GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
GO:0004518	nuclease activity	Gains
GO:0004521	endoribonuclease activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0004519	endonuclease activity	Gains
GO:0004064	arylesterase activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0008270	zinc ion binding	Gains
GO:0004540	ribonuclease activity	Gains
GO:0004965	G-protein coupled GABA receptor activity	Gains
GO:0004447	iodide peroxidase activity	Gains
GO:0005549	odorant binding	Gains
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	Gains
GO:0005201	extracellular matrix structural constituent	Gains
GO:0072509	divalent inorganic cation transmembrane transporter activity	Gains
GO:0005216	ion channel activity	Gains
GO:0005488	binding	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0004869	cysteine-type endopeptidase inhibitor activity	Gains
GO:0016917	GABA receptor activity	Gains
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Gains
GO:0046873	metal ion transmembrane transporter activity	Gains
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0015036	disulfide oxidoreductase activity	Gains
GO:0015081	sodium ion transmembrane transporter activity	Gains
GO:0003723	RNA binding	Gains
GO:0019955	cytokine binding	Gains
GO:0004035	alkaline phosphatase activity	Gains
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Gains
GO:0030151	molybdenum ion binding	Gains
GO:0005328	neurotransmitter:sodium symporter activity	Gains
GO:0005261	cation channel activity	Gains
GO:0061134	peptidase regulator activity	Gains
GO:0061135	endopeptidase regulator activity	Gains
GO:0003968	RNA-directed 5'-3' RNA polymerase activity	Gains
GO:0015294	solute:cation symporter activity	Gains
GO:0003939	L-iditol 2-dehydrogenase activity	Gains
GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
GO:0004971	AMPA glutamate receptor activity	Gains
GO:0008332	low voltage-gated calcium channel activity	Gains
GO:0015095	magnesium ion transmembrane transporter activity	Gains
GO:0043546	molybdopterin cofactor binding	Gains
GO:0008198	ferrous iron binding	Gains
GO:0018492	carbon-monoxide dehydrogenase (acceptor) activity	Gains
GO:0004427	inorganic diphosphatase activity	Gains
GO:0015154	disaccharide transmembrane transporter activity	Gains
GO:0015157	oligosaccharide transmembrane transporter activity	Gains
GO:0004820	glycine-tRNA ligase activity	Gains
GO:0015370	solute:sodium symporter activity	Gains
GO:0099600	transmembrane receptor activity	Losses
GO:0038023	signaling receptor activity	Losses
GO:0004872	receptor activity	Losses
GO:0004888	transmembrane signaling receptor activity	Losses
GO:0004871	signal transducer activity	Losses
GO:0060089	molecular transducer activity	Losses
GO:0004930	G-protein coupled receptor activity	Losses
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GO:0008324	cation transmembrane transporter activity	Losses
GO:0022890	inorganic cation transmembrane transporter activity	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0019199	transmembrane receptor protein kinase activity	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0015078	hydrogen ion transmembrane transporter activity	Losses
GO:0015002	heme-copper terminal oxidase activity	Losses
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
GO:0004129	cytochrome-c oxidase activity	Losses
GO:0008528	G-protein coupled peptide receptor activity	Losses
GO:0001653	peptide receptor activity	Losses
GO:0005242	inward rectifier potassium channel activity	Losses
GO:0022892	substrate-specific transporter activity	Losses
GO:0008238	exopeptidase activity	Losses
GO:0004713	protein tyrosine kinase activity	Losses
GO:0008271	secondary active sulfate transmembrane transporter activity	Losses
GO:0009055	electron transfer activity	Losses
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Losses
GO:0005215	transporter activity	Losses
GO:0004180	carboxypeptidase activity	Losses
GO:0030234	enzyme regulator activity	Losses
GO:0061134	peptidase regulator activity	Losses
GO:0008484	sulfuric ester hydrolase activity	Losses
GO:0015116	sulfate transmembrane transporter activity	Losses
GO:0004672	protein kinase activity	Losses
GO:0030414	peptidase inhibitor activity	Losses
