EOG8SN433 GO:0006084 26/109 acetyl-CoA metabolic process biological_process "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684] EOG8SN433 GO:0003824 23/109 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8SN433 GO:0016740 2/109 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8SN433 GO:0003986 2/109 acetyl-CoA hydrolase activity molecular_function "Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+)." [EC:3.1.2.1, RHEA:20292] EOG8SN433 GO:0022008 1/109 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8SN433 GO:0005811 1/109 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8V19FZ GO:0003676 5/31 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG876NFN GO:0006364 22/90 rRNA processing biological_process "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] EOG8WDGVN GO:0003677 8/32 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8WDGVN GO:0003682 4/32 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8KD921 GO:0016021 48/108 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KD921 GO:0030054 47/108 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8KD921 GO:0045202 47/108 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8KD921 GO:0005230 47/108 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8KD921 GO:0005886 47/108 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8KD921 GO:0006811 2/108 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8KD921 GO:0006909 1/108 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8KD921 GO:0016020 1/108 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CG2R8 GO:0003676 293/3952 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CG2R8 GO:0015074 167/3952 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8CG2R8 GO:0008270 165/3952 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8CG2R8 GO:0003723 66/3952 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8CG2R8 GO:0003964 66/3952 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8CG2R8 GO:0004190 48/3952 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8CG2R8 GO:0005634 3/3952 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8CG2R8 GO:0005509 3/3952 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8CG2R8 GO:0003677 3/3952 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CG2R8 GO:0016021 2/3952 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CG2R8 GO:0007166 2/3952 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG8CG2R8 GO:0004842 2/3952 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8CG2R8 GO:0023051 2/3952 regulation of signaling biological_process "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] EOG8CG2R8 GO:0046872 2/3952 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CG2R8 GO:0004871 2/3952 signal transducer activity molecular_function "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] EOG8CG2R8 GO:0003700 1/3952 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8CG2R8 GO:0016620 1/3952 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] EOG8CG2R8 GO:0004527 1/3952 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8CG2R8 GO:0005524 1/3952 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8CG2R8 GO:0055085 1/3952 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8CG2R8 GO:0043565 1/3952 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8CG2R8 GO:0004518 1/3952 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8CG2R8 GO:0004672 1/3952 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8CG2R8 GO:0004725 1/3952 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8CG2R8 GO:0005840 1/3952 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8CG2R8 GO:0006412 1/3952 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8CG2R8 GO:0022857 1/3952 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8CG2R8 GO:0019031 1/3952 viral envelope cellular_component "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope] EOG8CG2R8 GO:0003735 1/3952 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8CG2R8 GO:0016491 1/3952 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8CG2R8 GO:0005975 1/3952 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8V45Q1 GO:0031409 22/139 pigment binding molecular_function "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] EOG8V45Q1 GO:0005576 19/139 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8V45Q1 GO:0036094 7/139 small molecule binding molecular_function "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] EOG8V45Q1 GO:0005215 5/139 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8V45Q1 GO:0008289 2/139 lipid binding molecular_function "Interacting selectively and non-covalently with a lipid." [GOC:ai] EOG8WWTZN GO:0031314 1/86 extrinsic component of mitochondrial inner membrane cellular_component "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] EOG8WWTZN GO:0030150 1/86 protein import into mitochondrial matrix biological_process "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] EOG8ZGRS9 GO:0016747 14/63 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8X3KG4 GO:0004252 1/18 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8KSS18 GO:0005509 2/63 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8NP9JF GO:0016787 1/91 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8P5NRB GO:0008897 13/48 holo-[acyl-carrier-protein] synthase activity molecular_function "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709] EOG8P5NRB GO:0000287 13/48 magnesium ion binding molecular_function "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] EOG8P5NRB GO:0009059 13/48 macromolecule biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] EOG8W9MKD GO:0004719 26/111 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] EOG8W9MKD GO:0005737 1/111 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8W9MKD GO:0006479 1/111 protein methylation biological_process "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] EOG8W9MKD GO:0042742 1/111 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8XPSZ8 GO:0007021 22/57 tubulin complex assembly biological_process "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah] EOG8XPSZ8 GO:0005874 22/57 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8GB9N5 GO:0005524 29/125 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8GB9N5 GO:0004674 26/125 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8GB9N5 GO:0004693 4/125 cyclin-dependent protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] EOG8GB9N5 GO:0006468 1/125 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8GB9N5 GO:0000281 1/125 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8GB9N5 GO:0051301 1/125 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8H74VS GO:0007110 1/42 meiosis I cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8H74VS GO:0043147 1/42 meiotic spindle stabilization biological_process "The cell cycle process in which spindle integrity is maintained during M phase of meiosis." [GOC:go_curators] EOG8H74VS GO:0007476 1/42 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8H74VS GO:0004758 1/42 serine C-palmitoyltransferase activity molecular_function "Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA." [EC:2.3.1.50, RHEA:14764] EOG8H74VS GO:0030148 1/42 sphingolipid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] EOG8H74VS GO:0007111 1/42 meiosis II cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8H74VS GO:0000916 1/42 actomyosin contractile ring contraction biological_process "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] EOG870X09 GO:0003676 1/73 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DRCTS GO:0005853 48/165 eukaryotic translation elongation factor 1 complex cellular_component "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950] EOG8DRCTS GO:0003746 48/165 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8DRCTS GO:0006414 2/165 translational elongation biological_process "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] EOG8DRCTS GO:0005875 1/165 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8DRCTS GO:0005829 1/165 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8DRCTS GO:0005811 1/165 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8HMMT0 GO:0008076 53/210 voltage-gated potassium channel complex cellular_component "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] EOG8HMMT0 GO:0005249 52/210 voltage-gated potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] EOG8HMMT0 GO:0051260 48/210 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG8HMMT0 GO:0005251 2/210 delayed rectifier potassium channel activity molecular_function "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513] EOG8HMMT0 GO:0004114 2/210 3',5'-cyclic-nucleotide phosphodiesterase activity molecular_function "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] EOG8HMMT0 GO:0030431 1/210 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8HMMT0 GO:0046872 1/210 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8HMMT0 GO:0006813 1/210 potassium ion transport biological_process "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8HMMT0 GO:0005886 1/210 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG82VBX3 GO:0016021 10/76 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG82VBX3 GO:0005230 8/76 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG82VBX3 GO:0030054 2/76 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG82VBX3 GO:0045211 2/76 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG82VBX3 GO:0004889 2/76 acetylcholine-activated cation-selective channel activity molecular_function "Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967] EOG8FTZH1 GO:0005739 1/45 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8FTZH1 GO:0008137 1/45 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8642SW GO:0005975 33/55 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8642SW GO:0016810 32/55 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] EOG8642SW GO:0003824 1/55 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8T1M38 GO:0016021 25/54 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KM1GT GO:0003777 1/37 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8KM1GT GO:0005871 1/37 kinesin complex cellular_component "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] EOG8KM1GT GO:0007018 1/37 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8KM1GT GO:0005524 1/37 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KM1GT GO:0005874 1/37 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG81RS9B GO:0016787 10/56 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8BS026 GO:0007156 1/35 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG8BS026 GO:0005509 1/35 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8BS026 GO:0005886 1/35 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG84TRQR GO:0070613 1/82 regulation of protein processing biological_process "Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah] EOG84TRQR GO:0007311 1/82 maternal specification of dorsal/ventral axis, oocyte, germ-line encoded biological_process "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG84TRQR GO:0009951 1/82 polarity specification of dorsal/ventral axis biological_process "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] EOG84TRQR GO:0050708 1/82 regulation of protein secretion biological_process "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] EOG84TRQR GO:0005783 1/82 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG83XXJC GO:0016740 3/372 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG83XXJC GO:0005634 1/372 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83XXJC GO:0008168 1/372 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG83XXJC GO:0008270 1/372 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83XXJC GO:0022008 1/372 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG83XXJC GO:0005737 1/372 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8STVJT GO:0006810 1/58 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8STVJT GO:0005622 1/58 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8STVJT GO:0051028 1/58 mRNA transport biological_process "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8STVJT GO:0005634 1/58 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XH2H5 GO:0003964 8/565 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8XH2H5 GO:0003723 6/565 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8XH2H5 GO:0022857 1/565 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8XH2H5 GO:0016021 1/565 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S7N4Q GO:0008484 81/332 sulfuric ester hydrolase activity molecular_function "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] EOG8S7N4Q GO:0003943 34/332 N-acetylgalactosamine-4-sulfatase activity molecular_function "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] EOG8S7N4Q GO:0008270 1/332 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8S7N4Q GO:0042742 1/332 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG870WZN GO:0005524 52/162 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG870WZN GO:0016226 48/162 iron-sulfur cluster assembly biological_process "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] EOG870WZN GO:0051539 48/162 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG870WZN GO:0046872 48/162 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG870WZN GO:0005737 33/162 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG870WZN GO:0005829 15/162 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG870WZN GO:0051536 15/162 iron-sulfur cluster binding molecular_function "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] EOG870WZN GO:0017111 11/162 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8GQSN8 GO:0005634 1/25 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GQSN8 GO:0003677 1/25 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GQSN8 GO:0043565 1/25 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8GQSN8 GO:0003700 1/25 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8XD666 GO:0016021 9/25 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8XD666 GO:0004930 9/25 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8PP0WX GO:0005524 55/227 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8PP0WX GO:0004692 45/227 cGMP-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah] EOG8PP0WX GO:0030553 14/227 cGMP binding molecular_function "Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai] EOG8PP0WX GO:0004674 11/227 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8PP0WX GO:0005952 7/227 cAMP-dependent protein kinase complex cellular_component "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732] EOG8PP0WX GO:0008603 7/227 cAMP-dependent protein kinase regulator activity molecular_function "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] EOG8PP0WX GO:0006468 2/227 protein phosphorylation biological_process "The process of introducing a phosphate group on to a protein." [GOC:hb] EOG8PP0WX GO:0032095 1/227 regulation of response to food biological_process "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] EOG8PP0WX GO:0005886 1/227 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8PP0WX GO:0007526 1/227 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8PP0WX GO:0008345 1/227 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8PP0WX GO:0007616 1/227 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8PP0WX GO:0046959 1/227 habituation biological_process "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089] EOG8PP0WX GO:0009744 1/227 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG8PP0WX GO:0016301 1/227 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8PP0WX GO:0030536 1/227 larval feeding behavior biological_process "Feeding behavior in a larval (immature) organism." [GOC:mah] EOG8PP0WX GO:0007631 1/227 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8PP0WX GO:0004672 1/227 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8PP0WX GO:0004690 1/227 cyclic nucleotide-dependent protein kinase activity molecular_function "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah] EOG8PP0WX GO:0008016 1/227 regulation of heart contraction biological_process "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] EOG8PP0WX GO:0007614 1/227 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8S4RWV GO:0008137 17/92 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8S4RWV GO:0042773 3/92 ATP synthesis coupled electron transport biological_process "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] EOG8S4RWV GO:0016020 1/92 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8S4RWV GO:0004129 1/92 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8S4RWV GO:0016021 1/92 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S4RWV GO:0008080 1/92 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8S4RWV GO:0005743 1/92 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8S4RWV GO:0070469 1/92 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8S4RWV GO:0005507 1/92 copper ion binding molecular_function "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] EOG8TMTJ4 GO:0005901 9/42 caveola cellular_component "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include any of the minute pits or incuppings of the cell membrane formed during pinocytosis. Such caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, ISBN:0721662544, PMID:16645198] EOG8TMTJ4 GO:0000139 9/42 Golgi membrane cellular_component "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] EOG8TMTJ4 GO:0005794 2/42 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8TMTJ4 GO:0005886 2/42 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG87H867 GO:0003723 6/322 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG87H867 GO:0003964 6/322 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8HTC74 GO:0003964 161/557 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8HTC74 GO:0003723 161/557 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8HTC74 GO:0008270 5/557 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8HTC74 GO:0035556 1/557 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8HTC74 GO:0016787 1/557 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8HTC74 GO:0000166 1/557 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8HTC74 GO:0004519 1/557 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8CC6JB GO:0016021 1/60 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8BP3T3 GO:0003677 23/173 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8BP3T3 GO:0003676 12/173 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BP3T3 GO:0008270 6/173 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BP3T3 GO:0005634 3/173 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8BP3T3 GO:0046872 1/173 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8BP3T3 GO:0035556 1/173 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8ZKN1R GO:0016616 2/18 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG8ZKN1R GO:0005975 2/18 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8ZKN1R GO:0016615 1/18 malate dehydrogenase activity molecular_function "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] EOG8ZKN1R GO:0006108 1/18 malate metabolic process biological_process "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] EOG8RFP88 GO:0003700 20/70 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8RFP88 GO:0043565 20/70 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8RFP88 GO:0005634 19/70 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8RFP88 GO:0006351 19/70 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8RFP88 GO:0007389 1/70 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8RFP88 GO:0009888 1/70 tissue development biological_process "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] EOG8RFP88 GO:0008301 1/70 DNA binding, bending molecular_function "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] EOG8V9X72 GO:0008270 41/538 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8V9X72 GO:0003676 38/538 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8V9X72 GO:0003964 3/538 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8V9X72 GO:0003723 3/538 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8V9X72 GO:0006811 1/538 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8V9X72 GO:0005921 1/538 gap junction cellular_component "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181] EOG8SJ7XB GO:0005506 40/120 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8SJ7XB GO:0005739 40/120 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8SJ7XB GO:0070469 40/120 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8SJ7XB GO:0009055 40/120 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG8SJ7XB GO:0055114 40/120 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8SJ7XB GO:0020037 40/120 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8SJ7XB GO:0006119 2/120 oxidative phosphorylation biological_process "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] EOG8SJ7XB GO:0005743 2/120 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8SJ7XB GO:0005758 2/120 mitochondrial intermembrane space cellular_component "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] EOG8SJ7XB GO:0007291 1/120 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8SJ7XB GO:0046669 1/120 regulation of compound eye retinal cell programmed cell death biological_process "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] EOG8SJ7XB GO:0006919 1/120 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG8S1WQ5 GO:0003723 27/94 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8S1WQ5 GO:0005634 27/94 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8S1WQ5 GO:0005737 27/94 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8S1WQ5 GO:0006397 26/94 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8S1WQ5 GO:0071254 1/94 cytoplasmic U snRNP body cellular_component "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295] EOG8S1WQ5 GO:0017145 1/94 stem cell division biological_process "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] EOG8S1WQ5 GO:0031674 1/94 I band cellular_component "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] EOG8S1WQ5 GO:0000387 1/94 spliceosomal snRNP assembly biological_process "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897] EOG8S1WQ5 GO:0051276 1/94 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8S1WQ5 GO:0031594 1/94 neuromuscular junction cellular_component "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] EOG8S1WQ5 GO:0097113 1/94 AMPA glutamate receptor clustering biological_process "The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:pr, GOC:sjp, PMID:12796785] EOG8S1WQ5 GO:0030240 1/94 skeletal muscle thin filament assembly biological_process "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] EOG8S1WQ5 GO:0007274 1/94 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8S1WQ5 GO:0060079 1/94 excitatory postsynaptic potential biological_process "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef] EOG8S1WQ5 GO:0007528 1/94 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8S1WQ5 GO:0035154 1/94 terminal cell fate specification, open tracheal system biological_process "The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] EOG8S1WQ5 GO:0009790 1/94 embryo development biological_process "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] EOG8S1WQ5 GO:0048601 1/94 oocyte morphogenesis biological_process "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] EOG8S1WQ5 GO:0051393 1/94 alpha-actinin binding molecular_function "Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165] EOG8S1WQ5 GO:0048863 1/94 stem cell differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] EOG8S1WQ5 GO:0005681 1/94 spliceosomal complex cellular_component "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] EOG8S1WQ5 GO:0000398 1/94 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8S1WQ5 GO:0045175 1/94 basal protein localization biological_process "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf] EOG8S1WQ5 GO:1990194 1/94 cytoplasmic U snRNP body assembly biological_process "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body." [PMID:19464282] EOG8S1WQ5 GO:0072089 1/94 stem cell proliferation biological_process "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] EOG8S1WQ5 GO:0033962 1/94 cytoplasmic mRNA processing body assembly biological_process "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074] EOG8S1WQ5 GO:0034718 1/94 SMN-Gemin2 complex cellular_component "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873] EOG8S1WQ5 GO:0005515 1/94 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8S1WQ5 GO:0022618 1/94 ribonucleoprotein complex assembly biological_process "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] EOG8S1WQ5 GO:0034730 1/94 SmD-containing SMN-Sm protein complex cellular_component "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408] EOG8S1WQ5 GO:0042802 1/94 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG8S1WQ5 GO:0008345 1/94 larval locomotory behavior biological_process "Locomotory behavior in a larval (immature) organism." [GOC:ai] EOG8S1WQ5 GO:0015030 1/94 Cajal body cellular_component "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] EOG8S1WQ5 GO:0097504 1/94 Gemini of coiled bodies cellular_component "Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, http://en.wikipedia.org/wiki/Cell_nucleus#Cajal_bodies_and_gems, PMID:11031238, PMID:9683623] EOG8S1WQ5 GO:0072553 1/94 terminal button organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:BHF, GOC:mah] EOG8S1WQ5 GO:0030018 1/94 Z disc cellular_component "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] EOG8S1WQ5 GO:0002164 1/94 larval development biological_process "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088] EOG8S1WQ5 GO:0007417 1/94 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8S1WQ5 GO:0032224 1/94 positive regulation of synaptic transmission, cholinergic biological_process "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] EOG879HP9 GO:0004035 127/508 alkaline phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] EOG879HP9 GO:0016791 75/508 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG879HP9 GO:0035094 1/508 response to nicotine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089] EOG879HP9 GO:0003824 1/508 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG879HP9 GO:0016021 1/508 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG879HP9 GO:0005576 1/508 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG879HP9 GO:0005615 1/508 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG879HP9 GO:0031225 1/508 anchored component of membrane cellular_component "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG879HP9 GO:0046872 1/508 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG879HP9 GO:0007399 1/508 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG879HP9 GO:0032504 1/508 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG879HP9 GO:0042045 1/508 epithelial fluid transport biological_process "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830] EOG879HP9 GO:0005886 1/508 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG873S7G GO:0003700 25/86 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG873S7G GO:0043565 25/86 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG873S7G GO:0046983 1/86 protein dimerization activity molecular_function "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] EOG8DNHKP GO:0008270 3/46 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG869TC0 GO:0004190 1/88 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8ZGRTC GO:0004930 1/20 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8ZGRTC GO:0004984 1/20 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8ZGRTC GO:0016021 1/20 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZGRTC GO:0005549 1/20 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8M67XK GO:0005198 1/50 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8M67XK GO:0006890 1/50 retrograde vesicle-mediated transport, Golgi to ER biological_process "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524] EOG82C0RV GO:0006412 2/70 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG82C0RV GO:0005762 2/70 mitochondrial large ribosomal subunit cellular_component "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] EOG82C0RV GO:0005840 2/70 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG82C0RV GO:0003735 2/70 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG82C0RB GO:0003676 26/100 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82C0RB GO:0004527 25/100 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG84N16B GO:0003676 6/17 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SN449 GO:0003700 27/71 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8SN449 GO:0003677 27/71 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SN449 GO:0005634 17/71 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SN449 GO:0000390 9/71 spliceosomal complex disassembly biological_process "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897] EOG8SN449 GO:0071008 9/71 U2-type post-mRNA release spliceosomal complex cellular_component "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] EOG8SN449 GO:0071011 1/71 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8SN449 GO:0071013 1/71 catalytic step 2 spliceosome cellular_component "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] EOG8SN449 GO:0000398 1/71 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8FBM6Z GO:0048489 1/53 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG8FBM6Z GO:0007269 1/53 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8FBM6Z GO:0009612 1/53 response to mechanical stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] EOG8FBM6Z GO:0030139 1/53 endocytic vesicle cellular_component "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] EOG8FBM6Z GO:0007629 1/53 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG8FBM6Z GO:0048488 1/53 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8FBM6Z GO:0008021 1/53 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8FBM6Z GO:0016079 1/53 synaptic vesicle exocytosis biological_process "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] EOG8FBM6Z GO:0030054 1/53 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8FBM6Z GO:0005515 1/53 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8HX7G8 GO:0006281 13/83 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8HX7G8 GO:0000781 13/83 chromosome, telomeric region cellular_component "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] EOG8HX7G8 GO:0007126 13/83 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8HX7G8 GO:0045003 1/83 double-strand break repair via synthesis-dependent strand annealing biological_process "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855] EOG8HX7G8 GO:0007095 1/83 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8HX7G8 GO:0000723 1/83 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG8HX7G8 GO:0008630 1/83 intrinsic apoptotic signaling pathway in response to DNA damage biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] EOG8HX7G8 GO:0006974 1/83 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8HX7G8 GO:0016233 1/83 telomere capping biological_process "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] EOG8HX7G8 GO:0042770 1/83 signal transduction in response to DNA damage biological_process "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] EOG8HX7G8 GO:0051276 1/83 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8JHFW3 GO:0016491 83/244 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8JHFW3 GO:0046592 2/244 polyamine oxidase activity molecular_function "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380] EOG8JHFW3 GO:0046872 1/244 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8JHFW3 GO:0050232 1/244 putrescine oxidase activity molecular_function "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN] EOG8JHFW3 GO:0005615 1/244 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8JHFW3 GO:0003676 1/244 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88GZHW GO:0046872 20/86 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG88GZHW GO:0005634 3/86 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88GZHW GO:0003676 2/86 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88GZHW GO:0008017 1/86 microtubule binding molecular_function "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] EOG88GZHW GO:0035191 1/86 nuclear axial expansion biological_process "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839] EOG88GZHW GO:0005813 1/86 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG88GZHW GO:0006355 1/86 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG88GZHW GO:0005704 1/86 polytene chromosome band cellular_component "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] EOG88GZHW GO:0003682 1/86 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG88GZHW GO:0005515 1/86 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG88GZHW GO:0005875 1/86 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG88GZHW GO:0031208 1/86 POZ domain binding molecular_function "Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847] EOG88GZHW GO:0005874 1/86 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG88GZHW GO:0090202 1/86 gene looping biological_process "The formation and maintenance of DNA loops that juxtapose sequentially separated regions of RNA polymerase II-transcribed genes." [GOC:dph, GOC:rb, GOC:tb, PMID:19923429, PMID:19933150] EOG88GZHW GO:0016568 1/86 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG88GZHW GO:0005737 1/86 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG88GZHW GO:0007017 1/86 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG88GZHW GO:0005700 1/86 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG88GZHW GO:0006351 1/86 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG88GZHW GO:0051493 1/86 regulation of cytoskeleton organization biological_process "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] EOG88GZHW GO:0043035 1/86 chromatin insulator sequence binding molecular_function "Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795] EOG88GZHW GO:0003677 1/86 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8R7XRN GO:0016021 104/311 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8R7XRN GO:0015171 103/311 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8R7XRN GO:0003333 3/311 amino acid transmembrane transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] EOG8R7XRN GO:0006865 1/311 amino acid transport biological_process "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8R7XRN GO:0006629 1/311 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8R7XRN GO:0015326 1/311 basic amino acid transmembrane transporter activity molecular_function "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8R7XRN GO:0000398 1/311 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8R7XRN GO:0050829 1/311 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8R7XRN GO:0045824 1/311 negative regulation of innate immune response biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] EOG8R7XRN GO:0071011 1/311 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8R7XRN GO:0040007 1/311 growth biological_process "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] EOG8R7XRN