receptor activity molecular_function "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] EOG851H4X GO:0016063 2/291 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG851H4X GO:0007602 2/291 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG851H4X GO:0035071 2/291 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG851H4X GO:0006898 2/291 receptor-mediated endocytosis biological_process "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] EOG851H4X GO:0002433 1/291 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis biological_process "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149] EOG851H4X GO:0006909 1/291 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG851H4X GO:0006911 1/291 phagocytosis, engulfment biological_process "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149] EOG851H4X GO:0006915 1/291 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG851H4X GO:0006955 1/291 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG851H4X GO:0046867 1/291 carotenoid transport biological_process "The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai] EOG851H4X GO:0016116 1/291 carotenoid metabolic process biological_process "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684] EOG851H4X GO:0042116 1/291 macrophage activation biological_process "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301] EOG851H4X GO:0005886 1/291 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG851H4X GO:0050764 1/291 regulation of phagocytosis biological_process "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai] EOG851H4X GO:0004872 1/291 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG851H4X GO:0043052 1/291 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG851H4X GO:0005764 1/291 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG8G7FC4 GO:0003714 5/92 transcription corepressor activity molecular_function "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8G7FC4 GO:0006351 5/92 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8G7FC4 GO:0090204 1/92 protein localization to nuclear pore biological_process "A process in which a protein is transported to, or maintained in, a nuclear pore." [GOC:dph, GOC:rb, GOC:tb] EOG8G7FC4 GO:0003723 1/92 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8G7FC4 GO:0046826 1/92 negative regulation of protein export from nucleus biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] EOG8G7FC4 GO:0051028 1/92 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8G7FC4 GO:0005643 1/92 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG8G7FC4 GO:0004525 1/92 ribonuclease III activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] EOG8G7FC4 GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8G7FC4 GO:0000059 1/92 protein import into nucleus, docking biological_process "A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex." [GOC:isa_complete, GOC:mah, PMID:14570049, PMID:7878057, PMID:9126736] EOG8G7FC4 GO:0007184 1/92 SMAD protein import into nucleus biological_process "The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph] EOG8G7FC4 GO:0006396 1/92 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8G7FC4 GO:0005875 1/92 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8DNHMR GO:0016020 1/7 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8ZSCM4 GO:0003677 1/17 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8M0HFW GO:0046872 24/91 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8M0HFW GO:0000285 1/91 1-phosphatidylinositol-3-phosphate 5-kinase activity molecular_function "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612] EOG8M0HFW GO:0016020 1/91 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8M0HFW GO:0009405 1/91 pathogenesis biological_process "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] EOG8G7FC2 GO:0016773 26/127 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8G7FC2 GO:0016301 12/127 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8G7FC2 GO:0005524 12/127 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8G7FC2 GO:0005634 1/127 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8G7FC2 GO:0000184 1/127 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] EOG8G7FC2 GO:0006396 1/127 RNA processing biological_process "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] EOG8G7FC2 GO:0046777 1/127 protein autophosphorylation biological_process "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] EOG8G7FC2 GO:0007274 1/127 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8G7FC2 GO:0004674 1/127 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8G7FC2 GO:0016310 1/127 phosphorylation biological_process "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] EOG8G7FC2 GO:0006950 1/127 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8G7FC2 GO:0050808 1/127 synapse organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] EOG8G7FC2 GO:0018105 1/127 peptidyl-serine phosphorylation biological_process "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] EOG8G7FC2 GO:0005737 1/127 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8G7FC2 GO:0004672 1/127 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8G7FC2 GO:0046872 1/127 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8G7FC2 GO:0008144 1/127 drug binding molecular_function "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732] EOG8G7FC2 GO:0048489 1/127 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG84QWDR GO:0007615 1/103 anesthesia-resistant memory biological_process "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] EOG84QWDR GO:0048789 1/103 cytoskeletal matrix organization at active zone biological_process "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759] EOG84QWDR GO:0008344 1/103 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG84QWDR GO:0007274 1/103 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG84QWDR GO:0048790 1/103 maintenance of presynaptic active zone structure biological_process "The process in which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr] EOG84QWDR GO:0007614 1/103 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG84QWDR GO:0007268 1/103 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG84QWDR GO:0031594 1/103 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG84QWDR GO:0048786 1/103 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG84QWDR GO:0007269 1/103 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG84QWDR GO:0048167 1/103 regulation of synaptic plasticity biological_process "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290] EOG84QWDR GO:0032440 1/103 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG84QWDR GO:0048788 1/103 cytoskeleton of presynaptic active zone cellular_component "The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438] EOG8TQPQV GO:0016021 21/79 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TQPQW GO:0055114 5/70 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8TQPQW GO:0009186 5/70 deoxyribonucleoside diphosphate metabolic process biological_process "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] EOG8TQPQW GO:0015074 1/70 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8TQPQW GO:0003676 1/70 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82C0PP GO:0005272 34/119 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG82C0PP GO:0016021 32/119 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82C0PP GO:0016020 2/119 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82586J GO:0005089 29/101 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG82586J GO:0046928 1/101 regulation of neurotransmitter secretion biological_process "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] EOG82586J GO:0035011 1/101 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG82586J GO:0007480 1/101 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG82586J GO:0031594 1/101 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG82586J GO:0016740 1/101 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8NZX8B GO:0016021 3/176 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NZX8B GO:0006506 2/176 GPI anchor biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] EOG8NZX8B GO:0000139 2/176 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8NZX8B GO:0015031 2/176 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8NZX8B GO:0005789 2/176 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8NZX8B GO:0008565 2/176 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG8B5RMV GO:0003677 5/28 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8J9QCZ GO:0043565 1/88 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8J9QCZ GO:0006351 1/88 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8J9QCZ GO:0005634 1/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8J9QCZ GO:0003700 1/88 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8J9QCZ GO:0035859 1/88 Seh1-associated complex cellular_component "A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112] EOG8J9QCZ GO:0008270 1/88 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG886BTB GO:0004144 12/86 diacylglycerol O-acyltransferase activity molecular_function "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] EOG886BTB GO:0045017 10/86 glycerolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] EOG8M948F GO:0005739 1/5 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8M948F GO:0004129 1/5 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG89360S GO:0008270 3/41 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG89360S GO:0003676 3/41 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NCPVR GO:0004518 1/47 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8NCPVR GO:0006281 1/47 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8TQPQ1 GO:0005622 38/108 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8TQPQ1 GO:0005085 38/108 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8TQPQ1 GO:0007264 38/108 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8TQPQ1 GO:0051056 32/108 regulation of small GTPase mediated signal transduction biological_process "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] EOG8TQPQ1 GO:0016319 1/108 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8TQPQ1 GO:0008360 1/108 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG82RGNG GO:0016746 2/166 transferase activity, transferring acyl groups molecular_function "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG82RGNG GO:0050832 1/166 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG82RGNG GO:0007527 1/166 adult somatic muscle development biological_process "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG82RGNG GO:0072686 1/166 mitotic spindle cellular_component "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] EOG8C8B7K GO:0004190 2/31 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8RV55T GO:0003723 17/88 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8RV55T GO:0006397 17/88 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8RV55T GO:0005737 17/88 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8RV55T GO:0005634 17/88 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RV55T GO:0016747 1/88 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8RV55T GO:0046331 1/88 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG88PQ3W GO:0005634 1/2 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88PQ3W GO:0008270 1/2 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG88PQ3W GO:0003676 1/2 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VT8B5 GO:0030424 3/282 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8VT8B5 GO:0007411 3/282 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8VT8B5 GO:0008406 3/282 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8VT8B5 GO:0022409 2/282 positive regulation of cell-cell adhesion biological_process "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete] EOG8VT8B5 GO:0016319 2/282 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8VT8B5 GO:2000274 2/282 regulation of epithelial cell migration, open tracheal system biological_process "Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol] EOG8VT8B5 GO:0003151 2/282 outflow tract morphogenesis biological_process "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] EOG8VT8B5 GO:0048036 2/282 central complex development biological_process "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] EOG8VT8B5 GO:0035050 2/282 embryonic heart tube development biological_process "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] EOG8VT8B5 GO:0004872 2/282 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG8VT8B5 GO:0008038 2/282 neuron recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators] EOG8VT8B5 GO:0007419 2/282 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8VT8B5 GO:0007432 2/282 salivary gland boundary specification biological_process "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] EOG8VT8B5 GO:0005886 1/282 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8VT8B5 GO:0031987 1/282 locomotion involved in locomotory behavior biological_process "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] EOG8VT8B5 GO:0048854 1/282 brain morphogenesis biological_process "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] EOG8VT8B5 GO:0009649 1/282 entrainment of circadian clock biological_process "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] EOG8VT8B5 GO:0001764 1/282 neuron migration biological_process "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] EOG8VT8B5 GO:0007427 1/282 epithelial cell migration, open tracheal system biological_process "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8VT8B5 GO:0043025 1/282 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG8VT8B5 GO:0005887 1/282 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VT8B5 GO:0005515 1/282 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8VT8B5 GO:0035385 1/282 Roundabout signaling pathway biological_process "A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] EOG8VT8B5 GO:0044295 1/282 axonal growth cone cellular_component "The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954] EOG8VT8B5 GO:0016199 1/282 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8VT8B5 GO:0030425 1/282 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8VT8B5 GO:0001964 1/282 startle response biological_process "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] EOG8VT8B5 GO:0046716 1/282 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG8VT8B5 GO:0042685 1/282 cardioblast cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] EOG8VT8B5 GO:0071666 1/282 Slit-Robo signaling complex cellular_component "A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766] EOG8VT8B5 GO:0072499 1/282 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG8VT8B5 GO:0042803 1/282 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8VT8B5 GO:0031982 1/282 vesicle cellular_component "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] EOG8VT8B5 GO:0007426 1/282 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8VT8B5 GO:0008201 1/282 heparin binding molecular_function "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] EOG8VT8B5 GO:0048813 1/282 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8VT8B5 GO:0008039 1/282 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8VT8B5 GO:0043234 1/282 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8VT8B5 GO:0070983 1/282 dendrite guidance biological_process "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] EOG8VT8B5 GO:0050773 1/282 regulation of dendrite development biological_process "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] EOG8VT8B5 GO:0008045 1/282 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8C8B7Z GO:0016787 2/8 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8C8B7Z GO:0033883 1/8 pyridoxal phosphatase activity molecular_function "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74] EOG82RGNV GO:0016021 1/23 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8284J7 GO:0005509 2/6 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8H74TG GO:0003676 18/252 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8H74TG GO:0046872 18/252 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8H74TG GO:0016787 17/252 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8H74TG GO:0009405 1/252 pathogenesis biological_process "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] EOG8H74TG GO:0004222 1/252 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8H74TG GO:0005604 1/252 basement membrane cellular_component "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684] EOG8H74TG GO:0007155 1/252 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8H74TG GO:0003824 1/252 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8H74TG GO:0003677 1/252 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8H74TG GO:0005509 1/252 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8H74TG GO:0005576 1/252 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8ZGRV6 GO:0003964 4/61 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8ZGRV6 GO:0004519 4/61 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8ZGRV6 GO:0008270 2/61 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WQ3J3 GO:0004180 1/28 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG80P6P2 GO:0005975 1/7 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG80P6P2 GO:0003824 1/7 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG803098 GO:0016021 2/6 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG803098 GO:0004930 2/6 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG82Z73Z GO:0045202 1/86 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG82Z73Z GO:0008289 1/86 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG82Z73Z GO:0007269 1/86 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG82Z73Z GO:0008021 1/86 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG82Z73Z GO:0030659 1/86 cytoplasmic vesicle membrane cellular_component "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] EOG82Z73Z GO:0016079 1/86 synaptic vesicle exocytosis biological_process "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] EOG82Z73Z GO:0035249 1/86 synaptic transmission, glutamatergic biological_process "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv] EOG82Z73Z GO:0030054 1/86 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG82Z73Z GO:0016192 1/86 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG82Z73Z GO:0045956 1/86 positive regulation of calcium ion-dependent exocytosis biological_process "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] EOG82Z73Z GO:0015031 1/86 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG82Z73Z GO:0005509 1/86 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8FFGFP GO:0004725 27/98 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8FFGFP GO:0005856 23/98 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8FFGFP GO:0005737 12/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8FFGFP GO:0019898 2/98 extrinsic component of membrane cellular_component "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] EOG8FFGFP GO:0050254 2/98 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8FFGFP GO:0035071 1/98 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG8FFGFP GO:0006470 1/98 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8FFGFP GO:0048036 1/98 central complex development biological_process "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] EOG8FFGFP GO:0008092 1/98 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG8FFGFP GO:0035335 1/98 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG8FFGFP GO:0016319 1/98 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8FFGFP GO:0040040 1/98 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG8FFGFP GO:0048102 1/98 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG8FFGFP GO:0048846 1/98 axon extension involved in axon guidance biological_process "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid] EOG8NKF8C GO:0016021 5/107 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NKF8C GO:0046872 2/107 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NKF8C GO:0000166 2/107 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8NKF8B GO:0005319 30/134 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG8NKF8B GO:0005576 1/134 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8NKF8B GO:0006629 1/134 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8NKF8B GO:0015918 1/134 sterol transport biological_process "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] EOG8NKF8B GO:0005875 1/134 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8NKF8B GO:0034196 1/134 acylglycerol transport biological_process "The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl] EOG8NKF8B GO:0003700 1/134 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8NKF8B GO:0045178 1/134 basal part of cell cellular_component "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194] EOG8NKF8B GO:0043565 1/134 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8NKF8B GO:0004806 1/134 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG8NKF8B GO:0005615 1/134 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG86HJTN GO:0007275 2/5 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG86HJTN GO:0006355 2/5 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86HJTN GO:0006351 2/5 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG86HJTN GO:0005634 2/5 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86HJTN GO:0003677 2/5 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FFGFZ GO:0005509 20/63 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG81VNK4 GO:0007155 2/12 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG81VNK2 GO:0003810 1/3 protein-glutamine gamma-glutamyltransferase activity molecular_function "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] EOG81VNK2 GO:0018149 1/3 peptide cross-linking biological_process "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] EOG8THZ82 GO:0003824 41/113 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8THZ82 GO:0004165 3/113 dodecenoyl-CoA delta-isomerase activity molecular_function "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] EOG8THZ82 GO:0016853 2/113 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8QZB0T GO:0005249 1/81 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8QZB0T GO:0071805 1/81 potassium ion transmembrane transport biological_process "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] EOG8QZB0T GO:0005887 1/81 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QZB0T GO:0042391 1/81 regulation of membrane potential biological_process "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] EOG81ZHSK GO:0005886 1/59 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG81ZHSK GO:0016021 1/59 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81ZHSK GO:0050909 1/59 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8NGK1H GO:0007165 4/58 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8NGK1H GO:0004674 2/58 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8NGK1H GO:0005524 2/58 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NGK1H GO:0032440 1/58 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8NGK1H GO:0016301 1/58 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG88D389 GO:0007165 19/141 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG88D389 GO:0007432 1/141 salivary gland boundary specification biological_process "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] EOG88D389 GO:0008347 1/141 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG88D389 GO:0050919 1/141 negative chemotaxis biological_process "The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] EOG88D389 GO:0008045 1/141 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG88D389 GO:0007411 1/141 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG88D389 GO:0005515 1/141 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG88D389 GO:0005043 1/141 netrin receptor activity involved in chemorepulsion molecular_function "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling] EOG88D389 GO:0016021 1/141 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XH2DC GO:0022891 9/32 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG8XH2DC GO:0016021 9/32 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XH2DC GO:0008643 2/32 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8T4GBJ GO:0000166 14/72 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8T4GBJ GO:0003676 14/72 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8W6R9D GO:0046872 15/64 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8W6R9D GO:0003676 6/64 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XH2DG GO:0006826 23/81 iron ion transport biological_process "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8XH2DG GO:0008199 23/81 ferric iron binding molecular_function "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai] EOG8XH2DG GO:0005576 23/81 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XH2DG GO:0006879 23/81 cellular iron ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah] EOG8XH2DG GO:0042048 1/81 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG8N332Z GO:0003677 3/92 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8N332Z GO:0045886 1/92 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8N332Z GO:0006357 1/92 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8N332Z GO:0030177 1/92 positive regulation of Wnt signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] EOG8N332Z GO:0007517 1/92 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8N332Z GO:0007560 1/92 imaginal disc morphogenesis biological_process "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] EOG8N332Z GO:0007417 1/92 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8N332Z GO:0006351 1/92 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8N332Z GO:0005634 1/92 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82VBW6 GO:0007165 17/86 