GO:0003964 RNA-directed DNA polymerase activity Gains GO:0070001 aspartic-type peptidase activity Gains GO:0004190 aspartic-type endopeptidase activity Gains GO:0015291 secondary active transmembrane transporter activity Gains GO:0015075 ion transmembrane transporter activity Gains GO:0022857 transmembrane transporter activity Gains GO:0005215 transporter activity Gains GO:0022892 substrate-specific transporter activity Gains GO:0022804 active transmembrane transporter activity Gains GO:0034061 DNA polymerase activity Gains GO:0022891 substrate-specific transmembrane transporter activity Gains GO:0015293 symporter activity Gains GO:0046873 metal ion transmembrane transporter activity Gains GO:0016772 transferase activity, transferring phosphorus-containing groups Gains GO:0015081 sodium ion transmembrane transporter activity Gains GO:0005509 calcium ion binding Gains GO:0008324 cation transmembrane transporter activity Gains GO:0015294 solute:cation symporter activity Gains GO:0004857 enzyme inhibitor activity Gains GO:0016740 transferase activity Gains GO:0004674 protein serine/threonine kinase activity Gains GO:0022890 inorganic cation transmembrane transporter activity Gains GO:0008509 anion transmembrane transporter activity Gains GO:0015370 solute:sodium symporter activity Gains GO:0004984 olfactory receptor activity Gains GO:0030234 enzyme regulator activity Gains GO:0004672 protein kinase activity Gains GO:0008092 cytoskeletal protein binding Gains GO:0050839 cell adhesion molecule binding Gains GO:0022836 gated channel activity Gains GO:0004725 protein tyrosine phosphatase activity Gains GO:0004180 carboxypeptidase activity Gains GO:0072509 divalent inorganic cation transmembrane transporter activity Gains GO:0015296 anion:cation symporter activity Gains GO:0015103 inorganic anion transmembrane transporter activity Gains GO:0030414 peptidase inhibitor activity Gains GO:0099516 ion antiporter activity Gains GO:0022838 substrate-specific channel activity Gains GO:0008603 cAMP-dependent protein kinase regulator activity Gains GO:0004691 cAMP-dependent protein kinase activity Gains GO:0031683 G-protein beta/gamma-subunit complex binding Gains GO:0004344 glucose dehydrogenase activity Gains GO:0015267 channel activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0019899 enzyme binding Gains GO:0005216 ion channel activity Gains GO:0032403 protein complex binding Gains GO:0015085 calcium ion transmembrane transporter activity Gains GO:0061135 endopeptidase regulator activity Gains GO:0016301 kinase activity Gains GO:0004866 endopeptidase inhibitor activity Gains GO:0005549 odorant binding Gains GO:0022853 active ion transmembrane transporter activity Gains GO:0044877 macromolecular complex binding Gains GO:0004535 poly(A)-specific ribonuclease activity Gains GO:0008374 O-acyltransferase activity Gains GO:0004871 signal transducer activity Gains GO:0008514 organic anion transmembrane transporter activity Gains GO:0019900 kinase binding Gains GO:0008146 sulfotransferase activity Gains GO:0004690 cyclic nucleotide-dependent protein kinase activity Gains GO:0004523 RNA-DNA hybrid ribonuclease activity Gains GO:0098772 molecular function regulator Gains GO:0005342 organic acid transmembrane transporter activity Gains GO:0046943 carboxylic acid transmembrane transporter activity Gains GO:0015368 calcium:cation antiporter activity Gains GO:0016406 carnitine O-acyltransferase activity Gains GO:0005178 integrin binding Gains GO:0008889 glycerophosphodiester phosphodiesterase activity Gains GO:0034450 ubiquitin-ubiquitin ligase activity Gains GO:0061659 ubiquitin-like protein ligase activity Gains GO:0061630 ubiquitin protein ligase activity Gains GO:0008061 chitin binding Gains GO:0016791 phosphatase activity Gains GO:0016773 phosphotransferase activity, alcohol group as acceptor Gains GO:0003779 actin binding Gains GO:0015077 monovalent inorganic cation transmembrane transporter activity Gains GO:0061134 peptidase regulator activity Gains GO:0140097 catalytic activity, acting on DNA Gains GO:0042578 phosphoric ester hydrolase activity Gains GO:0005343 organic acid:sodium symporter activity Gains GO:0008195 phosphatidate phosphatase activity Gains GO:0015297 antiporter activity Gains GO:0004181 metallocarboxypeptidase activity Gains GO:0004869 cysteine-type endopeptidase inhibitor activity Gains GO:0035591 signaling adaptor activity Gains GO:0015491 cation:cation antiporter activity Gains GO:0005328 neurotransmitter:sodium symporter activity Gains GO:0004712 protein