GO:0006812 1/311 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG88GZHC GO:0006066 2/23 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG88GZHC GO:0050660 2/23 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG88GZHC GO:0008812 2/23 choline dehydrogenase activity molecular_function "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] EOG8H74RC GO:0016021 8/36 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8H74RC GO:0005524 8/36 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8H74RC GO:0042626 8/36 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8H74RC GO:0032440 1/36 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG805VGT GO:0031047 1/262 gene silencing by RNA biological_process "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] EOG805VGT GO:0048477 1/262 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG805VGT GO:0045892 1/262 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG805VGT GO:0005634 1/262 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8V71XG GO:0005737 26/89 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8V71XG GO:0009264 26/89 deoxyribonucleotide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] EOG8V71XG GO:0004139 26/89 deoxyribose-phosphate aldolase activity molecular_function "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12824] EOG87SVTT GO:0008270 1/39 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z0DPG GO:0016772 1/18 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8Z0DPG GO:0016301 1/18 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8M9459 GO:0005524 1/14 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8M9459 GO:0016887 1/14 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8T4G9Z GO:0005262 1/36 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8T4G9Z GO:0016020 1/36 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8W3W2P GO:0015031 3/17 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8W3W2P GO:0005789 3/17 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8W3W2P GO:0016021 3/17 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F4VS5 GO:0046872 24/87 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8F4VS5 GO:0003676 7/87 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8F4VS5 GO:0005634 1/87 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GB9M6 GO:0003676 17/52 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GB9M6 GO:0046872 17/52 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GB9M6 GO:0005634 2/52 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GB9M6 GO:0003677 1/52 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8GB9M6 GO:0006351 1/52 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8GB9M6 GO:0006355 1/52 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8GB9M6 GO:0007275 1/52 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8GB9M6 GO:0008270 1/52 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8KPWTB GO:0003676 8/59 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Z655X GO:0008270 7/77 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z655X GO:0003676 6/77 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NCPTT GO:0003676 13/210 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NCPTT GO:0003677 8/210 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NCPTT GO:0003964 1/210 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8NCPTT GO:0003723 1/210 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8ZCWMT GO:0008137 37/99 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8ZCWMT GO:0042773 37/99 ATP synthesis coupled electron transport biological_process "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] EOG8ZCWMT GO:0005743 37/99 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG837TWK GO:0004725 39/155 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG837TWK GO:0003993 32/155 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG837TWK GO:0005737 31/155 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG837TWK GO:0004726 30/155 non-membrane spanning protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48] EOG837TWK GO:0006470 3/155 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG837TWK GO:0035335 3/155 peptidyl-tyrosine dephosphorylation biological_process "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] EOG837TWK GO:0003963 1/155 RNA-3'-phosphate cyclase activity molecular_function "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] EOG8KSRZK GO:0005524 11/91 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8KSRZK GO:0004674 9/91 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8KSRZK GO:0004687 1/91 myosin light chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] EOG8KSRZK GO:0004672 1/91 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8GB9MZ GO:0050660 281/974 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8GB9MZ GO:0008812 249/974 choline dehydrogenase activity molecular_function "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] EOG8GB9MZ GO:0006066 249/974 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG8GB9MZ GO:0016614 32/974 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8GB9MZ GO:0004198 12/974 calcium-dependent cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] EOG8GB9MZ GO:0005622 12/974 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8GB9MZ GO:0004344 11/974 glucose dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] EOG8GB9MZ GO:0005509 10/974 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8GB9MZ GO:0016491 9/974 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8GB9MZ GO:0045455 9/974 ecdysteroid metabolic process biological_process "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] EOG8GB9MZ GO:0008270 1/974 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GB9MZ GO:0006915 1/974 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8GB9MZ GO:0042600 1/974 chorion cellular_component "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544] EOG8GB9MZ GO:0004190 1/974 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8GB9MZ GO:0003676 1/974 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GB9MZ GO:0004197 1/974 cysteine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8GB9MZ GO:0046331 1/974 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8GB9MZ GO:0015074 1/974 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8ZKN28 GO:0008168 24/162 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8ZKN28 GO:0030798 11/162 trans-aconitate 2-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972] EOG82NMF0 GO:0046872 1/76 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8QFZW8 GO:0005525 5/28 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8QFZW8 GO:0007264 5/28 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8F4VSG GO:0016491 199/611 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8F4VSG GO:0047886 2/611 farnesol dehydrogenase activity molecular_function "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14700] EOG8F4VSG GO:0004316 1/611 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8F4VSG GO:0016063 1/611 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG8F4VSG GO:0022008 1/611 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8CJXXJ GO:0004129 3/43 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8CJXXJ GO:0005506 3/43 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8CJXXJ GO:0009060 3/43 aerobic respiration biological_process "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] EOG8CJXXJ GO:0005743 3/43 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8CJXXJ GO:0016021 3/43 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CJXXJ GO:0006119 3/43 oxidative phosphorylation biological_process "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] EOG8CJXXJ GO:0020037 3/43 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8CJXXJ GO:0070469 3/43 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8CJXXJ GO:0008137 1/43 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8CJXXJ GO:0030431 1/43 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG84QWFZ GO:0003677 36/163 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8C5G20 GO:0003677 2/15 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8THZ7P GO:0003677 8/30 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8THZ7P GO:0006281 8/30 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8THZ7P GO:0000910 1/30 cytokinesis biological_process "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] EOG8THZ7P GO:0000226 1/30 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG805VG7 GO:0005506 679/2000 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG805VG7 GO:0020037 679/2000 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG805VG7 GO:0016705 629/2000 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG805VG7 GO:0004497 607/2000 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG805VG7 GO:0070330 31/2000 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG805VG7 GO:0005789 25/2000 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG805VG7 GO:0050591 15/2000 quinine 3-monooxygenase activity molecular_function "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152] EOG805VG7 GO:0004796 4/2000 thromboxane-A synthase activity molecular_function "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17140] EOG805VG7 GO:0031000 2/2000 response to caffeine biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] EOG805VG7 GO:0009055 2/2000 electron carrier activity molecular_function "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] EOG805VG7 GO:0016712 2/2000 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] EOG805VG7 GO:0017085 2/2000 response to insecticide biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] EOG805VG7 GO:0006697 1/2000 ecdysone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] EOG805VG7 GO:0050829 1/2000 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG805VG7 GO:0030178 1/2000 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG805VG7 GO:0017143 1/2000 insecticide metabolic process biological_process "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai] EOG805VG7 GO:0046701 1/2000 insecticide catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai] EOG805VG7 GO:0022416 1/2000 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG805VG7 GO:0042742 1/2000 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG805VG7 GO:0048252 1/2000 lauric acid metabolic process biological_process "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [CHEBI:30805, GOC:jid] EOG805VG7 GO:0016020 1/2000 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG805VG7 GO:1901563 1/2000 response to camptothecin biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie] EOG805VG7 GO:0018685 1/2000 alkane 1-monooxygenase activity molecular_function "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] EOG805VG7 GO:0033777 1/2000 lithocholate 6beta-hydroxylase activity molecular_function "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.13.94, RHEA:18860] EOG805VG7 GO:0002118 1/2000 aggressive behavior biological_process "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] EOG805VG7 GO:0046683 1/2000 response to organophosphorus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544] EOG805VG7 GO:0035220 1/2000 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG805VG7 GO:0048638 1/2000 regulation of developmental growth biological_process "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] EOG805VG7 GO:0040040 1/2000 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG805VG7 GO:0046680 1/2000 response to DDT biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544] EOG805VG7 GO:0046689 1/2000 response to mercury ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai] EOG8SXQVM GO:0003747 24/79 translation release factor activity molecular_function "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] EOG8SXQVM GO:0016740 1/79 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8DZ4BK GO:0000166 32/91 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8DZ4BK GO:0003676 30/91 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DZ4BK GO:0003729 2/91 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8S4RX5 GO:0004252 53/134 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8S4RX5 GO:0005576 2/134 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8S4RX5 GO:0003824 1/134 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8S4RX5 GO:0006508 1/134 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8F20HQ GO:0008270 9/89 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8J6V5F GO:0004649 27/84 poly(ADP-ribose) glycohydrolase activity molecular_function "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143] EOG8J6V5F GO:0005975 27/84 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8J6V5F GO:0006909 1/84 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8J6V5F GO:0005634 1/84 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8J6V5F GO:0036099 1/84 female germ-line stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart] EOG8J6V5F GO:0006342 1/84 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG8J6V5F GO:0035065 1/84 regulation of histone acetylation biological_process "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] EOG8J6V5F GO:0051457 1/84 maintenance of protein location in nucleus biological_process "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] EOG8J6V5F GO:0005654 1/84 nucleoplasm cellular_component "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] EOG8J6V5F GO:0030576 1/84 Cajal body organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] EOG8J6V5F GO:0009408 1/84 response to heat biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] EOG8J6V5F GO:0043484 1/84 regulation of RNA splicing biological_process "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] EOG8S1WNT GO:0016021 13/53 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8S1WNT GO:0005230 7/53 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8S1WNT GO:0030054 6/53 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8S1WNT GO:0045211 6/53 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8S1WNT GO:0004889 6/53 acetylcholine-activated cation-selective channel activity molecular_function "Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967] EOG82Z76D GO:0005743 51/132 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG82Z76D GO:0006850 51/132 mitochondrial pyruvate transport biological_process "The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai] EOG834ZMP GO:0003676 8/83 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8JDKNQ GO:0001965 1/77 G-protein alpha-subunit binding molecular_function "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] EOG8JDKNQ GO:0001736 1/77 establishment of planar polarity biological_process "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] EOG8JDKNQ GO:0031987 1/77 locomotion involved in locomotory behavior biological_process "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] EOG8JDKNQ GO:0008340 1/77 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8DBWV0 GO:0005856 25/104 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8DBWV0 GO:0019898 24/104 extrinsic component of membrane cellular_component "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] EOG8DBWV0 GO:0005737 24/104 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8DBWV0 GO:0008092 1/104 cytoskeletal protein binding molecular_function "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] EOG80CKXW GO:0008270 3/39 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80CKXW GO:0003676 2/39 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80CKXW GO:0003964 1/39 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG80CKXW GO:0003723 1/39 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG80CKXW GO:0015074 1/39 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8XWJCG GO:0005525 86/367 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8XWJCG GO:0006184 86/367 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8XWJCG GO:0016020 86/367 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XWJCG GO:0007264 81/367 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8XWJCG GO:0007165 5/367 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8XWJCG GO:0005622 1/367 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8XWJCG GO:0004767 1/367 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8XWJCG GO:0006909 1/367 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8JDKNN GO:0005576 1/126 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8JDKNN GO:0008592 1/126 regulation of Toll signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8JDKNN GO:0009620 1/126 response to fungus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] EOG8JDKNN GO:0008045 1/126 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8JDKNN GO:0006967 1/126 positive regulation of antifungal peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] EOG8JDKNN GO:0008083 1/126 growth factor activity molecular_function "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] EOG8JDKNN GO:0000578 1/126 embryonic axis specification biological_process "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] EOG8JDKNN GO:0019732 1/126 antifungal humoral response biological_process "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] EOG8JDKNN GO:0031640 1/126 killing of cells of other organism biological_process "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] EOG8JDKNN GO:0005615 1/126 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8JDKNN GO:0031334 1/126 positive regulation of protein complex assembly biological_process "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] EOG8JDKNN GO:0005125 1/126 cytokine activity molecular_function "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471] EOG8JDKNN GO:0007310 1/126 oocyte dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8JDKNN GO:0008063 1/126 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8JDKNN GO:0007311 1/126 maternal specification of dorsal/ventral axis, oocyte, germ-line encoded biological_process "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8JDKNN GO:0043234 1/126 protein complex cellular_component "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] EOG8JDKNN GO:0050830 1/126 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8JDKNN GO:0005121 1/126 Toll binding molecular_function "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb] EOG8JDKNN GO:0016015 1/126 morphogen activity molecular_function "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators] EOG8JDKNN GO:0050832 1/126 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8JDKNN GO:0045087 1/126 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8JDKNN GO:0042803 1/126 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG8JDKNN GO:0006965 1/126 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] EOG8JDKNN GO:0006952 1/126 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8JDKNN GO:0009953 1/126 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8JDKNN GO:0006955 1/126 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8JDKNN GO:0009950 1/126 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG825885 GO:0005634 1/317 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG825885 GO:0005576 1/317 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG825885 GO:0003743 1/317 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG825885 GO:0050830 1/317 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG825885 GO:0032504 1/317 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG825885 GO:0002759 1/317 regulation of antimicrobial humoral response biological_process "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] EOG825885 GO:0050829 1/317 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG825885 GO:0005615 1/317 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8642VD GO:0006334 10/35 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8642VD GO:0003677 10/35 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8642VD GO:0000786 10/35 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG8642VD GO:0005634 10/35 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG825881 GO:0003964 2/105 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG825881 GO:0003723 2/105 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8Z652P GO:0005234 3/56 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8Z652P GO:0016020 3/56 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8Z652P GO:0004970 3/56 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8Z652P GO:0015276 2/56 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8Z652P GO:0009593 2/56 detection of chemical stimulus biological_process "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] EOG8Z652P GO:0036081 2/56 extracellular ammonia-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] EOG8Z652P GO:0034220 2/56 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8Z652P GO:0016021 2/56 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8Z652P GO:0050909 1/56 sensory perception of taste biological_process "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8RNDRX GO:0016020 1/18 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG866Z0R GO:0005524 41/143 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG866Z0R GO:0003677 39/143 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG866Z0R GO:0004386 37/143 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG866Z0R GO:0008270 2/143 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG866Z0R GO:0003676 2/143 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG866Z0R GO:0046328 1/143 regulation of JNK cascade biological_process "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] EOG866Z0R GO:0070868 1/143 heterochromatin organization involved in chromatin silencing biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah] EOG866Z0R GO:0005634 1/143 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG866Z0R GO:0097193 1/143 intrinsic apoptotic signaling pathway biological_process "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] EOG866Z0R GO:0016887 1/143 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG866Z0R GO:0005722 1/143 beta-heterochromatin cellular_component "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678] EOG866Z0R GO:0008347 1/143 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG866Z0R GO:0051276 1/143 chromosome organization biological_process "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG866Z0R GO:0007399 1/143 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG866Z0R GO:0042585 1/143 germinal vesicle cellular_component "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837] EOG866Z0R GO:0007411 1/143 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG866Z0R GO:0006281 1/143 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG866Z0R GO:0005700 1/143 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG866Z0R GO:0006200 1/143 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG866Z0R GO:0006336 1/143 DNA replication-independent nucleosome assembly biological_process "The formation of nucleosomes outside the context of DNA replication." [GOC:mah] EOG866Z0R GO:0000775 1/143 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG837TWH GO:0006633 21/66 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG837TWH GO:0070469 1/66 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG837TWH GO:0031177 1/66 phosphopantetheine binding molecular_function "Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah, GOC:vw] EOG837TWH GO:0005739 1/66 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG837TWH GO:0006120 1/66 mitochondrial electron transport, NADH to ubiquinone biological_process "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] EOG837TWH GO:0000036 1/66 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process molecular_function "Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis." [CHEBI:22221, GOC:jl, GOC:vw] EOG8THZ77 GO:0006633 5/92 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8RV56C GO:0045196 1/89 establishment or maintenance of neuroblast polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083] EOG8RV56C GO:0005515 1/89 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8RV56C GO:0035003 1/89 subapical complex cellular_component "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938] EOG8RV56C GO:0045179 1/89 apical cortex cellular_component "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] EOG8RV56C GO:0045186 1/89 zonula adherens assembly biological_process "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] EOG8RV56C GO:0006909 1/89 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8RV56C GO:0045176 1/89 apical protein localization biological_process "Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf] EOG8RV56C GO:0045197 1/89 establishment or maintenance of epithelial cell apical/basal polarity biological_process "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] EOG8RV56C GO:0005938 1/89 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8RV56C GO:0055059 1/89 asymmetric neuroblast division biological_process "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] EOG8RV56C GO:0016332 1/89 establishment or maintenance of polarity of embryonic epithelium biological_process "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah] EOG8RV56C GO:0006469 1/89 negative regulation of protein kinase activity biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] EOG8RV56C GO:0060446 1/89 branching involved in open tracheal system development biological_process "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph] EOG8RV56C GO:0001738 1/89 morphogenesis of a polarized epithelium biological_process "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] EOG8RV56C GO:0007416 1/89 synapse assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah] EOG8RV56C GO:0007155 1/89 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8RV56C GO:0010592 1/89 positive regulation of lamellipodium assembly biological_process "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG8RV56C GO:0007309 1/89 oocyte axis specification biological_process "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8RV56C GO:0007298 1/89 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8RV56C GO:0016324 1/89 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG8RV56C GO:0051491 1/89 positive regulation of filopodium assembly biological_process "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] EOG8RV56C GO:0008360 1/89 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8RV56C GO:0045200 1/89 establishment of neuroblast polarity biological_process "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] EOG88PQ28 GO:0005887 1/73 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG88D3CN GO:0003676 8/343 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88D3CN GO:0008270 6/343 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG88D3CN GO:0004190 5/343 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG88D3CN GO:0015074 2/343 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG88D3CN GO:0003677 1/343 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG88D3CN GO:0006351 1/343 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG88D3CN GO:0005634 1/343 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88D3CN GO:0003964 1/343 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG88D3CN GO:0003723 1/343 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG87DCZV GO:0006919 6/32 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] EOG87DCZV GO:0005739 6/32 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG87DCZV GO:0005840 1/32 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8NP9K3 GO:0030154 1/86 cell differentiation biological_process "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] EOG8NP9K3 GO:0007275 1/86 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8NP9K3 GO:0016020 1/86 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8NP9K3 GO:0016021 1/86 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NP9K3 GO:0007283 1/86 spermatogenesis biological_process "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] EOG8FN6Z7 GO:0003676 19/196 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Q5C47 GO:0003964 34/377 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8Q5C47 GO:0003723 27/377 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8Q5C47 GO:0046872 14/377 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8Q5C47 GO:0003677 7/377 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8Q5C47 GO:0008270 3/377 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Q5C47 GO:0003676 2/377 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Q5C47 GO:0006355 2/377 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8Q5C47 GO:0004519 1/377 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8FXTND GO:0046872 5/104 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FXTND GO:0004842 1/104 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8FXTND GO:0000151 1/104 ubiquitin ligase complex cellular_component "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] EOG883GK9 GO:0003676 1/5 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG883GK9 GO:0046872 1/5 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8XWJF2 GO:0008299 22/108 isoprenoid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] EOG8XWJF2 GO:0005737 22/108 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8XWJF2 GO:0005524 22/108 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8XWJF2 GO:0004496 22/108 mevalonate kinase activity molecular_function "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17068] EOG80CKZM GO:0009107 23/135 lipoate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732] EOG80CKZM GO:0016415 23/135 octanoyltransferase activity molecular_function "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai] EOG80CKZM GO:0005739 22/135 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG80CKZM GO:0033819 22/135 lipoyl(octanoyl) transferase activity molecular_function "Catalysis of the reaction: octanoyl-[acyl-carrier protein] + protein = protein N6-(octanoyl)lysine + acyl-carrier protein." [EC:2.3.1.181] EOG80CKZM GO:0006464 22/135 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG80CKZM GO:0008408 18/135 3'-5' exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] EOG80CKZM GO:0003676 18/135 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80CKZM GO:0005634 12/135 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80CKZM GO:0045950 12/135 negative regulation of mitotic recombination biological_process "Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd] EOG80CKZM GO:0046872 12/135 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG80CKZM GO:0090305 11/135 nucleic acid phosphodiester bond hydrolysis biological_process "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] EOG80CKZM GO:0016874 5/135 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG80CKZM GO:0009249 1/135 protein lipoylation biological_process "The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah] EOG80CKZM GO:0000738 1/135 DNA catabolic process, exonucleolytic biological_process "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] EOG80CKZM GO:0005737 1/135 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG80CKZM GO:0008310 1/135 single-stranded DNA 3'-5' exodeoxyribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358] EOG80CKZM GO:0008311 1/135 double-stranded DNA 3'-5' exodeoxyribonuclease activity molecular_function "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358] EOG80GG5R GO:0003824 22/111 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG80GG5R GO:0004739 4/111 pyruvate dehydrogenase (acetyl-transferring) activity molecular_function "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1] EOG80GG5R GO:0005875 1/111 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG80GG5R GO:0031122 1/111 cytoplasmic microtubule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] EOG80GG5R GO:0005739 1/111 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG80GG5R GO:0005811 1/111 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8DV815 GO:0018738 19/140 S-formylglutathione hydrolase activity molecular_function "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14964] EOG8DV815 GO:0046294 19/140 formaldehyde catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] EOG8DV815 GO:0052689 2/140 carboxylic ester hydrolase activity molecular_function "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] EOG8K3PBV GO:0003723 24/85 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8K3PBV GO:0005737 24/85 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K3PBV GO:0003824 24/85 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8K3PBV GO:0006355 24/85 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8T1M2G GO:0003676 3/13 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8T1M2G GO:0046872 3/13 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG803081 GO:0003839 43/99 gamma-glutamylcyclotransferase activity molecular_function "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4] EOG803081 GO:0006750 43/99 glutathione biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, GOC:al, GOC:pde, ISBN:0198506732] EOG803081 GO:0005576 1/99 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG803081 GO:0042381 1/99 hemolymph coagulation biological_process "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] EOG81VNJJ GO:0016021 20/74 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81VNJJ GO:0004930 19/74 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8THZ9T GO:0016791 2/20 phosphatase activity molecular_function "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] EOG8THZ9T GO:0004035 1/20 alkaline phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] EOG80306V GO:0008270 329/890 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80306V GO:0004181 329/890 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG80306V GO:0005319 8/890 lipid transporter activity molecular_function "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] EOG80306V GO:0005615 3/890 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG80306V GO:0007586 1/890 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG80306V GO:0022008 1/890 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG80306V GO:0031982 1/890 vesicle cellular_component "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] EOG80306V GO:0004180 1/890 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG80306V GO:0005515 1/890 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG80306V GO:0005576 1/890 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80306V GO:0016021 1/890 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80306V GO:0004930 1/890 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8DV81S GO:0003676 6/1523 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8DV81S GO:0015074 4/1523 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8DV81S GO:0003677 3/1523 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8DV81S GO:0008270 2/1523 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DV81S GO:0003723 2/1523 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8DV81S GO:0003964 2/1523 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8DV81S GO:0005524 1/1523 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8DV81S