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG82VBW6 GO:0005622 16/86 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG82VBW6 GO:0046856 14/86 phosphatidylinositol dephosphorylation biological_process "The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732] EOG82VBW6 GO:0031011 1/86 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG82VBW6 GO:0004445 1/86 inositol-polyphosphate 5-phosphatase activity molecular_function "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56] EOG82VBW6 GO:0032187 1/86 actomyosin contractile ring localization biological_process "The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah] EOG82VBW6 GO:0006897 1/86 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG82VBW6 GO:0004439 1/86 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767] EOG82VBW6 GO:0055037 1/86 recycling endosome cellular_component "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] EOG82VBW6 GO:2000431 1/86 regulation of cytokinesis, actomyosin contractile ring assembly biological_process "Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] EOG82VBW6 GO:0034593 1/86 phosphatidylinositol bisphosphate phosphatase activity molecular_function "Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah] EOG82VBW6 GO:0052659 1/86 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11395] EOG82VBW6 GO:0005770 1/86 late endosome cellular_component "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] EOG82VBW6 GO:0052658 1/86 inositol-1,4,5-trisphosphate 5-phosphatase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19800] EOG82VBW6 GO:0005769 1/86 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG82VBW6 GO:0005737 1/86 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8RNDPZ GO:0016757 23/101 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8RNDPZ GO:0008466 4/101 glycogenin glucosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186] EOG86MF1H GO:0004871 28/103 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG86MF1H GO:0005634 24/103 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86MF1H GO:0006355 23/103 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG86MF1H GO:0006351 23/103 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG86MF1H GO:0003677 23/103 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86MF1H GO:0003700 2/103 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86MF1H GO:0046982 1/103 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG86MF1H GO:0043565 1/103 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG86MF1H GO:0006366 1/103 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG86MF1H GO:0005667 1/103 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG86MF1H GO:0000981 1/103 RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] EOG86MF1H GO:0072175 1/103 epithelial tube formation biological_process "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10] EOG86MF1H GO:0048813 1/103 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG86MF1H GO:0045944 1/103 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86MF1H GO:0046331 1/103 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG86MF1H GO:0007443 1/103 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG86MF1H GO:0007431 1/103 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG86MF1H GO:0035277 1/103 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG86MF1H GO:0007424 1/103 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG86MF1H GO:0007425 1/103 epithelial cell fate determination, open tracheal system biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940] EOG86MF1H GO:0005737 1/103 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG86MF1H GO:0007435 1/103 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG818F2D GO:0016021 43/132 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG818F2D GO:0044070 1/132 regulation of anion transport biological_process "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] EOG818F2D GO:0005247 1/132 voltage-gated chloride channel activity molecular_function "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG818F2D GO:0050829 1/132 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG818F2D GO:0005229 1/132 intracellular calcium activated chloride channel activity molecular_function "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] EOG818F2D GO:0006821 1/132 chloride transport biological_process "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] EOG818F2D GO:1902476 1/132 chloride transmembrane transport biological_process "The directed movement of chloride across a membrane." [GOC:TermGenie, GOC:vw] EOG82FW0Q GO:0016020 21/78 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG82FW0Q GO:0035556 21/78 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG82FW0Q GO:0016192 1/78 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8MGVN7 GO:0031248 1/92 protein acetyltransferase complex cellular_component "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] EOG8MGVN7 GO:0004596 1/92 peptide alpha-N-acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [EC:2.3.1.88, GOC:mah] EOG8MGVN7 GO:0072686 1/92 mitotic spindle cellular_component "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] EOG8MGVN7 GO:0022008 1/92 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MGVN7 GO:0016740 1/92 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8323CG GO:0006486 1/99 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8323CG GO:0000398 1/99 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8323CG GO:0008378 1/99 galactosyltransferase activity molecular_function "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] EOG8323CG GO:0016020 1/99 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8323CG GO:0071011 1/99 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8323CG GO:0022008 1/99 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG88SK8F GO:0046872 1/73 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8577MX GO:0016021 75/289 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8577MX GO:0006486 74/289 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8577MX GO:0005794 73/289 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8577MX GO:0046872 72/289 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8577MX GO:0016757 70/289 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8577MX GO:0004653 9/289 polypeptide N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] EOG8577MX GO:0000139 3/289 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8577MX GO:0005795 2/289 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG8577MX GO:0009312 2/289 oligosaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] EOG8577MX GO:0006493 1/289 protein O-linked glycosylation biological_process "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] EOG8577MX GO:0033628 1/289 regulation of cell adhesion mediated by integrin biological_process "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] EOG8577MX GO:0070278 1/289 extracellular matrix constituent secretion biological_process "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah] EOG8577MX GO:0031589 1/289 cell-substrate adhesion biological_process "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] EOG8577MX GO:0032504 1/289 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8577MX GO:0008376 1/289 acetylgalactosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732] EOG8577MX GO:0016266 1/289 O-glycan processing biological_process "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130] EOG8PCD6Q GO:0004842 23/96 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8QRKJ0 GO:0008270 49/217 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QRKJ0 GO:0016740 1/217 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8WDGSC GO:0008270 13/50 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8X99X2 GO:0000184 1/98 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] EOG8XD64V GO:0005216 20/141 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8XD64V GO:0016021 20/141 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XD64V GO:0046873 1/141 metal ion transmembrane transporter activity molecular_function "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] EOG8XD64V GO:0070838 1/141 divalent metal ion transport biological_process "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG8XD64V GO:0016049 1/141 cell growth biological_process "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] EOG8XD64V GO:0016787 1/141 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8XD64V GO:0010960 1/141 magnesium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb] EOG8XD64V GO:0055069 1/141 zinc ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] EOG8XD64V GO:0007005 1/141 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG8XD64V GO:0005261 1/141 cation channel activity molecular_function "Enables the selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8XD64V GO:0034703 1/141 cation channel complex cellular_component "An ion channel complex through which cations pass." [GOC:mah] EOG8CJXZR GO:0016021 21/53 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJXZR GO:0004930 20/53 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8CJXZR GO:0005887 1/53 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJXZR GO:0007218 1/53 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8CJXZR GO:0035236 1/53 proctolin receptor activity molecular_function "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf] EOG8CJXZR GO:0008188 1/53 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8CJXZR GO:0007186 1/53 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8T4GB3 GO:0016021 2/17 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88D38F GO:0006886 29/95 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG88D38F GO:0005801 29/95 cis-Golgi network cellular_component "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194] EOG88D38F GO:0016020 26/95 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG88D38F GO:0000139 3/95 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG88D38F GO:0017119 3/95 Golgi transport complex cellular_component "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665] EOG88D38F GO:0006891 3/95 intra-Golgi vesicle-mediated transport biological_process "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] EOG88D38F GO:0006888 3/95 ER to Golgi vesicle-mediated transport biological_process "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] EOG88D38F GO:0008565 3/95 protein transporter activity molecular_function "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] EOG88D38F GO:0022008 1/95 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG88D38F GO:0007112 1/95 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG88D38F GO:0033227 1/95 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG805VHF GO:0005737 21/66 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG805VHF GO:0007616 1/66 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG805VHF GO:0008344 1/66 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG805VHF GO:0007614 1/66 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG805VHF GO:0005515 1/66 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG805VHF GO:0008057 1/66 eye pigment granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] EOG805VHF GO:0051968 1/66 positive regulation of synaptic transmission, glutamatergic biological_process "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] EOG805VHF GO:0008021 1/66 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG805VHF GO:0031083 1/66 BLOC-1 complex cellular_component "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] EOG805VHF GO:0048167 1/66 regulation of synaptic plasticity biological_process "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290] EOG805VHF GO:0045963 1/66 negative regulation of dopamine metabolic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] EOG805VHF GO:0048047 1/66 mating behavior, sex discrimination biological_process "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700] EOG8C5G07 GO:0004252 2199/5565 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8C5G07 GO:0006508 98/5565 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8C5G07 GO:0005615 18/5565 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8C5G07 GO:0005576 17/5565 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8C5G07 GO:0007586 11/5565 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG8C5G07 GO:0004175 8/5565 endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8C5G07 GO:0016021 6/5565 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8C5G07 GO:0016787 5/5565 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8C5G07 GO:0016301 5/5565 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8C5G07 GO:0008236 5/5565 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8C5G07 GO:0045087 4/5565 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8C5G07 GO:0006629 4/5565 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8C5G07 GO:0006952 3/5565 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8C5G07 GO:0045752 3/5565 positive regulation of Toll signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8C5G07 GO:0050830 3/5565 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8C5G07 GO:0008063 3/5565 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8C5G07 GO:0008233 3/5565 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8C5G07 GO:0005829 3/5565 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8C5G07 GO:0008889 3/5565 glycerophosphodiester phosphodiesterase activity molecular_function "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] EOG8C5G07 GO:0006071 3/5565 glycerol metabolic process biological_process "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] EOG8C5G07 GO:0050832 3/5565 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8C5G07 GO:0022008 2/5565 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8C5G07 GO:0050829 2/5565 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8C5G07 GO:0009950 2/5565 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8C5G07 GO:0035006 2/5565 melanization defense response biological_process "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] EOG8C5G07 GO:0007311 2/5565 maternal specification of dorsal/ventral axis, oocyte, germ-line encoded biological_process "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8C5G07 GO:0031638 2/5565 zymogen activation biological_process "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] EOG8C5G07 GO:0008270 1/5565 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8C5G07 GO:0006964 1/5565 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] EOG8C5G07 GO:0005515 1/5565 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8C5G07 GO:0005622 1/5565 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8C5G07 GO:0004435 1/5565 phosphatidylinositol phospholipase C activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] EOG8C5G07 GO:0048812 1/5565 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8C5G07 GO:0008592 1/5565 regulation of Toll signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8C5G07 GO:0006967 1/5565 positive regulation of antifungal peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] EOG8C5G07 GO:0003964 1/5565 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8C5G07 GO:0035008 1/5565 positive regulation of melanization defense response biological_process "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf] EOG8C5G07 GO:0035007 1/5565 regulation of melanization defense response biological_process "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf] EOG8C5G07 GO:0035556 1/5565 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8C5G07 GO:0003723 1/5565 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8C5G07 GO:0005581 1/5565 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8C5G07 GO:0004930 1/5565 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8C5G07 GO:0006909 1/5565 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8C5G07 GO:0004180 1/5565 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8C5G07 GO:0006959 1/5565 humoral immune response biological_process "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] EOG8C5G07 GO:0004471 1/5565 malate dehydrogenase (decarboxylating) (NAD+) activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39] EOG8C5G07 GO:0016485 1/5565 protein processing biological_process "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] EOG8C5G07 GO:0003677 1/5565 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8C5G07 GO:0051287 1/5565 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8C5G07 GO:0042060 1/5565 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG805VHB GO:0015074 4/18 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG805VHB GO:0003676 3/18 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG805VHB GO:0004190 2/18 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG805VHB GO:0003723 1/18 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG805VHB GO:0003964 1/18 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8C5G03 GO:0003779 2/344 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8C5G03 GO:0006936 1/344 muscle contraction biological_process "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] EOG8C5G03 GO:0051015 1/344 actin filament binding molecular_function "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] EOG8C5G03 GO:0048477 1/344 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8C5G03 GO:0007507 1/344 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8C5G03 GO:0030017 1/344 sarcomere cellular_component "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] EOG8C5G03 GO:0010591 1/344 regulation of lamellipodium assembly biological_process "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG8C5G03 GO:0070865 1/344 investment cone cellular_component "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716] EOG8C5G03 GO:0045451 1/344 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8C5G03 GO:0007315 1/344 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8C5G03 GO:0048813 1/344 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8H1DB7 GO:0008168 5/11 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8H1DB6 GO:0007605 1/98 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8N8TJT GO:0018149 23/73 peptide cross-linking biological_process "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] EOG8N8TJT GO:0003810 21/73 protein-glutamine gamma-glutamyltransferase activity molecular_function "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] EOG8N8TJT GO:0046872 10/73 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81VNKQ GO:0003676 2/24 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG81VNKN GO:0043565 4/30 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG81VNKN GO:0006351 4/30 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG81VNKN GO:0005634 4/30 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81VNKN GO:0003700 4/30 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG81VNKN GO:0003707 4/30 steroid hormone receptor activity molecular_function "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] EOG81VNKN GO:0008270 4/30 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG805VHT GO:0005634 5/39 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG805VHT GO:0000245 5/39 spliceosomal complex assembly biological_process "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] EOG8HB112 GO:0016021 34/136 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HB112 GO:0055085 34/136 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8HB112 GO:0005886 12/136 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8HB112 GO:0005215 12/136 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8RNDR2 GO:0016301 1/30 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8NW24P GO:0042302 1/3 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8STVN9 GO:0005634 97/397 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8STVN9 GO:0006351 90/397 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8STVN9 GO:0007275 89/397 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8STVN9 GO:0006355 52/397 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8STVN9 GO:0003677 52/397 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8STVN9 GO:0003700 44/397 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8STVN9 GO:0043565 43/397 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8STVN9 GO:0006366 3/397 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8STVN9 GO:0003705 3/397 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8STVN9 GO:0045944 3/397 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8STVN9 GO:0048813 2/397 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8STVN9 GO:0048749 2/397 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8STVN9 GO:0048854 2/397 brain morphogenesis biological_process "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] EOG8STVN9 GO:0016319 2/397 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8STVN9 GO:0007526 1/397 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8STVN9 GO:0007420 1/397 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8STVN9 GO:0007628 1/397 adult walking behavior biological_process "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907] EOG8STVN9 GO:0043704 1/397 photoreceptor cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu] EOG8STVN9 GO:0045676 1/397 regulation of R7 cell differentiation biological_process "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] EOG8STVN9 GO:0035214 1/397 eye-antennal disc development biological_process "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8STVN9 GO:0007455 1/397 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8STVN9 GO:0043567 1/397 regulation of insulin-like growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] EOG8STVN9 GO:0001745 1/397 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8STVN9 GO:0001158 1/397 enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH] EOG8STVN9 GO:0048666 1/397 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8STVN9 GO:0030182 1/397 neuron differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] EOG8STVN9 GO:0008347 1/397 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8STVN9 GO:0042676 1/397 compound eye cone cell fate commitment biological_process "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu] EOG8STVN9 GO:0010628 1/397 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8STVN9 GO:0007517 1/397 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8STVN9 GO:0005515 1/397 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8STVN9 GO:0008056 1/397 ocellus development biological_process "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] EOG8STVN9 GO:0004000 1/397 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8STVN9 GO:0048036 1/397 central complex development biological_process "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] EOG8STVN9 GO:0040018 1/397 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8STVN9 GO:0042673 1/397 regulation of retinal cone cell fate specification biological_process "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators] EOG8STVN9 GO:0042682 1/397 regulation of compound eye cone cell fate specification biological_process "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu] EOG8STVN9 GO:0045893 1/397 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8STVN9 GO:0000976 1/397 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8SJ7VM GO:0046872 1/6 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SJ7VM GO:0004222 1/6 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8GMXC1 GO:0004252 23/60 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8GMXC1 GO:0006508 1/60 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8QVFS8 GO:0008081 29/133 phosphoric diester hydrolase activity molecular_function "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] EOG8QVFS8 GO:0006629 28/133 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8QVFS8 GO:0006650 1/133 glycerophospholipid metabolic process biological_process "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732] EOG8QVFS8 GO:0047396 1/133 glycosylphosphatidylinositol diacylglycerol-lyase activity molecular_function "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN] EOG8RZ1G2 GO:0016021 1/87 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GXJ3X GO:0005576 7/71 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8GXJ3X GO:0006869 7/71 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG8GXJ3X GO:0008289 7/71 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG88WFFS GO:0003735 1/49 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG88WFFS GO:0015934 1/49 large ribosomal subunit cellular_component "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] EOG88WFFS GO:0035091 1/49 phosphatidylinositol binding molecular_function "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] EOG88WFFS GO:0006412 1/49 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8WDGV7 GO:0042302 184/825 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8WDGV7 GO:0040003 5/825 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8WDGV7 GO:0031012 5/825 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8WDGV7 GO:0008010 5/825 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8WDGV7 GO:0022008 1/825 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8NCPSN GO:0008026 28/90 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8NCPSN GO:0005524 28/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NCPSN GO:0003676 26/90 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NCPSN GO:0003682 2/90 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8NCPSN GO:0001700 2/90 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8NCPSN GO:0090305 2/90 nucleic acid phosphodiester bond hydrolysis biological_process "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] EOG8NCPSN GO:2001141 2/90 regulation of RNA biosynthetic process biological_process "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] EOG8NCPSN GO:0004527 