GO:0003676 nucleic acid binding Gains GO:0003677 DNA binding Gains GO:0003964 RNA-directed DNA polymerase activity Gains GO:0034061 DNA polymerase activity Gains GO:0045134 uridine-diphosphatase activity Gains GO:0017110 nucleoside-diphosphatase activity Gains GO:1901363 heterocyclic compound binding Gains GO:0097159 organic cyclic compound binding Gains GO:0004000 adenosine deaminase activity Gains GO:0005267 potassium channel activity Gains GO:0016779 nucleotidyltransferase activity Gains GO:0005249 voltage-gated potassium channel activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0015267 channel activity Gains GO:0019199 transmembrane receptor protein kinase activity Gains GO:0015079 potassium ion transmembrane transporter activity Gains GO:0003990 acetylcholinesterase activity Gains GO:0004104 cholinesterase activity Gains GO:0003700 DNA binding transcription factor activity Gains GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Gains GO:0019239 deaminase activity Gains GO:0030628 pre-mRNA 3'-splice site binding Gains GO:0004517 nitric-oxide synthase activity Gains GO:0005025 transforming growth factor beta receptor activity, type I Gains GO:0005003 ephrin receptor activity Gains GO:0016361 activin receptor activity, type I Gains GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity Gains GO:0050431 transforming growth factor beta binding Gains GO:0004061 arylformamidase activity Gains GO:0016155 formyltetrahydrofolate dehydrogenase activity Gains GO:0005216 ion channel activity Gains GO:0022838 substrate-specific channel activity Gains GO:0022843 voltage-gated cation channel activity Gains GO:0004623 phospholipase A2 activity Gains GO:0061135 endopeptidase regulator activity Gains GO:0022836 gated channel activity Gains GO:0004518 nuclease activity Gains GO:0052689 carboxylic ester hydrolase activity Gains GO:0004872 receptor activity Gains GO:0005416 cation:amino acid symporter activity Losses GO:0005283 sodium:amino acid symporter activity Losses GO:0016209 antioxidant activity Losses GO:0005179 hormone activity Losses GO:0015179 L-amino acid transmembrane transporter activity Losses GO:0005343 organic acid:sodium symporter activity Losses GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity Losses GO:0008017 microtubule binding Losses GO:0016779 nucleotidyltransferase activity Losses GO:1901682 sulfur compound transmembrane transporter activity Losses GO:0004364 glutathione transferase activity Losses GO:0015631 tubulin binding Losses GO:0022857 transmembrane transporter activity Losses GO:0050093 methanol dehydrogenase activity Losses GO:0019811 cocaine binding Losses GO:0015175 neutral amino acid transmembrane transporter activity Losses GO:0004587 ornithine-oxo-acid transaminase activity Losses GO:0004528 phosphodiesterase I activity Losses GO:0003986 acetyl-CoA hydrolase activity Losses GO:0032542 sulfiredoxin activity Losses GO:0003919 FMN adenylyltransferase activity Losses GO:0015222 serotonin transmembrane transporter activity Losses GO:0004667 prostaglandin-D synthase activity Losses GO:0008934 inositol monophosphate 1-phosphatase activity Losses GO:0008936 nicotinamidase activity Losses GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity Losses GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process Losses GO:0018834 dichloromethane dehalogenase activity Losses GO:0016415 octanoyltransferase activity Losses GO:0035237 corazonin receptor activity Losses GO:0004055 argininosuccinate synthase activity Losses GO:0033819 lipoyl(octanoyl) transferase activity Losses GO:0005368 taurine transmembrane transporter activity Losses GO:0005369 taurine:sodium symporter activity Losses GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis Losses GO:0005329 dopamine transmembrane transporter activity Losses GO:0031434 mitogen-activated protein kinase kinase binding Losses GO:0045735 nutrient reservoir activity Losses GO:0042943 D-amino acid transmembrane transporter activity Losses GO:0035529 NADH pyrophosphatase activity Losses GO:0047964 glyoxylate reductase activity Losses