GO:0004252	serine-type endopeptidase activity	Gains
GO:0008236	serine-type peptidase activity	Gains
GO:0017171	serine hydrolase activity	Gains
GO:0008233	peptidase activity	Gains
GO:0004175	endopeptidase activity	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0042302	structural constituent of cuticle	Gains
GO:0005549	odorant binding	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0038023	signaling receptor activity	Gains
GO:0030165	PDZ domain binding	Gains
GO:0008812	choline dehydrogenase activity	Gains
GO:0045505	dynein intermediate chain binding	Gains
GO:0003939	L-iditol 2-dehydrogenase activity	Gains
GO:0005042	netrin receptor activity	Gains
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
GO:0004867	serine-type endopeptidase inhibitor activity	Gains
GO:0004181	metallocarboxypeptidase activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0000340	RNA 7-methylguanosine cap binding	Gains
GO:0004872	receptor activity	Gains
GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Gains
GO:0017110	nucleoside-diphosphatase activity	Gains
GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	Gains
GO:0045134	uridine-diphosphatase activity	Gains
GO:0003824	catalytic activity	Losses
GO:0005215	transporter activity	Losses
GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Losses
GO:0016740	transferase activity	Losses
GO:0016772	transferase activity, transferring phosphorus-containing groups	Losses
GO:0030554	adenyl nucleotide binding	Losses
GO:0005524	ATP binding	Losses
GO:0032559	adenyl ribonucleotide binding	Losses
GO:0015144	carbohydrate transmembrane transporter activity	Losses
GO:0051119	sugar transmembrane transporter activity	Losses
GO:0043168	anion binding	Losses
GO:0140097	catalytic activity, acting on DNA	Losses
GO:0015295	solute:proton symporter activity	Losses
GO:0005351	sugar:proton symporter activity	Losses
GO:0005402	cation:sugar symporter activity	Losses
GO:0016779	nucleotidyltransferase activity	Losses
GO:0097367	carbohydrate derivative binding	Losses
GO:0015291	secondary active transmembrane transporter activity	Losses
GO:0015293	symporter activity	Losses
GO:0017076	purine nucleotide binding	Losses
GO:0036094	small molecule binding	Losses
GO:0022804	active transmembrane transporter activity	Losses
GO:0003725	double-stranded RNA binding	Losses
GO:0035639	purine ribonucleoside triphosphate binding	Losses
GO:0032555	purine ribonucleotide binding	Losses
GO:0032553	ribonucleotide binding	Losses
GO:0015294	solute:cation symporter activity	Losses
GO:0000156	phosphorelay response regulator activity	Losses
GO:0034061	DNA polymerase activity	Losses
GO:0019842	vitamin binding	Losses
GO:0022857	transmembrane transporter activity	Losses
GO:0016491	oxidoreductase activity	Losses
GO:0003964	RNA-directed DNA polymerase activity	Losses
GO:0008324	cation transmembrane transporter activity	Losses
GO:0017111	nucleoside-triphosphatase activity	Losses
GO:0016829	lyase activity	Losses
GO:0008475	procollagen-lysine 5-dioxygenase activity	Losses
GO:0016887	ATPase activity	Losses
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Losses
GO:0016787	hydrolase activity	Losses
GO:0015075	ion transmembrane transporter activity	Losses
GO:0016462	pyrophosphatase activity	Losses
GO:0004518	nuclease activity	Losses
GO:0016849	phosphorus-oxygen lyase activity	Losses
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Losses
GO:0022892	substrate-specific transporter activity	Losses
GO:1901265	nucleoside phosphate binding	Losses
GO:0000166	nucleotide binding	Losses
GO:0016817	hydrolase activity, acting on acid anhydrides	Losses
GO:0005245	voltage-gated calcium channel activity	Losses
GO:0004525	ribonuclease III activity	Losses
GO:0032296	double-stranded RNA-specific ribonuclease activity	Losses
GO:0005343	organic acid:sodium symporter activity	Losses
GO:0030170	pyridoxal phosphate binding	Losses
GO:0070279	vitamin B6 binding	Losses
GO:0003700	DNA binding transcription factor activity	Losses
GO:0004519	endonuclease activity	Losses
GO:0048037	cofactor binding	Losses
GO:0004565	beta-galactosidase activity	Losses
GO:1901618	organic hydroxy compound transmembrane transporter activity	Losses
GO:0070815	peptidyl-lysine 5-dioxygenase activity	Losses
GO:0005262	calcium channel activity	Losses
GO:0046873	metal ion transmembrane transporter activity	Losses
GO:0015085	calcium ion transmembrane transporter activity	Losses
GO:0046914	transition metal ion binding	Losses
GO:0051213	dioxygenase activity	Losses
GO:0003993	acid phosphatase activity	Losses
GO:0043167	ion binding	Losses
GO:0022891	substrate-specific transmembrane transporter activity	Losses
GO:0015297	antiporter activity	Losses
GO:0072509	divalent inorganic cation transmembrane transporter activity	Losses
GO:0008514	organic anion transmembrane transporter activity	Losses
GO:0034483	heparan sulfate sulfotransferase activity	Losses
GO:0015925	galactosidase activity	Losses
GO:0008509	anion transmembrane transporter activity	Losses
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Losses
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Losses
GO:0099516	ion antiporter activity	Losses
GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	Losses
GO:0070001	aspartic-type peptidase activity	Losses
GO:0004190	aspartic-type endopeptidase activity	Losses
GO:0016763	transferase activity, transferring pentosyl groups	Losses
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Losses