2/90 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8NCPSN GO:0005634 2/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NCPSN GO:0032508 2/90 DNA duplex unwinding biological_process "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] EOG8NCPSN GO:0033677 2/90 DNA/RNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA." [GOC:mah] EOG8NCPSN GO:0006302 2/90 double-strand break repair biological_process "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] EOG8NCPSN GO:0008143 2/90 poly(A) binding molecular_function "Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl] EOG8NCPSN GO:0003712 2/90 transcription cofactor activity molecular_function "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8NCPSN GO:0004518 2/90 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8NCPSN GO:0006200 2/90 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8NCPSN GO:0042254 1/90 ribosome biogenesis biological_process "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma] EOG8NCPSN GO:0004386 1/90 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8MWBMC GO:0051539 40/124 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8MWBMC GO:0008137 28/124 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8MWBMC GO:0010181 27/124 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8MWBMC GO:0051287 25/124 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8MWBMC GO:0016651 12/124 oxidoreductase activity, acting on NAD(P)H molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8MWBMC GO:0005615 1/124 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8MWBMC GO:0032504 1/124 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG87M4CW GO:0008270 37/166 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG87M4CW GO:0016491 33/166 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG87M4CW GO:0003960 3/166 NADPH:quinone reductase activity molecular_function "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] EOG87M4CW GO:0047522 1/166 15-oxoprostaglandin 13-oxidase activity molecular_function "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG:R04556, KEGG:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN] EOG87M4CW GO:0036132 1/166 13-prostaglandin reductase activity molecular_function "Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG:R04556, KEGG:R04557, PMID:17449869] EOG8SN42W GO:0006950 1/5 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8SN42W GO:0006457 1/5 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8SN42W GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8616JD GO:0005524 29/133 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8616JD GO:0004713 25/133 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8616JD GO:0005509 19/133 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8616JD GO:0007156 19/133 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8616JD GO:0016021 18/133 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8616JD GO:0004715 2/133 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8616JD GO:0004714 2/133 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8616JD GO:0004672 2/133 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8616JD GO:0006468 1/133 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8616JD GO:0090303 1/133 positive regulation of wound healing biological_process "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] EOG8616JD GO:0007030 1/133 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8616JD GO:0016020 1/133 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8616JD GO:0016772 1/133 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8616JD GO:0045177 1/133 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG8616JD GO:0005887 1/133 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8616JD GO:0045792 1/133 negative regulation of cell size biological_process "Any process that reduces cell size." [GOC:go_curators] EOG8616JD GO:0042060 1/133 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8616JD GO:0018108 1/133 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8616JD GO:0016339 1/133 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] EOG8SN42R GO:0042626 3/14 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8SN42R GO:0005524 3/14 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8SN42R GO:0016021 3/14 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KPWR8 GO:0051536 5/10 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG8KPWR8 GO:0016491 4/10 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8KPWR8 GO:0005506 4/10 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8KPWR8 GO:0010181 4/10 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8KPWR8 GO:0003824 1/10 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8Q5C57 GO:0007155 30/134 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8Q5C57 GO:0031012 30/134 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8Q5C57 GO:0005198 30/134 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8Q5C57 GO:0005581 24/134 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8Q5C57 GO:0008045 1/134 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8Q5C57 GO:0030246 1/134 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8Q5C57 GO:2001046 1/134 positive regulation of integrin-mediated signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol] EOG8Q5C57 GO:0071711 1/134 basement membrane organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah] EOG8Q5C57 GO:0014732 1/134 skeletal muscle atrophy biological_process "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] EOG8Q5C57 GO:0007005 1/134 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG8Q5C57 GO:0014899 1/134 cardiac muscle atrophy biological_process "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle] EOG8S7N56 GO:0000287 26/87 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8S7N56 GO:0008253 26/87 5'-nucleotidase activity molecular_function "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] EOG8S7N56 GO:0005737 25/87 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8S7N56 GO:0016298 3/87 lipase activity molecular_function "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] EOG8S7N56 GO:0006629 3/87 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8S7N56 GO:0008252 1/87 nucleotidase activity molecular_function "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31] EOG8S7N56 GO:0000166 1/87 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8S7N56 GO:0009158 1/87 ribonucleoside monophosphate catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] EOG8S7N56 GO:0009117 1/87 nucleotide metabolic process biological_process "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] EOG8S7N56 GO:1901069 1/87 guanosine-containing compound catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines)." [GOC:TermGenie] EOG8S7N56 GO:0005829 1/87 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8S7N56 GO:0016311 1/87 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG8G4K71 GO:0003700 2/27 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8G4K71 GO:0005634 2/27 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8G4K71 GO:0043565 2/27 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG85QKVB GO:0003684 24/90 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG85QKVB GO:0006303 24/90 double-strand break repair via nonhomologous end joining biological_process "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021] EOG85QKVB GO:0000723 24/90 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG85QKVB GO:0042162 24/90 telomeric DNA binding molecular_function "Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624] EOG85QKVB GO:0004003 24/90 ATP-dependent DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] EOG85QKVB GO:0043564 24/90 Ku70:Ku80 complex cellular_component "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983] EOG85QKVB GO:0003677 1/90 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG85QKVB GO:0005524 1/90 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG85QKVB GO:0046982 1/90 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG85QKVB GO:0005694 1/90 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG85QKVB GO:0006310 1/90 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG83BQ4D GO:0008146 43/146 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG83BQ4D GO:0008459 4/146 chondroitin 6-sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] EOG83BQ4D GO:0016740 1/146 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81G5K3 GO:0030170 36/119 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG81G5K3 GO:0009058 35/119 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG81G5K3 GO:0003824 24/119 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG81G5K3 GO:0008483 6/119 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG81G5K3 GO:0004021 6/119 L-alanine:2-oxoglutarate aminotransferase activity molecular_function "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19456] EOG8R52HZ GO:0042302 1/116 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8R269W GO:0004222 32/200 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8R269W GO:0008270 28/200 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R269W GO:0005578 23/200 proteinaceous extracellular matrix cellular_component "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] EOG8R269W GO:0031012 2/200 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8R269W GO:0004143 1/200 diacylglycerol kinase activity molecular_function "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh] EOG8R269W GO:0007205 1/200 protein kinase C-activating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling] EOG8R269W GO:0003951 1/200 NAD+ kinase activity molecular_function "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18632] EOG8R269W GO:0042059 1/200 negative regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8XWJC2 GO:0005272 70/161 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8XWJC2 GO:0016021 67/161 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XWJC2 GO:0016020 3/161 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XWJC2 GO:0005886 1/161 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8XWJC2 GO:0009415 1/161 response to water biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] EOG8XWJC2 GO:0035002 1/161 liquid clearance, open tracheal system biological_process "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352] EOG8XWJC2 GO:0071462 1/161 cellular response to water stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah] EOG8XWJC2 GO:0042756 1/161 drinking behavior biological_process "The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr] EOG8PG8DR GO:0009253 3/17 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8PG8DR GO:0008745 3/17 N-acetylmuramoyl-L-alanine amidase activity molecular_function "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28] EOG8PG8DR GO:0004252 1/17 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8V720Z GO:0016021 2/5 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V720Z GO:0006810 1/5 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8MPM4G GO:0004177 1/5 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG8MPM4G GO:0046872 1/5 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TB6SK GO:0004553 1/3 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8TB6SK GO:0005975 1/3 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8PVRGJ GO:0005576 6/46 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PVRGJ GO:0007218 6/46 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8PVRGJ GO:0005184 2/46 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG8PVRGJ GO:0016084 2/46 myostimulatory hormone activity molecular_function "The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction." [GOC:mah, PMID:12204246] EOG8PVRGJ GO:0071855 1/46 neuropeptide receptor binding molecular_function "Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah] EOG8PVRGJ GO:0008613 1/46 diuretic hormone activity molecular_function "The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894] EOG8PVRGJ GO:0038060 1/46 nitric oxide-cGMP-mediated signaling pathway biological_process "Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632] EOG8PVRGJ GO:0007204 1/46 positive regulation of cytosolic calcium ion concentration biological_process "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] EOG8PVRGJ GO:0042045 1/46 epithelial fluid transport biological_process "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830] EOG8PVRGJ GO:0006812 1/46 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8PVRGJ GO:0005102 1/46 receptor binding molecular_function "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] EOG8PVRGJ GO:0005615 1/46 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG89GNZ9 GO:0046907 15/96 intracellular transport biological_process "The directed movement of substances within a cell." [GOC:ai] EOG89GNZ9 GO:0008258 1/96 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG89GNZ9 GO:0007303 1/96 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG89GNZ9 GO:0048813 1/96 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG89GNZ9 GO:0051489 1/96 regulation of filopodium assembly biological_process "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] EOG89GNZ9 GO:0007010 1/96 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG89GNZ9 GO:0005912 1/96 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG89GNZ9 GO:0010591 1/96 regulation of lamellipodium assembly biological_process "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG89GNZ9 GO:0030027 1/96 lamellipodium cellular_component "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] EOG89GNZ9 GO:0007015 1/96 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG89GNZ9 GO:0017124 1/96 SH3 domain binding molecular_function "Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018] EOG89GNZ9 GO:0005856 1/96 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG89GNZ9 GO:0035262 1/96 gonad morphogenesis biological_process "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001] EOG89GNZ9 GO:0007391 1/96 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG89GNZ9 GO:0007411 1/96 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG89GNZ9 GO:0007298 1/96 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG89GNZ9 GO:0032433 1/96 filopodium tip cellular_component "The end of a filopodium distal to the body of the cell." [GOC:mah] EOG89GNZ9 GO:0051491 1/96 positive regulation of filopodium assembly biological_process "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] EOG89GNZ9 GO:0008360 1/96 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG89GNZ9 GO:0008064 1/96 regulation of actin polymerization or depolymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] EOG89GNZ9 GO:0005911 1/96 cell-cell junction cellular_component "A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah] EOG89GNZ9 GO:0031346 1/96 positive regulation of cell projection organization biological_process "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] EOG89GNZ9 GO:0030335 1/96 positive regulation of cell migration biological_process "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] EOG89GNZ9 GO:0060288 1/96 formation of a compartment boundary biological_process "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] EOG89GNZ9 GO:0005515 1/96 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG89GNZ9 GO:0007390 1/96 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG89GNZ9 GO:0048749 1/96 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG89GNZ9 GO:0030424 1/96 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG89GNZ9 GO:0031252 1/96 cell leading edge cellular_component "The area of a motile cell closest to the direction of movement." [GOC:pg] EOG89GNZ9 GO:0007396 1/96 suture of dorsal opening biological_process "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138] EOG89GNZ9 GO:0030036 1/96 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG89GNZ9 GO:0003779 1/96 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG89GNZ9 GO:0003382 1/96 epithelial cell morphogenesis biological_process "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG89GNZ9 GO:0005829 1/96 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG89GNZ9 GO:0007409 1/96 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG88SK7C GO:0005085 23/53 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG88SK7C GO:0007264 23/53 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG88SK7C GO:0005622 23/53 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8PVRGC GO:0005549 63/151 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8PVRGC GO:0005576 2/151 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PVRGC GO:0007606 2/151 sensory perception of chemical stimulus biological_process "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] EOG8PVRGC GO:0005550 2/151 pheromone binding molecular_function "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] EOG8PVRGC GO:0006810 1/151 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8R52H1 GO:0005524 5/39 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8R52H1 GO:0003777 5/39 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8R52H1 GO:0005871 5/39 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8R52H1 GO:0007018 5/39 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8R52H1 GO:0005874 4/39 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8HHRGG GO:0005524 27/100 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HHRGG GO:0003676 26/100 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HHRGG GO:0006310 25/100 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG8HHRGG GO:0006260 25/100 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8HHRGG GO:0043140 25/100 ATP-dependent 3'-5' DNA helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] EOG8HHRGG GO:0006281 25/100 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8HHRGG GO:0005622 22/100 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8HHRGG GO:0005634 2/100 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8HHRGG GO:0004386 2/100 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8HHRGG GO:0000732 1/100 strand displacement biological_process "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855] EOG8HHRGG GO:0000403 1/100 Y-form DNA binding molecular_function "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] EOG8HHRGG GO:0008026 1/100 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8HHRGG GO:0006303 1/100 double-strand break repair via nonhomologous end joining biological_process "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021] EOG8HHRGG GO:0000733 1/100 DNA strand renaturation biological_process "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh] EOG8HHRGG GO:0032508 1/100 DNA duplex unwinding biological_process "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] EOG8HHRGG GO:0006302 1/100 double-strand break repair biological_process "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] EOG8HHRGG GO:0007131 1/100 reciprocal meiotic recombination biological_process "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] EOG8HHRGG GO:0006200 1/100 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG8HHRGG GO:1901291 1/100 negative regulation of double-strand break repair via single-strand annealing biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing." [GOC:sart, GOC:TermGenie] EOG8HHRGG GO:0044237 1/100 cellular metabolic process biological_process "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] EOG8HHRGG GO:0045003 1/100 double-strand break repair via synthesis-dependent strand annealing biological_process "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855] EOG8HHRGG GO:0008094 1/100 DNA-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] EOG8HHRGG GO:0006974 1/100 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8HHRGG GO:0000731 1/100 DNA synthesis involved in DNA repair biological_process "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855] EOG8HHRGG GO:0000724 1/100 double-strand break repair via homologous recombination biological_process "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] EOG8V720H GO:0003677 17/146 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8V720H GO:0006313 14/146 transposition, DNA-mediated biological_process "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] EOG8V720H GO:0015074 14/146 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8V720H GO:0004803 14/146 transposase activity molecular_function "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] EOG8V720H GO:0007476 1/146 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8V720H GO:0002121 1/146 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8D81NV GO:0046872 4/11 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D81NV GO:0003676 4/11 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG873S52 GO:0050660 110/344 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG873S52 GO:0009055 107/344 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG873S52 GO:0051537 105/344 2 iron, 2 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG873S52 GO:0016614 104/344 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG873S52 GO:0005506 90/344 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG873S52 GO:0046872 23/344 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG873S52 GO:0016491 9/344 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG873S52 GO:0008762 6/344 UDP-N-acetylmuramate dehydrogenase activity molecular_function "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] EOG873S52 GO:0051536 2/344 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG873S52 GO:0018492 1/344 carbon-monoxide dehydrogenase (acceptor) activity molecular_function "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2] EOG873S52 GO:0007155 1/344 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG873S52 GO:0016020 1/344 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8PG8DT GO:0032580 26/103 Golgi cisterna membrane cellular_component "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah] EOG8PG8DT GO:0016758 23/103 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8PG8DT GO:0047238 2/103 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN] EOG8PG8DT GO:0015020 1/103 glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] EOG8PG8DT GO:0030206 1/103 chondroitin sulfate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] EOG8PG8DT GO:0008375 1/103 acetylglucosaminyltransferase activity molecular_function "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] EOG8V45P7 GO:2000601 28/98 positive regulation of Arp2/3 complex-mediated actin nucleation biological_process "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476] EOG8V45P7 GO:0007015 27/98 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8V45P7 GO:0034314 1/98 Arp2/3 complex-mediated actin nucleation biological_process "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983] EOG8V45P7 GO:0016203 1/98 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8V45P7 GO:0008407 1/98 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8V45P7 GO:0007286 1/98 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8V45P7 GO:0006886 1/98 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8V45P7 GO:0045886 1/98 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8V45P7 GO:0007409 1/98 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8V45P7 GO:0005737 1/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8V45P7 GO:0016476 1/98 regulation of embryonic cell shape biological_process "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] EOG8V45P7 GO:0030833 1/98 regulation of actin filament polymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG8V45P7 GO:0009913 1/98 epidermal cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] EOG8V45P7 GO:0006900 1/98 membrane budding biological_process "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] EOG8V45P7 GO:0007423 1/98 sensory organ development biological_process "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] EOG8V45P7 GO:0035212 1/98 cell competition in a multicellular organism biological_process "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286] EOG8V45P7 GO:0072583 1/98 clathrin-mediated endocytosis biological_process "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965] EOG8V45P7 GO:0003779 1/98 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8V45P7 GO:0008582 1/98 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8V45P7 GO:0007413 1/98 axonal fasciculation biological_process "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] EOG8V45P7 GO:0001578 1/98 microtubule bundle formation biological_process "A process that results in a parallel arrangement of microtubules." [GOC:dph] EOG8V45P7 GO:0045165 1/98 cell fate commitment biological_process "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] EOG8V45P7 GO:0035017 1/98 cuticle pattern formation biological_process "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] EOG8V45P7 GO:0003383 1/98 apical constriction biological_process "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8V45P7 GO:0016028 1/98 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8V45P7 GO:0007520 1/98 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8V45P7 GO:0005199 1/98 structural constituent of cell wall molecular_function "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] EOG8V45P7 GO:0005902 1/98 microvillus cellular_component "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194] EOG8V45P7 GO:0008356 1/98 asymmetric cell division biological_process "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] EOG8V45P7 GO:0005515 1/98 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8V45P7 GO:0005634 1/98 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80S2VK GO:0003777 14/41 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG80S2VK GO:0007018 14/41 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8909QT GO:0046922 5/84 peptide-O-fucosyltransferase activity molecular_function "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221] EOG8909QT