GO:0004161	dimethylallyltranstransferase activity	Gains
GO:0004659	prenyltransferase activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0034061	DNA polymerase activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	Gains
GO:0008381	mechanically-gated ion channel activity	Gains
GO:0008384	IkappaB kinase activity	Gains
GO:0004337	geranyltranstransferase activity	Gains
GO:0022833	mechanically gated channel activity	Gains
GO:0008061	chitin binding	Gains
GO:0004713	protein tyrosine kinase activity	Gains
GO:0043167	ion binding	Gains
GO:0005085	guanyl-nucleotide exchange factor activity	Gains
GO:0016758	transferase activity, transferring hexosyl groups	Gains
GO:0043169	cation binding	Gains
GO:0004497	monooxygenase activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0008378	galactosyltransferase activity	Gains
GO:0046914	transition metal ion binding	Gains
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Gains
GO:0020037	heme binding	Gains
GO:0046872	metal ion binding	Gains
GO:0046906	tetrapyrrole binding	Gains
GO:0030976	thiamine pyrophosphate binding	Gains
GO:0030798	trans-aconitate 2-methyltransferase activity	Gains
GO:0017048	Rho GTPase binding	Gains
GO:0016757	transferase activity, transferring glycosyl groups	Gains
GO:0016740	transferase activity	Gains
GO:0004672	protein kinase activity	Gains
GO:0019899	enzyme binding	Gains
GO:0019199	transmembrane receptor protein kinase activity	Gains
GO:0004004	ATP-dependent RNA helicase activity	Gains
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Losses
GO:0015078	hydrogen ion transmembrane transporter activity	Losses
GO:0008134	transcription factor binding	Losses
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Losses
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	Losses
GO:0070491	repressing transcription factor binding	Losses
GO:0015002	heme-copper terminal oxidase activity	Losses
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Losses
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Losses
GO:0004129	cytochrome-c oxidase activity	Losses
GO:0009881	photoreceptor activity	Losses
GO:0005198	structural molecule activity	Losses
GO:0033218	amide binding	Losses
GO:0016854	racemase and epimerase activity	Losses
GO:0016788	hydrolase activity, acting on ester bonds	Losses
GO:0008135	translation factor activity, RNA binding	Losses
GO:0042277	peptide binding	Losses
GO:0003735	structural constituent of ribosome	Losses
GO:0044389	ubiquitin-like protein ligase binding	Losses
GO:0017150	tRNA dihydrouridine synthase activity	Losses
GO:0015368	calcium:cation antiporter activity	Losses
GO:0031625	ubiquitin protein ligase binding	Losses
GO:0022821	potassium ion antiporter activity	Losses
GO:0005272	sodium channel activity	Losses
GO:0022890	inorganic cation transmembrane transporter activity	Losses
GO:0042562	hormone binding	Losses
GO:0003743	translation initiation factor activity	Losses
GO:0004620	phospholipase activity	Losses
GO:0046961	proton-transporting ATPase activity, rotational mechanism	Losses
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Losses
GO:0036442	hydrogen-exporting ATPase activity	Losses
GO:0016877	ligase activity, forming carbon-sulfur bonds	Losses
GO:0052689	carboxylic ester hydrolase activity	Losses
GO:0004597	peptide-aspartate beta-dioxygenase activity	Losses
GO:0004503	monophenol monooxygenase activity	Losses
GO:0032033	myosin II light chain binding	Losses
GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Losses
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Losses
GO:0004033	aldo-keto reductase (NADP) activity	Losses
GO:0008445	D-aspartate oxidase activity	Losses
GO:0015922	aspartate oxidase activity	Losses
GO:0009882	blue light photoreceptor activity	Losses
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	Losses
GO:0008106	alcohol dehydrogenase (NADP+) activity	Losses
GO:0008273	calcium, potassium:sodium antiporter activity	Losses
GO:0004305	ethanolamine kinase activity	Losses
GO:0003858	3-hydroxybutyrate dehydrogenase activity	Losses
GO:0003884	D-amino-acid oxidase activity	Losses
GO:0004103	choline kinase activity	Losses
GO:0008545	JUN kinase kinase activity	Losses
GO:0050833	pyruvate transmembrane transporter activity	Losses
GO:0001221	transcription cofactor binding	Losses
GO:0001224	RNA polymerase II transcription cofactor binding	Losses
GO:0008641	ubiquitin-like modifier activating enzyme activity	Losses
GO:0016298	lipase activity	Losses
GO:0016411	acylglycerol O-acyltransferase activity	Losses
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	Losses
GO:0030234	enzyme regulator activity	Losses
GO:0008195	phosphatidate phosphatase activity	Losses
GO:0004623	phospholipase A2 activity	Losses
GO:0015078	hydrogen ion transmembrane transporter activity	Extinctions
GO:0015077	monovalent inorganic cation transmembrane transporter activity	Extinctions
GO:0016854	racemase and epimerase activity	Extinctions
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	Extinctions
GO:0003735	structural constituent of ribosome	Extinctions
GO:0008134	transcription factor binding	Extinctions
GO:0070491	repressing transcription factor binding	Extinctions
GO:0016877	ligase activity, forming carbon-sulfur bonds	Extinctions
GO:0017150	tRNA dihydrouridine synthase activity	Extinctions
GO:0015368	calcium:cation antiporter activity	Extinctions
GO:0022821	potassium ion antiporter activity	Extinctions
GO:0015002	heme-copper terminal oxidase activity	Extinctions
GO:0016675	oxidoreductase activity, acting on a heme group of donors	Extinctions
GO:0016676	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	Extinctions
GO:0004129	cytochrome-c oxidase activity	Extinctions
GO:0003743	translation initiation factor activity	Extinctions
GO:0004623	phospholipase A2 activity	Extinctions
GO:0008641	ubiquitin-like modifier activating enzyme activity	Extinctions
GO:0008135	translation factor activity, RNA binding	Extinctions
GO:0004597	peptide-aspartate beta-dioxygenase activity	Extinctions
GO:0008445	D-aspartate oxidase activity	Extinctions
GO:0015922	aspartate oxidase activity	Extinctions
GO:0008273	calcium, potassium:sodium antiporter activity	Extinctions
GO:0004305	ethanolamine kinase activity	Extinctions
GO:0003858	3-hydroxybutyrate dehydrogenase activity	Extinctions
GO:0003884	D-amino-acid oxidase activity	Extinctions
GO:0004103	choline kinase activity	Extinctions
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	Extinctions
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	Extinctions
GO:0036442	hydrogen-exporting ATPase activity	Extinctions
GO:0046961	proton-transporting ATPase activity, rotational mechanism	Extinctions