GO:0008234 1/1523 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8DV81S GO:0004518 1/1523 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG85TG2X GO:0003676 23/106 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85TG2X GO:0046872 1/106 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D295J GO:0003676 1/33 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8M680T GO:0016021 1/15 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M680T GO:0004930 1/15 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG85F05D GO:0004364 32/318 glutathione transferase activity molecular_function "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] EOG85F05D GO:0016740 19/318 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG85F05D GO:0004667 6/318 prostaglandin-D synthase activity molecular_function "Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10603] EOG85F05D GO:0008152 1/318 metabolic process biological_process "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] EOG85F05D GO:0006749 1/318 glutathione metabolic process biological_process "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] EOG85F05D GO:0055114 1/318 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG85F05D GO:0004602 1/318 glutathione peroxidase activity molecular_function "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] EOG8M3CQJ GO:0007498 1/145 mesoderm development biological_process "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] EOG8THZ99 GO:0003676 1/67 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8THZ90 GO:0003676 1/8 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG841SRP GO:0003677 15/58 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG841SRP GO:0003682 1/58 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG841SRP GO:0046331 1/58 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG841SRP GO:0048813 1/58 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG841SRP GO:0005524 1/58 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8935ZZ GO:0008234 5/251 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8935ZZ GO:0015074 1/251 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8935ZZ GO:0003964 1/251 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8935ZZ GO:0003723 1/251 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8935ZZ GO:0003676 1/251 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80CKZ6 GO:0006744 19/45 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG80CKZ6 GO:0005743 1/45 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8PCD8W GO:0005576 1/82 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PCD8W GO:0019991 1/82 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG8PCD8W GO:0046658 1/82 anchored component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] EOG8PCD8W GO:0035152 1/82 regulation of tube architecture, open tracheal system biological_process "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584] EOG81NX2H GO:0003677 2/69 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG81NX2H GO:0003676 2/69 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG812PM5 GO:0016021 31/92 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG812PM5 GO:0008324 30/92 cation transmembrane transporter activity molecular_function "Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] EOG812PM5 GO:0032440 2/92 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG812PM5 GO:0005622 2/92 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG812PM5 GO:0016324 1/92 apical plasma membrane cellular_component "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] EOG812PM5 GO:0006882 1/92 cellular zinc ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell." [GOC:ai, GOC:mah] EOG812PM5 GO:0016323 1/92 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG812PM5 GO:0046873 1/92 metal ion transmembrane transporter activity molecular_function "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] EOG812PM5 GO:0030001 1/92 metal ion transport biological_process "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG812PM5 GO:0010043 1/92 response to zinc ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] EOG81NX2M GO:0042752 1/56 regulation of circadian rhythm biological_process "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] EOG81NX2M GO:0000792 1/56 heterochromatin cellular_component "A compact and highly condensed form of chromatin." [GOC:elh] EOG81NX2M GO:0048542 1/56 lymph gland development biological_process "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] EOG81NX2M GO:0005634 1/56 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81NX2M GO:0005719 1/56 nuclear euchromatin cellular_component "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732] EOG81NX2M GO:0005721 1/56 pericentric heterochromatin cellular_component "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156] EOG81NX2M GO:0000775 1/56 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG81NX2M GO:0007076 1/56 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG81NX2M GO:0006915 1/56 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG883GKV GO:0003677 1/93 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FBM7Z GO:0005634 25/120 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8FBM7Z GO:0003700 25/120 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8FBM7Z GO:0006260 25/120 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8FBM7Z GO:0006351 22/120 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8FBM7Z GO:0003677 2/120 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8FBM7Z GO:0007179 1/120 transforming growth factor beta receptor signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] EOG8FBM7Z GO:0005667 1/120 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG880M9T GO:0003676 8/38 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG880M9T GO:0046872 2/38 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG880M9T GO:0003677 1/38 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VX4M2 GO:0042302 25/79 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8VX4M2 GO:0048471 1/79 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8VX4M2 GO:0008010 1/79 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8VX4M2 GO:0031012 1/79 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8VX4M2 GO:0022416 1/79 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8VX4M2 GO:0040003 1/79 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8VX4M2 GO:0035220 1/79 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG8VX4M2 GO:0005886 1/79 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8VX4M0 GO:0008270 76/1021 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8VX4M0 GO:0003676 72/1021 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VX4M0 GO:0003964 70/1021 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VX4M0 GO:0015074 70/1021 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8VX4M0 GO:0003723 69/1021 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8VX4M0 GO:0005198 14/1021 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8VX4M0 GO:0005882 14/1021 intermediate filament cellular_component "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] EOG8VX4M0 GO:0004190 10/1021 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8VX4M0 GO:0003677 4/1021 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VX4M0 GO:0005634 2/1021 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80P6NF GO:0016021 97/327 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80P6NF GO:0004995 41/327 tachykinin receptor activity molecular_function "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin] EOG80P6NF GO:0005886 40/327 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG80P6NF GO:0004983 35/327 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG80P6NF GO:0006935 33/327 chemotaxis biological_process "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] EOG80P6NF GO:0004950 33/327 chemokine receptor activity molecular_function "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823] EOG80P6NF GO:0004930 13/327 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG80P6NF GO:0050254 8/327 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG80P6NF GO:0007186 3/327 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG80P6NF GO:0008188 3/327 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG80P6NF GO:0007218 3/327 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG80P6NF GO:0007217 2/327 tachykinin receptor signaling pathway biological_process "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970] EOG80P6NF GO:0005887 2/327 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG80P6NF GO:0050911 1/327 detection of chemical stimulus involved in sensory perception of smell biological_process "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai] EOG80P6NF GO:0050805 1/327 negative regulation of synaptic transmission biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] EOG80P6NF GO:0042048 1/327 olfactory behavior biological_process "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] EOG80P6NF GO:0007166 1/327 cell surface receptor signaling pathway biological_process "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] EOG80P6NF GO:0004715 1/327 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG80P6NF GO:0001653 1/327 peptide receptor activity molecular_function "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] EOG80P6NF GO:0002121 1/327 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8HDW7B GO:0045475 1/146 locomotor rhythm biological_process "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] EOG8HDW7B GO:0072347 1/146 response to anesthetic biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart] EOG88SK94 GO:0016021 2/47 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PVRDQ GO:0004089 5/118 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8PVRDQ GO:0008270 4/118 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8PVRDQ GO:0006730 4/118 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8VQD3V GO:0004252 1/77 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8RZ1D2 GO:0003677 5/86 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8RZ1D2 GO:0005634 5/86 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG81RS89 GO:0055085 250/817 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG81RS89 GO:0005215 250/817 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG81RS89 GO:0016021 249/817 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG81RS89 GO:0016020 2/817 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG81RS89 GO:0006814 1/817 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG81RS89 GO:0051780 1/817 behavioral response to nutrient biological_process "Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai] EOG81RS89 GO:0008343 1/817 adult feeding behavior biological_process "Feeding behavior in a fully developed and mature organism." [GOC:mah] EOG81RS89 GO:0016323 1/817 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG81RS89 GO:0015293 1/817 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG81RS89 GO:0007156 1/817 homophilic cell adhesion via plasma membrane adhesion molecules biological_process "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] EOG81RS89 GO:0005509 1/817 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8ZW7RC GO:0050254 3/30 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8ZW7RC GO:0016162 1/30 cellulose 1,4-beta-cellobiosidase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] EOG86Q984 GO:0003899 2/30 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG86Q984 GO:0003677 2/30 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86Q984 GO:0006351 2/30 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8F7R03 GO:0000166 26/124 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8F7R03 GO:0005634 24/124 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8F7R03 GO:0003723 23/124 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8F7R03 GO:0006397 23/124 mRNA processing biological_process "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] EOG8F7R03 GO:0003676 2/124 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8F7R03 GO:0032440 2/124 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG8F7R03 GO:0008587 1/124 imaginal disc-derived wing margin morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG8F7R03 GO:0007319 1/124 negative regulation of oskar mRNA translation biological_process "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] EOG8F7R03 GO:0008103 1/124 oocyte microtubule cytoskeleton polarization biological_process "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] EOG8F7R03 GO:0003729 1/124 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8F7R03 GO:0007291 1/124 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8F7R03 GO:0006974 1/124 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8F7R03 GO:0007286 1/124 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8F7R03 GO:0030529 1/124 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG8F7R03 GO:0003730 1/124 mRNA 3'-UTR binding molecular_function "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] EOG8F7R03 GO:0008187 1/124 poly-pyrimidine tract binding molecular_function "Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl] EOG8F7R03 GO:0008586 1/124 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG8F7R03 GO:0005737 1/124 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8F7R03 GO:2001020 1/124 regulation of response to DNA damage stimulus biological_process "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] EOG8F7R03 GO:0000900 1/124 translation repressor activity, nucleic acid binding molecular_function "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw] EOG8F7R03 GO:0000398 1/124 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8H74SH GO:0046872 27/78 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8H74SH GO:0003676 26/78 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8H74SH GO:0001708 1/78 cell fate specification biological_process "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] EOG8H74SH GO:0010001 1/78 glial cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] EOG8H74SH GO:0007419 1/78 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8H74SH GO:0008134 1/78 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8H74SH GO:0005634 1/78 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8H74SH GO:0000122 1/78 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8H74SH GO:0007369 1/78 gastrulation biological_process "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] EOG8H74SH GO:0007499 1/78 ectoderm and mesoderm interaction biological_process "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete] EOG8H74SH GO:0043565 1/78 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8H74SH GO:0007362 1/78 terminal region determination biological_process "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8H74SH GO:0007374 1/78 posterior midgut invagination biological_process "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:08795694238] EOG8H74SH GO:0007492 1/78 endoderm development biological_process "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] EOG8H74SH GO:0061024 1/78 membrane organization biological_process "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] EOG8H74SH GO:0008293 1/78 torso signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] EOG8H74SH GO:0007435 1/78 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8H74SH GO:0007417 1/78 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8H74SH GO:0006351 1/78 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8H74SH GO:0007400 1/78 neuroblast fate determination biological_process "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] EOG8H74SH GO:0008354 1/78 germ cell migration biological_process "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] EOG8H74SH GO:0035239 1/78 tube morphogenesis biological_process "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] EOG8H74SH GO:0009948 1/78 anterior/posterior axis specification biological_process "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8H74SH GO:0001706 1/78 endoderm formation biological_process "The formation of the endoderm during gastrulation." [GOC:go_curators] EOG8H74SH GO:0007431 1/78 salivary gland development biological_process "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] EOG8H74SH GO:0046331 1/78 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG818F46 GO:0008270 1/173 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG818F46 GO:0003682 1/173 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG818F46 GO:0003676 1/173 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG889730 GO:0004930 1/17 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG889730 GO:0016021 1/17 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RZ1DS GO:0005576 2/143 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8RZ1DS GO:0042438 2/143 melanin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators] EOG8RZ1DS GO:0016853 2/143 isomerase activity molecular_function "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] EOG8RZ1DS GO:0048067 2/143 cuticle pigmentation biological_process "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] EOG834ZN4 GO:0005615 3/311 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8RZ1DX GO:0006633 132/423 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8RZ1DX GO:0016021 132/423 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RZ1DX GO:0016717 92/423 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] EOG8RZ1DX GO:0004768 40/423 stearoyl-CoA 9-desaturase activity molecular_function "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] EOG8RZ1DX GO:0005783 36/423 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8RZ1DX GO:0005506 35/423 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8RZ1DX GO:0060179 1/423 male mating behavior biological_process "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] EOG8RZ1DX GO:0042811 1/423 pheromone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] EOG8RZ1DX GO:0004984 1/423 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8RZ1DX GO:0010506 1/423 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG8RZ1DX GO:0007619 1/423 courtship behavior biological_process "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] EOG8RZ1DX GO:0005811 1/423 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8RZ1DX GO:0048047 1/423 mating behavior, sex discrimination biological_process "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700] EOG8RZ1DX GO:0042810 1/423 pheromone metabolic process biological_process "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] EOG8RZ1DX GO:0042593 1/423 glucose homeostasis biological_process "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] EOG8RZ1DX GO:0070328 1/423 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG8RZ1DX GO:0000281 1/423 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8RZ1DX GO:0006909 1/423 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8RZ1DX GO:0031410 1/423 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG8RZ1DX GO:0019216 1/423 regulation of lipid metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] EOG8RZ1DX GO:0005549 1/423 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8RZ1DX GO:0009744 1/423 response to sucrose biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] EOG8RZ1DX GO:0006723 1/423 cuticle hydrocarbon biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai] EOG8F7R0W GO:0003677 9/22 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8F7R0W GO:0008094 8/22 DNA-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] EOG8F7R0W GO:0005524 8/22 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8F7R0W GO:0007131 6/22 reciprocal meiotic recombination biological_process "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] EOG8F7R0W GO:0005634 6/22 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8F7R0W GO:0006281 5/22 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8F7R0W GO:0003908 1/22 methylated-DNA-[protein]-cysteine S-methyltransferase activity molecular_function "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] EOG8F7R0W GO:0006259 1/22 DNA metabolic process biological_process "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] EOG8F7R0W GO:0000166 1/22 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG808QQS GO:0003676 7/236 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG808QQS GO:0008270 3/236 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8B8MX0 GO:0003899 22/57 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8B8MX0 GO:0003677 22/57 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8B8MX0 GO:0006351 21/57 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8B8MX0 GO:0006366 1/57 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8B8MX0 GO:0005736 1/57 DNA-directed RNA polymerase I complex cellular_component "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8B8MX0 GO:0006383 1/57 transcription from RNA polymerase III promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH] EOG8B8MX0 GO:0005666 1/57 DNA-directed RNA polymerase III complex cellular_component "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8B8MX0 GO:0005665 1/57 DNA-directed RNA polymerase II, core complex cellular_component "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8B8MX0 GO:0006360 1/57 transcription from RNA polymerase I promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] EOG8RZ1DM GO:0016772 18/78 transferase activity, transferring phosphorus-containing groups molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] EOG8F7R0X GO:0005524 24/68 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8F7R0X GO:0008094 24/68 DNA-dependent ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] EOG8F7R0X GO:0003677 24/68 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8F7R0X GO:0006259 23/68 DNA metabolic process biological_process "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] EOG8F7R0X GO:0048477 1/68 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8F7R0X GO:0008298 1/68 intracellular mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] EOG8F7R0X GO:0016021 1/68 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8F7R0X GO:0009994 1/68 oocyte differentiation biological_process "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] EOG8F7R0X GO:0009951 1/68 polarity specification of dorsal/ventral axis biological_process "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] EOG8F7R0X GO:0046843 1/68 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8F7R0X GO:0005272 1/68 sodium channel activity molecular_function "Enables selective, facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8F7R0X GO:0031023 1/68 microtubule organizing center organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] EOG8F7R0X GO:0007294 1/68 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG8F7R0X GO:0030717 1/68 karyosome formation biological_process "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] EOG8F7R0X GO:0007131 1/68 reciprocal meiotic recombination biological_process "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] EOG8F7R0X GO:0030720 1/68 oocyte localization involved in germarium-derived egg chamber formation biological_process "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] EOG8F7R0X GO:0009949 1/68 polarity specification of anterior/posterior axis biological_process "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators] EOG8ZPHBR GO:0035299 21/82 inositol pentakisphosphate 2-kinase activity molecular_function "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [EC:2.7.1.158, RHEA:20316] EOG8ZPHBR GO:0005524 21/82 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8ZPHBR GO:0032958 1/82 inositol phosphate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah] EOG8QC3M8 GO:0019706 89/136 protein-cysteine S-palmitoyltransferase activity molecular_function "Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule." [EC:2.3.1.225, GOC:ai, GOC:pr] EOG8QC3M8 GO:0008270 88/136 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QC3M8 GO:0016021 87/136 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QC3M8 GO:0018345 9/136 protein palmitoylation biological_process "The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806] EOG8QC3M8 GO:0005783 8/136 endoplasmic reticulum cellular_component "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] EOG8QC3M8 GO:0005794 1/136 Golgi apparatus cellular_component "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] EOG8BGC8Z GO:0007186 14/75 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8BGC8Z GO:0019236 14/75 response to pheromone biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] EOG85HVCW GO:0003723 1/25 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG85HVCW GO:0003964 1/25 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG85HVCW GO:0008270 1/25 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MKQW2 GO:0003676 3/252 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MKQW2 GO:0000166 3/252 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8MKQW2 GO:0003677 2/252 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8MKQW2 GO:0006360 1/252 transcription from RNA polymerase I promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] EOG8MKQW2 GO:0042302 1/252 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8MKQW2 GO:0005201 1/252 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG8MKQW2 GO:0031012 1/252 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8MKQW2 GO:0000226 1/252 microtubule cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] EOG8MKQW2 GO:0007304 1/252 chorion-containing eggshell formation biological_process "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8MKQW2 GO:0016787 1/252 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8MKQW2 GO:0022008 1/252 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MKQW2 GO:0005736 1/252 DNA-directed RNA polymerase I complex cellular_component "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] EOG8MKQW2 GO:0042600 1/252 chorion cellular_component "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544] EOG8MKQW2 GO:0005874 1/252 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8QC3M0 GO:0003676 1/127 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KM1MB GO:0003676 1/11 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8KM1MB GO:0008270 1/11 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RNDQC GO:0016021 30/176 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8RNDQC GO:0006633 28/176 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG8RNDQC GO:0016740 28/176 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8RNDQC GO:0016491 26/176 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8RNDQC GO:0009922 2/176 fatty acid elongase activity molecular_function "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] EOG8RNDQC GO:0030497 2/176 fatty acid elongation biological_process "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094] EOG8RNDQC GO:0070524 2/176 11-beta-hydroxysteroid dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146] EOG8RNDQC GO:0042759 1/176 long-chain fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:go_curators] EOG8RNDQC GO:0042811 1/176 pheromone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] EOG8RNDQC GO:0018454 1/176 acetoacetyl-CoA reductase activity molecular_function "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36] EOG8RNDQC GO:0019368 1/176 fatty acid elongation, unsaturated fatty acid biological_process "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah] EOG8RNDQC GO:0004316 1/176 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] EOG8QNQC4 GO:0006811 2/32 ion transport biological_process "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8QNQC4 GO:0005921 2/32 gap junction cellular_component "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181] EOG8QNQC4 GO:0016021 1/32 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8N333F GO:0030170 53/186 pyridoxal phosphate binding molecular_function "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] EOG8N333F GO:0009058 51/186 biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] EOG8N333F GO:0006520 51/186 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG8N333F GO:0080130 37/186 L-phenylalanine:2-oxoglutarate aminotransferase activity molecular_function "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate." [GOC:pmn_curators, PMID:18394996] EOG8N333F GO:0004069 37/186 L-aspartate:2-oxoglutarate aminotransferase activity molecular_function "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] EOG8N333F GO:0008483 16/186 transaminase activity molecular_function "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] EOG8N333F GO:0006537 2/186 glutamate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] EOG8N333F GO:0000178 2/186 exosome (RNase complex) cellular_component "Complex of 3'-5' exoribonucleases." [PMID:10465791] EOG8N333F GO:0003723 2/186 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8N333F GO:0007416 1/186 synapse assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah] EOG8N333F GO:0045213 1/186 neurotransmitter receptor metabolic process biological_process "The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators] EOG8N333F GO:0005777 1/186 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8N333F GO:0005811 1/186 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8N333F GO:0005739 1/186 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8N333F GO:0007476 1/186 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG8B2WBP GO:0016592 1/75 mediator complex cellular_component "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] EOG8B2WBP GO:0001104 1/75 RNA polymerase II transcription cofactor activity molecular_function "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8QRKKZ GO:0008138 24/91 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG8QRKKZ GO:0006470 24/91 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG81RS8Z GO:0008270 23/84 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8G1PX8 GO:0004747 35/98 ribokinase activity molecular_function "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15] EOG8G1PX8 GO:0006014 35/98 D-ribose metabolic process biological_process "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732] EOG8G1PX8 GO:0003676 1/98 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8G1PX8 GO:0016829 1/98 lyase activity molecular_function "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] EOG8G1PX8 GO:0055085 1/98 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8G1PX8 GO:0016021 1/98 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8G1PX8 GO:0000166 1/98 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG84N17F GO:0000179 3/64 rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] EOG8NKFB8 GO:0004089 104/367 carbonate dehydratase activity molecular_function "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] EOG8NKFB8 GO:0006730 100/367 one-carbon metabolic process biological_process "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] EOG8NKFB8 GO:0008270 99/367 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NKFB8 GO:0031233 1/367 intrinsic component of external side of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah] EOG8TF30R GO:0004386 8/57 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8TF30R GO:0005524 8/57 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TF30R GO:0003677 8/57 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TF30R GO:0016740 2/57 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8QJV2V GO:0008146 160/572 sulfotransferase activity molecular_function "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] EOG8QJV2V GO:0004027 62/572 alcohol sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] EOG8QJV2V GO:0004304 10/572 estrone sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] EOG8QJV2V GO:0005829 3/572 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8QJV2V GO:0051923 3/572 sulfation biological_process "The addition of a sulfate group to a molecule." [http://www.onelook.com] EOG8QJV2V GO:0006805 2/572 xenobiotic metabolic process biological_process "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] EOG8QJV2V GO:0004062 1/572 aryl sulfotransferase activity molecular_function "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] EOG8C2KRT GO:0003993 96/479 acid phosphatase activity molecular_function "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] EOG8C2KRT GO:0006909 1/479 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG81K1T5 GO:0051287 73/226 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG81K1T5 GO:0016616 67/226 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] EOG81K1T5 GO:0030267 4/226 glyoxylate reductase (NADP) activity molecular_function "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79] EOG81K1T5 GO:0047964 2/226 glyoxylate reductase activity molecular_function "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN] EOG81K1T5 GO:0004617 1/226 phosphoglycerate dehydrogenase activity molecular_function "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] EOG81K1T5 GO:0005576 1/226 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG81K1T5 GO:0048037 1/226 cofactor binding molecular_function "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] EOG81K1T5 GO:0003676 1/226 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NS5SV GO:0003676 23/121 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NS5SV GO:0008276 20/121 protein methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732] EOG8NS5SV GO:0006886 8/121 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG8NS5SV GO:0031083 8/121 BLOC-1 complex cellular_component "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] EOG8NS5SV GO:0008168 4/121 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8NS5SV GO:0005634 1/121 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NS5SV GO:0008270 1/121 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8GJ23D GO:0007165 1/92 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8X9B0N GO:0003676 2/429 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8X9B0N GO:0003899 1/429 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8X9B0N GO:0003677 1/429 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8X9B0N GO:0006351 1/429 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8X9B0N GO:0031012 1/429 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8X9B0N GO:0004222 1/429 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8X9B0N GO:0008270 1/429 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG84N18H GO:0005737 26/91 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG84N18H GO:0005634 26/91 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG84N18H GO:0045892 26/91 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG84N18H GO:0046552 1/91 photoreceptor cell fate commitment biological_process "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] EOG84N18H GO:0046843 1/91 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG84N18H GO:0045466 1/91 R7 cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] EOG84N18H GO:0007286 1/91 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG84N18H GO:0046331 1/91 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG84N18H GO:0007476 1/91 