GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0030594	neurotransmitter receptor activity	Gains
GO:0005549	odorant binding	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0015075	ion transmembrane transporter activity	Gains
GO:0022857	transmembrane transporter activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0004872	receptor activity	Gains
GO:0022891	substrate-specific transmembrane transporter activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0005216	ion channel activity	Gains
GO:0008172	S-methyltransferase activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0022836	gated channel activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0009055	electron transfer activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0022892	substrate-specific transporter activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0008121	ubiquinol-cytochrome-c reductase activity	Gains
GO:0016681	oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0030246	carbohydrate binding	Gains
GO:0004587	ornithine-oxo-acid transaminase activity	Gains
GO:0000700	mismatch base pair DNA N-glycosylase activity	Gains
GO:0001614	purinergic nucleotide receptor activity	Gains
GO:0050897	cobalt ion binding	Gains
GO:0004020	adenylylsulfate kinase activity	Gains
GO:0004038	allantoinase activity	Gains
GO:0005368	taurine transmembrane transporter activity	Gains
GO:0005369	taurine:sodium symporter activity	Gains
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity	Gains
GO:0016502	nucleotide receptor activity	Gains
GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	Gains
GO:0008255	ecdysis-triggering hormone activity	Gains
GO:0004301	epoxide hydrolase activity	Gains
GO:0019153	protein-disulfide reductase (glutathione) activity	Gains
GO:0004459	L-lactate dehydrogenase activity	Gains
GO:0008810	cellulase activity	Gains
GO:0034584	piRNA binding	Gains
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	Gains
GO:0022890	inorganic cation transmembrane transporter activity	Gains
GO:0005215	transporter activity	Gains
GO:0015002	heme-copper terminal oxidase activity	Gains
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Gains
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Gains
GO:0004129	cytochrome-c oxidase activity	Gains
GO:0015078	hydrogen ion transmembrane transporter activity	Gains
GO:0008020	G-protein coupled photoreceptor activity	Gains
GO:0004621	glycosylphosphatidylinositol phospholipase D activity	Gains
GO:0015501	glutamate:sodium symporter activity	Gains
GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	Gains
GO:0050591	quinine 3-monooxygenase activity	Gains
GO:0008470	isovaleryl-CoA dehydrogenase activity	Gains
GO:0033777	lithocholate 6beta-hydroxylase activity	Gains
GO:0031386	protein tag	Gains
GO:0008273	calcium, potassium:sodium antiporter activity	Gains
GO:0004457	lactate dehydrogenase activity	Gains
GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity	Gains
GO:0016992	lipoate synthase activity	Gains
GO:0070283	radical SAM enzyme activity	Gains
GO:0016979	lipoate-protein ligase activity	Gains
GO:0035586	purinergic receptor activity	Gains
GO:0015183	L-aspartate transmembrane transporter activity	Gains
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Gains
GO:0033961	cis-stilbene-oxide hydrolase activity	Gains
GO:0070888	E-box binding	Gains
GO:0061731	ribonucleoside-diphosphate reductase activity	Gains
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0005215	transporter activity	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0003990	acetylcholinesterase activity	Losses
GO:0004104	cholinesterase activity	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0004803	transposase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GO:0022804	active transmembrane transporter activity	Losses
GO:0071855	neuropeptide receptor binding	Losses
GO:0015078	hydrogen ion transmembrane transporter activity	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0008301	DNA binding, bending	Losses
GO:0022853	active ion transmembrane transporter activity	Losses
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Losses
GO:0043492	ATPase activity, coupled to movement of substances	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	Losses
GO:0015399	primary active transmembrane transporter activity	Losses
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	Losses
GO:0008408	3'-5' exonuclease activity	Losses
GO:0015604	organic phosphonate transmembrane transporter activity	Losses
GO:0015416	ATPase-coupled organic phosphonate transmembrane transporter activity	Losses
GO:0022892	substrate-specific transporter activity	Losses
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity	Losses
GO:0004846	urate oxidase activity	Losses
GO:0050221	prostaglandin-E2 9-reductase activity	Losses
GO:0050232	putrescine oxidase activity	Losses
GO:0015574	trehalose transmembrane transporter activity	Losses
GO:0042654	ecdysis-triggering hormone receptor activity	Losses
GO:0047522	15-oxoprostaglandin 13-oxidase activity	Losses
GO:0004062	aryl sulfotransferase activity	Losses
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Losses
GO:0004027	alcohol sulfotransferase activity	Losses
GO:0004046	aminoacylase activity	Losses
GO:0047617	acyl-CoA hydrolase activity	Losses
GO:0032542	sulfiredoxin activity	Losses
GO:0004997	thyrotropin-releasing hormone receptor activity	Losses