GO:0008047	enzyme activator activity	Losses
GO:0098772	molecular function regulator	Losses
GO:0008188	neuropeptide receptor activity	Losses
GO:0016917	GABA receptor activity	Losses
GO:0022804	active transmembrane transporter activity	Losses
GO:0015291	secondary active transmembrane transporter activity	Losses
GO:0016301	kinase activity	Losses
GO:0046873	metal ion transmembrane transporter activity	Losses
GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
GO:0005261	cation channel activity	Losses
GO:0004849	uridine kinase activity	Losses
GO:0016215	acyl-CoA desaturase activity	Losses
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	Losses
GO:0030296	protein tyrosine kinase activator activity	Losses
GO:0004768	stearoyl-CoA 9-desaturase activity	Losses
GO:0004784	superoxide dismutase activity	Losses
GO:0001786	phosphatidylserine binding	Losses
GO:0004857	enzyme inhibitor activity	Losses
GO:0009881	photoreceptor activity	Losses
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Losses
GO:0016209	antioxidant activity	Losses
GO:0022803	passive transmembrane transporter activity	Losses
GO:0015267	channel activity	Losses
GO:0005267	potassium channel activity	Losses
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Losses
GO:0004952	dopamine neurotransmitter receptor activity	Losses
GO:0016500	protein-hormone receptor activity	Losses
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Losses
GO:0008241	peptidyl-dipeptidase activity	Losses
GO:0003700	DNA binding transcription factor activity	Losses
GO:0016798	hydrolase activity, acting on glycosyl bonds	Losses
GO:0008235	metalloexopeptidase activity	Losses
GO:0004866	endopeptidase inhibitor activity	Losses
GO:0005216	ion channel activity	Losses
GO:0022838	substrate-specific channel activity	Losses
GO:0008237	metallopeptidase activity	Losses
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Losses
GO:0005024	transforming growth factor beta-activated receptor activity	Losses
GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Losses
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	Losses
GO:0072341	modified amino acid binding	Losses
GO:0019209	kinase activator activity	Losses
GO:0030295	protein kinase activator activity	Losses
GO:0099094	ligand-gated cation channel activity	Losses
GO:0008484	sulfuric ester hydrolase activity	Extinctions
GO:0004930	G-protein coupled receptor activity	Extinctions
GO:0005242	inward rectifier potassium channel activity	Extinctions
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Extinctions
GO:0005024	transforming growth factor beta-activated receptor activity	Extinctions
GO:0030545	receptor regulator activity	Extinctions
GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
GO:1902936	phosphatidylinositol bisphosphate binding	Extinctions
GO:0031544	peptidyl-proline 3-dioxygenase activity	Extinctions
GO:0051721	protein phosphatase 2A binding	Extinctions
GO:0050262	ribosylnicotinamide kinase activity	Extinctions
GO:0016250	N-sulfoglucosamine sulfohydrolase activity	Extinctions
GO:0072542	protein phosphatase activator activity	Extinctions
GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity	Extinctions
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	Extinctions
GO:0032542	sulfiredoxin activity	Extinctions
GO:0016826	hydrolase activity, acting on acid sulfur-nitrogen bonds	Extinctions
GO:0052856	NADHX epimerase activity	Extinctions
GO:0008160	protein tyrosine phosphatase activator activity	Extinctions
GO:0004423	iduronate-2-sulfatase activity	Extinctions
GO:0034235	GPI anchor binding	Extinctions
GO:0005213	structural constituent of chorion	Extinctions
GO:0019211	phosphatase activator activity	Extinctions
GO:0016034	maleylacetoacetate isomerase activity	Extinctions
GO:0008881	glutamate racemase activity	Extinctions
GO:0008873	gluconate 2-dehydrogenase activity	Extinctions
GO:0008875	gluconate dehydrogenase activity	Extinctions
GO:0019797	procollagen-proline 3-dioxygenase activity	Extinctions
GO:0008815	citrate (pro-3S)-lyase activity	Extinctions
GO:0008816	citryl-CoA lyase activity	Extinctions
GO:0018271	biotin-protein ligase activity	Extinctions
GO:0099600	transmembrane receptor activity	Extinctions
GO:0098772	molecular function regulator	Extinctions