Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00002 0 1 0 0 0 0 PF00004 PF00439 1 0 0 0 0 0 PF00027 0 1 0 0 0 0 PF00063 PF00612 PF00784 1 0 3 0 0 0 PF00063 PF06017 1 0 0 0 0 0 PF00069 0 1 0 0 0 0 PF00069 PF00566 1 0 0 0 0 0 PF00069 PF08912 1 0 0 0 0 0 PF00071 PF07525 1 0 0 0 0 0 PF00076 0 1 0 0 0 0 PF00076 PF00646 1 0 0 0 0 0 PF00085 PF06201 1 0 0 0 0 0 PF00089 0 1 0 0 0 0 PF00094 0 1 0 0 0 0 PF00122 PF00702 0 1 0 0 0 0 PF00130 PF00620 1 0 0 0 0 0 PF00153 PF00059 1 0 0 0 0 0 PF00156 PF00215 1 0 0 0 0 0 PF00168 0 1 0 0 0 0 PF00169 PF01363 1 0 0 0 0 0 PF00240 PF00627 1 0 2 0 0 0 PF00240 PF02544 1 0 0 0 0 0 PF00254 PF07719 1 0 0 0 0 0 PF00267 0 0 0 0 1 0 PF00270 PF00271 PF00476 1 0 0 0 0 0 PF00275 0 0 0 0 1 0 PF00307 0 1 0 0 0 0 PF00313 PF00098 1 0 0 0 0 0 PF00341 0 1 0 0 0 0 PF00358 0 0 0 0 1 0 PF00373 PF09380 PF00595 1 0 0 0 0 0 PF00389 0 0 0 0 1 0 PF00397 PF00595 PF00373 1 0 0 0 0 0 PF00400 PF00160 1 0 0 0 0 0 PF00400 PF00439 1 0 0 0 0 0 PF00403 0 1 0 0 0 0 PF00412 PF02209 1 0 0 0 0 0 PF00419 0 0 0 0 1 0 PF00496 0 0 0 0 1 0 PF00498 PF00069 1 0 0 0 0 0 PF00498 PF01585 1 0 0 0 0 0 PF00498 PF13086 PF13087 1 0 0 0 0 0 PF00498 PF13920 1 0 0 0 0 0 PF00528 0 0 0 0 1 0 PF00566 PF07534 1 0 0 0 0 0 PF00579 PF01588 1 0 0 0 0 0 PF00595 PF01369 PF15410 1 0 0 0 0 0 PF00595 PF15936 PF00412 1 0 0 0 0 0 PF00609 0 0 4 0 0 0 PF00611 PF14604 1 0 0 0 0 0 PF00616 PF02204 1 0 0 0 0 0 PF00627 PF00069 1 0 0 0 0 0 PF00628 PF13621 1 0 0 0 0 0 PF00630 PF05686 1 0 0 0 0 0 PF00651 0 2 0 0 0 0 PF00675 PF05193 PF08367 1 0 0 0 0 0 PF00732 PF05199 PF00732 PF05199 1 0 0 0 0 0 PF00750 PF05746 0 0 1 0 0 0 PF00771 0 0 0 0 1 0 PF00787 PF00069 1 0 0 0 0 0 PF00792 PF00613 PF00454 1 0 1 0 0 0 PF00793 0 0 0 0 1 0 PF00856 PF01426 1 0 0 0 0 0 PF00873 0 0 0 0 1 0 PF00899 PF00581 1 0 0 0 0 0 PF00990 0 0 0 0 1 0 PF01011 0 0 0 0 1 0 PF01032 0 0 0 0 1 0 PF01074 PF09261 0 1 0 0 0 0 PF01094 PF07714 1 0 0 0 0 0 PF01306 0 0 0 0 1 0 PF01347 PF09172 0 1 0 0 0 0 PF01403 PF00090 1 0 0 0 0 0 PF01422 PF01424 1 0 0 0 0 0 PF01467 PF01121 1 0 0 0 0 0 PF01498 PF13358 1 0 0 0 0 0 PF01523 0 0 0 0 1 0 PF01585 PF00076 1 0 0 0 0 0 PF01602 PF02883 0 0 1 0 0 0 PF01717 0 0 0 0 1 0 PF01753 PF04194 1 0 0 0 0 0 PF01756 0 1 0 0 0 0 PF01977 0 0 0 0 1 0 PF02028 0 0 0 0 1 0 PF02037 0 1 0 0 0 0 PF02078 PF02750 1 0 0 0 0 0 PF02145 PF00780 1 0 0 0 0 0 PF02178 0 1 0 0 0 0 PF02197 0 1 0 0 0 0 PF02264 