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG84N18H GO:0001964 1/91 startle response biological_process "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] EOG84N18H GO:0008586 1/91 imaginal disc-derived wing vein morphogenesis biological_process "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] EOG84N18H GO:0007391 1/91 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG84N18H GO:0007541 1/91 sex determination, primary response to X:A ratio biological_process "The developmental process in which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete] EOG84N18H GO:0003677 1/91 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84N18H GO:0008283 1/91 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG84N18H GO:0042675 1/91 compound eye cone cell differentiation biological_process "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] EOG84N18H GO:0046982 1/91 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG84N18H GO:0007422 1/91 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG84N18H GO:0007460 1/91 R8 cell fate commitment biological_process "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883] EOG84N18H GO:0043392 1/91 negative regulation of DNA binding biological_process "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] EOG84N18H GO:0007494 1/91 midgut development biological_process "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] EOG84N18H GO:0002121 1/91 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG84N18H GO:0031987 1/91 locomotion involved in locomotory behavior biological_process "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] EOG84N18H GO:0048854 1/91 brain morphogenesis biological_process "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] EOG84N18H GO:0007530 1/91 sex determination biological_process "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] EOG84N18H GO:0007458 1/91 progression of morphogenetic furrow involved in compound eye morphogenesis biological_process "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] EOG84N18H GO:0001191 1/91 transcriptional repressor activity, RNA polymerase II transcription factor binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:9811836] EOG84N18H GO:0030381 1/91 chorion-containing eggshell pattern formation biological_process "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu] EOG84N18H GO:0008258 1/91 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG84N18H GO:0000122 1/91 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG84N18H GO:0048056 1/91 R3/R4 cell differentiation biological_process "The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] EOG8QNQD6 GO:0004190 4/578 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8QNQD6 GO:0003676 3/578 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8QNQD6 GO:0003964 1/578 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8QNQD6 GO:0008270 1/578 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8QNQD6 GO:0003723 1/578 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8QNQD6 GO:0015074 1/578 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG880MBH GO:0006108 1/18 malate metabolic process biological_process "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] EOG880MBH GO:0005975 1/18 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG880MBH GO:0030060 1/18 L-malate dehydrogenase activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37] EOG8SFCKQ GO:0016787 1/31 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8K9DS0 GO:0005737 3/56 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8K9DS0 GO:0000902 3/56 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG81K1TZ GO:0016740 9/88 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG81K1TZ GO:0006633 9/88 fatty acid biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] EOG81K1TZ GO:0016021 9/88 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8GF5V5 GO:0022900 35/131 electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] EOG8GF5V5 GO:0006099 35/131 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8GF5V5 GO:0050660 35/131 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8GF5V5 GO:0016627 31/131 oxidoreductase activity, acting on the CH-CH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG8GF5V5 GO:0016491 5/131 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8GF5V5 GO:0008177 4/131 succinate dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13716] EOG8GF5V5 GO:0005743 1/131 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8GF5V5 GO:0005739 1/131 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8VHNPX GO:0006355 1/57 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8VHNPX GO:0005634 1/57 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VHNPX GO:0003700 1/57 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8KWN7H GO:0016021 28/81 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KWN7H GO:0004983 25/81 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG8KWN7H GO:0004930 2/81 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8KWN7H GO:0050254 2/81 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8KWN7H GO:0004715 2/81 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8KWN7H GO:2000252 1/81 negative regulation of feeding behavior biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol] EOG8KWN7H GO:0042071 1/81 leucokinin receptor activity molecular_function "Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:2716741] EOG8KWN7H GO:0007186 1/81 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8KWN7H GO:0008188 1/81 neuropeptide receptor activity molecular_function "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] EOG8KWN7H GO:0007204 1/81 positive regulation of cytosolic calcium ion concentration biological_process "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] EOG8KWN7H GO:0016323 1/81 basolateral plasma membrane cellular_component "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] EOG8KWN7H GO:0007218 1/81 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8KWN7H GO:0009755 1/81 hormone-mediated signaling pathway biological_process "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] EOG8F4VR3 GO:0004386 8/71 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8F4VR3 GO:0005524 6/71 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8F4VR3 GO:0046872 5/71 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8F4VR3 GO:0017111 4/71 nucleoside-triphosphatase activity molecular_function "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] EOG8F4VR3 GO:0003677 1/71 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8QJV5J GO:0016021 23/129 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8QJV5J GO:0004965 22/129 G-protein coupled GABA receptor activity molecular_function "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor] EOG8QJV5J GO:0007186 1/129 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG80ZTDS GO:0007476 1/92 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG80ZTDS GO:0005887 1/92 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83N9TJ GO:0005506 404/1184 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG83N9TJ GO:0020037 404/1184 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG83N9TJ GO:0016705 391/1184 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] EOG83N9TJ GO:0004497 374/1184 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG83N9TJ GO:0005789 17/1184 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG83N9TJ GO:0070330 6/1184 aromatase activity molecular_function "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] EOG83N9TJ GO:0052869 6/1184 arachidonic acid omega-hydroxylase activity molecular_function "Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG:R07041] EOG83N9TJ GO:0018685 6/1184 alkane 1-monooxygenase activity molecular_function "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] EOG83N9TJ GO:0016539 3/1184 intein-mediated protein splicing biological_process "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html] EOG83N9TJ GO:0007165 2/1184 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG83N9TJ GO:0005622 2/1184 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG83N9TJ GO:0007618 1/1184 mating biological_process "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] EOG83N9TJ GO:0005201 1/1184 extracellular matrix structural constituent molecular_function "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] EOG83N9TJ GO:0005581 1/1184 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG83N9TJ GO:0050051 1/1184 leukotriene-B4 20-monooxygenase activity molecular_function "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN] EOG83N9TJ GO:0052871 1/1184 alpha-tocopherol omega-hydroxylase activity molecular_function "Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003] EOG83N9TJ GO:0006629 1/1184 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG83N9TJ GO:0005737 1/1184 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83N9TJ GO:0005811 1/1184 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG841SV9 GO:0046933 30/88 proton-transporting ATP synthase activity, rotational mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1] EOG841SV9 GO:0046961 30/88 proton-transporting ATPase activity, rotational mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14] EOG841SV9 GO:0000275 30/88 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) cellular_component "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] EOG841SV9 GO:0015986 30/88 ATP synthesis coupled proton transport biological_process "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] EOG841SV9 GO:0008553 2/88 hydrogen-exporting ATPase activity, phosphorylative mechanism molecular_function "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6] EOG841SV9 GO:0005515 1/88 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG841SV9 GO:0006979 1/88 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG841SV9 GO:0008340 1/88 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG841SV9 GO:0046331 1/88 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8G7FD8 GO:0006351 23/90 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8G7FD8 GO:0005634 23/90 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8G7FD8 GO:0003700 23/90 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8G7FD8 GO:0043565 22/90 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8G7FD8 GO:0008301 1/90 DNA binding, bending molecular_function "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] EOG8G7FD8 GO:0031571 1/90 mitotic G1 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8G7FD8 GO:0035050 1/90 embryonic heart tube development biological_process "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] EOG8G7FD8 GO:0007389 1/90 pattern specification process biological_process "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] EOG8G7FD8 GO:0000976 1/90 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8G7FD8 GO:0071456 1/90 cellular response to hypoxia biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] EOG8G7FD8 GO:0006909 1/90 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8G7FD8 GO:0051302 1/90 regulation of cell division biological_process "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] EOG8G7FD8 GO:0009888 1/90 tissue development biological_process "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] EOG8SN45G GO:0003682 14/229 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8SN45G GO:0006915 3/229 apoptotic process biological_process "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] EOG8SN45G GO:0005634 3/229 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SN45G GO:0003677 3/229 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SN45G GO:0008270 1/229 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8XPSWP GO:0005634 16/60 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XPSWP GO:0043565 16/60 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8XPSWP GO:0003700 16/60 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8SN45M GO:0005634 2/60 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SN45M GO:0007096 2/60 regulation of exit from mitosis biological_process "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn] EOG8STVJJ GO:0009435 27/103 NAD biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] EOG8STVJJ GO:0016779 24/103 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG8STVJJ GO:0000309 3/103 nicotinamide-nucleotide adenylyltransferase activity molecular_function "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] EOG8STVJJ GO:0051082 1/103 unfolded protein binding molecular_function "Interacting selectively and non-covalently with an unfolded protein." [GOC:ai] EOG8STVJJ GO:0045494 1/103 photoreceptor cell maintenance biological_process "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] EOG8STVJJ GO:0097062 1/103 dendritic spine maintenance biological_process "The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104] EOG82JR7S GO:0032542 28/62 sulfiredoxin activity molecular_function "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934] EOG82JR7S GO:0005524 26/62 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG84J50X GO:0003676 67/288 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG84J50X GO:0003677 3/288 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG84J50X GO:0005524 1/288 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG84J50X GO:0016020 1/288 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG84J50X GO:0001614 1/288 purinergic nucleotide receptor activity molecular_function "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] EOG84J50X GO:0005216 1/288 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG84J50X GO:0046872 1/288 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8MGVPJ GO:0003676 23/88 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MGVPJ GO:0004527 20/88 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8MGVPJ GO:0008859 1/88 exoribonuclease II activity molecular_function "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] EOG83XXHB GO:0004222 43/148 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG83XXHB GO:0008237 15/148 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG83XXHB GO:0007229 1/148 integrin-mediated signaling pathway biological_process "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] EOG8QFZTV GO:0003824 25/119 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8QFZTV GO:0005509 25/119 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8QFZTV GO:0008936 3/119 nicotinamidase activity molecular_function "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19] EOG8QFZTV GO:0003735 1/119 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8QFZTV GO:0043524 1/119 negative regulation of neuron apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] EOG8QFZTV GO:0008340 1/119 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8QFZTV GO:0005840 1/119 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8QFZTV GO:0006979 1/119 response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] EOG8QFZTV GO:0006412 1/119 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8JQ6CQ GO:0016021 12/30 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8JQ6CQ GO:0004930 12/30 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8JDKQK GO:0008061 1/4 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8JDKQK GO:0005576 1/4 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8JDKQK GO:0006030 1/4 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8909RR GO:0007076 49/148 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8909RR GO:0000796 49/148 condensin complex cellular_component "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] EOG8909RR GO:0072587 1/148 DNA topoisomerase (ATP-hydrolyzing) activator activity molecular_function "Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] EOG8909RR GO:0000793 1/148 condensed chromosome cellular_component "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] EOG8909RR GO:0007052 1/148 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8909RR GO:0002009 1/148 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8909RR GO:0022008 1/148 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8909RR GO:0000775 1/148 chromosome, centromeric region cellular_component "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] EOG8909RR GO:0051306 1/148 mitotic sister chromatid separation biological_process "The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai] EOG8909RR GO:0007443 1/148 Malpighian tubule morphogenesis biological_process "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] EOG8909RR GO:0007424 1/148 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8909RR GO:0048567 1/148 ectodermal digestive tract morphogenesis biological_process "The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm." [GOC:jid] EOG8909RR GO:0000070 1/148 mitotic sister chromatid segregation biological_process "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] EOG8909RR GO:0008258 1/148 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8909RR GO:0006099 1/148 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8909RR GO:0000785 1/148 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG8909RR GO:0007422 1/148 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8909RR GO:2000373 1/148 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity biological_process "Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] EOG8TMTHF GO:0003676 194/895 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TMTHF GO:0003677 58/895 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TMTHF GO:0004519 19/895 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8TMTHF GO:0003964 19/895 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8TMTHF GO:0003723 5/895 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8TMTHF GO:0015074 3/895 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8TMTHF GO:0005524 2/895 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TMTHF GO:0005525 1/895 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8TMTHF GO:0006313 1/895 transposition, DNA-mediated biological_process "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] EOG8TMTHF GO:0004736 1/895 pyruvate carboxylase activity molecular_function "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847] EOG8TMTHF GO:0006094 1/895 gluconeogenesis biological_process "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] EOG8TMTHF GO:0046872 1/895 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TMTHF GO:0004075 1/895 biotin carboxylase activity molecular_function "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] EOG8TMTHF GO:0004674 1/895 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8TMTHF GO:0004252 1/895 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8TMTHF GO:0008270 1/895 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8TMTHF GO:0005634 1/895 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TMTHF GO:0003924 1/895 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8TMTHF GO:0016021 1/895 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TMTHF GO:0004803 1/895 transposase activity molecular_function "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] EOG851H5K GO:0004984 4/16 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG851H5K GO:0005549 4/16 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG851H5K GO:0016021 3/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG851H5K GO:0004930 3/16 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG851H5K GO:0005886 3/16 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG851H5K GO:0016020 1/16 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CRPDB GO:0008241 7/22 peptidyl-dipeptidase activity molecular_function "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG8CRPDB GO:0008237 7/22 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8CRPDB GO:0016020 7/22 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8CRPDB GO:0004180 2/22 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8BS00V GO:0003964 1/142 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8BS00V GO:0003723 1/142 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG869T8K GO:0016021 1/16 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8WWV1R GO:0003676 182/2316 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8WWV1R GO:0008270 149/2316 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8WWV1R GO:0003677 110/2316 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8WWV1R GO:0005634 107/2316 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WWV1R GO:0015074 83/2316 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8WWV1R GO:0003964 8/2316 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8WWV1R GO:0003723 4/2316 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8WWV1R GO:0004519 4/2316 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8WWV1R GO:0046872 2/2316 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WWV1R GO:0004190 1/2316 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8WWV1R GO:0005524 1/2316 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8WWV1R GO:0008762 1/2316 UDP-N-acetylmuramate dehydrogenase activity molecular_function "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] EOG8WWV1R GO:0006351 1/2316 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8WWV1R GO:0050660 1/2316 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8WWV1R GO:0016043 1/2316 cellular component organization biological_process "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] EOG8WWV1R GO:0016787 1/2316 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8WWV1R GO:0016491 1/2316 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8P5NRX GO:0008270 66/179 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8P5NRX GO:0005634 2/179 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8P5NRX GO:0032183 1/179 SUMO binding molecular_function "Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO." [GOC:mah] EOG8P5NRX GO:0045893 1/179 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8P5NRX GO:0004842 1/179 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8P5NRX GO:0070201 1/179 regulation of establishment of protein localization biological_process "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] EOG8P5NRX GO:0016567 1/179 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG8P5NRX GO:0005737 1/179 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8P5NRX GO:0033768 1/179 SUMO-targeted ubiquitin ligase complex cellular_component "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865] EOG8P5NRX GO:0007530 1/179 sex determination biological_process "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] EOG8P5NRX GO:0001103 1/179 RNA polymerase II repressing transcription factor binding molecular_function "Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH] EOG8P5NRX GO:0043393 1/179 regulation of protein binding biological_process "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators] EOG8P5NRX GO:0022008 1/179 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8M0HH4 GO:0030246 43/188 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG851H5R GO:0006950 1/105 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8X6FPX GO:0003824 177/787 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8X6FPX GO:0047077 20/787 Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity molecular_function "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN] EOG8X6FPX GO:0016874 19/787 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8X6FPX GO:0004497 7/787 monooxygenase activity molecular_function "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] EOG8X6FPX GO:0008756 4/787 o-succinylbenzoate-CoA ligase activity molecular_function "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26] EOG8X6FPX GO:0004467 2/787 long-chain fatty acid-CoA ligase activity molecular_function "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3] EOG8X6FPX GO:0005524 2/787 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8X6FPX GO:0006637 1/787 acyl-CoA metabolic process biological_process "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732] EOG8X6FPX GO:0046627 1/787 negative regulation of insulin receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8X6FPX GO:0046949 1/787 fatty-acyl-CoA biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732] EOG8X6FPX GO:0005777 1/787 peroxisome cellular_component "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] EOG8X6FPX GO:0019433 1/787 triglyceride catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732] EOG8X6FPX GO:0001676 1/787 long-chain fatty acid metabolic process biological_process "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp] EOG8X6FPX GO:0004321 1/787 fatty-acyl-CoA synthase activity molecular_function "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] EOG8X6FPX GO:0071616 1/787 acyl-CoA biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk] EOG8X6FPX GO:0016021 1/787 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8X6FPX GO:0042626 1/787 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8X6FPX GO:0009062 1/787 fatty acid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] EOG8X6FPX GO:0016887 1/787 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG8X6FPX GO:0008218 1/787 bioluminescence biological_process "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732] EOG8Z6538 GO:0004046 96/196 aminoacylase activity molecular_function "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] EOG8Z6538 GO:0006520 96/196 cellular amino acid metabolic process biological_process "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] EOG8Z6538 GO:0005737 96/196 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8Z6538 GO:0008237 53/196 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8Z6538 GO:0016787 4/196 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8Z6538 GO:0004180 1/196 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8Z6539 GO:0045930 1/75 negative regulation of mitotic cell cycle biological_process "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8Z6539 GO:0007030 1/75 Golgi organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] EOG82NMGR GO:0005739 21/66 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG82NMGR GO:0004129 21/66 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8W3W3C GO:0006744 25/67 ubiquinone biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] EOG8W3W3C GO:0031314 22/67 extrinsic component of mitochondrial inner membrane cellular_component "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] EOG8W3W3C GO:0005743 1/67 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8FJBS3 GO:0003676 72/1100 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8FJBS3 GO:0003964 71/1100 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8FJBS3 GO:0004523 69/1100 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8FJBS3 GO:0003723 34/1100 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8FJBS3 GO:0008270 8/1100 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8FJBS3 GO:0004519 1/1100 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8FJBS3 GO:0004842 1/1100 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8N8TNV GO:0003700 1/5 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8N8TNV GO:0005634 1/5 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8N8TNV GO:0043565 1/5 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8K3P92 GO:0003777 4/28 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8K3P92 GO:0007018 4/28 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8M3CRQ GO:0005743 25/81 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8M3CRQ GO:0006120 25/81 mitochondrial electron transport, NADH to ubiquinone biological_process "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] EOG8M3CRQ GO:0008137 25/81 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8M3CRQ GO:0070469 20/81 respiratory chain cellular_component "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] EOG8M3CRQ GO:0016021 1/81 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8M3CRQ GO:0004930 1/81 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8KPWS4 GO:0016021 32/146 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KPWS4 GO:0055085 19/146 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8KPWS4 GO:0006839 10/146 mitochondrial transport biological_process "Transport of substances into, out of or within a mitochondrion." [GOC:ai] EOG8KPWS4 GO:0031966 10/146 mitochondrial membrane cellular_component "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] EOG8KPWS4 GO:0006810 3/146 transport biological_process "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] EOG8KPWS4 GO:0005743 1/146 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8KPWS4 GO:0007605 1/146 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8KPWS4 GO:0019222 1/146 regulation of metabolic process biological_process "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] EOG8KPWS4 GO:0005215 1/146 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8FBM95 GO:0003777 1/86 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG8FBM95 GO:0007018 1/86 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG8FBM95 GO:0030286 1/86 dynein complex cellular_component "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] EOG8N5ZCW GO:0007050 17/72 cell cycle arrest biological_process "A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb] EOG8N5ZCW GO:0030707 1/72 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8N5ZCW GO:0030713 1/72 ovarian follicle cell stalk formation biological_process "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8N5ZCW GO:0045746 1/72 negative regulation of Notch signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] EOG89PDCG GO:0003676 100/519 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG89PDCG GO:0046872 76/519 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG89PDCG GO:0008270 20/519 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG89PDCG GO:0005634 20/519 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG89PDCG GO:0015074 4/519 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG89PDCG GO:0045931 1/519 positive regulation of mitotic cell cycle biological_process "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG89PDCG GO:0006357 1/519 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG89PDCG GO:0030178 1/519 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG89PDCG GO:0007476 1/519 imaginal disc-derived wing morphogenesis biological_process "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] EOG89PDCG GO:0046331 1/519 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG89PDCG GO:0031935 1/519 regulation of chromatin silencing biological_process "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] EOG89PDCG GO:0007155 1/519 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG89PDCG GO:0045892 1/519 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8XSP3N GO:0008061 250/966 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP3N GO:0005576 250/966 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8XSP3N GO:0006030 246/966 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP3N GO:0004252 27/966 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8XSP3N GO:0005044 26/966 scavenger receptor activity molecular_function "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] EOG8XSP3N GO:0016020 24/966 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8XSP3N GO:0006032 4/966 chitin catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8XSP3N GO:0005975 4/966 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG8XSP3N GO:0004568 4/966 chitinase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] EOG8XSP3N GO:0006955 2/966 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8XSP3N GO:0030247 2/966 polysaccharide binding molecular_function "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah] EOG8XSP3N GO:0030246 2/966 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8XSP3N GO:0006508 1/966 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8XSP3N GO:0007616 1/966 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG8XSP3N GO:0004190 1/966 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8XSP3N GO:0007614 1/966 short-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG85B3WC GO:0006629 4/28 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG85B3WC GO:0005576 4/28 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG85B3WC GO:0016787 3/28 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG85B3WC GO:0004806 1/28 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG886BTX GO:0016905 1/151 myosin heavy chain kinase activity molecular_function "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] EOG886BTX GO:0004550 1/151 nucleoside diphosphate kinase activity molecular_function "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] EOG886BTX GO:0006241 1/151 CTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] EOG886BTX GO:0006228 1/151 UTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732] EOG886BTX GO:0006183 1/151 GTP biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732] EOG886BTX GO:0005524 1/151 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG886BTX GO:0010506 1/151 regulation of autophagy biological_process "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] EOG883GJD GO:0003676 64/244 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG883GJD GO:0003743 8/244 translation initiation factor activity molecular_function "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] EOG883GJD GO:0016246 2/244 RNA interference biological_process "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] EOG883GJD GO:0030422 2/244 production of siRNA involved in RNA interference biological_process "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] EOG883GJD GO:0005515 2/244 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG883GJD GO:0007367 2/244 segment polarity determination biological_process "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] EOG883GJD GO:0030423 2/244 targeting of mRNA for destruction involved in RNA interference biological_process "The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674] EOG883GJD GO:0005737 2/244 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG883GJD GO:0046872 1/244 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG883GJD GO:0030727 1/244 germarium-derived female germ-line cyst formation biological_process "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] EOG883GJD GO:0051607 1/244 defense response to virus biological_process "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] EOG883GJD GO:0070578 1/244 RISC-loading complex cellular_component "A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endorobonuclease activity." [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710] EOG883GJD GO:0035197 1/244 siRNA binding molecular_function "Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283] EOG883GJD GO:0007416 1/244 synapse assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah] EOG883GJD GO:0007279 1/244 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG883GJD GO:0035279 1/244 mRNA cleavage involved in gene silencing by miRNA biological_process "The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554] EOG883GJD GO:0005524 1/244 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG883GJD GO:0035196 1/244 production