serine/threonine/tyrosine kinase activity Gains GO:0008017 microtubule binding Gains GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds Gains GO:0005244 voltage-gated ion channel activity Gains GO:0022832 voltage-gated channel activity Gains GO:0005515 protein binding Gains GO:0046872 metal ion binding Gains GO:0060089 molecular transducer activity Gains GO:0043169 cation binding Gains GO:0015108 chloride transmembrane transporter activity Gains GO:0005057 signal transducer activity, downstream of receptor Gains GO:0016788 hydrolase activity, acting on ester bonds Gains GO:0019901 protein kinase binding Gains GO:0015238 drug transmembrane transporter activity Gains GO:0061783 peptidoglycan muralytic activity Gains GO:0090484 drug transporter activity Gains GO:0015925 galactosidase activity Gains GO:0004675 transmembrane receptor protein serine/threonine kinase activity Gains GO:0033041 sweet taste receptor activity Gains GO:0030798 trans-aconitate 2-methyltransferase activity Gains GO:0005078 MAP-kinase scaffold activity Gains GO:0005024 transforming growth factor beta-activated receptor activity Gains GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Gains GO:0015116 sulfate transmembrane transporter activity Gains GO:0019838 growth factor binding Gains GO:0015278 calcium-release channel activity Gains GO:0008381 mechanically-gated ion channel activity Gains GO:0035014 phosphatidylinositol 3-kinase regulator activity Gains GO:1901618 organic hydroxy compound transmembrane transporter activity Gains GO:0045159 myosin II binding Gains GO:0005432 calcium:sodium antiporter activity Gains GO:0099604 ligand-gated calcium channel activity Gains GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity Gains GO:0022833 mechanically gated channel activity Gains GO:0033868 Goodpasture-antigen-binding protein kinase activity Gains GO:0140096 catalytic activity, acting on a protein Gains GO:0015276 ligand-gated ion channel activity Gains GO:0022834 ligand-gated channel activity Gains GO:0005548 phospholipid transporter activity Gains GO:0015298 solute:cation antiporter activity Gains GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity Gains GO:0046914 transition metal ion binding Gains GO:0030551 cyclic nucleotide binding Gains GO:0008308 voltage-gated anion channel activity Gains GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Gains GO:0001102 RNA polymerase II activating transcription factor binding Gains GO:0032027 myosin light chain binding Gains GO:0005086 ARF guanyl-nucleotide exchange factor activity Gains GO:0016411 acylglycerol O-acyltransferase activity Gains GO:0008745 N-acetylmuramoyl-L-alanine amidase activity Gains GO:0008812 choline dehydrogenase activity Gains GO:0099094 ligand-gated cation channel activity Gains GO:0003677 DNA binding Losses GO:0043565 sequence-specific DNA binding Losses GO:0005200 structural constituent of cytoskeleton Losses GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Losses GO:0019239 deaminase activity Losses GO:0008301 DNA binding, bending Losses GO:0008252 nucleotidase activity Losses GO:0003700 DNA binding transcription factor activity Losses GO:0140110 transcription regulator activity Losses GO:0003774 motor activity Losses GO:0003690 double-stranded DNA binding Losses GO:0070330 aromatase activity Losses GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Losses GO:0004000 adenosine deaminase activity Losses GO:0003777 microtubule motor activity Losses GO:0005488 binding Losses GO:0031490 chromatin DNA binding Losses GO:0000257 nitrilase activity Losses GO:0005504 fatty acid binding Losses GO:0036440 citrate synthase activity Losses GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Losses GO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Losses GO:0000700 mismatch base pair DNA N-glycosylase activity Losses GO:0070410 co-SMAD binding Losses GO:0019841 retinol binding Losses GO:0004362 glutathione-disulfide reductase activity Losses GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity Losses GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity Losses GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity Losses GO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Losses GO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Losses GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity Losses GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity Losses GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity Losses GO:0016297 acyl-[acyl-carrier-protein] hydrolase