GO:0016757 4/84 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8909QT GO:0007219 1/84 Notch signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] EOG8909QT GO:0045746 1/84 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8909QT GO:0005737 1/84 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8909QT GO:0006004 1/84 fucose metabolic process biological_process "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732] EOG8909QT GO:0008417 1/84 fucosyltransferase activity molecular_function "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] EOG8909QT GO:0009790 1/84 embryo development biological_process "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] EOG8909QT GO:0046331 1/84 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8909QT GO:0008593 1/84 regulation of Notch signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG8909QT GO:0006493 1/84 protein O-linked glycosylation biological_process "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] EOG8909QT GO:0016266 1/84 O-glycan processing biological_process "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130] EOG8909QT GO:0036066 1/84 protein O-linked fucosylation biological_process "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734] EOG8909QT GO:0036065 1/84 fucosylation biological_process "The covalent attachment of a fucosyl group to an acceptor molecule." [CHEBI:62688, GOC:sart, PMID:19948734] EOG8909QT GO:0031410 1/84 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG8909QT GO:0006897 1/84 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8909QT GO:0005783 1/84 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8909QT GO:0005112 1/84 Notch binding molecular_function "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb] EOG8909QT GO:0006355 1/84 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8909QT GO:0030163 1/84 protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] EOG8909QT GO:0016337 1/84 single organismal cell-cell adhesion biological_process "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb] EOG89GNZ3 GO:0005890 79/270 sodium:potassium-exchanging ATPase complex cellular_component "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732] EOG89GNZ3 GO:0006813 78/270 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG89GNZ3 GO:0006814 76/270 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG89GNZ3 GO:0005886 3/270 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG89GNZ3 GO:0007605 2/270 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG89GNZ3 GO:0035725 2/270 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG89GNZ3 GO:0006812 2/270 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG89GNZ3 GO:0035158 1/270 regulation of tube diameter, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584] EOG89GNZ3 GO:0060857 1/270 establishment of glial blood-brain barrier biological_process "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] EOG89GNZ3 GO:0005391 1/270 sodium:potassium-exchanging ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9] EOG89GNZ3 GO:0035159 1/270 regulation of tube length, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] EOG89GNZ3 GO:0007424 1/270 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG89GNZ3 GO:0010996 1/270 response to auditory stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb] EOG89GNZ3 GO:0005515 1/270 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG89GNZ3 GO:0035151 1/270 regulation of tube size, open tracheal system biological_process "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360] EOG89GNZ3 GO:0019991 1/270 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG89GNZ3 GO:0005918 1/270 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG89GNZ3 GO:0061343 1/270 cell adhesion involved in heart morphogenesis biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] EOG86DPHT GO:0030060 1/9 L-malate dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37] EOG86DPHT GO:0044262 1/9 cellular carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] EOG86DPHT GO:0006108 1/9 malate metabolic process biological_process "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] EOG87SVX9 GO:0031012 5/52 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG87SVX9 GO:0004222 5/52 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG87SVX9 GO:0008270 5/52 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GJ23G GO:0034464 26/101 BBSome cellular_component "A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030] EOG8WWV0G GO:0005524 4/41 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WWV0G GO:0004674 3/41 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8WWV0G GO:0004687 1/41 myosin light chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] EOG8B013K GO:0005975 29/97 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8B013K GO:0000287 23/97 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8B013K GO:0004610 22/97 phosphoacetylglucosamine mutase activity molecular_function "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23807] EOG8B013K GO:0016868 7/97 intramolecular transferase activity, phosphotransferases molecular_function "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah] EOG8B013K GO:0045743 1/97 positive regulation of fibroblast growth factor receptor signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8B013K GO:0060438 1/97 trachea development biological_process "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] EOG8B013K GO:0001707 1/97 mesoderm formation biological_process "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] EOG8B013K GO:0006048 1/97 UDP-N-acetylglucosamine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] EOG8B013K GO:0005829 1/97 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8GQSMF GO:0008270 22/97 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GQSMF GO:0016740 1/97 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8KSS06 GO:0007095 1/89 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8KSS06 GO:0005737 1/89 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8KSS06 GO:0035257 1/89 nuclear hormone receptor binding molecular_function "Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell." [GOC:bf] EOG8KSS06 GO:0008231 1/89 repressor ecdysone receptor complex cellular_component "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333] EOG8KSS06 GO:0003714 1/89 transcription corepressor activity molecular_function "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8KSS06 GO:0022008 1/89 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8KSS06 GO:0008180 1/89 COP9 signalosome cellular_component "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] EOG8KSS06 GO:0007275 1/89 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8KSS06 GO:0005515 1/89 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8KSS06 GO:0045892 1/89 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8KSS06 GO:0006909 1/89 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8KSS06 GO:0016922 1/89 ligand-dependent nuclear receptor binding molecular_function "Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974] EOG8KSS06 GO:0042803 1/89 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8KSS06 GO:0048477 1/89 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8KSS06 GO:0050821 1/89 protein stabilization biological_process "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] EOG8KSS06 GO:0051726 1/89 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG880MC4 GO:0007156 1/33 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG880MC4 GO:0016021 1/33 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG880MC4 GO:0005509 1/33 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8NS5R9 GO:0016021 33/146 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NS5R9 GO:0046872 33/146 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NS5R9 GO:0005524 31/146 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NS5R9 GO:0019829 30/146 cation-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] EOG8NS5R9 GO:0005388 2/146 calcium-transporting ATPase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] EOG8NS5R9 GO:0000166 2/146 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8NS5R9 GO:0016887 1/146 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8NS5R9 GO:0006812 1/146 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8NS5R9 GO:0004721 1/146 phosphoprotein phosphatase activity molecular_function "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] EOG8F20J0 GO:0016907 21/103 G-protein coupled acetylcholine receptor activity molecular_function "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] EOG8F20J0 GO:0005887 21/103 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F20J0 GO:0016021 6/103 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F20J0 GO:0004930 5/103 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8F20J0 GO:0004715 2/103 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8F20J0 GO:0045211 1/103 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8F20J0 GO:0007200 1/103 phospholipase C-activating G-protein coupled receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] EOG8F20J0 GO:0007213 1/103 G-protein coupled acetylcholine receptor signaling pathway biological_process "Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194] EOG8F20J0 GO:0030054 1/103 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8F20J0 GO:0008227 1/103 G-protein coupled amine receptor activity molecular_function "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] EOG8GJ25H GO:0008270 22/86 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GJ25H GO:0003677 19/86 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NKF8D GO:0017112 1/96 Rab guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8NKF8D GO:0032313 1/96 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8NKF8D GO:0016020 1/96 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DFS2D GO:0005216 18/68 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8DFS2D GO:0016021 18/68 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DFS2D GO:0006812 1/68 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8DFS2D GO:0004692 1/68 cGMP-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah] EOG8DFS2D GO:0005221 1/68 intracellular cyclic nucleotide activated cation channel activity molecular_function "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] EOG8DFS2D GO:0017071 1/68 intracellular cyclic nucleotide activated cation channel complex cellular_component "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah] EOG8DFS2D GO:0019935 1/68 cyclic-nucleotide-mediated signaling biological_process "Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] EOG8MSGC8 GO:0005622 24/92 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8MSGC8 GO:0004198 24/92 calcium-dependent cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] EOG8MSGC8 GO:0005509 24/92 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8MSGC8 GO:0005737 1/92 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG86Q97N GO:0016021 3/36 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q97N GO:0019646 3/36 aerobic electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] EOG86Q97N GO:0004129 3/36 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG86Q97N GO:0005739 2/36 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG86Q97N GO:0005743 1/36 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8GTNWV GO:0000166 4/29 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8GTNWV GO:0003676 4/29 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG86Q97J GO:0016491 34/115 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG86Q97J GO:0032934 25/115 sterol binding molecular_function "Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah] EOG86Q97J GO:0047936 1/115 glucose 1-dehydrogenase [NAD(P)] activity molecular_function "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47, MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN] EOG86Q97J GO:0050038 1/115 L-xylulose reductase (NADP+) activity molecular_function "Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH." [EC:1.1.1.10, RHEA:17028] EOG86Q97J GO:0005875 1/115 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG86Q97J GO:0033814 1/115 propanoyl-CoA C-acyltransferase activity molecular_function "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA." [EC:2.3.1.176] EOG86Q97J GO:0005811 1/115 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG86Q97J GO:0005777 1/115 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8T1M4K GO:0003676 1/14 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8T1M4K GO:0015074 1/14 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG84F8R8 GO:0005216 27/104 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG84F8R8 GO:0016021 27/104 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG84F8R8 GO:0048512 1/104 circadian behavior biological_process "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr] EOG84F8R8 GO:0008344 1/104 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG84F8R8 GO:0050975 1/104 sensory perception of touch biological_process "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] EOG84F8R8 GO:0042752 1/104 regulation of circadian rhythm biological_process "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] EOG84F8R8 GO:0086010 1/104 membrane depolarization during action potential biological_process "The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] EOG84F8R8 GO:0022008 1/104 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG84F8R8 GO:0070509 1/104 calcium ion import biological_process "The directed movement of calcium ions into a cell or organelle." [GOC:mah] EOG84F8R8 GO:0005245 1/104 voltage-gated calcium channel activity molecular_function "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] EOG84F8R8 GO:0045475 1/104 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG84F8R8 GO:0072347 1/104 response to anesthetic biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart] EOG84F8R8 GO:0035176 1/104 social behavior biological_process "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior] EOG84F8R8 GO:0005886 1/104 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG84F8R8 GO:0043025 1/104 neuronal cell body cellular_component "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] EOG84F8R8 GO:0043679 1/104 axon terminus cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl] EOG80ZTCP GO:0036054 8/45 protein-malonyllysine demalonylase activity molecular_function "Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide." [GOC:sp, PMID:21908771, PMID:22076378] EOG80ZTCP GO:0070403 8/45 NAD+ binding molecular_function "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] EOG80ZTCP GO:0036055 8/45 protein-succinyllysine desuccinylase activity molecular_function "Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide." [GOC:sp, PMID:22076378] EOG80ZTCP GO:0005739 7/45 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG80ZTCP GO:0034979 7/45 NAD-dependent protein deacetylase activity molecular_function "Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD." [GOC:BHF, GOC:mah] EOG80ZTCP GO:0008270 7/45 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG87SVVC GO:0005215 27/101 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG87SVVC GO:0008021 27/101 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG87SVVC GO:0016020 26/101 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG87SVVC GO:0030054 1/101 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG87SVVC GO:0000149 1/101 SNARE binding molecular_function "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] EOG87SVVC GO:0005515 1/101 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG87SVVC GO:0005509 1/101 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG87SVVC GO:0008345 1/101 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG87SVVC GO:0007317 1/101 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG87SVVC GO:0042803 1/101 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG87SVVC GO:0050803 1/101 regulation of synapse structure or activity biological_process "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] EOG87SVVC GO:0031340 1/101 positive regulation of vesicle fusion biological_process "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] EOG87SVVC GO:0048488 1/101 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG87SVVC GO:0007268 1/101 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG87SVVC GO:0031594 1/101 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG87SVVC GO:0016192 1/101 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG87SVVC GO:0030285 1/101 integral component of synaptic vesicle membrane cellular_component "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87SVVC GO:0043195 1/101 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG87SVVC GO:0001786 1/101 phosphatidylserine binding molecular_function "Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961] EOG87SVVC GO:0005544 1/101 calcium-dependent phospholipid binding molecular_function "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] EOG87SVVC GO:0060024 1/101 rhythmic synaptic transmission biological_process "Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit." [GOC:dph] EOG87SVVC GO:0016079 1/101 synaptic vesicle exocytosis biological_process "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] EOG87SVVC GO:0007269 1/101 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG87SVVC GO:1900073 1/101 regulation of neuromuscular synaptic transmission biological_process "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] EOG87SVVC GO:0048791 1/101 calcium ion-dependent exocytosis of neurotransmitter biological_process "The release of a neurotransmitter into the synaptic cleft, where the release step is dependent on the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators] EOG87SVVC GO:0035005 1/101 1-phosphatidylinositol-4-phosphate 3-kinase activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18376] EOG8TF314 GO:0003964 1/6 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8TF314 GO:0008270 1/6 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TF314 GO:0003723 1/6 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8TF314 GO:0006351 1/6 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8TF314 GO:0003677 1/6 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TF314 GO:0003899 1/6 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG89W4VJ GO:0016021 22/239 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89W4VJ GO:0022891 15/239 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG89W4VJ GO:0022857 6/239 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG89W4VJ GO:0008643 1/239 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG8P8HXV GO:0015031 2/97 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8B014J GO:0046872 21/82 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8QJV35 GO:0050909 1/104 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8QJV35 GO:0005886 1/104 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8QJV35 GO:0016021 1/104 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86HJQV GO:0016021 25/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86HJQV GO:0055085 25/94 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG86HJQV GO:0035556 25/94 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG82NMDM GO:0003743 1/15 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG82NMDM GO:0016779 1/15 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG82NMDM GO:0003924 1/15 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG82NMDM GO:0005525 1/15 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG82NMDM GO:0005622 1/15 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8PZMMK GO:0004970 24/96 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8PZMMK GO:0005234 24/96 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8PZMMK GO:0030054 23/96 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8PZMMK GO:0016021 23/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PZMMK GO:0045211 23/96 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8PZMMK GO:0071683 1/96 sensory dendrite cellular_component "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah] EOG8PZMMK GO:0034220 1/96 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8PZMMK GO:0008328 1/96 ionotropic glutamate receptor complex cellular_component "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] EOG8PZMMK GO:0035249 1/96 synaptic transmission, glutamatergic biological_process "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv] EOG8PZMMK GO:0016020 1/96 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8PZMMK GO:0005929 1/96 cilium cellular_component "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684] EOG8PZMMK GO:0007608 1/96 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8PZMMK GO:0015276 1/96 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8PZMMK GO:0050907 1/96 detection of chemical stimulus involved in sensory perception biological_process "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] EOG8PZMMK GO:0035235 1/96 ionotropic glutamate receptor signaling pathway biological_process "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732] EOG82NMD3 GO:0046872 18/93 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82NMD3 GO:0050807 1/93 regulation of synapse organization biological_process "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] EOG82NMD3 GO:0008340 1/93 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG82NMD3 GO:0005737 1/93 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG82NMD3 GO:0022416 1/93 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG82NMD3 GO:0003676 1/93 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82NMD3 GO:0031396 1/93 regulation of protein ubiquitination biological_process "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] EOG82NMD3 GO:0008270 1/93 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG82NMD3 GO:0031594 1/93 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG82NMD3 GO:0048786 1/93 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG82NMD3 GO:0007409 1/93 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG82NMD3 GO:0048749 1/93 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG82NMD4 GO:0045177 1/151 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG82NMD4 GO:0030424 1/151 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG82NMD4 GO:0005938 1/151 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG82NMD4 GO:0035316 1/151 non-sensory hair organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425] EOG82NMD4 GO:0035317 1/151 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG82NMD4 GO:0045860 1/151 positive regulation of protein kinase activity biological_process "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] EOG82NMD4 GO:0044297 1/151 cell body cellular_component "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] EOG82NMD4 GO:0005515 1/151 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG82NMD4 GO:0048800 1/151 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG82NMD4 GO:0030425 1/151 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG82NMD4 GO:0050773 1/151 regulation of dendrite development biological_process "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] EOG82NMD4 GO:0008407 1/151 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG82NMD4 GO:0007476 1/151 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG82NMD4 GO:0048601 1/151 oocyte morphogenesis biological_process "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] EOG82NMD4 GO:0042052 1/151 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG82NMD4 GO:0005737 1/151 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG82NMD4 GO:0070593 1/151 dendrite self-avoidance biological_process "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551] EOG82NMD4 GO:0048814 1/151 regulation of dendrite morphogenesis biological_process "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG82NMD4 GO:0045893 1/151 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82NMD4 GO:0006351 1/151 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8G7FGJ GO:0003924 2/3 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8G7FGJ GO:0005525 2/3 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG82FVXS GO:0016758 251/467 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG82FVXS GO:0015020 15/467 glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] EOG82FVXS GO:0030259 7/467 lipid glycosylation biological_process "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] EOG82FVXS GO:0016999 4/467 antibiotic metabolic process biological_process "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] EOG82FVXS GO:0030246 4/467 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG82FVXS GO:0003851 1/467 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity molecular_function "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] EOG818F28 GO:0000139 1/91 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG818F28 GO:0015031 1/91 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG86T5GD GO:0022891 3/45 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG86T5GD GO:0016021 3/45 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BZQKZ GO:0004519 2/5 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8BZQKZ GO:0003964 2/5 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8BZQKZ GO:0003723 2/5 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG85F03H GO:0030170 119/445 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG85F03H GO:0006520 119/445 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG85F03H GO:0016831 110/445 carboxy-lyase activity molecular_function "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/] EOG85F03H GO:0004058 9/445 aromatic-L-amino-acid decarboxylase activity molecular_function "Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28] EOG85F03H GO:0016491 6/445 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG85F03H GO:0006584 2/445 