GO:0005548	phospholipid transporter activity	Losses
GO:0008519	ammonium transmembrane transporter activity	Losses
GO:0017153	sodium:dicarboxylate symporter activity	Losses
GO:0004012	phospholipid-translocating ATPase activity	Losses
GO:0008270	zinc ion binding	Losses
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	Losses
GO:0031406	carboxylic acid binding	Losses
GO:0043177	organic acid binding	Losses
GO:0008982	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	Extinctions
GO:0005215	transporter activity	Extinctions
GO:0015295	solute:proton symporter activity	Extinctions
GO:0005351	sugar:proton symporter activity	Extinctions
GO:0005402	cation:sugar symporter activity	Extinctions
GO:0015144	carbohydrate transmembrane transporter activity	Extinctions
GO:0051119	sugar transmembrane transporter activity	Extinctions
GO:0015294	solute:cation symporter activity	Extinctions
GO:0003824	catalytic activity	Extinctions
GO:0016829	lyase activity	Extinctions
GO:0015293	symporter activity	Extinctions
GO:0000156	phosphorelay response regulator activity	Extinctions
GO:0015291	secondary active transmembrane transporter activity	Extinctions
GO:0016849	phosphorus-oxygen lyase activity	Extinctions
GO:0000155	phosphorelay sensor kinase activity	Extinctions
GO:0004673	protein histidine kinase activity	Extinctions
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	Extinctions
GO:0016763	transferase activity, transferring pentosyl groups	Extinctions
GO:0022804	active transmembrane transporter activity	Extinctions
GO:0016887	ATPase activity	Extinctions
GO:0017153	sodium:dicarboxylate symporter activity	Extinctions
GO:0016491	oxidoreductase activity	Extinctions
GO:0003700	DNA binding transcription factor activity	Extinctions
GO:0030976	thiamine pyrophosphate binding	Extinctions
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Extinctions
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	Extinctions
GO:0017111	nucleoside-triphosphatase activity	Extinctions
GO:0005343	organic acid:sodium symporter activity	Extinctions
GO:0140097	catalytic activity, acting on DNA	Extinctions
GO:0140104	molecular carrier activity	Extinctions
GO:0016462	pyrophosphatase activity	Extinctions
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Extinctions
GO:0016817	hydrolase activity, acting on acid anhydrides	Extinctions
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	Extinctions
GO:0015296	anion:cation symporter activity	Extinctions
GO:0050662	coenzyme binding	Extinctions
GO:0004107	chorismate synthase activity	Extinctions
GO:0008861	formate C-acetyltransferase activity	Extinctions
GO:0015665	alcohol transmembrane transporter activity	Extinctions
GO:0042925	benzoate transmembrane transporter activity	Extinctions
GO:0008811	chloramphenicol O-acetyltransferase activity	Extinctions
GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	Extinctions
GO:0033862	UMP kinase activity	Extinctions
GO:0008690	3-deoxy-manno-octulosonate cytidylyltransferase activity	Extinctions
GO:0000234	phosphoethanolamine N-methyltransferase activity	Extinctions
GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	Extinctions
GO:0043914	NADPH:sulfur oxidoreductase activity	Extinctions
GO:0008964	phosphoenolpyruvate carboxylase activity	Extinctions
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	Extinctions
GO:0008974	phosphoribulokinase activity	Extinctions
GO:0008976	polyphosphate kinase activity	Extinctions
GO:0008922	long-chain fatty acid [acyl-carrier-protein] ligase activity	Extinctions
GO:0052657	guanine phosphoribosyltransferase activity	Extinctions
GO:0009381	excinuclease ABC activity	Extinctions
GO:0016987	sigma factor activity	Extinctions
GO:0030743	rRNA (adenosine-2'-O-)-methyltransferase activity	Extinctions
GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	Extinctions
GO:0015166	polyol transmembrane transporter activity	Extinctions
GO:0000990	transcription factor activity, core RNA polymerase binding	Extinctions
GO:0000996	core DNA-dependent RNA polymerase binding promoter specificity activity	Extinctions
GO:0004397	histidine ammonia-lyase activity	Extinctions
GO:0030604	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Extinctions
GO:0034986	iron chaperone activity	Extinctions
GO:0004455	ketol-acid reductoisomerase activity	Extinctions
GO:0004422	hypoxanthine phosphoribosyltransferase activity	Extinctions
GO:0045148	tripeptide aminopeptidase activity	Extinctions
GO:0003864	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	Extinctions
GO:0008760	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity	Extinctions
GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity	Extinctions
GO:0015577	galactitol transmembrane transporter activity	Extinctions
GO:0003964	RNA-directed DNA polymerase activity	Extinctions
GO:0048037	cofactor binding	Extinctions
GO:0008514	organic anion transmembrane transporter activity	Extinctions
GO:0016798	hydrolase activity, acting on glycosyl bonds	Extinctions
GO:0022857	transmembrane transporter activity	Extinctions
GO:0004523	RNA-DNA hybrid ribonuclease activity	Extinctions
GO:0005310	dicarboxylic acid transmembrane transporter activity	Extinctions
GO:0034061	DNA polymerase activity	Extinctions
GO:0008324	cation transmembrane transporter activity	Extinctions
GO:0016779	nucleotidyltransferase activity	Extinctions
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	Extinctions
GO:0050661	NADP binding	Extinctions