GO:0140097 catalytic activity, acting on DNA Gains GO:0003964 RNA-directed DNA polymerase activity Gains GO:0003824 catalytic activity Gains GO:0034061 DNA polymerase activity Gains GO:0016787 hydrolase activity Gains GO:0004497 monooxygenase activity Gains GO:0016779 nucleotidyltransferase activity Gains GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Gains GO:0046914 transition metal ion binding Gains GO:0004185 serine-type carboxypeptidase activity Gains GO:0042626 ATPase activity, coupled to transmembrane movement of substances Gains GO:0022804 active transmembrane transporter activity Gains GO:0043492 ATPase activity, coupled to movement of substances Gains GO:0015399 primary active transmembrane transporter activity Gains GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity Gains GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Gains GO:0003916 DNA topoisomerase activity Gains GO:0072510 trivalent inorganic cation transmembrane transporter activity Gains GO:0045289 luciferin monooxygenase activity Gains GO:0070008 serine-type exopeptidase activity Gains GO:0015408 ferric-transporting ATPase activity Gains GO:0015091 ferric iron transmembrane transporter activity Gains GO:0016798 hydrolase activity, acting on glycosyl bonds Gains GO:0005496 steroid binding Gains GO:0004180 carboxypeptidase activity Gains GO:0008094 DNA-dependent ATPase activity Gains GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds Gains GO:0004344 glucose dehydrogenase activity Gains GO:0061505 DNA topoisomerase II activity Gains GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Gains GO:0016703 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) Gains GO:0016772 transferase activity, transferring phosphorus-containing groups Gains GO:0008270 zinc ion binding Gains GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity Gains GO:0033777 lithocholate 6beta-hydroxylase activity Gains GO:0019187 beta-1,4-mannosyltransferase activity Gains GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors Gains GO:0004040 amidase activity Gains GO:0015321 sodium-dependent phosphate transmembrane transporter activity Gains GO:0004335 galactokinase activity Gains GO:0047077 Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity Gains GO:0050591 quinine 3-monooxygenase activity Gains GO:0018685 alkane 1-monooxygenase activity Gains GO:0008011 structural constituent of pupal chitin-based cuticle Gains GO:0005215 transporter activity Gains GO:0016491 oxidoreductase activity Gains GO:0022857 transmembrane transporter activity Gains GO:0016868 intramolecular transferase activity, phosphotransferases Gains GO:0005506 iron ion binding Gains GO:0016853 isomerase activity Gains GO:0005381 iron ion transmembrane transporter activity Gains GO:0008812 choline dehydrogenase activity Gains GO:0070330 aromatase activity Gains GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Gains GO:0090484 drug transporter activity Gains GO:0015238 drug transmembrane transporter activity Gains GO:0042623 ATPase activity, coupled Gains GO:0046906 tetrapyrrole binding Gains GO:0020037 heme binding Gains GO:0016740 transferase activity Gains GO:0016887 ATPase activity Gains GO:0004725 protein tyrosine phosphatase activity Gains GO:0003777 microtubule motor activity Gains GO:0016801 hydrolase activity, acting on ether bonds Gains GO:0015925 galactosidase activity Gains GO:0004013 adenosylhomocysteinase activity Gains GO:0004035 alkaline phosphatase activity Gains GO:0008756 o-succinylbenzoate-CoA ligase activity Gains GO:0015114 phosphate ion transmembrane transporter activity Gains GO:0015101 organic cation transmembrane transporter activity Gains GO:1901677 phosphate transmembrane transporter activity Gains GO:0003917 DNA topoisomerase type I activity Gains GO:0016725 oxidoreductase activity, acting on CH or CH2 groups Gains GO:0004500 dopamine beta-monooxygenase activity Gains GO:0004654 polyribonucleotide nucleotidyltransferase activity Gains GO:0016802 trialkylsulfonium hydrolase activity Gains GO:0016614 oxidoreductase activity, acting on CH-OH group of donors Gains GO:0016791 phosphatase activity Gains GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Gains GO:0008559 xenobiotic transmembrane transporting ATPase activity Gains GO:0005272 sodium channel activity Gains GO:0008757 S-adenosylmethionine-dependent methyltransferase activity Gains GO:0004300 enoyl-CoA hydratase activity Gains GO:0004435 phosphatidylinositol phospholipase C activity Gains GO:0016411 acylglycerol O-acyltransferase activity Gains GO:0016408 C-acyltransferase activity Gains GO:0016886 ligase activity, forming phosphoric ester bonds Gains GO:0004629 phospholipase C activity Gains GO:0008289 lipid binding Gains GO:0019829 cation-transporting ATPase activity Gains GO:0042054 histone methyltransferase activity Gains GO:0008276 protein methyltransferase activity Gains GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Gains GO:0042910 xenobiotic transmembrane transporter activity Gains GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Gains GO:0004930 G-protein coupled receptor activity Losses GO:0003964 RNA-directed DNA polymerase activity Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0099600 transmembrane receptor activity Losses GO:0038023 signaling receptor activity Losses GO:0004872 receptor activity Losses GO:0060089 molecular transducer activity Losses GO:0008528 G-protein coupled peptide receptor activity Losses GO:0001653 peptide receptor activity Losses GO:0004871 signal transducer activity Losses GO:0034061 DNA polymerase activity Losses GO:0008188 neuropeptide receptor activity Losses GO:0043565 sequence-specific DNA binding Losses GO:0140097 catalytic activity, acting on DNA Losses GO:0004523 RNA-DNA hybrid ribonuclease activity Losses GO:0003700 DNA binding