activity Losses GO:0005159 insulin-like growth factor receptor binding Losses GO:0004164 diphthine synthase activity Losses GO:0046332 SMAD binding Losses GO:0004131 cytosine deaminase activity Losses GO:0050111 mycocerosate synthase activity Losses GO:0004108 citrate (Si)-synthase activity Losses GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity Losses GO:0016815 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles Losses GO:0004791 thioredoxin-disulfide reductase activity Losses GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Losses GO:0003682 chromatin binding Losses GO:0015038 glutathione disulfide oxidoreductase activity Losses GO:0016531 copper chaperone activity Losses GO:0003960 NADPH:quinone reductase activity Losses GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity Losses GO:0004032 alditol:NADP+ 1-oxidoreductase activity Losses GO:0004033 aldo-keto reductase (NADP) activity Losses GO:0047710 bis(5'-adenosyl)-triphosphatase activity Losses GO:0016420 malonyltransferase activity Losses GO:0016419 S-malonyltransferase activity Losses GO:0008177 succinate dehydrogenase (ubiquinone) activity Losses GO:0004328 formamidase activity Losses GO:0008106 alcohol dehydrogenase (NADP+) activity Losses GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity Losses GO:0004333 fumarate hydratase activity Losses GO:0033293 monocarboxylic acid binding Losses GO:0043539 protein serine/threonine kinase activator activity Losses GO:0015037 peptide disulfide oxidoreductase activity Losses GO:1901363 heterocyclic compound binding Losses GO:0097159 organic cyclic compound binding Losses GO:0016787 hydrolase activity Losses GO:0008236 serine-type peptidase activity Losses GO:0017171 serine hydrolase activity Losses GO:0016530 metallochaperone activity Losses GO:0004830 tryptophan-tRNA ligase activity Losses GO:0005501 retinoid binding Losses GO:0019104 DNA N-glycosylase activity Losses GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity Losses GO:0052591 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Losses GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Losses GO:0016909 SAP kinase activity Losses GO:0016418 S-acetyltransferase activity Losses GO:0004368 glycerol-3-phosphate dehydrogenase activity Losses GO:0005160 transforming growth factor beta receptor binding Losses GO:0004484 mRNA guanylyltransferase activity Losses GO:0004185 serine-type carboxypeptidase activity Losses GO:0003677 DNA binding Extinctions GO:0008301 DNA binding, bending Extinctions GO:0008252 nucleotidase activity Extinctions GO:0003700 DNA binding transcription factor activity Extinctions GO:0140110 transcription regulator activity Extinctions GO:0043565 sequence-specific DNA binding Extinctions GO:0003676 nucleic acid binding Extinctions GO:0005504 fatty acid binding Extinctions GO:0000700 mismatch base pair DNA N-glycosylase activity Extinctions GO:0019841 retinol binding Extinctions GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity Extinctions GO:0005159 insulin-like growth factor receptor binding Extinctions GO:0003690 double-stranded DNA binding Extinctions GO:0016531 copper chaperone activity Extinctions GO:0047710 bis(5'-adenosyl)-triphosphatase activity Extinctions GO:0033293 monocarboxylic acid binding Extinctions GO:0005488 binding Extinctions GO:0005507 copper ion binding Extinctions GO:0004000 adenosine deaminase activity Extinctions GO:0016530 metallochaperone activity Extinctions GO:0005501 retinoid binding Extinctions GO:0019104 DNA N-glycosylase activity Extinctions GO:0005160 transforming growth factor beta receptor binding Extinctions GO:0004484 mRNA guanylyltransferase activity Extinctions GO:0003774 motor activity Extinctions GO:1901363 heterocyclic compound binding Extinctions GO:0050824 water binding Extinctions GO:0050825 ice binding Extinctions GO:0043178 alcohol binding Extinctions GO:0008192 RNA guanylyltransferase activity Extinctions GO:0005126 cytokine receptor binding Extinctions GO:0043548 phosphatidylinositol 3-kinase binding Extinctions GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds Extinctions GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding Extinctions GO:0097159 organic cyclic compound binding Extinctions GO:0005549 odorant binding Extinctions GO:0004551 nucleotide diphosphatase activity Extinctions GO:0019840 isoprenoid binding Extinctions GO:0008253 5'-nucleotidase activity Extinctions GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Extinctions GO:0019239 deaminase activity Extinctions