catecholamine metabolic process biological_process "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] EOG85F03H GO:0042302 2/445 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG85F03H GO:0043052 2/445 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG85F03H GO:0040003 2/445 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG85F03H GO:0004837 2/445 tyrosine decarboxylase activity molecular_function "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25] EOG85F03H GO:0042423 2/445 catecholamine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] EOG85F03H GO:0007611 1/445 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG85F03H GO:0048066 1/445 developmental pigmentation biological_process "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] EOG85F03H GO:0035220 1/445 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG85F03H GO:0007626 1/445 locomotory behavior biological_process "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] EOG85F03H GO:0007619 1/445 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG85F03H GO:0046592 1/445 polyamine oxidase activity molecular_function "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380] EOG85F03H GO:0048148 1/445 behavioral response to cocaine biological_process "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] EOG85F03H GO:0048082 1/445 regulation of adult chitin-containing cuticle pigmentation biological_process "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] EOG85F03H GO:0048085 1/445 adult chitin-containing cuticle pigmentation biological_process "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] EOG85F03H GO:0007615 1/445 anesthesia-resistant memory biological_process "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] EOG85F03H GO:0006587 1/445 serotonin biosynthetic process from tryptophan biological_process "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] EOG85F03H GO:0048149 1/445 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG85F03H GO:0009611 1/445 response to wounding biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] EOG85F03H GO:0040040 1/445 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG85F03H GO:0018991 1/445 oviposition biological_process "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems] EOG85F03H GO:0019239 1/445 deaminase activity molecular_function "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl] EOG85F03H GO:0040007 1/445 growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] EOG85F03H GO:0008062 1/445 eclosion rhythm biological_process "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] EOG85F03H GO:0004398 1/445 histidine decarboxylase activity molecular_function "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22] EOG85F03H GO:0006585 1/445 dopamine biosynthetic process from tyrosine biological_process "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732] EOG85F03H GO:0007616 1/445 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG808QPW GO:0003677 4/11 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG808QPW GO:0005634 4/11 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SBHBV GO:0005524 24/88 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8SBHBV GO:0042623 23/88 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG8SBHBV GO:0005778 23/88 peroxisomal membrane cellular_component "The lipid bilayer surrounding a peroxisome." [GOC:mah] EOG8SBHBV GO:0006625 23/88 protein targeting to peroxisome biological_process "The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai] EOG8SBHBV GO:0007031 2/88 peroxisome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] EOG8SBHBV GO:0004672 2/88 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8SBHBV GO:0021782 1/88 glial cell development biological_process "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8SBHBV GO:0017111 1/88 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8SBHBV GO:0007422 1/88 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8SBHBV GO:0004713 1/88 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8SBHBV GO:0016021 1/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8SBHBV GO:0048137 1/88 spermatocyte division biological_process "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238] EOG8SBHBV GO:0007417 1/88 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8SBHBV GO:0005777 1/88 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8TF31F GO:0005875 2/137 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8TF31F GO:0003676 1/137 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TF31F GO:0008270 1/137 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SXQTD GO:0004222 5/19 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8KH59Q GO:0004129 45/129 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8KH59Q GO:0004252 1/129 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8KH59Q GO:0000278 1/129 mitotic cell cycle biological_process "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] EOG8KH59Q GO:0005739 1/129 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8KH59Q GO:0005811 1/129 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8KH59Q GO:0007030 1/129 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG8KH59Q GO:0008283 1/129 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8MSGCF GO:0016021 47/174 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MSGCF GO:0005234 44/174 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8MSGCF GO:0030054 42/174 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8MSGCF GO:0004970 42/174 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8MSGCF GO:0045211 42/174 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8MSGCF GO:0035249 2/174 synaptic transmission, glutamatergic biological_process "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv] EOG8MSGCF GO:0032281 2/174 AMPA glutamate receptor complex cellular_component "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef] EOG8MSGCF GO:0006812 2/174 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8MSGCF GO:0008328 2/174 ionotropic glutamate receptor complex cellular_component "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] EOG8MSGCF GO:0034220 2/174 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8MSGCF GO:0004971 2/174 AMPA glutamate receptor activity molecular_function "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111] EOG8MSGCF GO:0005230 2/174 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8MSGCF GO:0035235 2/174 ionotropic glutamate receptor signaling pathway biological_process "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732] EOG8MSGCF GO:0030425 2/174 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8MSGCF GO:0009253 1/174 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8MSGCF GO:0016020 1/174 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8MSGCF GO:0005886 1/174 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8MSGCF GO:0008745 1/174 N-acetylmuramoyl-L-alanine amidase activity molecular_function "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28] EOG8MSGCF GO:0005215 1/174 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8KSS0T GO:0005887 1/55 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DFS5H GO:0016021 1/9 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DFS5H GO:0004930 1/9 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8KSS0N GO:0006207 29/92 'de novo' pyrimidine nucleobase biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] EOG8KSS0N GO:0006222 28/92 UMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732] EOG8KSS0N GO:0004158 28/92 dihydroorotate oxidase activity molecular_function "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444] EOG8KSS0N GO:0016020 27/92 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8KSS0N GO:0004152 2/92 dihydroorotate dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18076] EOG8KSS0N GO:0005743 1/92 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8KSS0N GO:0044205 1/92 'de novo' UMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl] EOG8KSS0N GO:0005758 1/92 mitochondrial intermembrane space cellular_component "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] EOG8KSS0N GO:0016021 1/92 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KSS0N GO:0052888 1/92 obsolete OBSOLETE:dihydroorotate oxidase (fumarate) activity molecular_function "Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [EC:1.3.98.1, RHEA:30062] EOG8577R0 GO:0003676 1/12 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8577R0 GO:0000166 1/12 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8MSGCV GO:0004540 1/92 ribonuclease activity molecular_function "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] EOG8MSGCV GO:0007274 1/92 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8MSGCV GO:0043487 1/92 regulation of RNA stability biological_process "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] EOG8MSGCV GO:0000184 1/92 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] EOG8MSGCV GO:0050808 1/92 synapse organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] EOG8MSGCV GO:0090501 1/92 RNA phosphodiester bond hydrolysis biological_process "The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] EOG80042H GO:0016301 1/5 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8S4RWK GO:0016798 25/117 hydrolase activity, acting on glycosyl bonds molecular_function "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] EOG8S4RWK GO:0016020 25/117 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8S4RWK GO:0005975 4/117 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8S4RWK GO:0015991 2/117 ATP hydrolysis coupled proton transport biological_process "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] EOG8S4RWK GO:0015078 2/117 hydrogen ion transmembrane transporter activity molecular_function "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] EOG8S4RWK GO:0033179 2/117 proton-transporting V-type ATPase, V0 domain cellular_component "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] EOG8S4RWK GO:0005811 1/117 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8SBHFB GO:0005761 23/78 mitochondrial ribosome cellular_component "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732] EOG81NX0Z GO:0003682 10/102 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG81NX0Z GO:0008270 3/102 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG81NX0Z GO:0009649 1/102 entrainment of circadian clock biological_process "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] EOG81NX0Z GO:0000077 1/102 DNA damage checkpoint biological_process "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] EOG8FN73F GO:0003993 3/5 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG8FN73F GO:0005840 1/5 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8QC3KP GO:0005234 18/135 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8QC3KP GO:0004970 13/135 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8QC3KP GO:0016020 12/135 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8QC3KP GO:0005215 9/135 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8QC3KP GO:0015276 8/135 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8QC3KP GO:0034220 8/135 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8QC3KP GO:0009593 8/135 detection of chemical stimulus biological_process "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] EOG8QC3KP GO:0016021 8/135 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QC3KP GO:0035235 5/135 ionotropic glutamate receptor signaling pathway biological_process "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732] EOG8QC3KP GO:0030425 5/135 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8QC3KP GO:0045211 5/135 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8QC3KP GO:0035249 5/135 synaptic transmission, glutamatergic biological_process "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv] EOG8QC3KP GO:0004971 3/135 AMPA glutamate receptor activity molecular_function "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111] EOG8QC3KP GO:0032281 3/135 AMPA glutamate receptor complex cellular_component "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef] EOG8QC3KP GO:0036081 3/135 extracellular ammonia-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] EOG8QC3KP GO:0050909 2/135 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8QC3KP GO:0008328 1/135 ionotropic glutamate receptor complex cellular_component "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] EOG8QC3KP GO:0017146 1/135 NMDA selective glutamate receptor complex cellular_component "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] EOG8QC3KP GO:0004972 1/135 NMDA glutamate receptor activity molecular_function "An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate." [GOC:mah, PMID:10049997] EOG88PQ0M GO:0035556 24/111 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG88PQ0M GO:0046872 24/111 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG88PQ0M GO:0005089 23/111 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG88PQ0M GO:0016477 1/111 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG88PQ0M GO:0016740 1/111 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG88PQ0M GO:0004697 1/111 protein kinase C activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] EOG88PQ0M GO:0072499 1/111 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG88PQ0M GO:0007015 1/111 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG88PQ0M GO:0032314 1/111 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG88PQ0M GO:0007520 1/111 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG88PQ0M GO:0007391 1/111 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG88PQ0M GO:0007411 1/111 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG88PQ0M GO:0007417 1/111 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG88PQ0M GO:0031532 1/111 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG88PQ0M GO:0032863 1/111 activation of GTPase activity biological_process "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] EOG88PQ0M GO:0030676 1/111 Rac guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG88PQ0M GO:0007155 1/111 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG88PQ0M GO:0007409 1/111 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG88PQ0M GO:0007424 1/111 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG88PQ0M GO:0035011 1/111 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG88PQ0M GO:0008360 1/111 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8P2SG3 GO:0045859 1/105 regulation of protein kinase activity biological_process "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] EOG8P2SG3 GO:0009047 1/105 dosage compensation by hyperactivation of X chromosome biological_process "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577] EOG8P2SG3 GO:0005737 1/105 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8P2SG3 GO:0008023 1/105 transcription elongation factor complex cellular_component "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] EOG8P2SG3 GO:0016301 1/105 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8P2SG3 GO:0006351 1/105 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8P2SG3 GO:0003676 1/105 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8P2SG3 GO:0008607 1/105 phosphorylase kinase regulator activity molecular_function "Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19] EOG8P2SG3 GO:0016246 1/105 RNA interference biological_process "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] EOG8P2SG3 GO:0006357 1/105 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8P2SG3 GO:0000166 1/105 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG89CSR1 GO:0032504 1/68 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG89CSR1 GO:0015918 1/68 sterol transport biological_process "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] EOG89CSR1 GO:0045456 1/68 ecdysteroid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] EOG89CSR1 GO:0005615 1/68 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8323CZ GO:0003677 1/119 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8323CZ GO:0003676 1/119 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8323CZ GO:0046872 1/119 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG81C9C7 GO:0016021 60/123 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81C9C7 GO:0015078 60/123 hydrogen ion transmembrane transporter activity molecular_function "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] EOG81C9C7 GO:0015991 60/123 ATP hydrolysis coupled proton transport biological_process "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] EOG81C9C7 GO:0033179 57/123 proton-transporting V-type ATPase, V0 domain cellular_component "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] EOG81C9C7 GO:0016787 4/123 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG81C9C7 GO:0000220 3/123 vacuolar proton-transporting V-type ATPase, V0 domain cellular_component "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] EOG81C9C7 GO:0045169 1/123 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG81C9C7 GO:0007476 1/123 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG81C9C7 GO:0005774 1/123 vacuolar membrane cellular_component "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] EOG81C9C7 GO:0033181 1/123 plasma membrane proton-transporting V-type ATPase complex cellular_component "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] EOG81C9C7 GO:0033227 1/123 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG81C9C7 GO:0006909 1/123 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG844P06 GO:0016021 81/188 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG844P06 GO:0005524 81/188 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG844P06 GO:0042626 77/188 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG844P06 GO:0008559 6/188 xenobiotic-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] EOG844P06 GO:0031427 4/188 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG844P06 GO:0005886 4/188 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG844P06 GO:0055085 4/188 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG844P06 GO:0015440 2/188 peptide-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43] EOG844P06 GO:0006855 2/188 drug transmembrane transport biological_process "The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:ai, GOC:bf] EOG844P06 GO:0015238 1/188 drug transmembrane transporter activity molecular_function "Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732] EOG844P06 GO:0060857 1/188 establishment of glial blood-brain barrier biological_process "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] EOG844P06 GO:0008354 1/188 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG844P06 GO:0042908 1/188 xenobiotic transport biological_process "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] EOG844P06 GO:0001666 1/188 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG844P06 GO:0005919 1/188 pleated septate junction cellular_component "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] EOG844P06 GO:0015562 1/188 efflux transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG844P06 GO:0043190 1/188 ATP-binding cassette (ABC) transporter complex cellular_component "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107] EOG844P06 GO:0005887 1/188 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BCH20 GO:0006438 1/6 valyl-tRNA aminoacylation biological_process "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG8BCH20 GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BCH20 GO:0002161 1/6 aminoacyl-tRNA editing activity molecular_function "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] EOG8BCH20 GO:0004832 1/6 valine-tRNA ligase activity molecular_function "Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10707] EOG8BCH20 GO:0004823 1/6 leucine-tRNA ligase activity molecular_function "Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [EC:6.1.1.4, RHEA:11691] EOG8P5NQN GO:0005737 26/96 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8P5NQN GO:0008104 1/96 protein localization biological_process "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] EOG8P5NQN GO:0042052 1/96 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8P5NQN GO:0045313 1/96 rhabdomere membrane biogenesis biological_process "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl] EOG8P5NQN GO:0006937 1/96 regulation of muscle contraction biological_process "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] EOG8P5NQN GO:0045202 1/96 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8P5NQN GO:0005886 1/96 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8P5NQN GO:0048488 1/96 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8P5NQN GO:0006887 1/96 exocytosis biological_process "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] EOG8P5NQN GO:0032154 1/96 cleavage furrow cellular_component "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] EOG8P5NQN GO:0007269 1/96 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8KH59F GO:0042052 1/98 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8KH59F GO:0031468 1/98 nuclear envelope reassembly biological_process "The reformation of the nuclear envelope following its breakdown in the context of a normal process." [GOC:mah] EOG8P5NQB GO:0016020 20/138 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FXTP8 GO:0043754 1/3 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity molecular_function "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168] EOG8FXTP8 GO:0006090 1/3 pyruvate metabolic process biological_process "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] EOG8FXTP8 GO:0004742 1/3 dihydrolipoyllysine-residue acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12] EOG8FXTP8 GO:0045254 1/3 pyruvate dehydrogenase complex cellular_component "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094] EOG844P08 GO:0042593 1/78 glucose homeostasis biological_process "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] EOG844P08 GO:0046982 1/78 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG844P08 GO:0007067 1/78 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG844P08 GO:0000775 1/78 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG844P08 GO:0006355 1/78 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG844P08 GO:0006357 1/78 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG844P08 GO:0005667 1/78 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG844P08 GO:0009744 1/78 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG844P08 GO:0008134 1/78 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG844P08 GO:0070328 1/78 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG8R7XQK GO:0003676 25/95 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8R7XQK GO:0005634 25/95 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8R7XQK GO:0006378 1/95 mRNA polyadenylation biological_process "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732] EOG8R7XQK GO:0017022 1/95 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8R7XQK GO:0006379 1/95 mRNA cleavage biological_process "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] EOG8R7XQK GO:0022008 1/95 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8R7XQK GO:0005847 1/95 mRNA cleavage and polyadenylation specificity factor complex cellular_component "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727] EOG8R7XQK GO:0003730 1/95 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG8B8MT5 GO:0045010 15/99 actin nucleation biological_process "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194] EOG8B8MT5 GO:0005884 15/99 actin filament cellular_component "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] EOG8B8MT5 GO:0006950 1/99 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8B8MT5 GO:0007304 1/99 chorion-containing eggshell formation biological_process "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8B8MT5 GO:0008017 1/99 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG8B8MT5 GO:0048477 1/99 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8B8MT5 GO:0007015 1/99 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8B8MT5 GO:0005938 1/99 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8B8MT5 GO:0030659 1/99 cytoplasmic vesicle membrane cellular_component "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] EOG8B8MT5 GO:0030029 1/99 actin filament-based process biological_process "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] EOG8B8MT5 GO:0007315 1/99 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8B8MT5 GO:0045451 1/99 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8B8MT5 GO:0007316 1/99 pole plasm RNA localization biological_process "Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG8B8MT5 GO:0005737 1/99 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8B8MT5 GO:0003779 1/99 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8B8MT5 GO:0015031 1/99 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8B8MT5 GO:0005829 1/99 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8V71ZQ GO:0016787 1/28 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8S1WP5 GO:0006457 25/85 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8S1WP5 GO:0000502 2/85 proteasome complex cellular_component "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome] EOG8S1WP5 GO:0005515 1/85 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8S1WP5 GO:0006974 1/85 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8003Z0 GO:0016887 27/102 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8003Z0 GO:0005524 27/102 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8003Z0 GO:0006461 3/102 protein complex assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai] EOG8003Z0 GO:0005634 3/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8003Z0 GO:0051116 1/102 cobaltochelatase activity molecular_function "Catalysis of the reaction: ATP + Co(2+) + H(2)O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H(+) + phosphate." [EC:6.6.1.2, RHEA:15344] EOG8FJBRF