Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00010 PF14598 1 0 0 0 0 0 PF00018 PF00017 1 0 2 0 0 0 PF00023 PF12796 1 0 0 0 0 0 PF00050 PF07648 1 0 0 0 0 0 PF00057 PF00084 1 0 0 0 0 0 PF00057 PF00089 0 1 0 0 0 0 PF00057 PF00151 1 0 0 0 0 0 PF00057 PF09342 PF00057 0 1 0 0 0 0 PF00063 PF06017 0 1 0 0 0 0 PF00076 PF00646 1 0 0 0 0 0 PF00078 PF00589 1 0 0 0 0 0 PF00078 PF00665 1 0 0 0 0 0 PF00091 0 1 0 0 0 0 PF00093 PF01391 PF01410 1 0 0 0 0 0 PF00098 PF00665 1 0 0 0 0 0 PF00112 0 1 0 0 0 0 PF00120 0 0 1 0 0 0 PF00128 0 2 0 0 0 0 PF00169 0 1 0 0 0 0 PF00173 PF00174 0 0 1 0 0 0 PF00200 0 0 3 0 0 0 PF00229 0 0 0 0 1 0 PF00240 0 1 0 0 0 0 PF00241 PF00018 1 0 0 0 0 0 PF00254 PF07719 1 0 0 0 0 0 PF00258 PF00667 PF00175 0 1 0 0 0 0 PF00270 0 1 30 0 0 0 PF00270 PF00271 0 1 0 0 0 0 PF00271 0 1 0 0 0 0 PF00271 PF04408 PF07717 0 1 0 0 0 0 PF00412 PF00069 1 0 0 0 0 0 PF00412 PF00880 PF14604 1 0 0 0 0 0 PF00415 0 1 0 0 0 0 PF00415 PF13540 0 1 2 0 0 0 PF00454 PF02260 0 0 7 0 0 0 PF00501 PF13193 PF00550 1 0 0 0 0 0 PF00536 0 1 0 0 0 0 PF00611 PF14604 PF00018 1 0 0 0 0 0 PF00617 PF00169 1 0 0 0 0 0 PF00621 PF00620 1 0 1 0 0 0 PF00628 PF13832 PF00628 1 0 0 0 0 0 PF00642 PF00097 1 0 0 0 0 0 PF00651 PF01344 1 0 0 0 0 0 PF00651 PF13912 1 0 0 0 0 0 PF00689 0 0 10 0 0 0 PF00732 0 1 0 0 0 0 PF00790 0 0 5 0 0 0 PF01082 0 0 1 0 0 0 PF01370 0 1 0 0 0 0 PF01388 0 1 0 0 0 0 PF01421 0 0 2 0 0 0 PF01466 0 1 0 0 0 0 PF01472 PF01189 1 0 0 0 0 0 PF01472 PF01253 1 0 0 0 0 0 PF01565 0 0 1 0 0 0 PF01715 PF12171 1 0 0 0 0 0 PF01754 0 1 0 0 0 0 PF01839 0 0 3 0 0 0 PF01851 PF13646 1 0 0 0 0 0 PF01909 0 1 0 0 0 0 PF01926 PF06071 1 0 0 0 0 0 PF02171 0 0 10 0 0 0 PF02178 0 0 0 0 1 0 PF02263 PF01363 1 0 0 0 0 0 PF02319 0 0 2 0 0 0 PF02338 0 1 0 0 0 0 PF02434 PF05679 1 0 0 0 0 0 PF02437 0 1 0 0 0 0 PF02580 0 0 0 0 1 0 PF02661 0 0 0 0 1 0 PF02759 PF01363 1 0 0 0 0 0 PF02770 PF00441 0 0 2 0 0 0 PF02781 0 0 1 0 0 0 PF02806 0 1 0 0 0 0 PF02820 0 1 3 0 0 0 PF02898 0 1 0 0 0 0 PF02985 PF13646 PF02985 1 0 0 0 0 0 PF03097 0 1 0 0 0 0 PF03101 0 0 0 0 1 0 PF03266 0 0 0 0 1 0 PF03283 0 0 0 0 1 0 PF03372 PF00078 1 0 0 0 0 0 PF03564 PF05380 PF00665 1 0 0 0 0 0 PF03564 PF05585 PF05380 1 0 0 0 0 0 PF03732 PF00078 1 0 0 0 0 0 PF03732 PF00098 1 0 0 0 0 0 PF03828 0 1 0 0 0 0 PF03859 PF01833 0 1 0 0 0 0 PF03931 0 1 0 0 0 0 PF03953 0 1 0 0 0 0 PF04083 PF00561 1 0 0 0 0 0 PF04096 0 1 0 0 0 0 PF04218 PF03221 PF03184 1 0 0 0 0 0 PF04408 PF07717 0 1 11 0 0 0 PF04568 0 1 0 0 0 0 PF04597 0 0 1 0 0 0 PF04937 PF05699 1 0 0 0 0 0 PF05185 0 1 0 0 0 0 PF05199 0 1 3 0 0 0 PF05219 0 0 0 0 1 0 PF05485 PF13613 1 0 0 0 