of miRNAs involved in gene silencing by miRNA biological_process "Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283] EOG883GJD GO:0019899 1/244 enzyme binding molecular_function "Interacting selectively and non-covalently with any enzyme." [GOC:jl] EOG883GJD GO:0035071 1/244 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG883GJD GO:0035195 1/244 gene silencing by miRNA biological_process "Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortgening and subsequent degredation of the mRNA." [PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154] EOG883GJD GO:0048102 1/244 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG883GJD GO:0035190 1/244 syncytial nuclear migration biological_process "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839] EOG883GJD GO:0006342 1/244 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG883GJD GO:0036099 1/244 female germ-line stem cell population maintenance biological_process "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart] EOG883GJD GO:0035198 1/244 miRNA binding molecular_function "Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283] EOG883GJD GO:0006402 1/244 mRNA catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] EOG883GJD GO:0017148 1/244 negative regulation of translation biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] EOG883GJD GO:0045071 1/244 negative regulation of viral genome replication biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators] EOG883GJD GO:0030529 1/244 ribonucleoprotein complex cellular_component "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] EOG883GJD GO:0007294 1/244 germarium-derived oocyte fate determination biological_process "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG883GJD GO:0033227 1/244 dsRNA transport biological_process "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] EOG883GJD GO:0004521 1/244 endoribonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG883GJD GO:0048471 1/244 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG883GJD GO:0009047 1/244 dosage compensation by hyperactivation of X chromosome biological_process "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577] EOG883GJD GO:0016032 1/244 viral process biological_process "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] EOG883GJD GO:0035087 1/244 siRNA loading onto RISC involved in RNA interference biological_process "The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631] EOG883GJD GO:0090502 1/244 RNA phosphodiester bond hydrolysis, endonucleolytic biological_process "The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] EOG883GJD GO:0007349 1/244 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG883GJD GO:0016442 1/244 RISC complex cellular_component "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] EOG883GJD GO:0005634 1/244 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG883GJD GO:0070868 1/244 heterochromatin organization involved in chromatin silencing biological_process "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah] EOG85HVCN GO:0016817 1/19 hydrolase activity, acting on acid anhydrides molecular_function "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] EOG85HVCN GO:0003676 1/19 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG85HVCN GO:0005524 1/19 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG85HVCN GO:0008026 1/19 ATP-dependent helicase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] EOG8VT8BT GO:0003995 32/99 acyl-CoA dehydrogenase activity molecular_function "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] EOG8VT8BT GO:0050660 31/99 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8VT8BT GO:0043958 2/99 acryloyl-CoA reductase activity molecular_function "Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323] EOG8VT8BT GO:0005811 1/99 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8VT8BT GO:0005739 1/99 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8VT8BT GO:0005759 1/99 mitochondrial matrix cellular_component "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] EOG8VT8BT GO:0005875 1/99 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8VT8BT GO:0006635 1/99 fatty acid beta-oxidation biological_process "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY] EOG8VT8BT GO:0005524 1/99 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG886BTH GO:0016021 56/247 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG886BTH GO:0055085 55/247 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG886BTH GO:0005743 55/247 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG886BTH GO:0005215 54/247 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG886BTH GO:0031532 24/247 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG886BTH GO:0007155 24/247 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG886BTH GO:0005811 2/247 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG886BTH GO:0009612 1/247 response to mechanical stimulus biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] EOG886BTH GO:0034599 1/247 cellular response to oxidative stress biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] EOG886BTH GO:0007268 1/247 synaptic transmission biological_process "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] EOG886BTH GO:0040011 1/247 locomotion biological_process "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] EOG886BTH GO:0051480 1/247 cytosolic calcium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph] EOG886BTH GO:0007475 1/247 apposition of dorsal and ventral imaginal disc-derived wing surfaces biological_process "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] EOG886BTH GO:0015866 1/247 ADP transport biological_process "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG886BTH GO:0005471 1/247 ATP:ADP antiporter activity molecular_function "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1] EOG886BTH GO:0005925 1/247 focal adhesion cellular_component "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] EOG886BTH GO:0051560 1/247 mitochondrial calcium ion homeostasis biological_process "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah] EOG886BTH GO:0006839 1/247 mitochondrial transport biological_process "Transport of substances into, out of or within a mitochondrion." [GOC:ai] EOG886BTH GO:0008340 1/247 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG886BTH GO:0015867 1/247 ATP transport biological_process "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG886BTH GO:0007629 1/247 flight behavior biological_process "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] EOG886BTH GO:0070050 1/247 neuron cellular homeostasis biological_process "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] EOG886BTH GO:0048489 1/247 synaptic vesicle transport biological_process "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jid, GOC:lmg, GOC:pr] EOG886BTH GO:0016203 1/247 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG886BTH GO:0003779 1/247 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG886BTH GO:0051124 1/247 synaptic growth at neuromuscular junction biological_process "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] EOG886BTH GO:0001508 1/247 action potential biological_process "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] EOG886BTH GO:0046716 1/247 muscle cell cellular homeostasis biological_process "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] EOG886BTC GO:0051260 16/86 protein homooligomerization biological_process "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] EOG886BTC GO:0048102 1/86 autophagic cell death biological_process "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, PMID:18846107] EOG886BTC GO:0016740 1/86 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG886BTC GO:0050975 1/86 sensory perception of touch biological_process "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] EOG886BTC GO:0035071 1/86 salivary gland cell autophagic cell death biological_process "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] EOG886BTC GO:0046331 1/86 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG85B3WX GO:0003677 5/70 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG85B3WX GO:0003682 5/70 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8C8B7H GO:0008270 55/132 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8C8B7H GO:0016874 2/132 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8Q2GZG GO:0042302 8/42 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG82RGNW GO:0016811 1/110 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] EOG8C8B7R GO:0004674 2/7 protein serine/threonine kinase activity molecular_function "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] EOG8C8B7R GO:0005524 2/7 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8Z91D3 GO:0003676 5/104 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Z91D3 GO:0008270 5/104 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8Z91D3 GO:0003723 1/104 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8Z91D3 GO:0004190 1/104 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8Z91D3 GO:0003964 1/104 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8H74TG GO:0003676 18/252 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8H74TG GO:0046872 18/252 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8H74TG GO:0016787 17/252 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8H74TG GO:0009405 1/252 pathogenesis biological_process "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] EOG8H74TG GO:0004222 1/252 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8H74TG GO:0005604 1/252 basement membrane cellular_component "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684] EOG8H74TG GO:0007155 1/252 cell adhesion biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] EOG8H74TG GO:0003824 1/252 catalytic activity molecular_function "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] EOG8H74TG GO:0003677 1/252 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8H74TG GO:0005509 1/252 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8H74TG GO:0005576 1/252 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8TTK15 GO:0003677 28/194 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8TTK15 GO:0004518 28/194 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8TTK15 GO:0005634 7/194 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TTK15 GO:0016568 7/194 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG8PZMQM GO:0005742 22/54 mitochondrial outer membrane translocase complex cellular_component "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629] EOG8PZMQM GO:0030150 22/54 protein import into mitochondrial matrix biological_process "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] EOG8D2962 GO:0003964 185/1227 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8D2962 GO:0003723 151/1227 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8D2962 GO:0004519 49/1227 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8D2962 GO:0006355 11/1227 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8D2962 GO:0003676 2/1227 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8D2962 GO:0003677 2/1227 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8D2962 GO:0008270 1/1227 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D2962 GO:0046872 1/1227 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D2962 GO:0008234 1/1227 cysteine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8D2962 GO:0050660 1/1227 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG8D2962 GO:0016021 1/1227 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8D2962 GO:0008033 1/1227 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8D2962 GO:0005634 1/1227 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D2962 GO:0022857 1/1227 transmembrane transporter activity molecular_function "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] EOG8JWXWV GO:0043039 15/67 tRNA aminoacylation biological_process "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs] EOG8JWXWV GO:0005524 15/67 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8JWXWV GO:0016876 15/67 ligase activity, forming aminoacyl-tRNA and related compounds molecular_function "Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah] EOG8JWXWV GO:0005737 15/67 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8JWXWV GO:0003746 2/67 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8JWXWV GO:0005875 1/67 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8D2968 GO:0003677 56/1616 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8D2968 GO:0006313 36/1616 transposition, DNA-mediated biological_process "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] EOG8D2968 GO:0015074 36/1616 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8D2968 GO:0004803 36/1616 transposase activity molecular_function "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] EOG8D2968 GO:0006355 9/1616 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8D2968 GO:0008270 4/1616 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D2968 GO:0007275 3/1616 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8D2968 GO:0005634 3/1616 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8D2968 GO:0006351 3/1616 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG80P6P7 GO:0005576 94/324 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG80P6P7 GO:0008061 94/324 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG80P6P7 GO:0006030 94/324 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG80P6P7 GO:0005581 1/324 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8FFGFX GO:0003677 1/19 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8HB11K GO:0046580 1/89 negative regulation of Ras protein signal transduction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] EOG81VNK1 GO:0001539 1/52 cilium or flagellum-dependent cell motility biological_process "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] EOG81VNK1 GO:0003774 1/52 motor activity molecular_function "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] EOG81VNK1 GO:0009288 1/52 bacterial-type flagellum cellular_component "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060] EOG8RR8X3 GO:0008270 14/45 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8RR8X3 GO:0035556 10/45 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8RR8X3 GO:0042393 1/45 histone binding molecular_function "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] EOG8RR8X3 GO:0035076 1/45 ecdysone receptor-mediated signaling pathway biological_process "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf] EOG8RR8X3 GO:0018990 1/45 ecdysis, chitin-based cuticle biological_process "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8RR8X3 GO:0005700 1/45 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8RR8X3 GO:1900114 1/45 positive regulation of histone H3-K9 trimethylation biological_process "Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie] EOG8RR8X3 GO:0044666 1/45 MLL3/4 complex cellular_component "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] EOG8RR8X3 GO:0051568 1/45 histone H3-K4 methylation biological_process "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] EOG8RR8X3 GO:0007474 1/45 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG8RR8X3 GO:0030374 1/45 ligand-dependent nuclear receptor transcription coactivator activity molecular_function "The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] EOG8RR8X3 GO:0008230 1/45 ecdysone receptor holocomplex cellular_component "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] EOG8RR8X3 GO:0071390 1/45 cellular response to ecdysone biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah] EOG8RR8X3 GO:2001141 1/45 regulation of RNA biosynthetic process biological_process "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] EOG8RR8X3 GO:0006909 1/45 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8RR8X3 GO:0003682 1/45 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8H1DBH GO:0006511 68/146 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8H1DBH GO:0016301 5/146 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8H1DBH GO:0022008 2/146 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8H1DBH GO:0005515 2/146 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8H1DBH GO:0016874 2/146 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8H1DBH GO:0046627 1/146 negative regulation of insulin receptor signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] EOG8H1DBH GO:0007095 1/146 mitotic G2 DNA damage checkpoint biological_process "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] EOG8H1DBH GO:0004842 1/146 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8H1DBH GO:0016322 1/146 neuron remodeling biological_process "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] EOG8H1DBH GO:0051298 1/146 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8H1DBH GO:0010824 1/146 regulation of centrosome duplication biological_process "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] EOG8H1DBH GO:0005875 1/146 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8H1DBH GO:0030261 1/146 chromosome condensation biological_process "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG8H1DBH GO:0042023 1/146 DNA endoreduplication biological_process "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] EOG8H1DBH GO:0005813 1/146 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8H1DBH GO:0031647 1/146 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8H1DBH GO:0045931 1/146 positive regulation of mitotic cell cycle biological_process "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] EOG8H1DBH GO:0007067 1/146 mitotic nuclear division biological_process "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] EOG8H1DBH GO:0019005 1/146 SCF ubiquitin ligase complex cellular_component "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] EOG8H1DBH GO:0005819 1/146 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8BCH22 GO:0016758 383/1077 transferase activity, transferring hexosyl groups molecular_function "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] EOG8BCH22 GO:0030259 14/1077 lipid glycosylation biological_process "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] EOG8BCH22 GO:0015020 13/1077 glucuronosyltransferase activity molecular_function "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] EOG8BCH22 GO:0030246 12/1077 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8BCH22 GO:0016999 11/1077 antibiotic metabolic process biological_process "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] EOG8BCH22 GO:0016740 3/1077 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8BCH22 GO:0004181 1/1077 metallocarboxypeptidase activity molecular_function "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] EOG8BCH22 GO:0008168 1/1077 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8BCH22 GO:0003851 1/1077 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity molecular_function "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] EOG8BCH22 GO:0008270 1/1077 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8BCH22 GO:0003676 1/1077 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8BCH22 GO:0002121 1/1077 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG83XXJ1 GO:0016787 15/58 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG83XXJ1 GO:0007632 1/58 visual behavior biological_process "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] EOG83XXJ1 GO:0008103 1/58 oocyte microtubule cytoskeleton polarization biological_process "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] EOG83XXJ1 GO:0007315 1/58 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG83XXJ1 GO:0007616 1/58 long-term memory biological_process "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] EOG83XXJ1 GO:0048477 1/58 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG83XXJ1 GO:0007279 1/58 pole cell formation biological_process "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] EOG83XXJ1 GO:0007277 1/58 pole cell development biological_process "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid] EOG83XXJ1 GO:0043488 1/58 regulation of mRNA stability biological_process "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] EOG83XXJ1 GO:0046011 1/58 regulation of oskar mRNA translation biological_process "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512] EOG83XXJ1 GO:0040040 1/58 thermosensory behavior biological_process "Behavior that is dependent upon the sensation of temperature." [GOC:ems] EOG83XXJ1 GO:0019094 1/58 pole plasm mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG83XXJ1 GO:0007359 1/58 posterior abdomen determination biological_process "The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG83XXJ1 GO:0008595 1/58 anterior/posterior axis specification, embryo biological_process "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG83XXJ1 GO:0043186 1/58 P granule cellular_component "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] EOG83XXJ1 GO:0007281 1/58 germ cell development biological_process "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] EOG83XXJ1 GO:0030719 1/58 P granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] EOG83XXJ1 GO:0007314 1/58 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG83XXJ1 GO:0045727 1/58 positive regulation of translation biological_process "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] EOG83XXJ1 GO:0007318 1/58 pole plasm protein localization biological_process "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] EOG83XXJ1 GO:0008542 1/58 visual learning biological_process "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089] EOG83XXJ1 GO:0045495 1/58 pole plasm cellular_component "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380] EOG83XXJ1 GO:0007275 1/58 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8PCD66 GO:0005089 1/112 Rho guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] EOG8N332X GO:0000398 26/107 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8N332X GO:0046540 26/107 U4/U6 x U5 tri-snRNP complex cellular_component "A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:krc, GOC:pr, PMID:11867543] EOG8N332X GO:0019013 3/107 viral nucleocapsid cellular_component "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] EOG8N332X GO:0030532 1/107 small nuclear ribonucleoprotein complex cellular_component "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] EOG8N332X GO:0005634 1/107 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8N332X GO:0005681 1/107 spliceosomal complex cellular_component "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] EOG8N332X GO:0071011 1/107 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8N332X GO:0031935 1/107 regulation of chromatin silencing biological_process "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] EOG82FW0K GO:0016740 9/186 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG82FW0K GO:0004364 2/186 glutathione transferase activity molecular_function "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] EOG82FW0K GO:0005811 1/186 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG82FW0K GO:0050220 1/186 prostaglandin-E synthase activity molecular_function "Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12896] EOG8PRW50 GO:0005245 1/281 voltage-gated calcium channel activity molecular_function "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] EOG8PRW50 GO:0045886 1/281 negative regulation of synaptic growth at neuromuscular junction biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] EOG8PRW50 GO:0048488 1/281 synaptic vesicle endocytosis biological_process "An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release." [GOC:jid, GOC:lmg, GOC:mah] EOG8PRW50 GO:0019233 1/281 sensory perception of pain biological_process "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [http://www.onelook.com/] EOG8PRW50 GO:0045202 1/281 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8PRW50 GO:0048786 1/281 presynaptic active zone cellular_component "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] EOG8PRW50 GO:0007528 1/281 neuromuscular junction development biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] EOG8PRW50 GO:0070588 1/281 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8PRW50 GO:0007274 1/281 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG86MF1W GO:0005085 23/77 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG86MF1W GO:0007264 23/77 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG86MF1W GO:0008270 1/77 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG86MF1W GO:0015031 1/77 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG89GP04 GO:0003677 1/69 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG89GP04 GO:0005737 1/69 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG89GP04 GO:0005700 1/69 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG89GP04 GO:0042803 1/69 protein homodimerization activity molecular_function "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] EOG89GP04 GO:0035102 1/69 PRC1 complex cellular_component "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979] EOG89GP04 GO:0007076 1/69 mitotic chromosome condensation biological_process "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] EOG89GP04 GO:0007474 1/69 imaginal disc-derived wing vein specification biological_process "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] EOG89GP04 GO:0005813 1/69 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG89GP04 GO:0060429 1/69 epithelium development biological_process "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] EOG89GP04 GO:0035098 1/69 ESC/E(Z) complex cellular_component "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375] EOG89GP04 GO:0010468 1/69 regulation of gene expression biological_process "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG89GP04 GO:0005634 1/69 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG89GP04 GO:0006342 1/69 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG89GP04 GO:0005515 1/69 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG89GP04 GO:0005911 1/69 cell-cell junction cellular_component "A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah] EOG89GP04 GO:0042802 1/69 identical protein binding molecular_function "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] EOG89GP04 GO:0045433 1/69 male courtship behavior, veined wing generated song production biological_process "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] EOG89GP04 GO:0003682 1/69 chromatin binding molecular_function "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] EOG8PRW55 GO:0003676 6/83 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88SK8B GO:0006351 24/100 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG88SK8B GO:0005634 24/100 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG88SK8B GO:0003677 24/100 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8MGVNF GO:0003676 5/132 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MGVNF GO:0008270 5/132 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8MGVNF GO:0003723 2/132 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8MGVNF GO:0003964 2/132 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8MGVNF GO:0003677 2/132 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8MGVNF GO:0015074 2/132 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8MGVNF GO:0045202 1/132 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8MGVNF GO:0003012 1/132 muscle system process biological_process "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] EOG8MGVNF GO:0042595 1/132 behavioral response to starvation biological_process "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] EOG8MGVNF GO:0030017 1/132 sarcomere cellular_component "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] EOG854CDN GO:0005549 2/33 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG854CDN GO:0004984 2/33 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG854CDN GO:0016020 1/33 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG854CDN GO:0016021 1/33 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG854CDN GO:0004930 1/33 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG854CDN GO:0005886 1/33 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG88D38W GO:0016788 294/950 hydrolase activity, acting on ester bonds molecular_function "Catalysis of the hydrolysis of any ester bond." [GOC:jl] EOG88D38W GO:0016042 262/950 lipid catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] EOG88D38W GO:0006629 148/950 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG88D38W GO:0004806 8/950 triglyceride lipase activity molecular_function "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] EOG88D38W GO:0005615 5/950 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG88D38W GO:0032504 5/950 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG88D38W GO:0016298 4/950 lipase activity molecular_function "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] EOG88D38W GO:0030246 1/950 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG88D38W GO:0016787 1/950 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG88D38W GO:0003676 1/950 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG88D38W GO:0007586 1/950 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG88D38W GO:0042632 1/950 cholesterol homeostasis biological_process "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators] EOG88D38W GO:0006886 1/950 intracellular protein transport biological_process "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] EOG88D38W GO:0048812 1/950 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG88D38W GO:0016192 1/950 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG88D38W GO:0005576 1/950 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG88D38W GO:0030132 1/950 clathrin coat of coated pit cellular_component "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah] EOG88D38W GO:0030130 1/950 clathrin coat of trans-Golgi network vesicle cellular_component "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] EOG88D38W GO:0005198 1/950 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG88D38W GO:0031410 1/950 cytoplasmic vesicle cellular_component "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] EOG88D38W GO:0070328 1/950 triglyceride homeostasis biological_process "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] EOG88D38W GO:0004771 1/950 sterol esterase activity molecular_function "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] EOG8W6R92 GO:0003684 19/72 damaged DNA binding molecular_function "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] EOG8W6R92 GO:0003887 19/72 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8W6R92 GO:0006281 18/72 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8W6R92 GO:0019985 1/72 translesion synthesis biological_process "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, PMID:10535901] EOG8W6R92 GO:0006261 1/72 DNA-dependent DNA replication biological_process "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] EOG8WDGSR GO:0005622 7/98 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8WDGSR GO:0005215 7/98 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8WDGSR GO:0005501 1/98 retinoid binding molecular_function "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732] EOG8WDGSR GO:0007602 1/98 phototransduction biological_process "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] EOG8WDGSR GO:0016063 1/98 rhodopsin biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] EOG8C5G07 GO:0004252 2199/5565 serine-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8C5G07 GO:0006508 98/5565 proteolysis biological_process "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] EOG8C5G07 GO:0005615 18/5565 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8C5G07 GO:0005576 17/5565 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8C5G07 GO:0007586 11/5565 digestion biological_process "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] EOG8C5G07 GO:0004175 8/5565 endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG8C5G07 GO:0016021 6/5565 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8C5G07 GO:0016787 5/5565 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8C5G07 GO:0016301 5/5565 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8C5G07 GO:0008236 5/5565 serine-type peptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] EOG8C5G07 GO:0045087 4/5565 innate immune response biological_process "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] EOG8C5G07 GO:0006629 4/5565 lipid metabolic process biological_process "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] EOG8C5G07 GO:0006952 3/5565 defense response biological_process "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] EOG8C5G07 GO:0045752 3/5565 positive regulation of Toll signaling pathway biological_process "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8C5G07 GO:0050830 3/5565 defense response to Gram-positive bacterium biological_process "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] EOG8C5G07 GO:0008063 3/5565 Toll signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] EOG8C5G07 GO:0008233 3/5565 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8C5G07 GO:0005829 3/5565 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8C5G07 GO:0008889 3/5565 glycerophosphodiester phosphodiesterase activity molecular_function "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] EOG8C5G07 GO:0006071 3/5565 glycerol metabolic process biological_process "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] EOG8C5G07 GO:0050832 3/5565 defense response to fungus biological_process "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] EOG8C5G07 GO:0022008 2/5565 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8C5G07 GO:0050829 2/5565 defense response to Gram-negative bacterium biological_process "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] EOG8C5G07 GO:0009950 2/5565 dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] EOG8C5G07 GO:0035006 2/5565 melanization defense response biological_process "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] EOG8C5G07 GO:0007311 2/5565 maternal specification of dorsal/ventral axis, oocyte, germ-line encoded biological_process "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG8C5G07 GO:0031638 2/5565 zymogen activation biological_process "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] EOG8C5G07 GO:0008270 1/5565 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8C5G07 GO:0006964 1/5565 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria biological_process "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] EOG8C5G07 GO:0005515 1/5565 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8C5G07 GO:0005622 1/5565 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8C5G07 GO:0004435 1/5565 phosphatidylinositol phospholipase C activity molecular_function "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] EOG8C5G07 GO:0048812 1/5565 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8C5G07 GO:0008592 1/5565 regulation of Toll signaling pathway biological_process "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] EOG8C5G07 GO:0006967 1/5565 positive regulation of antifungal peptide biosynthetic process biological_process "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] EOG8C5G07 GO:0003964 1/5565 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8C5G07 GO:0035008 1/5565 positive regulation of melanization defense response biological_process "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf] EOG8C5G07 GO:0035007 1/5565 regulation of melanization defense response biological_process "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf] EOG8C5G07 GO:0035556 1/5565 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG8C5G07 GO:0003723 1/5565 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8C5G07 GO:0005581 1/5565 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8C5G07 GO:0004930 1/5565 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8C5G07 GO:0006909 1/5565 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8C5G07 GO:0004180 1/5565 carboxypeptidase activity molecular_function "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] EOG8C5G07 GO:0006959 1/5565 humoral immune response biological_process "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] EOG8C5G07 GO:0004471 1/5565 malate dehydrogenase (decarboxylating) (NAD+) activity molecular_function "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39] EOG8C5G07 GO:0016485 1/5565 protein processing biological_process "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] EOG8C5G07 GO:0003677 1/5565 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8C5G07 GO:0051287 1/5565 NAD binding molecular_function "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] EOG8C5G07 GO:0042060 1/5565 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8C5G03 GO:0003779 2/344 actin binding molecular_function "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] EOG8C5G03 GO:0006936 1/344 muscle contraction biological_process "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] EOG8C5G03 GO:0051015 1/344 actin filament binding molecular_function "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] EOG8C5G03 GO:0048477 1/344 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8C5G03 GO:0007507 1/344 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8C5G03 GO:0030017 1/344 sarcomere cellular_component "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] EOG8C5G03 GO:0010591 1/344 regulation of lamellipodium assembly biological_process "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG8C5G03 GO:0070865 1/344 investment cone cellular_component "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716] EOG8C5G03 GO:0045451 1/344 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG8C5G03 GO:0007315 1/344 pole plasm assembly biological_process "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8C5G03 GO:0048813 1/344 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8T1M1H GO:0003676 1/25 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8T1M1H GO:0046872 1/25 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8H1DB2 GO:0030246 1/10 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG8BCH2D GO:0005524 24/99 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8BCH2D GO:0016874 21/99 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG8BCH2D GO:0046872 18/99 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8BCH2D GO:0004775 3/99 succinate-CoA ligase (ADP-forming) activity molecular_function "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5] EOG8BCH2D GO:0007052 1/99 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8BCH2D GO:0005875 1/99 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8BCH2D GO:0005813 1/99 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8BCH2D GO:0010824 1/99 regulation of centrosome duplication biological_process "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] EOG8THZ8Q GO:0005509 37/100 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8THZ8Q GO:0005955 2/100 calcineurin complex cellular_component "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951] EOG8THZ8Q GO:0008597 2/100 calcium-dependent protein serine/threonine phosphatase regulator activity molecular_function "Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai] EOG8THZ8Q GO:0005516 2/100 calmodulin binding molecular_function "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] EOG8THZ8Q GO:0030431 2/100 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8THZ8Q GO:0016192 2/100 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG8THZ8Q GO:0050790 2/100 regulation of catalytic activity biological_process "Any process that modulates the activity of an enzyme." [GOC:ai] EOG8THZ8Q GO:0007269 2/100 neurotransmitter secretion biological_process "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [CHEBI:25512, GOC:dph] EOG8THZ8Q GO:0006470 2/100 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8THZ8Q GO:0008021 2/100 synaptic vesicle cellular_component "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] EOG8THZ8Q GO:0045214 1/100 sarcomere organization biological_process "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] EOG8THZ8Q GO:0005515 1/100 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8THZ8Q GO:0051533 1/100 positive regulation of NFAT protein import into nucleus biological_process "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] EOG8THZ8Q GO:0007126 1/100 meiotic nuclear division biological_process "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] EOG8THZ8Q GO:0030241 1/100 skeletal muscle myosin thick filament assembly biological_process "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] EOG8THZ8Q GO:0032440 1/100 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG86HJT4 GO:0007399 1/75 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG86HJT5 GO:0003700 35/127 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG86HJT5 GO:0005634 35/127 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG86HJT5 GO:0043565 26/127 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG86HJT5 GO:0000060 3/127 protein import into nucleus, translocation biological_process "A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736] EOG86HJT5 GO:0001654 3/127 eye development biological_process "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] EOG86HJT5 GO:0003677 3/127 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG86HJT5 GO:0007422 3/127 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG86HJT5 GO:0006357 3/127 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86HJT5 GO:0005667 3/127 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG86HJT5 GO:0006351 2/127 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG86HJT5 GO:0007432 1/127 salivary gland boundary specification biological_process "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] EOG86HJT5 GO:0045944 1/127 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG86HJT5 GO:0007479 1/127 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG86HJT5 GO:0004801 1/127 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity molecular_function "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2] EOG86HJT5 GO:0003713 1/127 transcription coactivator activity molecular_function "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG86HJT5 GO:0005737 1/127 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG86HJT5 GO:0007525 1/127 somatic muscle development biological_process "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] EOG86HJT5 GO:0007438 1/127 oenocyte development biological_process "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] EOG86HJT5 GO:0046982 1/127 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG86HJT5 GO:0003705 1/127 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG86HJT5 GO:0006366 1/127 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG86HJT5 GO:0042659 1/127 regulation of cell fate specification biological_process "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators] EOG86HJT5 GO:0033613 1/127 activating transcription factor binding molecular_function "Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription." [GOC:mah, GOC:txnOH] EOG86HJT5 GO:0008134 1/127 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG86HJT5 GO:0005515 1/127 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG86HJT5 GO:0007420 1/127 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8S4RZ2 GO:0003746 2/49 translation elongation factor activity molecular_function "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] EOG8STVN9 GO:0005634 97/397 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8STVN9 GO:0006351 90/397 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8STVN9 GO:0007275 89/397 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8STVN9 GO:0006355 52/397 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8STVN9 GO:0003677 52/397 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8STVN9 GO:0003700 44/397 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8STVN9 GO:0043565 43/397 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8STVN9 GO:0006366 3/397 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG8STVN9 GO:0003705 3/397 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding molecular_function "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH] EOG8STVN9 GO:0045944 3/397 positive regulation of transcription from RNA polymerase II promoter biological_process "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8STVN9 GO:0048813 2/397 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8STVN9 GO:0048749 2/397 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8STVN9 GO:0048854 2/397 brain morphogenesis biological_process "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] EOG8STVN9 GO:0016319 2/397 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8STVN9 GO:0007526 1/397 larval somatic muscle development biological_process "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] EOG8STVN9 GO:0007420 1/397 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8STVN9 GO:0007628 1/397 adult walking behavior biological_process "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907] EOG8STVN9 GO:0043704 1/397 photoreceptor cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu] EOG8STVN9 GO:0045676 1/397 regulation of R7 cell differentiation biological_process "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] EOG8STVN9 GO:0035214 1/397 eye-antennal disc development biological_process "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8STVN9 GO:0007455 1/397 eye-antennal disc morphogenesis biological_process "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] EOG8STVN9 GO:0043567 1/397 regulation of insulin-like growth factor receptor signaling pathway biological_process "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] EOG8STVN9 GO:0001745 1/397 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG8STVN9 GO:0001158 1/397 enhancer sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH] EOG8STVN9 GO:0048666 1/397 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8STVN9 GO:0030182 1/397 neuron differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] EOG8STVN9 GO:0008347 1/397 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8STVN9 GO:0042676 1/397 compound eye cone cell fate commitment biological_process "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu] EOG8STVN9 GO:0010628 1/397 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8STVN9 GO:0007517 1/397 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8STVN9 GO:0005515 1/397 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8STVN9 GO:0008056 1/397 ocellus development biological_process "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] EOG8STVN9 GO:0004000 1/397 adenosine deaminase activity molecular_function "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] EOG8STVN9 GO:0048036 1/397 central complex development biological_process "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] EOG8STVN9 GO:0040018 1/397 positive regulation of multicellular organism growth biological_process "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] EOG8STVN9 GO:0042673 1/397 regulation of retinal cone cell fate specification biological_process "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators] EOG8STVN9 GO:0042682 1/397 regulation of compound eye cone cell fate specification biological_process "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu] EOG8STVN9 GO:0045893 1/397 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8STVN9 GO:0000976 1/397 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG8HHRKW GO:0005576 2/101 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8HHRKW GO:0008233 2/101 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8HHRKW GO:0005215 2/101 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8HHRKW GO:0048190 1/101 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8HHRKW GO:0030178 1/101 negative regulation of Wnt signaling pathway biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] EOG8MWBMX GO:0005622 143/592 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8MWBMX GO:0005215 143/592 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8MWBMX GO:0022008 1/592 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8MWBMX GO:0016787 1/592 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG85XBD5 GO:0005509 62/282 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG85XBD5 GO:0048190 1/282 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG85XBD5 GO:0048812 1/282 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8WHC0K GO:0005814 1/87 centriole cellular_component "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] EOG8WHC0K GO:0035044 1/87 sperm aster formation biological_process "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238] EOG8WHC0K GO:0030953 1/87 astral microtubule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah] EOG8WHC0K GO:0005813 1/87 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8WHC0K GO:0000242 1/87 pericentriolar material cellular_component "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] EOG8WHC0K GO:0051297 1/87 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8WHC0K GO:0007052 1/87 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG87M4CW GO:0008270 37/166 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG87M4CW GO:0016491 33/166 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG87M4CW GO:0003960 3/166 NADPH:quinone reductase activity molecular_function "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] EOG87M4CW GO:0047522 1/166 15-oxoprostaglandin 13-oxidase activity molecular_function "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG:R04556, KEGG:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN] EOG87M4CW GO:0036132 1/166 13-prostaglandin reductase activity molecular_function "Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG:R04556, KEGG:R04557, PMID:17449869] EOG8QC3N6 GO:0008080 28/96 N-acetyltransferase activity molecular_function "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] EOG8QC3N6 GO:0004145 1/96 diamine N-acetyltransferase activity molecular_function "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57] EOG8VMHXJ GO:0020037 88/334 heme binding molecular_function "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] EOG8VMHXJ GO:0046872 70/334 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8VMHXJ GO:0009703 3/334 nitrate reductase (NADH) activity molecular_function "Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+." [EC:1.7.1.1] EOG8VMHXJ GO:0045610 1/334 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG8VMHXJ GO:0005789 1/334 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG8VMHXJ GO:0055114 1/334 oxidation-reduction process biological_process "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] EOG8VMHXJ GO:0003723 1/334 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8VMHXJ GO:0016021 1/334 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VMHXJ GO:0035206 1/334 regulation of hemocyte proliferation biological_process "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8VMHXJ GO:0005811 1/334 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8G4K71 GO:0003700 2/27 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8G4K71 GO:0005634 2/27 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8G4K71 GO:0043565 2/27 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8616JT GO:0006260 4/30 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG8616JT GO:0005524 4/30 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8616JT GO:0003677 4/30 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8616JT GO:0007131 1/30 reciprocal meiotic recombination biological_process "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] EOG8616JT GO:0016321 1/30 female meiosis chromosome segregation biological_process "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] EOG8616JT GO:0007143 1/30 female meiotic division biological_process "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] EOG8616JT GO:0005737 1/30 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG83BQ4M GO:0005085 6/45 guanyl-nucleotide exchange factor activity molecular_function "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] EOG83BQ4M GO:0007264 6/45 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG866Z2N GO:0005525 24/61 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG866Z2N GO:0007264 24/61 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG866Z2N GO:0015031 2/61 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG866Z2N GO:0006412 1/61 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG866Z2N GO:0005840 1/61 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG866Z2N GO:0003735 1/61 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG866Z2N GO:0045202 1/61 synapse cellular_component "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8HHRGX GO:0005549 9/94 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8HHRGX GO:0004984 9/94 olfactory receptor activity molecular_function "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] EOG8HHRGX GO:0016021 6/94 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8HHRGX GO:0004930 6/94 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8HHRGX GO:0016020 3/94 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8HHRGX GO:0005886 2/94 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8Z91BT GO:0006166 2/30 purine ribonucleoside salvage biological_process "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] EOG8Z91BT GO:0004001 2/30 adenosine kinase activity molecular_function "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] EOG8Z91BT GO:0016773 1/30 phosphotransferase activity, alcohol group as acceptor molecular_function "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] EOG80ZTCC GO:0016740 1/32 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG83XXMT GO:0003676 3/277 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83XXMT GO:0015074 2/277 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG83XXMT GO:0003678 1/277 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG83XXMT GO:0000723 1/277 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG83XXMT GO:0006281 1/277 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG8VDSFF GO:0016020 35/2018 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8VDSFF GO:0051781 22/2018 positive regulation of cell division biological_process "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] EOG8VDSFF GO:0007435 2/2018 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8VDSFF GO:0035099 2/2018 hemocyte migration biological_process "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] EOG8VDSFF GO:0003964 1/2018 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8VDSFF GO:0008039 1/2018 synaptic target recognition biological_process "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] EOG8VDSFF GO:0035172 1/2018 hemocyte proliferation biological_process "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG8KD936 GO:0016021 77/225 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8KD936 GO:0005918 3/225 septate junction cellular_component "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] EOG8KD936 GO:0019991 3/225 septate junction assembly biological_process "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] EOG8KD936 GO:0060857 3/225 establishment of glial blood-brain barrier biological_process "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] EOG8KD936 GO:0035151 2/225 regulation of tube size, open tracheal system biological_process "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360] EOG8KD936 GO:0007424 2/225 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8KD936 GO:0005919 1/225 pleated septate junction cellular_component "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] EOG8KD936 GO:0005198 1/225 structural molecule activity molecular_function "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] EOG8KD936 GO:0005923 1/225 bicellular tight junction cellular_component "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] EOG8KD936 GO:0005886 1/225 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8KD936 GO:0061343 1/225 cell adhesion involved in heart morphogenesis biological_process "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] EOG8KD936 GO:0005515 1/225 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8KD936 GO:0035159 1/225 regulation of tube length, open tracheal system biological_process "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] EOG8KD936 GO:0003015 1/225 heart process biological_process "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] EOG8KD936 GO:0007391 1/225 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8KD936 GO:0035002 1/225 liquid clearance, open tracheal system biological_process "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352] EOG8PG8GZ GO:0032006 22/74 regulation of TOR signaling biological_process "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah] EOG8PG8GZ GO:0016301 3/74 kinase activity molecular_function "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] EOG8PG8GZ GO:0034613 1/74 cellular protein localization biological_process "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] EOG8PG8GZ GO:0043087 1/74 regulation of GTPase activity biological_process "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] EOG8PG8GZ GO:0071986 1/74 Ragulator complex cellular_component "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1), ROBLD3 (p14, Mapbpip), C11orf59 (p18), LAMTOR4 and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via C11orf59, recruits mTORC1 to lysosomal membranes in amino acid signaling to mTORC1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases, and is also involved in ERK/MAPK signaling." [GOC:lb, PMID:19177150, PMID:20381137, PMID:22980980] EOG8PG8GZ GO:0071230 1/74 cellular response to amino acid stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah] EOG8PG8GZ GO:0032008 1/74 positive regulation of TOR signaling biological_process "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah] EOG8MD0FT GO:0004725 1/45 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8V45P6 GO:0004970 1/8 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8V45P6 GO:0005234 1/8 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8V45P6 GO:0016020 1/8 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG80P6MX GO:0016021 41/137 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MD0FH GO:0003676 1/47 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8MD0FH GO:0008270 1/47 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D81NH GO:0003676 14/76 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8D81NH GO:0046872 14/76 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8D81NH GO:0008270 13/76 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8D81NH GO:0022008 1/76 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8PRW6K GO:0005549 2/19 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG80GG71 GO:0003676 20/947 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG80GG71 GO:0008270 20/947 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80GG71 GO:0003677 3/947 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG80GG71 GO:0005634 3/947 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG80GG71 GO:0004190 2/947 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG80GG71 GO:0003964 2/947 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG80GG71 GO:0003723 2/947 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG80GG71 GO:0000786 1/947 nucleosome cellular_component "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] EOG80GG71 GO:0015074 1/947 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG80GG71 GO:0004812 1/947 aminoacyl-tRNA ligase activity molecular_function "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] EOG80GG71 GO:0006334 1/947 nucleosome assembly biological_process "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] EOG8TMTGQ GO:0016021 1/80 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q97P GO:0016021 129/334 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q97P GO:0004672 1/334 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG86Q97P GO:0005524 1/334 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG86Q97P GO:0045169 1/334 fusome cellular_component "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] EOG8CZDZX GO:0003677 17/2665 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8CZDZX GO:0015074 6/2665 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8CZDZX GO:0004803 6/2665 transposase activity molecular_function "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] EOG8CZDZX GO:0006313 6/2665 transposition, DNA-mediated biological_process "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] EOG8CZDZX GO:0006355 3/2665 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8CZDZX GO:0003676 3/2665 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CZDZX GO:0016021 1/2665 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8CZDZX GO:0015171 1/2665 amino acid transmembrane transporter activity molecular_function "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] EOG8CZDZX GO:0046872 1/2665 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CZDZX GO:0008270 1/2665 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DFS2Z GO:0008270 23/86 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8DFS2Z GO:0016567 1/86 protein ubiquitination biological_process "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] EOG8DFS2Z GO:0016197 1/86 endosomal transport biological_process "The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732] EOG8DFS2Z GO:0005768 1/86 endosome cellular_component "A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] EOG8DFS2Z GO:0004842 1/86 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8NZX77 GO:0015074 206/1674 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8NZX77 GO:0003964 173/1674 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8NZX77 GO:0003723 170/1674 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8NZX77 GO:0003676 151/1674 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8NZX77 GO:0008270 67/1674 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8NZX77 GO:0004190 64/1674 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8NZX77 GO:0004523 2/1674 RNA-DNA hybrid ribonuclease activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] EOG8NZX77 GO:0003677 2/1674 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8NZX77 GO:0003899 1/1674 DNA-directed RNA polymerase activity molecular_function "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] EOG8NZX77 GO:0043565 1/1674 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8NZX77 GO:0005634 1/1674 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8NZX77 GO:0003700 1/1674 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8NZX77 GO:0004519 1/1674 endonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] EOG8NZX77 GO:0046872 1/1674 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8NZX77 GO:0019048 1/1674 modulation by virus of host morphology or physiology biological_process "The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945] EOG8NZX77 GO:0019031 1/1674 viral envelope cellular_component "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope] EOG8NZX77 GO:0006351 1/1674 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8NZX77 GO:0008233 1/1674 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8Z38X5 GO:0005549 5/46 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8DFS51 GO:0016020 8/51 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8DFS51 GO:0008237 8/51 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8DFS51 GO:0008241 8/51 peptidyl-dipeptidase activity molecular_function "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] EOG86Q97N GO:0016021 3/36 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG86Q97N GO:0019646 3/36 aerobic electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] EOG86Q97N GO:0004129 3/36 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG86Q97N GO:0005739 2/36 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG86Q97N GO:0005743 1/36 mitochondrial inner membrane cellular_component "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] EOG8BS01B GO:0005215 139/496 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8BS01B GO:0005622 138/496 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8BS01B GO:0016787 14/496 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8BS01B GO:0005811 1/496 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8TTK0S GO:0016021 2/22 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TTK0S GO:0004672 1/22 protein kinase activity molecular_function "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] EOG8TTK0S GO:0005524 1/22 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8TTK0D GO:0003676 1/28 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8XSP42 GO:0032006 2/78 regulation of TOR signaling biological_process "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah] EOG8XSP42 GO:0008233 1/78 peptidase activity molecular_function "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] EOG8XSP42 GO:0008168 1/78 methyltransferase activity molecular_function "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] EOG8B014B GO:0005887 1/105 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8B014B GO:0046331 1/105 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8PZMMK GO:0004970 24/96 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8PZMMK GO:0005234 24/96 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8PZMMK GO:0030054 23/96 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8PZMMK GO:0016021 23/96 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8PZMMK GO:0045211 23/96 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8PZMMK GO:0071683 1/96 sensory dendrite cellular_component "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah] EOG8PZMMK GO:0034220 1/96 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8PZMMK GO:0008328 1/96 ionotropic glutamate receptor complex cellular_component "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] EOG8PZMMK GO:0035249 1/96 synaptic transmission, glutamatergic biological_process "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv] EOG8PZMMK GO:0016020 1/96 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8PZMMK GO:0005929 1/96 cilium cellular_component "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:kmv, GOC:vw, ISBN:0198547684] EOG8PZMMK GO:0007608 1/96 sensory perception of smell biological_process "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] EOG8PZMMK GO:0015276 1/96 ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8PZMMK GO:0050907 1/96 detection of chemical stimulus involved in sensory perception biological_process "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] EOG8PZMMK GO:0035235 1/96 ionotropic glutamate receptor signaling pathway biological_process "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732] EOG8Z38WJ GO:0008061 10/45 chitin binding molecular_function "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8Z38WJ GO:0005576 10/45 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8Z38WJ GO:0006030 10/45 chitin metabolic process biological_process "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] EOG8QRKN0 GO:0017183 1/64 peptidyl-diphthamide biosynthetic process from peptidyl-histidine biological_process "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040] EOG8QRKN0 GO:0046872 1/64 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8G7FGR GO:0003676 1/4 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8N8TM1 GO:0043066 22/68 negative regulation of apoptotic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8N8TM1 GO:0048812 1/68 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8XSP4Z GO:0005509 4/17 calcium ion binding molecular_function "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] EOG8XSP4Z GO:0005581 1/17 collagen trimer cellular_component "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] EOG8XSP4Z GO:0004842 1/17 ubiquitin-protein transferase activity molecular_function "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] EOG8XSP4Z GO:0005634 1/17 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8XSP4Z GO:0006511 1/17 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8XSP4Z GO:0008270 1/17 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8XSP4Z GO:0007275 1/17 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8MSGCF GO:0016021 47/174 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8MSGCF GO:0005234 44/174 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8MSGCF GO:0030054 42/174 cell junction cellular_component "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8MSGCF GO:0004970 42/174 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG8MSGCF GO:0045211 42/174 postsynaptic membrane cellular_component "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] EOG8MSGCF GO:0035249 2/174 synaptic transmission, glutamatergic biological_process "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv] EOG8MSGCF GO:0032281 2/174 AMPA glutamate receptor complex cellular_component "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef] EOG8MSGCF GO:0006812 2/174 cation transport biological_process "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8MSGCF GO:0008328 2/174 ionotropic glutamate receptor complex cellular_component "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] EOG8MSGCF GO:0034220 2/174 ion transmembrane transport biological_process "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8MSGCF GO:0004971 2/174 AMPA glutamate receptor activity molecular_function "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111] EOG8MSGCF GO:0005230 2/174 extracellular ligand-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8MSGCF GO:0035235 2/174 ionotropic glutamate receptor signaling pathway biological_process "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732] EOG8MSGCF GO:0030425 2/174 dendrite cellular_component "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] EOG8MSGCF GO:0009253 1/174 peptidoglycan catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] EOG8MSGCF GO:0016020 1/174 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8MSGCF GO:0005886 1/174 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8MSGCF GO:0008745 1/174 N-acetylmuramoyl-L-alanine amidase activity molecular_function "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28] EOG8MSGCF GO:0005215 1/174 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8GJ23P GO:0030723 1/143 ovarian fusome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] EOG8GJ23P GO:0004518 1/143 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8GJ23P GO:0030727 1/143 germarium-derived female germ-line cyst formation biological_process "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] EOG8GJ23P GO:0030717 1/143 karyosome formation biological_process "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] EOG8GJ23P GO:0048471 1/143 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8GJ23P GO:0005737 1/143 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8GJ23P GO:0030719 1/143 P granule organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] EOG8GJ23P GO:0046872 1/143 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8GJ23P GO:0005634 1/143 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GJ23P GO:0030422 1/143 production of siRNA involved in RNA interference biological_process "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] EOG8GJ23P GO:0048477 1/143 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8GJ23P GO:0034587 1/143 piRNA metabolic process biological_process "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] EOG8GJ23P GO:0000166 1/143 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8GJ23P GO:0003723 1/143 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8GJ23P GO:0009953 1/143 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG8GJ23P GO:0005694 1/143 chromosome cellular_component "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] EOG8VMHV6 GO:0005524 2/148 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8VMHV6 GO:0003677 2/148 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8VMHV6 GO:0050254 1/148 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8VMHV6 GO:0005887 1/148 integral component of plasma membrane cellular_component "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8VMHV6 GO:0016480 1/148 negative regulation of transcription from RNA polymerase III promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators] EOG8VMHV6 GO:0004386 1/148 helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] EOG8VMHV6 GO:0016162 1/148 cellulose 1,4-beta-cellobiosidase activity molecular_function "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] EOG8284GG GO:0016602 22/84 CCAAT-binding factor complex cellular_component "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bm, PMID:7828851] EOG8284GG GO:0043565 22/84 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8284GG GO:0003700 22/84 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8284GG GO:0009987 1/84 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8284GG GO:0007411 1/84 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8284GG GO:0003887 1/84 DNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] EOG8C5G1W GO:0006122 23/67 mitochondrial electron transport, ubiquinol to cytochrome c biological_process "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] EOG8C5G1W GO:0005750 23/67 mitochondrial respiratory chain complex III cellular_component "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] EOG8C5G1W GO:0007286 1/67 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8C5G1W GO:0008121 1/67 ubiquinol-cytochrome-c reductase activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] EOG805VH0 GO:0016021 1/19 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83FKD8 GO:0008270 7/84 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83FKD8 GO:0003723 4/84 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG83FKD8 GO:0003964 4/84 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG83FKD8 GO:0003676 2/84 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83FKD8 GO:0003678 1/84 DNA helicase activity molecular_function "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] EOG83FKD8 GO:0005524 1/84 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG83FKD8 GO:0007018 1/84 microtubule-based movement biological_process "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] EOG83FKD8 GO:0003777 1/84 microtubule motor activity molecular_function "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] EOG83FKD8 GO:0015074 1/84 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG83FKD8 GO:0006281 1/84 DNA repair biological_process "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] EOG83FKD8 GO:0000723 1/84 telomere maintenance biological_process "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] EOG83JFMQ GO:0035556 27/78 intracellular signal transduction biological_process "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] EOG83JFMQ GO:0016020 25/78 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG83JFMQ GO:0015031 2/78 protein transport biological_process "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG83JFMQ GO:0005789 2/78 endoplasmic reticulum membrane cellular_component "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] EOG83JFMQ GO:0006888 2/78 ER to Golgi vesicle-mediated transport biological_process "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] EOG83JFMQ GO:0016021 2/78 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG83JFMQ GO:0007275 1/78 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG83JFMQ GO:0007310 1/78 oocyte dorsal/ventral axis specification biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] EOG83JFMQ GO:0009952 1/78 anterior/posterior pattern specification biological_process "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG83JFMQ GO:0046843 1/78 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG83JFMQ GO:0007314 1/78 oocyte anterior/posterior axis specification biological_process "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] EOG83JFMQ GO:0008314 1/78 gurken signaling pathway biological_process "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf, PMID:23972992] EOG83JFMQ GO:0030722 1/78 establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification biological_process "The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. In the insect oocyte, for example, the nucleus is repositioned to a dorso-anterior position." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] EOG83JFMQ GO:0016192 1/78 vesicle-mediated transport biological_process "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] EOG83JFMQ GO:0009953 1/78 dorsal/ventral pattern formation biological_process "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] EOG83JFMQ GO:0008298 1/78 intracellular mRNA localization biological_process "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] EOG83JFMQ GO:0045450 1/78 bicoid mRNA localization biological_process "Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators] EOG83JFMQ GO:0005515 1/78 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG83JFMQ GO:0045451 1/78 pole plasm oskar mRNA localization biological_process "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] EOG83JFMQ GO:0007350 1/78 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG847J7N GO:0003677 22/137 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG847J7N GO:0003676 20/137 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG847J7N GO:0010628 1/137 positive regulation of gene expression biological_process "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG847J7N GO:0008270 1/137 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG847J7N GO:2000495 1/137 regulation of cell proliferation involved in compound eye morphogenesis biological_process "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] EOG847J7N GO:0051726 1/137 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG847J7N GO:0042023 1/137 DNA endoreduplication biological_process "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] EOG847J7N GO:0006355 1/137 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG847J7N GO:0048749 1/137 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG847J7N GO:0006366 1/137 transcription from RNA polymerase II promoter biological_process "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] EOG847J7N GO:0006357 1/137 regulation of transcription from RNA polymerase II promoter biological_process "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG847J7N GO:0005667 1/137 transcription factor complex cellular_component "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] EOG847J7N GO:0051123 1/137 RNA polymerase II transcriptional preinitiation complex assembly biological_process "The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047] EOG847J7N GO:0042981 1/137 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG847J7N GO:0003700 1/137 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG847J7N GO:0022416 1/137 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG847J7N GO:0005634 1/137 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG847J7N GO:0048813 1/137 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG847J7N GO:2000278 1/137 regulation of DNA biosynthetic process biological_process "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] EOG847J7N GO:0001745 1/137 compound eye morphogenesis biological_process "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] EOG847J7N GO:0004222 1/137 metalloendopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] EOG847J7N GO:0022008 1/137 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG847J7N GO:0045035 1/137 sensory organ precursor cell division biological_process "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] EOG847J7N GO:0006260 1/137 DNA replication biological_process "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] EOG847J7N GO:0006264 1/137 mitochondrial DNA replication biological_process "The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai] EOG847J7N GO:0005700 1/137 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG847J7N GO:0000976 1/137 transcription regulatory region sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] EOG847J7N GO:0031012 1/137 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG847J7N GO:0045893 1/137 positive regulation of transcription, DNA-templated biological_process "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG847J7N GO:0007052 1/137 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG889719 GO:0005524 280/803 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG889719 GO:0016021 278/803 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG889719 GO:0042626 272/803 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG889719 GO:0008559 6/803 xenobiotic-transporting ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] EOG889719 GO:0032440 5/803 2-alkenal reductase [NAD(P)] activity molecular_function "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] EOG889719 GO:0003676 2/803 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG889719 GO:0016887 2/803 ATPase activity molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] EOG889719 GO:0008270 2/803 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG889719 GO:0042060 1/803 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG889719 GO:0000776 1/803 kinetochore cellular_component "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] EOG889719 GO:0048190 1/803 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG889719 GO:0006200 1/803 obsolete ATP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] EOG889719 GO:0034508 1/803 centromere complex assembly biological_process "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw] EOG889719 GO:0046688 1/803 response to copper ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai] EOG889719 GO:0034059 1/803 response to anoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv] EOG889719 GO:0046331 1/803 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG889719 GO:0007275 1/803 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG889719 GO:0010043 1/803 response to zinc ion biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] EOG889719 GO:0031427 1/803 response to methotrexate biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] EOG889719 GO:0001666 1/803 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG889719 GO:0043492 1/803 ATPase activity, coupled to movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl] EOG8FJBR0 GO:0006725 6/14 cellular aromatic compound metabolic process biological_process "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732] EOG8FJBR0 GO:0008815 4/14 citrate (pro-3S)-lyase activity molecular_function "Catalysis of the reaction: citrate = acetate + oxaloacetate." [EC:4.1.3.6, RHEA:10763] EOG8FJBR0 GO:0009346 4/14 citrate lyase complex cellular_component "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX] EOG8FJBR0 GO:0046872 3/14 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8FJBR0 GO:0016830 2/14 carbon-carbon lyase activity molecular_function "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] EOG8FJBR0 GO:0008816 1/14 citryl-CoA lyase activity molecular_function "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34] EOG8FJBRF GO:0042302 572/1336 structural constituent of cuticle molecular_function "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] EOG8FJBRF GO:0040003 37/1336 chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] EOG8FJBRF GO:0008010 37/1336 structural constituent of chitin-based larval cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8FJBRF GO:0031012 37/1336 extracellular matrix cellular_component "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] EOG8FJBRF GO:0005576 13/1336 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8FJBRF GO:0008363 8/1336 larval chitin-based cuticle development biological_process "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] EOG8FJBRF GO:0005215 7/1336 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8FJBRF GO:0008011 2/1336 structural constituent of pupal chitin-based cuticle molecular_function "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] EOG8FJBRF GO:0005615 1/1336 extracellular space cellular_component "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] EOG8FJBRF GO:0032504 1/1336 multicellular organism reproduction biological_process "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] EOG8FJBRF GO:0042381 1/1336 hemolymph coagulation biological_process "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] EOG8616N8 GO:0003676 7/1106 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8616N8 GO:0003677 3/1106 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8616N8 GO:0008270 3/1106 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8616N8 GO:0003964 2/1106 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8616N8 GO:0015074 2/1106 DNA integration biological_process "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] EOG8616N8 GO:0003723 2/1106 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8616N8 GO:0004190 1/1106 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG8616N8 GO:0008237 1/1106 metallopeptidase activity molecular_function "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] EOG8FXTPX GO:0005525 83/290 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8FXTPX GO:0007264 81/290 small GTPase mediated signal transduction biological_process "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] EOG8FXTPX GO:0005622 81/290 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8FXTPX GO:0016020 77/290 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8FXTPX GO:0005886 5/290 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8FXTPX GO:0004767 4/290 sphingomyelin phosphodiesterase activity molecular_function "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256] EOG8FXTPX GO:0031532 4/290 actin cytoskeleton reorganization biological_process "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] EOG8FXTPX GO:0005912 4/290 adherens junction cellular_component "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] EOG8FXTPX GO:0035099 4/290 hemocyte migration biological_process "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] EOG8FXTPX GO:0007391 4/290 dorsal closure biological_process "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] EOG8FXTPX GO:0090303 4/290 positive regulation of wound healing biological_process "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] EOG8FXTPX GO:0007254 4/290 JNK cascade biological_process "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] EOG8FXTPX GO:0007275 3/290 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8FXTPX GO:0050770 3/290 regulation of axonogenesis biological_process "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] EOG8FXTPX GO:0007394 3/290 dorsal closure, elongation of leading edge cells biological_process "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] EOG8FXTPX GO:0051017 3/290 actin filament bundle assembly biological_process "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] EOG8FXTPX GO:0006184 3/290 obsolete GTP catabolic process biological_process "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] EOG8FXTPX GO:0006909 3/290 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8FXTPX GO:0008258 3/290 head involution biological_process "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] EOG8FXTPX GO:0003924 3/290 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8FXTPX GO:0045185 3/290 maintenance of protein location biological_process "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] EOG8FXTPX GO:0035011 3/290 melanotic encapsulation of foreign target biological_process "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] EOG8FXTPX GO:0030032 3/290 lamellipodium assembly biological_process "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194] EOG8FXTPX GO:0007390 3/290 germ-band shortening biological_process "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] EOG8FXTPX GO:0005515 3/290 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8FXTPX GO:0046843 3/290 dorsal appendage formation biological_process "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] EOG8FXTPX GO:0035010 3/290 encapsulation of foreign target biological_process "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920] EOG8FXTPX GO:0007435 3/290 salivary gland morphogenesis biological_process "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] EOG8FXTPX GO:0045860 3/290 positive regulation of protein kinase activity biological_process "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] EOG8FXTPX GO:0006974 2/290 cellular response to DNA damage stimulus biological_process "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] EOG8FXTPX GO:0007424 2/290 open tracheal system development biological_process "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] EOG8FXTPX GO:0050975 2/290 sensory perception of touch biological_process "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] EOG8FXTPX GO:0002009 2/290 morphogenesis of an epithelium biological_process "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] EOG8FXTPX GO:0008045 2/290 motor neuron axon guidance biological_process "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] EOG8FXTPX GO:0007411 2/290 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8FXTPX GO:0007015 2/290 actin filament organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] EOG8FXTPX GO:0007520 2/290 myoblast fusion biological_process "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] EOG8FXTPX GO:0002433 2/290 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis biological_process "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149] EOG8FXTPX GO:0031175 2/290 neuron projection development biological_process "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] EOG8FXTPX GO:0007426 2/290 tracheal outgrowth, open tracheal system biological_process "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8FXTPX GO:0048813 2/290 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8FXTPX GO:0030707 2/290 ovarian follicle cell development biological_process "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8FXTPX GO:0042067 2/290 establishment of ommatidial planar polarity biological_process "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] EOG8FXTPX GO:0030036 2/290 actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] EOG8FXTPX GO:0016203 2/290 muscle attachment biological_process "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] EOG8FXTPX GO:0051491 2/290 positive regulation of filopodium assembly biological_process "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] EOG8FXTPX GO:0000902 2/290 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8FXTPX GO:0016028 2/290 rhabdomere cellular_component "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] EOG8FXTPX GO:0097206 2/290 nephrocyte filtration biological_process "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929] EOG8FXTPX GO:0032794 2/290 GTPase activating protein binding molecular_function "Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln] EOG8FXTPX GO:0030866 2/290 cortical actin cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] EOG8FXTPX GO:0034334 2/290 adherens junction maintenance biological_process "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] EOG8FXTPX GO:0007266 2/290 Rho protein signal transduction biological_process "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] EOG8FXTPX GO:0007516 1/290 hemocyte development biological_process "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] EOG8FXTPX GO:0016199 1/290 axon midline choice point recognition biological_process "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] EOG8FXTPX GO:0007017 1/290 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8FXTPX GO:0010592 1/290 positive regulation of lamellipodium assembly biological_process "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG8FXTPX GO:0051450 1/290 myoblast proliferation biological_process "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] EOG8FXTPX GO:0051963 1/290 regulation of synapse assembly biological_process "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] EOG8FXTPX GO:0007413 1/290 axonal fasciculation biological_process "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] EOG8FXTPX GO:0007617 1/290 mating behavior biological_process "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] EOG8FXTPX GO:0030041 1/290 actin filament polymerization biological_process "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG8FXTPX GO:0005829 1/290 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8FXTPX GO:0060446 1/290 branching involved in open tracheal system development biological_process "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph] EOG8FXTPX GO:0045177 1/290 apical part of cell cellular_component "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] EOG8FXTPX GO:0051726 1/290 regulation of cell cycle biological_process "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] EOG8FXTPX GO:0035320 1/290 imaginal disc-derived wing hair site selection biological_process "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551] EOG8FXTPX GO:0008347 1/290 glial cell migration biological_process "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] EOG8FXTPX GO:0007422 1/290 peripheral nervous system development biological_process "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] EOG8FXTPX GO:0007396 1/290 suture of dorsal opening biological_process "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138] EOG8FXTPX GO:0010593 1/290 negative regulation of lamellipodium assembly biological_process "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] EOG8FXTPX GO:0005938 1/290 cell cortex cellular_component "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] EOG8FXTPX GO:0071907 1/290 determination of digestive tract left/right asymmetry biological_process "Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs] EOG8FXTPX GO:0048615 1/290 embryonic anterior midgut (ectodermal) morphogenesis biological_process "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] EOG8FXTPX GO:0042742 1/290 defense response to bacterium biological_process "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] EOG8FXTPX GO:0045200 1/290 establishment of neuroblast polarity biological_process "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] EOG8FXTPX GO:0010883 1/290 regulation of lipid storage biological_process "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] EOG8FXTPX GO:0008360 1/290 regulation of cell shape biological_process "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] EOG8FXTPX GO:0048747 1/290 muscle fiber development biological_process "The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] EOG8FXTPX GO:0007631 1/290 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8FXTPX GO:0030011 1/290 maintenance of cell polarity biological_process "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah] EOG8FXTPX GO:0002118 1/290 aggressive behavior biological_process "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] EOG8FXTPX GO:0030031 1/290 cell projection assembly biological_process "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] EOG8FXTPX GO:0007286 1/290 spermatid development biological_process "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] EOG8FXTPX GO:0046331 1/290 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8FXTPX GO:0019897 1/290 extrinsic component of plasma membrane cellular_component "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] EOG8FXTPX GO:0048477 1/290 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8FXTPX GO:0045610 1/290 regulation of hemocyte differentiation biological_process "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] EOG8FXTPX GO:0071902 1/290 positive regulation of protein serine/threonine kinase activity biological_process "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] EOG8FXTPX GO:0007274 1/290 neuromuscular synaptic transmission biological_process "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] EOG8FXTPX GO:0007419 1/290 ventral cord development biological_process "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] EOG8FXTPX GO:0048675 1/290 axon extension biological_process "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] EOG8FXTPX GO:0030426 1/290 growth cone cellular_component "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] EOG8FXTPX GO:0007409 1/290 axonogenesis biological_process "De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] EOG8FXTPX GO:0008078 1/290 mesodermal cell migration biological_process "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047] EOG8FXTPX GO:0030833 1/290 regulation of actin filament polymerization biological_process "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] EOG8FXTPX GO:0035318 1/290 imaginal disc-derived wing hair outgrowth biological_process "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551] EOG8FXTPX GO:0008582 1/290 regulation of synaptic growth at neuromuscular junction biological_process "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] EOG8FXTPX GO:0035212 1/290 cell competition in a multicellular organism biological_process "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286] EOG8FXTPX GO:0030424 1/290 axon cellular_component "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] EOG8FXTPX GO:0016335 1/290 morphogenesis of larval imaginal disc epithelium biological_process "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl] EOG8FXTPX GO:0001737 1/290 establishment of imaginal disc-derived wing hair orientation biological_process "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] EOG8FXTPX GO:0045216 1/290 cell-cell junction organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8FXTPX GO:0051301 1/290 cell division biological_process "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] EOG8FXTPX GO:0007298 1/290 border follicle cell migration biological_process "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] EOG8FXTPX GO:0042052 1/290 rhabdomere development biological_process "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] EOG8FXTPX GO:0007179 1/290 transforming growth factor beta receptor signaling pathway biological_process "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] EOG8FXTPX GO:0048814 1/290 regulation of dendrite morphogenesis biological_process "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] EOG8FXTPX GO:0005737 1/290 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8FXTPX GO:0050807 1/290 regulation of synapse organization biological_process "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] EOG8FXTPX GO:0008283 1/290 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8FXTPX GO:0042060 1/290 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8FXTPX GO:0007164 1/290 establishment of tissue polarity biological_process "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid] EOG8FXTPX GO:0046664 1/290 dorsal closure, amnioserosa morphology change biological_process "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138] EOG8FXTPX GO:0007010 1/290 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8FXTPX GO:0007349 1/290 cellularization biological_process "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] EOG8FXTPX GO:0005634 1/290 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8STVKR GO:0003676 4/38 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8B8MTT GO:0019310 25/78 inositol catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, GOC:go_curators] EOG8B8MTT GO:0005506 25/78 iron ion binding molecular_function "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] EOG8B8MTT GO:0005737 25/78 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8B8MTT GO:0050113 25/78 inositol oxygenase activity molecular_function "Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23699] EOG8SR09W GO:0005634 27/143 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8SR09W GO:0043704 1/143 photoreceptor cell fate specification biological_process "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu] EOG8SR09W GO:0016319 1/143 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8SR09W GO:0005515 1/143 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8SR09W GO:0007483 1/143 genital disc morphogenesis biological_process "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] EOG8SR09W GO:0042051 1/143 compound eye photoreceptor development biological_process "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] EOG8SR09W GO:0035263 1/143 genital disc sexually dimorphic development biological_process "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] EOG8SR09W GO:0010629 1/143 negative regulation of gene expression biological_process "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] EOG8SR09W GO:0048749 1/143 compound eye development biological_process "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] EOG8SR09W GO:0030182 1/143 neuron differentiation biological_process "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] EOG8SR09W GO:0007411 1/143 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8SR09W GO:0006351 1/143 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8SR09W GO:0007479 1/143 leg disc proximal/distal pattern formation biological_process "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] EOG8SR09W GO:0035215 1/143 genital disc development biological_process "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] EOG8SR09W GO:0035211 1/143 spermathecum morphogenesis biological_process "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097] EOG8SR09W GO:0048098 1/143 antennal joint development biological_process "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jid] EOG8TB6V2 GO:0000166 25/106 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8TB6V2 GO:0003676 24/106 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TB6V2 GO:0005634 1/106 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TB6V2 GO:0005849 1/106 mRNA cleavage factor complex cellular_component "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856] EOG8TB6V2 GO:0000381 1/106 regulation of alternative mRNA splicing, via spliceosome biological_process "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] EOG8TB6V2 GO:0006379 1/106 mRNA cleavage biological_process "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] EOG8TB6V2 GO:0003729 1/106 mRNA binding molecular_function "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234] EOG8284G8 GO:0016021 294/728 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8284G8 GO:0055085 283/728 transmembrane transport biological_process "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] EOG8284G8 GO:0005215 14/728 transporter activity molecular_function "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] EOG8284G8 GO:0015114 10/728 phosphate ion transmembrane transporter activity molecular_function "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] EOG8284G8 GO:0005886 2/728 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8284G8 GO:0006814 2/728 sodium ion transport biological_process "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8284G8 GO:0015293 2/728 symporter activity molecular_function "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] EOG8284G8 GO:0005314 1/728 high-affinity glutamate transmembrane transporter activity molecular_function "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5] EOG8284G8 GO:0015321 1/728 sodium-dependent phosphate transmembrane transporter activity molecular_function "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl] EOG8284G8 GO:0051938 1/728 L-glutamate import biological_process "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah] EOG8284G8 GO:0048190 1/728 wing disc dorsal/ventral pattern formation biological_process "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] EOG8284G8 GO:0006541 1/728 glutamine metabolic process biological_process "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] EOG8284G8 GO:0035725 1/728 sodium ion transmembrane transport biological_process "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] EOG8284G8 GO:0001666 1/728 response to hypoxia biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] EOG8284G8 GO:0007005 1/728 mitochondrion organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] EOG8284G8 GO:0035435 1/728 phosphate ion transmembrane transport biological_process "The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] EOG8284G8 GO:0044341 1/728 sodium-dependent phosphate transport biological_process "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl] EOG8284G8 GO:0005436 1/728 sodium:phosphate symporter activity molecular_function "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai] EOG8284G8 GO:0004930 1/728 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8TXF7C GO:0003676 5/113 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8TXF7C GO:0003677 1/113 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8SFCMS GO:0008270 12/102 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8SFCMS GO:0003676 11/102 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8SFCMS GO:0003677 1/102 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8M946Q GO:0043565 19/52 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8M946Q GO:0005634 19/52 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8M946Q GO:0003700 19/52 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8M946Q