GO:0042302 572/1336 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8FJBRF GO:0040003 37/1336 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8FJBRF GO:0008010 37/1336 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8FJBRF GO:0031012 37/1336 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8FJBRF GO:0005576 13/1336 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8FJBRF GO:0008363 8/1336 larval chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG8FJBRF GO:0005215 7/1336 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8FJBRF GO:0008011 2/1336 structural constituent of pupal chitin-based cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8FJBRF GO:0005615 1/1336 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8FJBRF GO:0032504 1/1336 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8FJBRF GO:0042381 1/1336 hemolymph coagulation biological_process "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] EOG8NZX7M GO:0016055 26/120 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8NZX7M GO:0072091 1/120 regulation of stem cell proliferation biological_process "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] EOG8NZX7M GO:0005667 1/120 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG8NZX7M GO:0005875 1/120 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8NZX7M GO:0045892 1/120 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8NZX7M GO:0005515 1/120 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NZX7M GO:0060070 1/120 canonical Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488] EOG8NZX7M GO:0005634 1/120 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NZX7M GO:0044212 1/120 transcription regulatory region DNA binding molecular_function "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836] EOG8NZX7M GO:0008013 1/120 beta-catenin binding molecular_function "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf] EOG8NZX7M GO:0010628 1/120 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8NZX7M GO:0070491 1/120 repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] EOG8NZX7M GO:0043565 1/120 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8NZX7M GO:0030178 1/120 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG8NZX7M GO:0006366 1/120 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8NZX7M GO:0003705 1/120 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8NZX7M GO:0006355 1/120 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8NZX7M GO:0045610 1/120 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG8NZX7M GO:0007435 1/120 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8NZX7M GO:0009880 1/120 embryonic pattern specification biological_process "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] EOG8NZX7M GO:0019900 1/120 kinase binding molecular_function "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] EOG8NZX7M GO:0045893 1/120 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8NZX7M GO:0030111 1/120 regulation of Wnt signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] EOG8NZX7M GO:0045944 1/120 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8NZX7M GO:0035277 1/120 spiracle morphogenesis, open tracheal system biological_process "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] EOG8NZX7M GO:0007500 1/120 mesodermal cell fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] EOG8NZX7M GO:0007476 1/120 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8NZX7M GO:0007507 1/120 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8NZX7M GO:0007367 1/120 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG86HJSH GO:0006310 1/17 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG86HJSH GO:0006302 1/17 double-strand break repair biological_process "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] EOG86HJSH GO:0003677 1/17 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86HJSH GO:0005634 1/17 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG844P0X GO:0006434 1/6 seryl-tRNA aminoacylation biological_process "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG844P0X GO:0005524 1/6 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG844P0X GO:0005737 1/6 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG844P0X GO:0004828 1/6 serine-tRNA ligase activity molecular_function "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] EOG8N336C GO:0030955 1/2 potassium ion binding molecular_function "Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah] EOG8N336C GO:0000287 1/2 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8N336C GO:0004743 1/2 pyruvate kinase activity molecular_function "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40] EOG8N336C GO:0006096 1/2 glycolytic process biological_process "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] EOG87Q0NX GO:0003700 2/18 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG87Q0NX GO:0005634 2/18 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86HJSZ GO:0046872 2/4 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82JR6B GO:0005509 23/87 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG82JR6B GO:0005975 7/87 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG82JR6B GO:0003824 7/87 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG82JR6B GO:0050829 1/87 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG82JR6B GO:0032504 1/87 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG82JR6B GO:0005794 1/87 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG82JR6B GO:0005615 1/87 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8K0T47 GO:0008270 5/119 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8K0T47 GO:0003676 5/119 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8K0T47 GO:0004190 2/119 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG847J72 GO:0005737 23/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG847J72 GO:0048312 22/97 intracellular distribution of mitochondria biological_process "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid] EOG847J72 GO:0003743 3/97 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG847J72 GO:0051646 1/97 mitochondrion localization biological_process "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] EOG847J72 GO:0055059 1/97 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG847J72 GO:0072686 1/97 mitotic spindle cellular_component "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] EOG8QVFT8 GO:0006869 21/119 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG8QVFT8 GO:0033868 2/119 Goodpasture-antigen-binding protein kinase activity molecular_function "Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9] EOG8QVFT8 GO:0006886 1/119 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8QVFT8 GO:0005524 1/119 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QVFT8 GO:0007291 1/119 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8QVFT8 GO:0005783 1/119 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8QVFT8 GO:0004672 1/119 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8QVFT8 GO:0005794 1/119 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8QVFT8 GO:0007030 1/119 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG89KJ4V GO:0005634 1/79 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG89KJ4V GO:0007067 1/79 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG89KJ4V GO:0006260 1/79 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8R2689 GO:0008270 25/78 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8R2689 GO:0003676 4/78 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88PQ03 GO:0004822 1/5 isoleucine-tRNA ligase activity molecular_function "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11063] EOG88PQ03 GO:0005737 1/5 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG88PQ03 GO:0006428 1/5 isoleucyl-tRNA aminoacylation biological_process "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] EOG88PQ03 GO:0002161 1/5 aminoacyl-tRNA editing activity molecular_function "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] EOG88PQ03 GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG89KJ4G GO:0016021 36/111 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG89KJ4G GO:0005509 35/111 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG89KJ4G GO:0004872 1/111 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG89KJ4G GO:0048812 1/111 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG89KJ4G GO:0004714 1/111 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG89KJ4G GO:0016787 1/111 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG89KJ4G GO:0006898 1/111 receptor-mediated endocytosis biological_process "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] EOG89KJ4G GO:0005886 1/111 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8G1PW9 GO:0016192 23/89 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8G1PW9 GO:0006886 23/89 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8G1PW9 GO:0008270 21/89 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8G1PW9 GO:0035542 1/89 regulation of SNARE complex assembly biological_process "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] EOG8G1PW9 GO:0033263 1/89 CORVET complex cellular_component "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625] EOG8G1PW9 GO:0006728 1/89 pteridine biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732] EOG8G1PW9 GO:0007298 1/89 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8G1PW9 GO:0005768 1/89 endosome cellular_component "A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] EOG8G1PW9 GO:0006622 1/89 protein targeting to lysosome biological_process "The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators] EOG8G1PW9 GO:0008057 1/89 eye pigment granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] EOG8G1PW9 GO:0051301 1/89 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8G1PW9 GO:0007220 1/89 Notch receptor processing biological_process "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] EOG8G1PW9 GO:0007032 1/89 endosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah] EOG8G1PW9 GO:0006726 1/89 eye pigment biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] EOG8G1PW9 GO:0008333 1/89 endosome to lysosome transport biological_process "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] EOG8G1PW9 GO:0005764 1/89 lysosome cellular_component "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] EOG8G1PW9 GO:0005765 1/89 lysosomal membrane cellular_component "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] EOG8G1PW9 GO:0031902 1/89 late endosome membrane cellular_component "The lipid bilayer surrounding a late endosome." [GOC:pz] EOG8G1PW9 GO:0006897 1/89 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8G1PW9 GO:0030897 1/89 HOPS complex cellular_component "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161] EOG8G1PW9 GO:0008340 1/89 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8G1PW9 GO:0005515 1/89 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8G1PW9 GO:0045202 1/89 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8G1PW9 GO:0016197 1/89 endosomal transport biological_process "The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732] EOG8G1PW9 GO:0006727 1/89 ommochrome biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] EOG8G1PW9 GO:0048072 1/89 compound eye pigmentation biological_process "Establishment of a pattern of pigment in the compound eye." [GOC:jid] EOG8P2SGX GO:0005975 50/140 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8P2SGX GO:0004553 43/140 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8P2SGX GO:0004566 7/140 beta-glucuronidase activity molecular_function "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31] EOG8P2SGX GO:0032504 1/140 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8P2SGX GO:0005615 1/140 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8QZB1Q GO:0008270 29/97 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QZB1Q GO:0016874 3/97 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8QZB1Q GO:0030713 1/97 ovarian follicle cell stalk formation biological_process "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8QZB1Q GO:0007126 1/97 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8QZB1Q GO:0006351 1/97 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8QZB1Q GO:0007275 1/97 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8QZB1Q GO:0022008 1/97 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8QZB1Q GO:0008278 1/97 cohesin complex cellular_component "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:sp, PMID:9887095] EOG8QZB1Q GO:0045498 1/97 sex comb development biological_process "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] EOG8QZB1Q GO:0007062 1/97 sister chromatid cohesion biological_process "The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194] EOG8QZB1Q GO:0006342 1/97 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG8QZB1Q GO:0005634 1/97 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8QZB1Q GO:0005515 1/97 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QZB1Q GO:0030708 1/97 germarium-derived female germ-line cyst encapsulation biological_process "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336] EOG8QZB1Q GO:0035518 1/97 histone H2A monoubiquitination biological_process "The modification of histone H2A by addition of a single ubiquitin group." [PMID:18206970] EOG8QZB1Q GO:0005730 1/97 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8QZB1Q GO:0035102 1/97 PRC1 complex cellular_component "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979] EOG88D39Z GO:0006744 32/131 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG88D39Z GO:0008425 32/131 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity molecular_function "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] EOG88D39Z GO:0008689 2/131 3-demethylubiquinone-9 3-O-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [GOC:dph] EOG88D39Z GO:0008757 1/131 S-adenosylmethionine-dependent methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] EOG88D39Z GO:0006470 1/131 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG88D39Z GO:0017017 1/131 MAP kinase tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] EOG88D39Z GO:0030798 1/131 trans-aconitate 2-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972] EOG88D39Z GO:0042060 1/131 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG88D39Z GO:0004395 1/131 hexaprenyldihydroxybenzoate methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] EOG82RGNF GO:0032793 5/36 positive regulation of CREB transcription factor activity biological_process "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] EOG82RGNF GO:0005634 5/36 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82RGNF GO:0005737 5/36 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG82RGNF GO:0051289 3/36 protein homotetramerization biological_process "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators] EOG82RGNF GO:0008140 3/36 cAMP response element binding protein binding molecular_function "Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein)." [GOC:mah] EOG82RGNF GO:0004792 1/36 thiosulfate sulfurtransferase activity molecular_function "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884] EOG88KTR2 GO:0035859 1/89 Seh1-associated complex cellular_component "A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112] EOG88KTR2 GO:0004402 1/89 histone acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] EOG8SFCMS GO:0008270 12/102 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SFCMS GO:0003676 11/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SFCMS GO:0003677 1/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8XD65N GO:0016021 31/110 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XD65N GO:0055085 31/110 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8XD65N GO:0045477 1/110 regulation of nurse cell apoptotic process biological_process "Any process that modulates the frequency, rate or extent of nurse cell apoptotic process." [GOC:mtg_apoptosis, PMID:11973306] EOG8XD65N GO:0045476 1/110 nurse cell apoptotic process biological_process "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] EOG8XD65N GO:0035193 1/110 larval central nervous system remodeling biological_process "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692] EOG8XD65N GO:0007619 1/110 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8XD65N GO:0051124 1/110 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG8XD65N GO:0006869 1/110 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG8XD65N GO:0008582 1/110 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8XD65N GO:0004174 1/110 electron-transferring-flavoprotein dehydrogenase activity molecular_function "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1] EOG8XD65N GO:0009267 1/110 cellular response to starvation biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] EOG8XD65N GO:0043067 1/110 regulation of programmed cell death biological_process "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] EOG8XD65N GO:0008333 1/110 endosome to lysosome transport biological_process "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] EOG8XD65N GO:0010001 1/110 glial cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] EOG8XD65N GO:0031902 1/110 late endosome membrane cellular_component "The lipid bilayer surrounding a late endosome." [GOC:pz] EOG8XD65N GO:0006897 1/110 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8XD65N GO:0005765 1/110 lysosomal membrane cellular_component "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] EOG8XD65N GO:0090099 1/110 negative regulation of decapentaplegic signaling pathway biological_process "Any process that decreases the frequency, rate, or extent of the decapentaplegic signaling pathway. The decapentaplegic signaling pathway is the series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors." [GOC:dph, GOC:tb] EOG8XD65N GO:0045924 1/110 regulation of female receptivity biological_process "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb] EOG8XD65N GO:0007040 1/110 lysosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] EOG8XD65N GO:0008347 1/110 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8XD65N GO:0007422 1/110 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8XD65N GO:0040011 1/110 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG8XD65N GO:0031982 1/110 vesicle cellular_component "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] EOG8XD65N GO:0048488 1/110 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8XD65N GO:0048477 1/110 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8XD65N GO:0012501 1/110 programmed cell death biological_process "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] EOG8GTNSN GO:0005509 5/40 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8GTNSN GO:0005975 1/40 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8GTNSN GO:0016773 1/40 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG8PCD69 GO:0008270 29/157 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PCD69 GO:0003677 2/157 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8PCD69 GO:0001047 1/157 core promoter binding molecular_function "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] EOG8PCD69 GO:0006338 1/157 chromatin remodeling biological_process "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] EOG8PCD69 GO:0005704 1/157 polytene chromosome band cellular_component "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] EOG8PCD69 GO:0032440 1/157 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8PCD69 GO:0035102 1/157 PRC1 complex cellular_component "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979] EOG8PCD69 GO:0005725 1/157 intercalary heterochromatin cellular_component "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] EOG8PCD69 GO:0006342 1/157 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG8PCD69 GO:0005634 1/157 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8PCD69 GO:0007411 1/157 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8PCD69 GO:0035186 1/157 syncytial blastoderm mitotic cell cycle biological_process "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] EOG82C0Q4 GO:0046872 32/102 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82C0Q4 GO:0003676 30/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82C0Q4 GO:0016458 2/102 gene silencing biological_process "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] EOG82C0Q4 GO:0043565 2/102 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG82C0Q4 GO:0005634 2/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG82C0Q4 GO:0005515 2/102 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG82C0Q4 GO:0003677 2/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG82C0Q4 GO:0005704 1/102 polytene chromosome band cellular_component "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] EOG82C0Q4 GO:0006355 1/102 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82C0Q4 GO:0006310 1/102 DNA recombination biological_process "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] EOG82C0Q4 GO:0010629 1/102 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG82C0Q4 GO:0031011 1/102 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG82C0Q4 GO:0006342 1/102 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG82C0Q4 GO:0048813 1/102 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG82C0Q4 GO:0045892 1/102 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG82C0Q4 GO:0000980 1/102 RNA polymerase II distal enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] EOG82C0Q4 GO:0003682 1/102 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG82C0Q4 GO:0000790 1/102 nuclear chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] EOG82C0Q4 GO:0048096 1/102 chromatin-mediated maintenance of transcription biological_process "Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jid] EOG82C0Q4 GO:0005703 1/102 polytene chromosome puff cellular_component "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] EOG82C0Q4 GO:0006281 1/102 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG82C0Q4 GO:0006351 1/102 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG82C0Q4 GO:0006265 1/102 DNA topological change biological_process "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] EOG82C0Q4 GO:0031490 1/102 chromatin DNA binding molecular_function "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah] EOG82C0Q4 GO:0005700 1/102 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG83V295 GO:0008603 28/100 cAMP-dependent protein kinase regulator activity molecular_function "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] EOG83V295 GO:0005952 28/100 cAMP-dependent protein kinase complex cellular_component "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732] EOG83V295 GO:0016301 3/100 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG83V295 GO:0004715 2/100 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG83V295 GO:0007622 1/100 rhythmic behavior biological_process "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] EOG83V295 GO:0048149 1/100 behavioral response to ethanol biological_process "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] EOG83V295 GO:0004691 1/100 cAMP-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11] EOG83V295 GO:0007623 1/100 circadian rhythm biological_process "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] EOG83V295 GO:0030552 1/100 cAMP binding molecular_function "Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai] EOG83V295 GO:0005737 1/100 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83V295 GO:0045475 1/100 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG83V295 GO:0007411 1/100 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG83V295 GO:0005515 1/100 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG83V295 GO:0048148 1/100 behavioral response to cocaine biological_process "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] EOG83BQ33 GO:0004177 167/275 aminopeptidase activity molecular_function "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] EOG83BQ33 GO:0005737 163/275 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83BQ33 GO:0030145 163/275 manganese ion binding molecular_function "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] EOG83BQ33 GO:0008235 163/275 metalloexopeptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] EOG83BQ33 GO:0005622 4/275 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG83BQ33 GO:0005615 1/275 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG83BQ33 GO:0003676 1/275 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83BQ33 GO:0032504 1/275 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG83BQ33 GO:0016319 1/275 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG83BQ33 GO:0016706 1/275 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] EOG83BQ33 GO:0007498 1/275 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG83BQ33 GO:0015074 1/275 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8SFCMG GO:0046872 28/91 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8SFCMG GO:0048227 1/91 plasma membrane to endosome transport biological_process "Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid] EOG8SFCMG GO:0005769 1/91 early endosome cellular_component "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] EOG8SFCMG GO:0001737 1/91 establishment of imaginal disc-derived wing hair orientation biological_process "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] EOG8SFCMG GO:0031267 1/91 small GTPase binding molecular_function "Interacting selectively and non-covalently with a small monomeric GTPase." [GOC:mah] EOG8SFCMG GO:0045451 1/91 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8SFCMG GO:0034058 1/91 endosomal vesicle fusion biological_process "The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733] EOG8SFCMG GO:0030100 1/91 regulation of endocytosis biological_process "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] EOG8SFCMG GO:0008103 1/91 oocyte microtubule