0 0 PF05585 PF05380 1 0 0 0 0 0 PF05889 0 0 0 0 1 0 PF05916 0 1 0 0 0 0 PF06292 0 1 0 0 0 0 PF06384 0 0 0 0 1 0 PF06524 0 0 0 0 1 0 PF06888 0 0 0 0 1 0 PF07114 0 0 0 0 1 0 PF07228 0 0 0 0 1 0 PF07258 PF00001 1 0 0 0 0 0 PF07679 PF00041 PF00069 1 0 0 0 0 0 PF07679 PF13927 PF07679 PF07714 1 0 0 0 0 0 PF07719 PF00515 1 0 0 0 0 0 PF07732 0 0 2 0 0 0 PF07779 0 0 0 0 1 0 PF07809 0 0 0 0 1 0 PF07815 0 1 0 0 0 0 PF08241 PF05093 1 0 0 0 0 0 PF08246 0 1 0 0 0 0 PF08257 0 0 0 0 1 0 PF08338 0 1 0 0 0 0 PF08393 0 1 0 0 0 0 PF08511 0 0 0 0 1 0 PF08729 0 0 1 0 0 0 PF08782 0 1 0 0 0 0 PF09258 0 0 1 0 0 0 PF09334 PF00133 PF08264 1 0 0 0 0 0 PF09380 PF00769 0 0 2 0 0 0 PF09495 0 0 0 0 1 0 PF09668 0 1 0 0 0 0 PF09747 0 0 0 0 1 0 PF09791 PF00970 PF00175 1 0 0 0 0 0 PF09817 0 0 0 0 1 0 PF10231 0 0 0 0 1 0 PF10288 0 0 0 0 1 0 PF10300 PF07738 1 0 0 0 0 0 PF10392 0 0 0 0 1 0 PF10442 0 0 0 0 1 0 PF10474 0 0 1 0 0 0 PF10505 0 0 0 0 1 0 PF10512 0 0 1 0 0 0 PF10561 0 0 0 0 1 0 PF11232 0 0 1 0 0 0 PF11531 0 1 0 0 0 0 PF11566 0 0 1 0 0 0 PF11618 0 0 0 0 1 0 PF12031 0 1 0 0 0 0 PF12110 0 1 0 0 0 0 PF12417 0 0 1 0 0 0 PF12698 PF00005 0 2 0 0 0 0 PF12774 0 1 0 0 0 0 PF12796 0 1 0 0 0 0 PF12796 PF00023 0 1 0 0 0 0 PF12796 PF00023 PF12796 PF13857 1 0 0 0 0 0 PF12796 PF00023 PF13637 PF12796 1 0 0 0 0 0 PF12796 PF00651 1 0 0 0 0 0 PF12796 PF13857 PF12796 1 0 0 0 0 0 PF12874 PF00096 PF13894 1 0 0 0 0 0 PF12874 PF13894 PF13912 1 0 0 0 0 0 PF12998 PF00628 1 0 0 0 0 0 PF13085 0 0 1 0 0 0 PF13086 PF13087 PF01428 1 0 0 0 0 0 PF13180 0 1 2 0 0 0 PF13181 PF13432 1 0 0 0 0 0 PF13365 0 1 0 0 0 0 PF13405 PF13499 1 0 0 0 0 0 PF13499 PF00307 1 0 0 0 0 0 PF13606 0 1 0 0 0 0 PF13613 PF13359 1 0 0 0 0 0 PF13637 PF00788 1 0 0 0 0 0 PF13672 0 0 0 0 1 0 PF13847 PF01564 1 0 0 0 0 0 PF13873 0 1 0 0 0 0 PF13894 PF12874 PF13912 1 0 0 0 0 0 PF13894 PF13912 PF00096 1 0 0 0 0 0 PF13894 PF13912 PF12874 1 0 0 0 0 0 PF13912 PF00096 PF13894 1 0 0 0 0 0 PF13912 PF00096 PF13912 1 0 0 0 0 0 PF13912 PF13894 PF12874 1 0 0 0 0 0 PF13919 0 0 1 0 0 0 PF13927 PF00041 1 0 3 0 0 0 PF13949 0 1 0 0 0 0 PF13959 0 1 0 0 0 0 PF13976 PF00665 1 0 0 0 0 0 PF14214 PF05970 1 0 0 0 0 0 PF14223 PF00098 1 0 0 0 0 0 PF14223 PF00665 1 0 0 0 0 0 PF14529 PF00078 PF00075 1 0 0 0 0 0 PF14555 PF13899 PF00789 1 0 0 0 0 0 PF14559 0 0 1 0 0 0 PF14604 0 2 0 0 0 0 PF14924 0 1 0 0 0 0 PF15072 0 0 0 0 1 0 PF15139 0 0 0 0 1 0 PF15502 0 0 0 0 1 0 PF15936 PF00412 1 0 0 0 0 0 PF15952 0 0 0 0 1 0 PF16003 0 1 0 0 0 0 PF16028 0 1 0 0 0 0 PF16029 0 0 0 0 1 0 PF16179 0 0 1 0 0 0 PF16474 0 0 0 0 1 0 PF16550 0 0 1 0 0 0 PF16589 0 0 1 0 0 0 PF16922 0 1 0 0 0 0