GO:0047988 hydroxyacid-oxoacid transhydrogenase activity Losses GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity Losses GO:0005122 torso binding Losses GO:0050700 CARD domain binding Losses GO:0004339 glucan 1,4-alpha-glucosidase activity Losses GO:0000016 lactase activity Losses GO:0004459 L-lactate dehydrogenase activity Losses GO:0030267 glyoxylate reductase (NADP) activity Losses GO:0008873 gluconate 2-dehydrogenase activity Losses GO:0008875 gluconate dehydrogenase activity Losses GO:0052832 inositol monophosphate 3-phosphatase activity Losses GO:0052833 inositol monophosphate 4-phosphatase activity Losses GO:0052834 inositol monophosphate phosphatase activity Losses GO:0019182 histamine-gated chloride channel activity Losses GO:0004170 dUTP diphosphatase activity Losses GO:0004131 cytosine deaminase activity Losses GO:0008536 Ran GTPase binding Losses GO:0005550 pheromone binding Losses GO:0005534 galactose binding Losses GO:0018445 prothoracicotrophic hormone activity Losses GO:0004930 G-protein coupled receptor activity Losses GO:0004222 metalloendopeptidase activity Losses GO:0015171 amino acid transmembrane transporter activity Losses GO:0016408 C-acyltransferase activity Losses GO:0034061 DNA polymerase activity Losses GO:0038023 signaling receptor activity Losses GO:0004871 signal transducer activity Losses GO:0005179 hormone activity Extinctions GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity Extinctions GO:0004888 transmembrane signaling receptor activity Extinctions GO:0038023 signaling receptor activity Extinctions GO:0004930 G-protein coupled receptor activity Extinctions GO:0004871 signal transducer activity Extinctions GO:0099600 transmembrane receptor activity Extinctions GO:0048018 receptor ligand activity Extinctions GO:0016408 C-acyltransferase activity Extinctions GO:0004528 phosphodiesterase I activity Extinctions GO:0032542 sulfiredoxin activity Extinctions GO:0008934 inositol monophosphate 1-phosphatase activity Extinctions GO:0018834 dichloromethane dehalogenase activity Extinctions GO:0035237 corazonin receptor activity Extinctions GO:0004055 argininosuccinate synthase activity Extinctions GO:0031434 mitogen-activated protein kinase kinase binding Extinctions GO:0035529 NADH pyrophosphatase activity Extinctions GO:0005122 torso binding Extinctions GO:0050700 CARD domain binding Extinctions GO:0004339 glucan 1,4-alpha-glucosidase activity Extinctions GO:0000016 lactase activity Extinctions GO:0008873 gluconate 2-dehydrogenase activity Extinctions GO:0008875 gluconate dehydrogenase activity Extinctions GO:0052832 inositol monophosphate 3-phosphatase activity Extinctions GO:0052833 inositol monophosphate 4-phosphatase activity Extinctions GO:0052834 inositol monophosphate phosphatase activity Extinctions GO:0004170 dUTP diphosphatase activity Extinctions GO:0008536 Ran GTPase binding Extinctions GO:0005550 pheromone binding Extinctions GO:0018445 prothoracicotrophic hormone activity Extinctions GO:0008017 microtubule binding Extinctions GO:0030545 receptor regulator activity Extinctions GO:0015631 tubulin binding Extinctions GO:0016879 ligase activity, forming carbon-nitrogen bonds Extinctions GO:0008066 glutamate receptor activity Extinctions GO:0005184 neuropeptide hormone activity Extinctions GO:0015440 peptide-transporting ATPase activity Extinctions GO:0003997 acyl-CoA oxidase activity Extinctions GO:0003933 GTP cyclohydrolase activity Extinctions GO:0003934 GTP cyclohydrolase I activity Extinctions GO:0032050 clathrin heavy chain binding Extinctions GO:0015562 efflux transmembrane transporter activity Extinctions GO:0043539 protein serine/threonine kinase activator activity Extinctions GO:0016848 carbon-halide lyase activity Extinctions GO:0004496 mevalonate kinase activity Extinctions GO:0004447 iodide peroxidase activity Extinctions GO:0008890 glycine C-acetyltransferase activity Extinctions GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding Extinctions GO:0097003 adipokinetic hormone receptor activity Extinctions GO:0097004 adipokinetic hormone binding Extinctions