cytoskeleton polarization biological_process "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] EOG8SFCMG GO:0005515 1/91 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SFCMG GO:0006897 1/91 endocytosis biological_process "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] EOG8SFCMG GO:0005768 1/91 endosome cellular_component "A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] EOG8M946D GO:0008270 2/84 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8M946D GO:0003682 2/84 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8M946D GO:0003676 1/84 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8M946D GO:0016853 1/84 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8PCD7C GO:0005509 9/36 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8WDGRV GO:0008649 26/174 rRNA methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah] EOG8WDGRV GO:0005525 25/174 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8WDGRV GO:0005634 25/174 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WDGRV GO:0003924 25/174 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8WDGRV GO:0003746 4/174 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8WDGRV GO:0020037 2/174 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8WDGRV GO:0016705 2/174 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG8WDGRV GO:0005506 2/174 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8WDGRV GO:0004568 1/174 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8WDGRV GO:0005975 1/174 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8WDGRV GO:0004497 1/174 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8WDGRV GO:0006032 1/174 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG825878 GO:0022008 1/93 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8DZ4CF GO:0003700 2/11 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8DZ4CF GO:0043565 2/11 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8DZ4CF GO:0005634 1/11 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8V9X5Z GO:0005525 23/71 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8V9X5Z GO:0035998 23/71 7,8-dihydroneopterin 3'-triphosphate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [CHEBI:18372, GOC:yaf, UniPathway:UPA00848] EOG8V9X5Z GO:0046872 23/71 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8V9X5Z GO:0003934 23/71 GTP cyclohydrolase I activity molecular_function "Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16] EOG83R62R GO:0003676 1/20 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83R62R GO:0004523 1/20 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8GQSJZ GO:0046330 1/92 positive regulation of JNK cascade biological_process "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG8GQSJZ GO:0005515 1/92 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8GQSJZ GO:0030041 1/92 actin filament polymerization biological_process "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG8DJNC1 GO:0007165 25/88 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8DJNC1 GO:0003676 1/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DJNC1 GO:0008270 1/88 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8CJXZ0 GO:0016020 1/7 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8BZQHM GO:0016042 1/103 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG8BZQHM GO:0005576 1/103 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8BZQHM GO:0046843 1/103 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8BZQHM GO:0002121 1/103 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8BZQHM GO:0016787 1/103 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8BZQHM GO:0007444 1/103 imaginal disc development biological_process "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] EOG8XWJBR GO:0005509 25/91 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8XWJBR GO:0007156 20/91 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8XWJBR GO:0016021 19/91 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XWJBR GO:0005576 1/91 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XWJBR GO:0045211 1/91 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8XWJBR GO:0005887 1/91 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XWJBR GO:0016339 1/91 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] EOG898XFV GO:0050660 1/4 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG898XFV GO:0050797 1/4 thymidylate synthase (FAD) activity molecular_function "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+." [EC:2.1.1.148] EOG898XFV GO:0006231 1/4 dTMP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732] EOG83R627 GO:0003676 1/5 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83R627 GO:0008026 1/5 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG83R627 GO:0005524 1/5 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8N5ZDF GO:0006457 2/40 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8BZQHT GO:0003723 30/101 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8BZQHT GO:0003735 30/101 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8BZQHT GO:0015935 30/101 small ribosomal subunit cellular_component "The smaller of the two subunits of a ribosome." [GOC:mah] EOG8BZQHT GO:0006412 30/101 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8BZQHT GO:0007275 1/101 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8BZQHT GO:0048477 1/101 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8BZQHT GO:0005730 1/101 nucleolus cellular_component "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] EOG8BZQHT GO:0000228 1/101 nuclear chromosome cellular_component "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] EOG8BZQHT GO:0005840 1/101 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8BZQHT GO:0005737 1/101 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8M0HGV GO:0004252 14/19 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8M0HGV GO:0016787 1/19 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8M0HGV GO:0006508 1/19 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG84N15S GO:0007317 1/101 regulation of pole plasm oskar mRNA localization biological_process "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] EOG80CKX2 GO:0003676 25/86 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80CKX2 GO:0005524 25/86 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG80CKX2 GO:0008026 24/86 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG80CKX2 GO:0004386 2/86 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG80CKX2 GO:0071011 1/86 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG80CKX2 GO:0032797 1/86 SMN complex cellular_component "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] EOG80CKX2 GO:0016779 1/86 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG80CKX2 GO:0000398 1/86 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG80CKX2 GO:0071013 1/86 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8616HZ GO:0007155 51/345 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8616HZ GO:0005524 32/345 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8616HZ GO:0004672 17/345 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8616HZ GO:0004713 14/345 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8616HZ GO:0004714 7/345 transmembrane receptor protein tyrosine kinase activity molecular_function "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] EOG8616HZ GO:0004715 1/345 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8616HZ GO:0007169 1/345 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG8616HZ GO:0006468 1/345 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8616HZ GO:0018108 1/345 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8616HZ GO:0016020 1/345 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8TTJXP GO:0004842 8/68 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8TTJXP GO:0008270 1/68 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z38TT GO:0008270 23/94 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83BQ3X GO:0007281 1/98 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG83BQ3X GO:0005737 1/98 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83BQ3X GO:0019099 1/98 female germ-line sex determination biological_process "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah] EOG83BQ3X GO:0018992 1/98 germ-line sex determination biological_process "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems] EOG83BQ3X GO:0048134 1/98 germ-line cyst formation biological_process "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920] EOG83BQ3X GO:0051276 1/98 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG83BQ3X GO:0048477 1/98 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG83BQ3X GO:0032877 1/98 positive regulation of DNA endoreduplication biological_process "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah] EOG8WM79H GO:0031083 9/110 BLOC-1 complex cellular_component "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] EOG8WM79H GO:0030133 9/110 transport vesicle cellular_component "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] EOG8WM79H GO:0008270 1/110 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8577N4 GO:0007165 1/3 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG88D396 GO:0032440 2/117 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG88D396 GO:0008544 1/117 epidermis development biological_process "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] EOG88D396 GO:0035317 1/117 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG88D396 GO:0048477 1/117 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG88D396 GO:0045177 1/117 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG88D396 GO:0030725 1/117 germline ring canal formation biological_process "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238] EOG88D396 GO:0016311 1/117 dephosphorylation biological_process "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] EOG88D396 GO:0007560 1/117 imaginal disc morphogenesis biological_process "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] EOG88D396 GO:0017018 1/117 myosin phosphatase activity molecular_function "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] EOG88D396 GO:0048675 1/117 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG88D396 GO:0007391 1/117 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG88D396 GO:0045314 1/117 regulation of compound eye photoreceptor development biological_process "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] EOG88D396 GO:0045179 1/117 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8TQPRX GO:0016787 1/20 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8J3ZXD GO:0003779 1/92 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8J3ZXD GO:0009913 1/92 epidermal cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] EOG8J3ZXD GO:0035317 1/92 imaginal disc-derived wing hair organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] EOG8J3ZXD GO:0051017 1/92 actin filament bundle assembly biological_process "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] EOG8J3ZXD GO:0035017 1/92 cuticle pattern formation biological_process "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] EOG8J3ZXD GO:0008407 1/92 chaeta morphogenesis biological_process "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] EOG8J3ZXD GO:0007605 1/92 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8J3ZXD GO:0048800 1/92 antennal morphogenesis biological_process "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] EOG83V29H GO:0006351 1/5 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG83V29H GO:0003899 1/5 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG83V29H GO:0003677 1/5 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Q87DM GO:0005622 4/16 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8Q87DM GO:0005215 4/16 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8S7N54 GO:0005975 19/45 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8S7N54 GO:0004553 17/45 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG8S7N54 GO:0003940 2/45 L-iduronidase activity molecular_function "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate." [EC:3.2.1.76] EOG8VX4K4 GO:0005576 4/62 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8VX4K4 GO:0042742 3/62 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8VX4K4 GO:0007498 1/62 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8VX4K4 GO:0009405 1/62 pathogenesis biological_process "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] EOG8HDW89 GO:0006810 25/93 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8HDW89 GO:0005622 24/93 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8HDW89 GO:0033206 1/93 meiotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8HDW89 GO:0001700 1/93 embryonic development via the syncytial blastoderm biological_process "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8HDW89 GO:0032154 1/93 cleavage furrow cellular_component "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] EOG8HDW89 GO:0031566 1/93 actomyosin contractile ring maintenance biological_process "The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb, GOC:vw] EOG8HDW89 GO:0005886 1/93 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8HDW89 GO:0007112 1/93 male meiosis cytokinesis biological_process "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] EOG8HDW89 GO:0070732 1/93 spindle envelope cellular_component "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889] EOG8HDW89 GO:0000916 1/93 actomyosin contractile ring contraction biological_process "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] EOG8HDW89 GO:0048137 1/93 spermatocyte division biological_process "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238] EOG8HDW89 GO:0007111 1/93 meiosis II cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8HDW89 GO:0000915 1/93 actomyosin contractile ring assembly biological_process "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] EOG8HDW89 GO:0005794 1/93 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8HDW89 GO:0043147 1/93 meiotic spindle stabilization biological_process "The cell cycle process in which spindle integrity is maintained during M phase of meiosis." [GOC:go_curators] EOG8HDW89 GO:0007110 1/93 meiosis I cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8HDW89 GO:0016006 1/93 Nebenkern cellular_component "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] EOG8HDW89 GO:0031965 1/93 nuclear membrane cellular_component "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] EOG87Q0M3 GO:0016021 25/89 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG87Q0M3 GO:0004983 17/89 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG87Q0M3 GO:0004930 9/89 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG87Q0M3 GO:0007218 2/89 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG87Q0M3 GO:0050254 2/89 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG87Q0M3 GO:0008528 1/89 G-protein coupled peptide receptor activity molecular_function "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb] EOG87Q0M3 GO:0008340 1/89 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG87Q0M3 GO:0008188 1/89 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG87Q0M3 GO:0007186 1/89 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG87Q0M3 GO:0005887 1/89 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG866Z1D GO:0016021 35/124 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG866Z1D GO:0022857 28/124 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG866Z1D GO:0022891 7/124 substrate-specific transmembrane transporter activity molecular_function "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] EOG866Z1D GO:0008643 7/124 carbohydrate transport biological_process "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] EOG866Z1D GO:0032440 1/124 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8G4K6X GO:0016021 2/3 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G4K6X GO:0015171 2/3 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8TB6RW GO:0005680 1/9 anaphase-promoting complex cellular_component "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] EOG8TB6RH GO:0005509 4/21 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8TB6RH GO:0005216 3/21 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8TB6RH GO:0016021 3/21 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8DBWX0 GO:0003723 15/68 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8PVRFG GO:0016021 2/5 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NKF98 GO:0016021 134/389 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NKF98 GO:0007602 130/389 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG8NKF98 GO:0007601 128/389 visual perception biological_process "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] EOG8NKF98 GO:0004930 128/389 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8NKF98 GO:0018298 122/389 protein-chromophore linkage biological_process "The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma] EOG8NKF98 GO:0009881 116/389 photoreceptor activity molecular_function "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] EOG8NKF98 GO:0009584 6/389 detection of visible light biological_process "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] EOG8NKF98 GO:0008020 6/389 G-protein coupled photoreceptor activity molecular_function "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732] EOG8NKF98 GO:0007186 6/389 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8NKF98 GO:0009589 3/389 detection of UV biological_process "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732] EOG8NKF98 GO:0016028 3/389 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8NKF98 GO:0007604 2/389 phototransduction, UV biological_process "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732] EOG8NKF98 GO:0043153 2/389 entrainment of circadian clock by photoperiod biological_process "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl] EOG8NKF98 GO:0007605 2/389 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8NKF98 GO:0005767 1/389 secondary lysosome cellular_component "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194] EOG8NKF98 GO:0009642 1/389 response to light intensity biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators] EOG8NKF98 GO:0008344 1/389 adult locomotory behavior biological_process "Locomotory behavior in a fully developed and mature organism." [GOC:ai] EOG8NKF98 GO:0042052 1/389 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8NKF98 GO:0043052 1/389 thermotaxis biological_process "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] EOG8NKF98 GO:0008594 1/389 photoreceptor cell morphogenesis biological_process "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] EOG8NKF98 GO:0016027 1/389 inaD signaling complex cellular_component "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] EOG8NKF98 GO:0009416 1/389 response to light stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] EOG8NKF98 GO:0030265 1/389 phospholipase C-activating rhodopsin mediated signaling pathway biological_process "The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931] EOG8NKF98 GO:0046673 1/389 negative regulation of compound eye retinal cell programmed cell death biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8NKF98 GO:0042331 1/389 phototaxis biological_process "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] EOG8NKF98 GO:0016038 1/389 absorption of visible light biological_process "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732] EOG8NKF98 GO:0005771 1/389 multivesicular body cellular_component "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950] EOG8NKF98 GO:0016039 1/389 absorption of UV light biological_process "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732] EOG8NKF98 GO:0005791 1/389 rough endoplasmic reticulum cellular_component "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] EOG8NKF98 GO:0016023 1/389 cytoplasmic membrane-bounded vesicle cellular_component "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] EOG8NKF98 GO:0009588 1/389 UV-A, blue light phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm." [GOC:mah] EOG8NKF98 GO:0016029 1/389 subrhabdomeral cisterna cellular_component "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774] EOG8NKF98 GO:0005515 1/389 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NKF98 GO:0000122 1/389 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8NKF98 GO:0071632 1/389 optomotor response biological_process "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195] EOG8NKF98 GO:0005886 1/389 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FFGG5 GO:0005524 25/97 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8FFGG5 GO:0006457 25/97 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG8FFGG5 GO:0017111 25/97 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8FFGG5 GO:0008233 3/97 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8VDSFF GO:0016020 35/2018 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VDSFF GO:0051781 22/2018 positive regulation of cell division biological_process "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] EOG8VDSFF GO:0007435 2/2018 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8VDSFF GO:0035099 2/2018 hemocyte migration biological_process "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] EOG8VDSFF GO:0003964 1/2018 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VDSFF GO:0008039 1/2018 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8VDSFF GO:0035172 1/2018 hemocyte proliferation biological_process "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG8ZSCHB GO:0016757 23/78 transferase activity, transferring glycosyl groups molecular_function "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8ZSCHB GO:0006486 23/78 protein glycosylation biological_process "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] EOG8ZSCHB GO:0016021 23/78 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZSCHB GO:0005794 22/78 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8ZSCHB GO:0046872 8/78 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8ZSCHB GO:0004653 4/78 polypeptide N-acetylgalactosaminyltransferase activity molecular_function "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] EOG8ZSCHB GO:0009312 1/78 oligosaccharide biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] EOG8ZSCHB GO:0000139 1/78 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8ZSCHB GO:0005795 1/78 Golgi stack cellular_component "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] EOG8QJV20 GO:0005524 124/478 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8QJV20 GO:0004713 95/478 protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] EOG8QJV20 GO:0004715 33/478 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8QJV20 GO:0035556 18/478 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8QJV20 GO:0006468 5/478 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8QJV20 GO:0018108 5/478 peptidyl-tyrosine phosphorylation biological_process "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] EOG8QJV20 GO:0004672 4/478 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8QJV20 GO:0007391 4/478 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8QJV20 GO:0045886 3/478 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8QJV20 GO:0007435 3/478 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8QJV20 GO:0007254 3/478 JNK cascade biological_process "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] EOG8QJV20 GO:0007424 3/478 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8QJV20 GO:0030036 2/478 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8QJV20 GO:0030723 2/478 ovarian fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] EOG8QJV20 GO:0048749 2/478 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8QJV20 GO:0045172 2/478 germline ring canal cellular_component "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] EOG8QJV20 GO:0005515 2/478 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8QJV20 GO:0030717 2/478 karyosome formation biological_process "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] EOG8QJV20 GO:0005737 2/478 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8QJV20 GO:0007293 2/478 germarium-derived egg chamber formation biological_process "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8QJV20 GO:0034332 2/478 adherens junction organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah] EOG8QJV20 GO:0007349 2/478 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8QJV20 GO:0090136 2/478 epithelial cell-cell adhesion biological_process "The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8QJV20 GO:0007476 2/478 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8QJV20 GO:0008064 2/478 regulation of actin polymerization or depolymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] EOG8QJV20 GO:0007300 2/478 ovarian nurse cell to oocyte transport biological_process "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8QJV20 GO:0048477 2/478 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8QJV20 GO:0005912 2/478 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8QJV20 GO:0007301 2/478 female germline ring canal formation biological_process "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238] EOG8QJV20 GO:0007169 1/478 transmembrane receptor protein tyrosine kinase signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] EOG8QJV20 GO:0046872 1/478 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8QJV20 GO:0046960 1/478 sensitization biological_process "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089] EOG8QJV20 GO:0007409 1/478 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8QJV20 GO:0032880 1/478 regulation of protein localization biological_process "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] EOG8QJV20 GO:0042059 1/478 negative regulation of epidermal growth factor receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] EOG8QJV20 GO:0008302 1/478 female germline ring canal formation, actin