0 0 0 0 1 0 PF02302 0 0 0 0 1 0 PF02383 0 1 0 0 0 0 PF02384 0 0 0 0 1 0 PF02403 PF00587 1 0 0 0 0 0 PF02425 0 0 0 0 0 1 PF02525 0 0 0 0 1 0 PF02575 0 0 0 0 1 0 PF02609 0 0 0 0 1 0 PF02624 0 0 0 0 1 0 PF02653 0 0 0 0 1 0 PF02755 0 1 0 0 0 0 PF02759 0 1 0 0 0 0 PF02825 PF00632 1 0 0 0 0 0 PF02854 PF02847 1 0 0 0 0 0 PF02921 PF00355 0 0 1 0 0 0 PF02985 PF13646 1 0 0 0 0 0 PF03128 0 1 0 0 0 0 PF03180 0 0 0 0 1 0 PF03279 0 0 0 0 1 0 PF03455 0 1 0 0 0 0 PF03456 PF02141 0 1 0 0 0 0 PF03607 0 1 0 0 0 0 PF03810 PF13513 PF02985 1 0 0 0 0 0 PF03960 0 0 0 0 1 0 PF04088 0 1 0 0 0 0 PF04261 0 0 0 0 1 0 PF04293 0 0 0 0 1 0 PF04810 PF04811 PF08033 PF04815 PF00626 1 0 0 0 0 0 PF04937 0 0 0 0 1 0 PF05225 PF03184 1 0 0 0 0 0 PF05591 0 0 0 0 1 0 PF05605 0 1 1 0 0 0 PF06039 0 0 0 0 1 0 PF06220 PF00397 1 0 0 0 0 0 PF06468 PF00090 1 0 0 0 0 0 PF06585 0 1 0 0 0 0 PF06652 0 1 0 0 0 0 PF07679 PF00047 1 0 0 0 0 0 PF07679 PF07714 1 0 0 0 0 0 PF07686 PF08205 1 0 0 0 0 0 PF07686 PF13927 PF08205 PF13927 1 0 0 0 0 0 PF07707 0 1 0 0 0 0 PF07714 PF07701 PF00211 1 0 0 0 0 0 PF07748 0 1 0 0 0 0 PF07776 PF00096 PF13894 1 0 0 0 0 0 PF07776 PF13912 PF00096 1 0 0 0 0 0 PF07885 PF03493 1 0 0 0 0 0 PF07898 PF07841 1 0 0 0 0 0 PF08241 PF12589 1 0 0 0 0 0 PF08786 0 0 0 0 1 0 PF09409 PF00789 1 0 0 0 0 0 PF09457 0 1 0 0 0 0 PF09791 PF00970 PF00175 1 0 0 0 0 0 PF10242 PF03148 1 0 0 0 0 0 PF12032 0 1 0 0 0 0 PF12171 PF12756 1 0 0 0 0 0 PF12456 0 1 0 0 0 0 PF12510 0 1 0 0 0 0 PF12762 0 0 0 0 1 0 PF12796 PF00013 1 0 0 0 0 0 PF12796 PF00018 1 0 0 0 0 0 PF12833 0 0 0 0 1 0 PF12874 0 1 0 0 0 0 PF12937 PF00179 1 0 0 0 0 0 PF13181 PF00515 1 0 0 0 0 0 PF13377 0 0 0 0 1 0 PF13499 PF01694 1 0 0 0 0 0 PF13499 PF13833 1 0 0 0 0 0 PF13510 PF10588 PF00384 0 0 1 0 0 0 PF13622 0 0 0 0 1 0 PF13638 0 1 0 0 0 0 PF13855 PF00001 1 0 0 0 0 0 PF13855 PF13306 PF13855 PF01582 1 0 0 0 0 0 PF13865 0 1 0 0 0 0 PF13901 0 1 0 0 0 0 PF13912 PF13894 PF13912 1 0 0 0 0 0 PF13927 PF07679 PF13927 1 0 0 0 0 0 PF13927 PF07679 PF13927 PF00041 1 0 0 0 0 0 PF14237 PF00226 1 0 0 0 0 0 PF14486 0 0 0 0 1 0 PF14555 PF00789 1 0 0 0 0 0 PF14555 PF03556 1 0 0 0 0 0 PF14604 0 1 0 0 0 0 PF14604 PF08824 PF12026 1 0 0 0 0 0 PF14749 PF02770 0 1 0 0 0 0 PF14924 0 1 0 0 0 0 PF16003 0 1 0 0 0 0 PF16275 PF00013 PF00098 1 0 0 0 0 0 PF16399 PF13086 1 0 0 0 0 0 PF16984 0 1 0 0 0 0 PF17180 0 0 1 0 0 0 PF17216 PF00773 0 1 0 0 0 0