GO:0008473	ornithine cyclodeaminase activity	Losses
GO:0042947	glucoside transmembrane transporter activity	Losses
GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Losses
GO:0000036	acyl carrier activity	Losses
GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Losses
GO:0047964	glyoxylate reductase activity	Losses
GO:0005436	sodium:phosphate symporter activity	Losses
GO:0035274	diphenyl phthalate binding	Losses
GO:0035275	dibutyl phthalate binding	Losses
GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific	Losses
GO:0004304	estrone sulfotransferase activity	Losses
GO:0003839	gamma-glutamylcyclotransferase activity	Losses
GO:0031177	phosphopantetheine binding	Losses
GO:0005225	volume-sensitive anion channel activity	Losses
GO:0072320	volume-sensitive chloride channel activity	Losses
GO:0004139	deoxyribose-phosphate aldolase activity	Losses
GO:0015438	teichoic-acid-transporting ATPase activity	Losses
GO:0036132	13-prostaglandin reductase activity	Losses
GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity	Losses
GO:0015162	teichoic acid transmembrane transporter activity	Losses
GO:0015151	alpha-glucoside transmembrane transporter activity	Losses
GO:0044620	ACP phosphopantetheine attachment site binding	Losses
GO:0004796	thromboxane-A synthase activity	Losses
GO:0030267	glyoxylate reductase (NADP) activity	Losses
GO:0004747	ribokinase activity	Losses
GO:0051192	prosthetic group binding	Losses
GO:0018738	S-formylglutathione hydrolase activity	Losses
GO:0042625	ATPase coupled ion transmembrane transporter activity	Losses
GO:0016651	oxidoreductase activity, acting on NAD(P)H	Losses
GO:0003676	nucleic acid binding	Losses
GO:0022890	inorganic cation transmembrane transporter activity	Losses
GO:0005549	odorant binding	Losses
GO:0008270	zinc ion binding	Losses
GO:0043225	ATPase-coupled anion transmembrane transporter activity	Losses
GO:0051287	NAD binding	Losses
GO:0015293	symporter activity	Losses
GO:0008324	cation transmembrane transporter activity	Losses
GO:0031490	chromatin DNA binding	Losses
GO:0008559	xenobiotic transmembrane transporting ATPase activity	Losses
GO:0071855	neuropeptide receptor binding	Extinctions
GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
GO:0005549	odorant binding	Extinctions
GO:0004846	urate oxidase activity	Extinctions
GO:0047522	15-oxoprostaglandin 13-oxidase activity	Extinctions
GO:0004062	aryl sulfotransferase activity	Extinctions
GO:0004027	alcohol sulfotransferase activity	Extinctions
GO:0047617	acyl-CoA hydrolase activity	Extinctions
GO:0032542	sulfiredoxin activity	Extinctions
GO:0008473	ornithine cyclodeaminase activity	Extinctions
GO:0016663	oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor	Extinctions
GO:0000036	acyl carrier activity	Extinctions
GO:0035274	diphenyl phthalate binding	Extinctions
GO:0035275	dibutyl phthalate binding	Extinctions
GO:0004304	estrone sulfotransferase activity	Extinctions
GO:0003839	gamma-glutamylcyclotransferase activity	Extinctions
GO:0031177	phosphopantetheine binding	Extinctions
GO:0004139	deoxyribose-phosphate aldolase activity	Extinctions
GO:0015438	teichoic-acid-transporting ATPase activity	Extinctions
GO:0036132	13-prostaglandin reductase activity	Extinctions
GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity	Extinctions
GO:0015162	teichoic acid transmembrane transporter activity	Extinctions
GO:0044620	ACP phosphopantetheine attachment site binding	Extinctions
GO:0004747	ribokinase activity	Extinctions
GO:0051192	prosthetic group binding	Extinctions
GO:0042625	ATPase coupled ion transmembrane transporter activity	Extinctions
GO:0016651	oxidoreductase activity, acting on NAD(P)H	Extinctions
GO:0008408	3'-5' exonuclease activity	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0005184	neuropeptide hormone activity	Extinctions
GO:0032129	histone deacetylase activity (H3-K9 specific)	Extinctions
GO:0008020	G-protein coupled photoreceptor activity	Extinctions
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	Extinctions
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	Extinctions
GO:0031078	histone deacetylase activity (H3-K14 specific)	Extinctions
GO:0016841	ammonia-lyase activity	Extinctions
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Extinctions
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	Extinctions
GO:0004496	mevalonate kinase activity	Extinctions
GO:0016084	myostimulatory hormone activity	Extinctions
GO:0043958	acryloyl-CoA reductase activity	Extinctions
GO:0034739	histone deacetylase activity (H4-K16 specific)	Extinctions
GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	Extinctions
GO:0008526	phosphatidylinositol transporter activity	Extinctions
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)	Extinctions
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	Extinctions
GO:0005550	pheromone binding	Extinctions
GO:0047134	protein-disulfide reductase activity	Extinctions
GO:0046961	proton-transporting ATPase activity, rotational mechanism	Extinctions
GO:0008301	DNA binding, bending	Extinctions
GO:0022853	active ion transmembrane transporter activity	Extinctions
GO:0005215	transporter activity	Extinctions
GO:0005179	hormone activity	Extinctions
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
GO:0004532	exoribonuclease activity	Extinctions
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	Extinctions