assembly biological_process "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238] EOG8QJV20 GO:0030833 1/478 regulation of actin filament polymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG8QJV20 GO:0007619 1/478 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8QJV20 GO:0030424 1/478 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8QJV20 GO:0008335 1/478 female germline ring canal stabilization biological_process "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators] EOG8QJV20 GO:0030046 1/478 parallel actin filament bundle assembly biological_process "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194] EOG8QJV20 GO:0003402 1/478 planar cell polarity pathway involved in axis elongation biological_process "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8QJV20 GO:0008340 1/478 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8QJV20 GO:0045179 1/478 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8QJV20 GO:0005911 1/478 cell-cell junction cellular_component "A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah] EOG8QJV20 GO:0030708 1/478 germarium-derived female germ-line cyst encapsulation biological_process "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336] EOG8QJV20 GO:0035014 1/478 phosphatidylinositol 3-kinase regulator activity molecular_function "Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069] EOG8QJV20 GO:0036058 1/478 filtration diaphragm assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929] EOG8QJV20 GO:0007370 1/478 ventral furrow formation biological_process "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] EOG8QJV20 GO:0046529 1/478 imaginal disc fusion, thorax closure biological_process "The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm] EOG8QJV20 GO:0005942 1/478 phosphatidylinositol 3-kinase complex cellular_component "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488] EOG8QJV20 GO:0010669 1/478 epithelial structure maintenance biological_process "A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb] EOG8QJV20 GO:0007395 1/478 dorsal closure, spreading of leading edge cells biological_process "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138] EOG8QJV20 GO:0031647 1/478 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8QJV20 GO:0045197 1/478 establishment or maintenance of epithelial cell apical/basal polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] EOG8QJV20 GO:0045860 1/478 positive regulation of protein kinase activity biological_process "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] EOG8QJV20 GO:0046827 1/478 positive regulation of protein export from nucleus biological_process "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] EOG8QJV20 GO:0007616 1/478 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8QJV20 GO:0034334 1/478 adherens junction maintenance biological_process "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] EOG8QJV20 GO:0008355 1/478 olfactory learning biological_process "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] EOG8QJV20 GO:0005927 1/478 muscle tendon junction cellular_component "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007] EOG8QJV20 GO:0016301 1/478 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8QJV20 GO:0007303 1/478 cytoplasmic transport, nurse cell to oocyte biological_process "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] EOG8QJV20 GO:0044719 1/478 regulation of imaginal disc-derived wing size biological_process "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] EOG8QJV20 GO:0007611 1/478 learning or memory biological_process "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] EOG8QJV20 GO:0016199 1/478 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8QJV20 GO:0007417 1/478 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8QJV20 GO:0003382 1/478 epithelial cell morphogenesis biological_process "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8QJV20 GO:0043277 1/478 apoptotic cell clearance biological_process "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684] EOG8QJV20 GO:0005829 1/478 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8QJV20 GO:0043068 1/478 positive regulation of programmed cell death biological_process "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] EOG8QJV20 GO:0007485 1/478 imaginal disc-derived male genitalia development biological_process "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] EOG8QJV20 GO:0001764 1/478 neuron migration biological_process "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] EOG8QJV20 GO:0005938 1/478 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8QJV20 GO:0051017 1/478 actin filament bundle assembly biological_process "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] EOG8QJV20 GO:0005886 1/478 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8QJV20 GO:0006099 1/478 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8QJV20 GO:0016477 1/478 cell migration biological_process "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] EOG8QJV20 GO:0016319 1/478 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8QJV20 GO:0008360 1/478 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8QJV20 GO:0002009 1/478 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8QJV20 GO:0008285 1/478 negative regulation of cell proliferation biological_process "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] EOG8QJV20 GO:0008045 1/478 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8QJV20 GO:0007411 1/478 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8QJV20 GO:0050254 1/478 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8QJV20 GO:0019897 1/478 extrinsic component of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] EOG8QJV20 GO:0045926 1/478 negative regulation of growth biological_process "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] EOG8QJV20 GO:0042023 1/478 DNA endoreduplication biological_process "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] EOG8QJV20 GO:0072499 1/478 photoreceptor cell axon guidance biological_process "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] EOG8QJV20 GO:0007419 1/478 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8QJV20 GO:0008258 1/478 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8MD0GT GO:0007275 1/19 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8MD0GT GO:0004872 1/19 receptor activity molecular_function "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732] EOG8MD0GT GO:0018149 1/19 peptide cross-linking biological_process "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] EOG8MD0GT GO:0016020 1/19 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8MD0GT GO:0005737 1/19 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84TRNQ GO:0005634 21/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84TRNQ GO:0006886 21/94 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG84TRNQ GO:0005737 1/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84TRNQ GO:0003964 1/94 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG84TRNQ GO:0005815 1/94 microtubule organizing center cellular_component "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416] EOG84TRNQ GO:0003682 1/94 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG84TRNQ GO:0005049 1/94 nuclear export signal receptor activity molecular_function "Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm." [GOC:bf, GOC:mah, GOC:vw, PMID:11743003, PMID:12486120] EOG84TRNQ GO:0000922 1/94 spindle pole cellular_component "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] EOG84TRNQ GO:0003677 1/94 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84TRNQ GO:0000226 1/94 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG84TRNQ GO:0003723 1/94 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG84TRNQ GO:0006352 1/94 DNA-templated transcription, initiation biological_process "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] EOG84TRNQ GO:0005643 1/94 nuclear pore cellular_component "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] EOG84TRNQ GO:0051028 1/94 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG84TRNQ GO:0006611 1/94 protein export from nucleus biological_process "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] EOG8ZSCHK GO:0050661 87/284 NADP binding molecular_function "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] EOG8ZSCHK GO:0004499 87/284 N,N-dimethylaniline monooxygenase activity molecular_function "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8] EOG8ZSCHK GO:0050660 87/284 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8ZSCHK GO:0005789 9/284 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8ZSCHK GO:0005829 2/284 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8ZSCHK GO:0004497 2/284 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8ZSCHK GO:0005739 2/284 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8ZSCHK GO:0043231 2/284 intracellular membrane-bounded organelle cellular_component "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] EOG8ZSCHK GO:0016021 1/284 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZSCHK GO:0016042 1/284 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG8ZSCHK GO:0045454 1/284 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8ZSCHK GO:0003847 1/284 1-alkyl-2-acetylglycerophosphocholine esterase activity molecular_function "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] EOG8M0HJC GO:0004672 1/10 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG86DPGS GO:0004725 29/119 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG86DPGS GO:0008138 29/119 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG86DPGS GO:0006470 1/119 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8GMXBG GO:0016021 21/124 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GMXBG GO:0005249 17/124 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8GMXBG GO:0005216 5/124 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8GMXBG GO:0008603 2/124 cAMP-dependent protein kinase regulator activity molecular_function "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] EOG8GMXBG GO:0004692 2/124 cGMP-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah] EOG8GMXBG GO:0005952 2/124 cAMP-dependent protein kinase complex cellular_component "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732] EOG8GMXBG GO:0071805 1/124 potassium ion transmembrane transport biological_process "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] EOG8GMXBG GO:0045938 1/124 positive regulation of circadian sleep/wake cycle, sleep biological_process "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] EOG8GMXBG GO:0007637 1/124 proboscis extension reflex biological_process "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid] EOG8GMXBG GO:0004691 1/124 cAMP-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11] EOG8GMXBG GO:0004715 1/124 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8GMXBG GO:0005887 1/124 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GMXBG GO:0014059 1/124 regulation of dopamine secretion biological_process "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef] EOG8GMXBG GO:0042391 1/124 regulation of membrane potential biological_process "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] EOG8GMXBG GO:0045475 1/124 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8GMXBG GO:0008340 1/124 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8GMXBG GO:0050802 1/124 circadian sleep/wake cycle, sleep biological_process "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai] EOG8T4G85 GO:0005737 12/117 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8T4G85 GO:0005634 11/117 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8T4G85 GO:0048489 1/117 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG8T4G85 GO:0005524 1/117 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8T4G85 GO:0000132 1/117 establishment of mitotic spindle orientation biological_process "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] EOG8T4G85 GO:0016020 1/117 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8T4G85 GO:0042626 1/117 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8T4G85 GO:0048812 1/117 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8T4G85 GO:0008088 1/117 axon cargo transport biological_process "The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194] EOG8GMXBH GO:0006370 31/135 7-methylguanosine mRNA capping biological_process "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] EOG8GMXBH GO:0004484 31/135 mRNA guanylyltransferase activity molecular_function "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50] EOG8GMXBH GO:0008138 28/135 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG8GMXBH GO:0004725 27/135 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8GMXBH GO:0004651 23/135 polynucleotide 5'-phosphatase activity molecular_function "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] EOG8GMXBH GO:0005634 23/135 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GMXBH GO:0004527 1/135 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8GMXBH GO:0010181 1/135 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8GMXBH GO:0003676 1/135 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GMXBH GO:0051539 1/135 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8GMXBH GO:0008137 1/135 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8GMXBH GO:0016491 1/135 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8GMXBH GO:0006470 1/135 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8CZDWD GO:0005622 23/100 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8CZDWD GO:0007165 22/100 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8CZDWD GO:0007480 1/100 imaginal disc-derived leg morphogenesis biological_process "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8CZDWD GO:0007370 1/100 ventral furrow formation biological_process "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] EOG8CZDWD GO:0032321 1/100 positive regulation of GTPase activity biological_process "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] EOG8CZDWD GO:0007266 1/100 Rho protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] EOG8CZDWD GO:0051497 1/100 negative regulation of stress fiber assembly biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] EOG8CZDWD GO:0045887 1/100 positive regulation of synaptic growth at neuromuscular junction biological_process "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8CZDWD GO:0005100 1/100 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8K6JJ5 GO:0007264 3/40 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8K6JJ5 GO:0005085 3/40 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG8K6JJ5 GO:0005622 3/40 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8CRPFF GO:0005576 1/33 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8CC6FD GO:0006355 25/87 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CC6FD GO:0005634 24/87 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CC6FD GO:0032783 1/87 ELL-EAF complex cellular_component "A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956] EOG8CC6FD GO:0005674 1/87 transcription factor TFIIF complex cellular_component "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077] EOG8CC6FD GO:0005669 1/87 transcription factor TFIID complex cellular_component "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] EOG8CC6FD GO:0006367 1/87 transcription initiation from RNA polymerase II promoter biological_process "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] EOG8NKF9Q GO:0016020 55/747 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NKF9Q GO:0007157 8/747 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules biological_process "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] EOG8NKF9Q GO:0005887 3/747 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NKF9Q GO:0007415 2/747 defasciculation of motor neuron axon biological_process "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] EOG8NKF9Q GO:0007411 2/747 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8NKF9Q GO:0004252 2/747 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8NKF9Q GO:0005576 1/747 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8NKF9Q GO:0005515 1/747 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8NKF9Q GO:0001746 1/747 Bolwig's organ morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] EOG8NKF9Q GO:0016198 1/747 axon choice point recognition biological_process "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152] EOG8NKF9Q GO:0008045 1/747 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8NKF9Q GO:0016201 1/747 synaptic target inhibition biological_process "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] EOG8NKF9Q GO:0031225 1/747 anchored component of membrane cellular_component "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG8BCH4R GO:0004930 6/24 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8BCH4R GO:0016021 6/24 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BCH4R GO:0004715 2/24 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG80S2W1 GO:0016021 18/35 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80S2W1 GO:0055085 18/35 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG80S2W1 GO:0005886 4/35 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80S2W1 GO:0005215 4/35 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8CRPFP GO:0016020 7/47 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CRPFP GO:0007264 7/47 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8CRPFP GO:0006184 7/47 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8CRPFP GO:0005525 7/47 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8R52JR GO:0016020 2/3 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HDW8D GO:0030983 1/10 mismatched DNA binding molecular_function "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] EOG8HDW8D GO:0005524 1/10 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8HDW8D GO:0043565 1/10 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8HDW8D GO:0006298 1/10 mismatch repair biological_process "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] EOG8Q87DG GO:0005525 22/78 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8Q87DG GO:0005622 20/78 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8Q87DG GO:0007264 20/78 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8Q87DG GO:0046872 1/78 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8Q87DG GO:0020037 1/78 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG87Q0MQ GO:0016616 4/47 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG87Q0MQ GO:0044262 3/47 cellular carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] EOG87Q0MQ GO:0005975 1/47 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8Q87C7 GO:0070469 1/5 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8Q87C7 GO:0009055 1/5 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8Q87C7 GO:0055114 1/5 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8Q87C7 GO:0005506 1/5 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8Q87C7 GO:0005739 1/5 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8Q87C7 GO:0020037 1/5 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8Q87DC GO:0040007 9/56 growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] EOG8Q87DC GO:0005576 3/56 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8V19GN GO:0004386 3/8 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8V19GN GO:0003676 3/8 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8V19GN GO:0005524 3/8 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8H1D99 GO:0004518 1/250 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8H1D99 GO:0004812 1/250 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG8H1D99 GO:0003677 1/250 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VX4KZ GO:0003676 2/7 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG866Z12 GO:0030170 26/95 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG866Z12 GO:0003870 25/95 5-aminolevulinate synthase activity molecular_function "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12924] EOG866Z12 GO:0006782 24/95 protoporphyrinogen IX biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators] EOG866Z12 GO:0005759 24/95 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG866Z12 GO:0033014 1/95 tetrapyrrole biosynthetic process biological_process "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah] EOG866Z12 GO:0009058 1/95 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG866Z12 GO:0040003 1/95 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG866Z12 GO:0003824 1/95 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG837TXH GO:0005576 6/76 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG837TXH GO:0008061 6/76 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG837TXH GO:0006030 6/76 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG837TXH GO:0005201 1/76 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG837TXH GO:0031012 1/76 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG837TXH GO:0005581 1/76 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8MGVR1 GO:0005524 2/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8MGVR1 GO:0004672 2/7 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8QRKMD GO:0003700 1/46 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8QRKMD GO:0043565 1/46 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG879HN6 GO:0016021 18/74 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG879HN6 GO:0007523 1/74 larval visceral muscle development biological_process "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] EOG879HN6 GO:0006869 1/74 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG879HN6 GO:0005737 1/74 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG879HN6 GO:0048471 1/74 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG879HN6 GO:0006200 1/74 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG879HN6 GO:0061024 1/74 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG879HN6 GO:0005811 1/74 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG879HN6 GO:0031887 1/74 lipid particle transport along microtubule biological_process "The directed movement of a lipid particle along a microtubule, mediated by motor proteins." [PMID:9491895] EOG879HN6 GO:0035149 1/74 lumen formation, open tracheal system biological_process "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] EOG879HN6 GO:0030286 1/74 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG879HN6 GO:0035239 1/74 tube morphogenesis biological_process "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] EOG879HN6 GO:0001745 1/74 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG879HN6 GO:0005881 1/74 cytoplasmic microtubule cellular_component "Any microtubule in the cytoplasm of a cell." [GOC:mah] EOG879HN6 GO:0005515 1/74 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG879HN6 GO:0051640 1/74 organelle localization biological_process "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] EOG879HN6 GO:0060361 1/74 flight biological_process "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] EOG879HN6 GO:0007018 1/74 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG879HN6 GO:0042623 1/74 ATPase activity, coupled molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] EOG879HN6 GO:0007097 1/74 nuclear migration biological_process "The directed movement of the nucleus." [GOC:ai] EOG879HN6 GO:0040011 1/74 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG879HN6 GO:0042051 1/74 compound eye photoreceptor development biological_process "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] EOG879HN6 GO:0005635 1/74 nuclear envelope cellular_component "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] EOG86MF2D GO:0046872 25/102 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG86MF2D GO:0000166 25/102 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG86MF2D GO:0003723 23/102 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG86MF2D GO:0006397 20/102 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG86MF2D GO:0003729 1/102 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG86MF2D GO:0010628 1/102 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG86MF2D GO:0046833 1/102 positive regulation of RNA export from nucleus biological_process "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] EOG86MF2D GO:1900364 1/102 negative regulation of mRNA polyadenylation biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841] EOG86MF2D GO:0045879 1/102 negative regulation of smoothened signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG86MF2D GO:0005634 1/102 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8Q87DX GO:0000166 1/8 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8Q87DX GO:0003676 1/8 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VQD5Z GO:0045089 1/11 positive regulation of innate immune response biological_process "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] EOG8VQD5Z GO:0050829 1/11 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8642W1 GO:0045454 1/5 cell redox homeostasis biological_process "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] EOG8642W1 GO:0042302 1/5 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8SFCNG GO:0005525 27/147 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8SFCNG GO:0003924 25/147 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8SFCNG GO:0003743 5/147 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG8SFCNG GO:0004781 1/147 sulfate adenylyltransferase (ATP) activity molecular_function "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4] EOG8SFCNG GO:0005737 1/147 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8SFCNG GO:0017151 1/147 DEAD/H-box RNA helicase binding molecular_function "Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase." [GOC:jl] EOG8SFCNG GO:0006413 1/147 translational initiation biological_process "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]