GO:0007412 1/52 axon target recognition biological_process "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] EOG8M946Q GO:0007417 1/52 central nervous system development biological_process "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] EOG8M946Q GO:0046331 1/52 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8M946Q GO:0007399 1/52 nervous system development biological_process "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] EOG8WDGRM GO:0003735 47/309 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8WDGRM GO:0005840 47/309 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8WDGRM GO:0006412 47/309 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8WDGRM GO:0005875 4/309 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8WDGRM GO:0005634 4/309 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8WDGRM GO:0005829 3/309 cytosol cellular_component "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] EOG8WDGRM GO:0003950 3/309 NAD+ ADP-ribosyltransferase activity molecular_function "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] EOG8WDGRM GO:0009987 2/309 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8WDGRM GO:0022008 1/309 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8WDGRM GO:0046872 1/309 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8WDGRM GO:2000242 1/309 negative regulation of reproductive process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] EOG8WDGRM GO:0051438 1/309 regulation of ubiquitin-protein transferase activity biological_process "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] EOG8WDGRM GO:0010992 1/309 ubiquitin homeostasis biological_process "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb] EOG8WDGRM GO:0031386 1/309 protein tag molecular_function "Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators] EOG8WDGRM GO:0006464 1/309 cellular protein modification process biological_process "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] EOG8WDGRM GO:0045116 1/309 protein neddylation biological_process "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580] EOG8WDGRM GO:0048812 1/309 neuron projection morphogenesis biological_process "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] EOG8WDGRM GO:0008283 1/309 cell proliferation biological_process "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] EOG8WDGRM GO:0007141 1/309 male meiosis I biological_process "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah] EOG8WDGRM GO:0048515 1/309 spermatid differentiation biological_process "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] EOG8WDGRM GO:0030431 1/309 sleep biological_process "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] EOG8WDGRM GO:0031647 1/309 regulation of protein stability biological_process "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] EOG8WDGRM GO:0006511 1/309 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG8WDGRM GO:0030162 1/309 regulation of proteolysis biological_process "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] EOG8WDGRM GO:0008589 1/309 regulation of smoothened signaling pathway biological_process "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators] EOG8WDGRM GO:0022625 1/309 cytosolic large ribosomal subunit cellular_component "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] EOG8WDGRM GO:0006909 1/309 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8WDGRM GO:0008340 1/309 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8TXF7N GO:0016021 1/76 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8TXF7Q GO:0004129 29/141 cytochrome-c oxidase activity molecular_function "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] EOG8TXF7Q GO:0005739 28/141 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8TXF7Q GO:0008340 1/141 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8TXF7Q GO:0022008 1/141 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8X99Z2 GO:0005739 26/74 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG8X99Z2 GO:0006461 26/74 protein complex assembly biological_process "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai] EOG8QRKJV GO:0071011 1/82 precatalytic spliceosome cellular_component "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] EOG8QRKJV GO:0000398 1/82 mRNA splicing, via spliceosome biological_process "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] EOG8K9DTK GO:0016740 3/69 transferase activity molecular_function "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] EOG8K9DTK GO:0046331 1/69 lateral inhibition biological_process "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] EOG8V9X5Z GO:0005525 23/71 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8V9X5Z GO:0035998 23/71 7,8-dihydroneopterin 3'-triphosphate biosynthetic process biological_process "The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [CHEBI:18372, GOC:yaf, UniPathway:UPA00848] EOG8V9X5Z GO:0046872 23/71 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8V9X5Z GO:0003934 23/71 GTP cyclohydrolase I activity molecular_function "Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16] EOG83R62Q GO:0003676 55/341 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83R62Q GO:0005622 1/341 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG83R62Q GO:0008270 1/341 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG83R62Q GO:0046872 1/341 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG83R62Q GO:0003964 1/341 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG83R62Q GO:0003723 1/341 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG83R62Q GO:0042981 1/341 regulation of apoptotic process biological_process "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] EOG8VDSF8 GO:0003676 3/73 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8VDSF8 GO:0004526 3/73 ribonuclease P activity molecular_function "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] EOG8VDSF8 GO:0008033 3/73 tRNA processing biological_process "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] EOG8VDSF8 GO:0005634 3/73 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8VDSF8 GO:0016021 1/73 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8V9X5D GO:0003676 7/41 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8HTC84 GO:0046872 3/29 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82FVZP GO:0000062 18/68 fatty-acyl-CoA binding molecular_function "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732] EOG82FVZP GO:0004190 1/68 aspartic-type endopeptidase activity molecular_function "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] EOG82FVZP GO:0003676 1/68 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82FVZP GO:0000166 1/68 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG8M0HGJ GO:0048471 1/134 perinuclear region of cytoplasm cellular_component "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] EOG8M0HGJ GO:0007097 1/134 nuclear migration biological_process "The directed movement of the nucleus." [GOC:ai] EOG8M0HGJ GO:0034399 1/134 nuclear periphery cellular_component "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] EOG83R628 GO:0003676 26/225 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG83R628 GO:0005634 1/225 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG83R628 GO:0046872 1/225 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8BZQHH GO:0004867 3/66 serine-type endopeptidase inhibitor activity molecular_function "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] EOG873S6H GO:0004719 11/52 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity molecular_function "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] EOG8DJNCF GO:0008270 1/110 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG898XFH GO:0016020 2/32 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG898XFH GO:0006955 2/32 immune response biological_process "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] EOG8Q2GWW GO:0032994 1/143 protein-lipid complex cellular_component "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." [GOC:mah] EOG8Q2GWW GO:0006869 1/143 lipid transport biological_process "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] EOG8Q2GWW GO:0006642 1/143 triglyceride mobilization biological_process "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625] EOG8Q2GWW GO:0005737 1/143 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8Q2GWW GO:0010898 1/143 positive regulation of triglyceride catabolic process biological_process "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] EOG8Q2GWW GO:0005811 1/143 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8Q2GWW GO:0034389 1/143 lipid particle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] EOG8Q2GWW GO:1990044 1/143 protein localization to lipid particle biological_process "A process in which a protein is transported to, or maintained in, a location on or within a lipid particle." [GOC:sart, PMID:22505614] EOG8Q2GWW GO:0022008 1/143 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8Q2GWW GO:0019915 1/143 lipid storage biological_process "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] EOG8Q2GWW GO:0010883 1/143 regulation of lipid storage biological_process "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] EOG80CKX9 GO:0050660 12/64 flavin adenine dinucleotide binding molecular_function "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732] EOG80CKX9 GO:0008812 11/64 choline dehydrogenase activity molecular_function "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17436] EOG80CKX9 GO:0006066 11/64 alcohol metabolic process biological_process "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] EOG80CKX9 GO:0004344 1/64 glucose dehydrogenase activity molecular_function "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] EOG80CKX9 GO:0016614 1/64 oxidoreductase activity, acting on CH-OH group of donors molecular_function "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] EOG82C0QT GO:0003676 21/60 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82C0QT GO:0046872 21/60 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8935XT GO:0016021 22/122 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8935XT GO:0005216 21/122 ion channel activity molecular_function "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8935XT GO:0005840 1/122 ribosome cellular_component "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] EOG8935XT GO:0070588 1/122 calcium ion transmembrane transport biological_process "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] EOG8935XT GO:0006412 1/122 translation biological_process "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] EOG8935XT GO:0007605 1/122 sensory perception of sound biological_process "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] EOG8935XT GO:0009270 1/122 response to humidity biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl] EOG8935XT GO:0003735 1/122 structural constituent of ribosome molecular_function "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] EOG8935XT GO:0005262 1/122 calcium channel activity molecular_function "Enables the selective, facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] EOG8935XT GO:0006816 1/122 calcium ion transport biological_process "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] EOG8935XT GO:0004623 1/122 phospholipase A2 activity molecular_function "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] EOG841STZ GO:0004843 1/73 ubiquitin-specific protease activity molecular_function "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin." [GOC:jh2, ISBN:0120793709] EOG841STZ GO:0003964 1/73 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG841STZ GO:0006511 1/73 ubiquitin-dependent protein catabolic process biological_process "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] EOG85B3VW GO:0006839 1/126 mitochondrial transport biological_process "Transport of substances into, out of or within a mitochondrion." [GOC:ai] EOG85B3VW GO:0005739 1/126 mitochondrion cellular_component "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] EOG85B3VW GO:0005856 1/126 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG82587R GO:0006457 26/86 protein folding biological_process "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] EOG82587R GO:0003755 1/86 peptidyl-prolyl cis-trans isomerase activity molecular_function "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] EOG8Q2GWH GO:0003676 13/42 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8Q2GWH GO:0046872 1/42 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8TB6RT GO:0097372 28/97 NAD-dependent histone deacetylase activity (H3-K18 specific) molecular_function "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein." [EC:3.5.1.17, GOC:sp, PMID:22722849, RHEA:24551] EOG8TB6RT GO:0006355 28/97 regulation of transcription, DNA-templated biological_process "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8TB6RT GO:0005634 28/97 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8TB6RT GO:0046969 28/97 NAD-dependent histone deacetylase activity (H3-K9 specific) molecular_function "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551] EOG8TB6RT GO:0006351 28/97 transcription, DNA-templated biological_process "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] EOG8TB6RT GO:0046970 28/97 NAD-dependent histone deacetylase activity (H4-K16 specific) molecular_function "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [EC:3.5.1.17, GOC:vw, RHEA:24551] EOG8TB6RT GO:0032041 28/97 NAD-dependent histone deacetylase activity (H3-K14 specific) molecular_function "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551] EOG8TB6RT GO:0004407 3/97 histone deacetylase activity molecular_function "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272] EOG8TB6RT GO:0035098 1/97 ESC/E(Z) complex cellular_component "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375] EOG8TB6RT GO:0048477 1/97 oogenesis biological_process "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] EOG8TB6RT GO:0016458 1/97 gene silencing biological_process "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] EOG8TB6RT GO:0007350 1/97 blastoderm segmentation biological_process "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] EOG8TB6RT GO:0008134 1/97 transcription factor binding molecular_function "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] EOG8TB6RT GO:0048813 1/97 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8TB6RT GO:0045892 1/97 negative regulation of transcription, DNA-templated biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] EOG8TB6RT GO:0003714 1/97 transcription corepressor activity molecular_function "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867] EOG8TB6RT GO:0070983 1/97 dendrite guidance biological_process "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] EOG8TB6RT GO:0000118 1/97 histone deacetylase complex cellular_component "A protein complex that possesses histone deacetylase activity." [GOC:mah] EOG8TB6RT GO:0005737 1/97 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8TB6RT GO:0031523 1/97 Myb complex cellular_component "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] EOG8TB6RT GO:0007517 1/97 muscle organ development biological_process "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] EOG8TB6RT GO:0000785 1/97 chromatin cellular_component "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] EOG8TB6RT GO:0070822 1/97 Sin3-type complex cellular_component "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778] EOG8TB6RT GO:0008340 1/97 determination of adult lifespan biological_process "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] EOG8TB6RT GO:0006099 1/97 tricarboxylic acid cycle biological_process "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] EOG8TB6RT GO:0017053 1/97 transcriptional repressor complex cellular_component "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] EOG8TB6RT GO:0000122 1/97 negative regulation of transcription from RNA polymerase II promoter biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] EOG8TB6RT GO:0016575 1/97 histone deacetylation biological_process "The modification of histones by removal of acetyl groups." [GOC:ai] EOG8TB6RT GO:0006342 1/97 chromatin silencing biological_process "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] EOG8TB6RT GO:0022904 1/97 respiratory electron transport chain biological_process "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094] EOG8TB6RT GO:0005515 1/97 protein binding molecular_function "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] EOG8TB6RT GO:0016787 1/97 hydrolase activity molecular_function "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] EOG8TB6RT GO:0005705 1/97 polytene chromosome interband cellular_component "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] EOG8TB6RT GO:0022008 1/97 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8TB6RT GO:0016568 1/97 chromatin modification biological_process "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] EOG8TB6RT GO:0016581 1/97 NuRD complex cellular_component "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569] EOG8TB6RT GO:2001229 1/97 negative regulation of response to gamma radiation biological_process "Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation." [GOC:obol] EOG8TB6RT GO:0005700 1/97 polytene chromosome cellular_component "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] EOG8TB6RT GO:0016580 1/97 Sin3 complex cellular_component "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422] EOG8TB6RT GO:0050771 1/97 negative regulation of axonogenesis biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai] EOG8JMB6D GO:0016874 1/8 ligase activity molecular_function "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] EOG82FW10 GO:0003954 1/72 NADH dehydrogenase activity molecular_function "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] EOG879HNV GO:0005975 12/47 carbohydrate metabolic process biological_process "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] EOG879HNV GO:0004553 11/47 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] EOG879HNV GO:0030246 8/47 carbohydrate binding molecular_function "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] EOG879HNV GO:0032450 1/47 maltose alpha-glucosidase activity molecular_function "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] EOG8284H3 GO:0003700 6/29 transcription factor activity, sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH] EOG8284H3 GO:0005634 6/29 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8284H3 GO:0043565 6/29 sequence-specific DNA binding molecular_function "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] EOG8284H3 GO:0006950 3/29 response to stress biological_process "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] EOG8284H3 GO:0005576 1/29 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG82Z749 GO:0000166 4/62 nucleotide binding molecular_function "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] EOG82Z749 GO:0003676 4/62 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG82Z749 GO:0016779 1/62 nucleotidyltransferase activity molecular_function "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] EOG82Z749 GO:0046872 1/62 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG82Z749 GO:0008270 1/62 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG8B2WDC GO:0003677 3/350 DNA binding molecular_function "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] EOG8B2WDC GO:0004518 2/350 nuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] EOG8B2WDC GO:0016747 1/350 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] EOG8B2WDC GO:0004527 1/350 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8NKF92 GO:0005524 101/307 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8NKF92 GO:0005737 101/307 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8NKF92 GO:0005856 95/307 cytoskeleton cellular_component "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] EOG8NKF92 GO:0007010 6/307 cytoskeleton organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] EOG8NKF92 GO:0005200 6/307 structural constituent of cytoskeleton molecular_function "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] EOG8NKF92 GO:0005884 6/307 actin filament cellular_component "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] EOG8NKF92 GO:0000281 3/307 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8NKF92 GO:0005875 3/307 microtubule associated complex cellular_component "Any multimeric complex connected to a microtubule." [GOC:jl] EOG8NKF92 GO:0006909 3/307 phagocytosis biological_process "An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] EOG8NKF92 GO:0005811 2/307 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG8NKF92 GO:0031011 1/307 Ino80 complex cellular_component "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] EOG8NKF92 GO:0002121 1/307 inter-male aggressive behavior biological_process "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] EOG8NKF92 GO:0016319 1/307 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG8NKF92 GO:0051297 1/307 centrosome organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] EOG8NKF92 GO:0007507 1/307 heart development biological_process "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] EOG8NKF92 GO:0014866 1/307 skeletal myofibril assembly biological_process "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] EOG8NKF92 GO:0007291 1/307 sperm individualization biological_process "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] EOG8NKF92 GO:0032507 1/307 maintenance of protein location in cell biological_process "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] EOG8NKF92 GO:0051533 1/307 positive regulation of NFAT protein import into nucleus biological_process "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] EOG8NW227 GO:0016021 1/11 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8NW227 GO:0004930 1/11 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG86DPGN GO:0005097 36/84 GTPase activator activity molecular_function "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] EOG8JT2NV GO:0008270 1/16 zinc ion binding molecular_function "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] EOG80S2WJ GO:0016491 161/516 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG80S2WJ GO:0004032 11/516 alditol:NADP+ 1-oxidoreductase activity molecular_function "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] EOG80S2WJ GO:0035220 1/516 wing disc development biological_process "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] EOG80S2WJ GO:0047006 1/516 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity molecular_function "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] EOG80S2WJ GO:0016319 1/516 mushroom body development biological_process "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] EOG80S2WJ GO:0008106 1/516 alcohol dehydrogenase (NADP+) activity molecular_function "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] EOG80S2WJ GO:0022416 1/516 chaeta development biological_process "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] EOG8KM1KB GO:0005576 5/153 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8KM1KB GO:0046982 2/153 protein heterodimerization activity molecular_function "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] EOG8KM1KB GO:0031395 2/153 bursicon neuropeptide hormone complex cellular_component "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc] EOG8KM1KB GO:0007593 2/153 chitin-based cuticle sclerotization biological_process "The process of hardening of a chitin-based cuticle." [GOC:dos, GOC:mtg_sensu] EOG8KM1KB GO:0005179 1/153 hormone activity molecular_function "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] EOG8KM1KB GO:0090175 1/153 regulation of establishment of planar polarity biological_process "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb] EOG8KM1KB GO:0048067 1/153 cuticle pigmentation biological_process "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] EOG8KM1KB GO:0007186 1/153 G-protein coupled receptor signaling pathway biological_process "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] EOG8KM1KB GO:0018990 1/153 ecdysis, chitin-based cuticle biological_process "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] EOG8KM1KB GO:0001664 1/153 G-protein coupled receptor binding molecular_function "Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph] EOG8KM1KB GO:0043195 1/153 terminal bouton cellular_component "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] EOG8GMXBH GO:0006370 31/135 7-methylguanosine mRNA capping biological_process "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] EOG8GMXBH GO:0004484 31/135 mRNA guanylyltransferase activity molecular_function "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50] EOG8GMXBH GO:0008138 28/135 protein tyrosine/serine/threonine phosphatase activity molecular_function "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] EOG8GMXBH GO:0004725 27/135 protein tyrosine phosphatase activity molecular_function "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] EOG8GMXBH GO:0004651 23/135 polynucleotide 5'-phosphatase activity molecular_function "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] EOG8GMXBH GO:0005634 23/135 nucleus cellular_component "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] EOG8GMXBH GO:0004527 1/135 exonuclease activity molecular_function "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] EOG8GMXBH GO:0010181 1/135 FMN binding molecular_function "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] EOG8GMXBH GO:0003676 1/135 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8GMXBH GO:0051539 1/135 4 iron, 4 sulfur cluster binding molecular_function "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] EOG8GMXBH GO:0008137 1/135 NADH dehydrogenase (ubiquinone) activity molecular_function "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] EOG8GMXBH GO:0016491 1/135 oxidoreductase activity molecular_function "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] EOG8GMXBH GO:0006470 1/135 protein dephosphorylation biological_process "The process of removing one or more phosphoric residues from a protein." [GOC:hb] EOG8935Z7 GO:0051258 63/183 protein polymerization biological_process "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] EOG8935Z7 GO:0003924 63/183 GTPase activity molecular_function "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] EOG8935Z7 GO:0005874 63/183 microtubule cellular_component "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] EOG8935Z7 GO:0005525 63/183 GTP binding molecular_function "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] EOG8935Z7 GO:0005200 63/183 structural constituent of cytoskeleton molecular_function "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] EOG8935Z7 GO:0005737 62/183 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] EOG8935Z7 GO:0007017 61/183 microtubule-based process biological_process "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] EOG8935Z7 GO:0009987 3/183 cellular process biological_process "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] EOG8935Z7 GO:0007052 2/183 mitotic spindle organization biological_process "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] EOG8935Z7 GO:0007094 2/183 mitotic spindle assembly checkpoint biological_process "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190] EOG8935Z7 GO:0005819 1/183 spindle cellular_component "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] EOG8935Z7 GO:0000902 1/183 cell morphogenesis biological_process "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] EOG8935Z7 GO:0000235 1/183 astral microtubule cellular_component "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] EOG8935Z7 GO:0005813 1/183 centrosome cellular_component "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] EOG8935Z7 GO:0005524 1/183 ATP binding molecular_function "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] EOG8935Z7 GO:0000281 1/183 mitotic cytokinesis biological_process "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] EOG8935Z7 GO:0042626 1/183 ATPase activity, coupled to transmembrane movement of substances molecular_function "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] EOG8935Z7 GO:0016021 1/183 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8935Z7 GO:0051298 1/183 centrosome duplication biological_process "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] EOG8935Z7 GO:0019730 1/183 antimicrobial humoral response biological_process "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] EOG8935Z7 GO:0017022 1/183 myosin binding molecular_function "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] EOG8935Z7 GO:0005811 1/183 lipid particle cellular_component "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] EOG83N9TW GO:0004970 1/12 ionotropic glutamate receptor activity molecular_function "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] EOG83N9TW GO:0016020 1/12 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG83N9TW GO:0005234 1/12 extracellular-glutamate-gated ion channel activity molecular_function "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] EOG8HB12Z GO:0005576 4/48 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8HB12Z GO:0009405 3/48 pathogenesis biological_process "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] EOG8HB12Z GO:0008200 3/48 ion channel inhibitor activity molecular_function "Stops, prevents, or reduces the activity of an ion channel." [GOC:mah] EOG8HB12Z GO:0009755 1/48 hormone-mediated signaling pathway biological_process "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] EOG8K6JJ1 GO:0046872 6/37 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CZDWC GO:0003676 14/55 nucleic acid binding molecular_function "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] EOG8CZDWC GO:0046872 14/55 metal ion binding molecular_function "Interacting selectively and non-covalently with any metal ion." [GOC:ai] EOG8CZDWC GO:0048813 1/55 dendrite morphogenesis biological_process "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732] EOG8CZDWC GO:0007411 1/55 axon guidance biological_process "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] EOG8CZDWC GO:0048666 1/55 neuron development biological_process "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] EOG8FFGGB GO:0016021 20/129 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8FFGGB GO:0004930 10/129 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8FFGGB GO:0016499 5/129 orexin receptor activity molecular_function "Combining with orexin to initiate a change in cell activity." [GOC:ai] EOG8FFGGB GO:0007631 5/129 feeding behavior biological_process "Behavior associated with the intake of food." [GOC:mah] EOG8FFGGB GO:0004983 5/129 neuropeptide Y receptor activity molecular_function "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] EOG8FFGGB GO:0004715 1/129 non-membrane spanning protein tyrosine kinase activity molecular_function "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2] EOG8FFGGB GO:0003723 1/129 RNA binding molecular_function "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] EOG8FFGGB GO:0050254 1/129 rhodopsin kinase activity molecular_function "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] EOG8FFGGB GO:0003964 1/129 RNA-directed DNA polymerase activity molecular_function "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] EOG8T4G8V GO:0018095 38/135 protein polyglutamylation biological_process "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202] EOG8T4G8V GO:0004835 3/135 tubulin-tyrosine ligase activity molecular_function "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] EOG8T4G8V GO:0042060 1/135 wound healing biological_process "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] EOG8T4G8V GO:0022008 1/135 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8M0HJ0 GO:0005549 3/58 odorant binding molecular_function "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] EOG8V19GG GO:0007218 1/73 neuropeptide signaling pathway biological_process "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] EOG8V19GG GO:0005179 1/73 hormone activity molecular_function "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] EOG8V19GG GO:0045968 1/73 negative regulation of juvenile hormone biosynthetic process biological_process "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] EOG8V19GG GO:0005184 1/73 neuropeptide hormone activity molecular_function "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] EOG8V19GG GO:0005102 1/73 receptor binding molecular_function "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] EOG8V19GG GO:0071855 1/73 neuropeptide receptor binding molecular_function "Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah] EOG8V19GG GO:0005576 1/73 extracellular region cellular_component "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] EOG8PVRF4 GO:0007165 2/16 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8PVRF4 GO:0005622 2/16 intracellular cellular_component "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] EOG8DBWXS GO:0022008 1/101 neurogenesis biological_process "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] EOG8ZCWJP GO:0004930 20/63 G-protein coupled receptor activity molecular_function "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] EOG8ZCWJP GO:0016055 19/63 Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] EOG8ZCWJP GO:0007275 19/63 multicellular organismal development biological_process "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] EOG8ZCWJP GO:0016021 17/63 integral component of membrane cellular_component "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] EOG8ZCWJP GO:0016020 3/63 membrane cellular_component "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] EOG8ZCWJP GO:0005886 1/63 plasma membrane cellular_component "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] EOG8ZCWJP GO:0042995 1/63 cell projection cellular_component "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] EOG8ZCWJP GO:0017147 1/63 Wnt-protein binding molecular_function "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] EOG8ZCWJP GO:0060070 1/63 canonical Wnt signaling pathway biological_process "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488] EOG8ZCWJP GO:0007420 1/63 brain development biological_process "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] EOG8ZCWJP GO:0030165 1/63 PDZ domain binding molecular_function "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] EOG8ZCWJP GO:0007165 1/63 signal transduction biological_process "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] EOG8ZCWJP GO:0004888 1/63 transmembrane signaling receptor activity molecular_function "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:go_curators, Wikipedia:Transmembrane_receptor] EOG8ZCWJP GO:0042813 1/63 Wnt-activated receptor activity molecular_function "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators] EOG8ZCWJP GO:0001944 1/63 vasculature development biological_process "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] EOG8ZCWJP GO:0008406 1/63 gonad development biological_process "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] EOG8ZCWJP GO:0005737 1/63 cytoplasm cellular_component "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]