transcription factor activity Losses GO:0008061 chitin binding Losses GO:0003676 nucleic acid binding Losses GO:0005549 odorant binding Losses GO:0019239 deaminase activity Losses GO:0004950 chemokine receptor activity Losses GO:0004977 melanocortin receptor activity Losses GO:0001637 G-protein coupled chemoattractant receptor activity Losses GO:0004000 adenosine deaminase activity Losses GO:0044212 transcription regulatory region DNA binding Losses GO:0004993 G-protein coupled serotonin receptor activity Losses GO:0099589 serotonin receptor activity Losses GO:0001067 regulatory region nucleic acid binding Losses GO:0000975 regulatory region DNA binding Losses GO:0008227 G-protein coupled amine receptor activity Losses GO:0016779 nucleotidyltransferase activity Losses GO:0004935 adrenergic receptor activity Losses GO:0030296 protein tyrosine kinase activator activity Losses GO:0019992 diacylglycerol binding Losses GO:0004896 cytokine receptor activity Losses GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Losses GO:0004983 neuropeptide Y receptor activity Losses GO:0001158 enhancer sequence-specific DNA binding Losses GO:0035326 enhancer binding Losses GO:0004715 non-membrane spanning protein tyrosine kinase activity Losses GO:0008273 calcium, potassium:sodium antiporter activity Losses GO:0030297 transmembrane receptor protein tyrosine kinase activator activity Losses GO:0030546 receptor activator activity Losses GO:0030545 receptor regulator activity Losses GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Losses GO:0140110 transcription regulator activity Losses GO:0015368 calcium:cation antiporter activity Losses GO:0031208 POZ domain binding Losses GO:0030246 carbohydrate binding Losses GO:0016722 oxidoreductase activity, oxidizing metal ions Losses GO:0000976 transcription regulatory region sequence-specific DNA binding Losses GO:0001012 RNA polymerase II regulatory region DNA binding Losses GO:0005506 iron ion binding Losses GO:0019887 protein kinase regulator activity Losses GO:0030594 neurotransmitter receptor activity Losses GO:0016500 protein-hormone receptor activity Losses GO:0019209 kinase activator activity Losses GO:0015269 calcium-activated potassium channel activity Losses GO:0030295 protein kinase activator activity Losses GO:0015267 channel activity Losses GO:0022803 passive transmembrane transporter activity Losses GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Losses GO:0003677 DNA binding Losses GO:1990837 sequence-specific double-stranded DNA binding Losses GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Losses GO:0016675 oxidoreductase activity, acting on a heme group of donors Losses GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor Losses GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding Losses GO:0004129 cytochrome-c oxidase activity Losses GO:0015002 heme-copper terminal oxidase activity Losses GO:0005230 extracellular ligand-gated ion channel activity Losses GO:0022838 substrate-specific channel activity Losses GO:0004930 G-protein coupled receptor activity Extinctions GO:0004888 transmembrane signaling receptor activity Extinctions GO:0099600 transmembrane receptor activity Extinctions GO:0038023 signaling receptor activity Extinctions GO:0004872 receptor activity Extinctions GO:0003964 RNA-directed DNA polymerase activity Extinctions GO:0008528 G-protein coupled peptide receptor activity Extinctions GO:0001653 peptide receptor activity Extinctions GO:0060089 molecular transducer activity Extinctions GO:0004871 signal transducer activity Extinctions GO:0008188 neuropeptide receptor activity Extinctions GO:0034061 DNA polymerase activity Extinctions GO:0008061 chitin binding Extinctions GO:0005549 odorant binding Extinctions GO:0016722 oxidoreductase activity, oxidizing metal ions Extinctions GO:0003676 nucleic acid binding Extinctions GO:0019239 deaminase activity Extinctions GO:0004000 adenosine deaminase activity Extinctions GO:0030297 transmembrane receptor protein tyrosine kinase activator activity Extinctions GO:0030546 receptor activator activity Extinctions GO:0015269 calcium-activated potassium channel activity Extinctions GO:0030594 neurotransmitter receptor activity Extinctions GO:0008227 G-protein coupled amine receptor activity Extinctions GO:0005506 iron ion binding Extinctions GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Extinctions GO:0004983 neuropeptide Y receptor activity Extinctions GO:0140104 molecular carrier activity Extinctions GO:0004935 adrenergic receptor activity Extinctions GO:0005227 calcium activated cation channel activity Extinctions GO:0071855 neuropeptide receptor binding Extinctions GO:0005267 potassium channel activity Extinctions GO:0042805 actinin binding Extinctions GO:0004950 chemokine receptor activity Extinctions GO:0030306 ADP-ribosylation factor binding Extinctions GO:0051393 alpha-actinin binding Extinctions GO:0016286 small conductance calcium-activated potassium channel activity Extinctions GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor Extinctions GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives Extinctions GO:0001637 G-protein coupled chemoattractant receptor activity Extinctions GO:0140097 catalytic activity, acting on DNA Extinctions GO:0005184 neuropeptide hormone activity Extinctions GO:0030545 receptor regulator activity Extinctions GO:0022839 ion gated channel activity Extinctions GO:0017137 Rab GTPase binding Extinctions GO:0016779 nucleotidyltransferase activity Extinctions GO:0005216 ion channel activity Extinctions GO:0005344 oxygen carrier activity Extinctions GO:0030296 protein tyrosine kinase activator activity Extinctions GO:0019992 diacylglycerol binding Extinctions GO:0004896 cytokine receptor activity Extinctions GO:0022838 substrate-specific channel activity Extinctions