Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00010 PF00989 PF08447 1 0 0 0 0 0 PF00018 PF00620 1 0 0 0 0 0 PF00019 PF00688 PF00019 1 0 0 0 0 0 PF00023 PF12796 PF01734 1 0 0 0 0 0 PF00023 PF13606 1 0 0 0 0 0 PF00043 0 2 0 0 0 0 PF00046 PF03029 1 0 0 0 0 0 PF00047 PF07679 PF13927 PF00041 1 0 0 0 0 0 PF00053 PF00052 PF00053 0 1 4 0 0 0 PF00055 0 1 0 0 0 0 PF00057 0 1 0 0 0 0 PF00057 PF13855 1 0 0 0 0 0 PF00060 PF10613 1 0 0 0 0 0 PF00063 PF01576 1 0 1 0 0 0 PF00069 PF02828 PF00595 PF07653 PF00625 1 0 0 0 0 0 PF00069 PF08332 1 0 0 0 0 0 PF00071 0 1 0 0 0 0 PF00076 0 1 0 0 0 0 PF00076 PF00646 PF13516 1 0 0 0 0 0 PF00078 PF12017 1 0 0 0 0 0 PF00078 PF14223 1 0 0 0 0 0 PF00085 PF13848 PF00085 PF13848 1 0 0 0 0 0 PF00092 0 1 0 0 0 0 PF00097 PF01485 1 0 0 0 0 0 PF00098 PF00078 1 0 0 0 0 0 PF00098 PF14529 PF00078 1 0 0 0 0 0 PF00109 PF02801 PF16197 PF00698 0 0 5 0 0 0 PF00125 PF00089 1 0 0 0 0 0 PF00130 PF00780 1 0 0 0 0 0 PF00133 0 0 1 0 0 0 PF00137 PF01055 1 0 0 0 0 0 PF00149 0 1 0 0 0 0 PF00160 PF13181 1 0 0 0 0 0 PF00168 PF00616 0 1 4 0 0 0 PF00176 PF00271 0 1 0 0 0 0 PF00176 PF00271 PF09110 PF09111 0 0 1 0 0 0 PF00200 0 1 0 0 0 0 PF00208 0 0 1 0 0 0 PF00225 0 1 0 0 0 0 PF00225 PF00787 1 0 0 0 0 0 PF00225 PF16183 0 1 3 0 0 0 PF00227 0 1 0 0 0 0 PF00307 0 1 0 0 0 0 PF00307 PF00412 1 0 0 0 0 0 PF00312 0 1 0 0 0 0 PF00333 0 0 1 0 0 0 PF00372 PF03723 0 0 1 0 0 0 PF00385 PF00176 1 0 4 0 0 0 PF00385 PF00176 PF00271 1 0 1 0 0 0 PF00394 PF07731 0 1 0 0 0 0 PF00397 PF00168 1 0 0 0 0 0 PF00400 0 1 0 0 0 0 PF00400 PF12894 PF00400 PF08662 1 0 0 0 0 0 PF00415 PF13540 PF00415 PF00632 1 0 0 0 0 0 PF00424 0 0 0 0 0 1 PF00435 PF07679 1 0 0 0 0 0 PF00454 PF02260 0 1 0 0 0 0 PF00479 0 1 0 0 0 0 PF00488 0 0 5 0 0 0 PF00498 0 1 0 0 0 0 PF00498 PF00097 1 0 0 0 0 0 PF00514 PF16186 0 1 0 0 0 0 PF00520 PF03493 1 0 0 0 0 0 PF00549 0 0 2 0 0 0 PF00554 PF16179 PF12796 PF00023 1 0 0 0 0 0 PF00561 PF08451 PF00962 1 0 0 0 0 0 PF00567 0 1 0 0 0 0 PF00575 0 1 0 0 0 0 PF00581 PF00443 1 0 0 0 0 0 PF00589 PF03932 1 0 0 0 0 0 PF00595 PF01369 PF15410 1 0 0 0 0 0 PF00612 PF00616 PF03836 0 1 0 0 0 0 PF00620 PF00089 1 0 0 0 0 0 PF00621 PF00169 PF00618 PF00617 1 0 0 0 0 0 PF00628 PF13621 1 0 0 0 0 0 PF00641 0 1 0 0 0 0 PF00642 PF13634 1 0 0 0 0 0 PF00651 PF05890 1 0 0 0 0 0 PF00651 PF07707 PF00612 1 0 0 0 0 0 PF00651 PF13894 1 0 0 0 0 0 PF00665 PF00653 1 0 0 0 0 0 PF00665 PF02898 1 0 0 0 0 0 PF00665 PF07727 1 0 0 0 0 0 PF00665 PF12017 1 0 0 0 0 0 PF00665 PF12259 1 0 0 0 0 0 PF00670 0 0 1 0 0 0 PF00690 PF00122 PF13246 0 0 4 0 0 0 PF00790 0 1 0 0 0 0 PF00790 PF13920 1 0 0 0 0 0 PF00808 PF12796 1 0 0 0 0 0 PF00855 PF03446 PF14833 1 0 0 0 0 0 PF00856 0 1 0 0 0 0 PF00856 PF00096 PF13912 1 0 0 0 0 0 PF00867 0 0 1 0 0 0 PF00887 PF12796 1 0 0 0 0 0 PF00940 0 0 1 0 0 0 PF00965 0 0 0 0 1 0 PF01064 0 1 2 0 0 0 PF01363 0 1 0 0 0 0 PF01411 PF07973 PF02272 0 1 0 0 0 0 PF01417 0 1 0 0 0 0 PF01429 PF07727 1 0 0 0 0 0 PF01433 PF11838 PF01433 PF11838 PF01433 0 1 0 0 0 0 PF01454 0 0 0 0 1 0 PF01476 PF07534 1 0 0 0 0 0 PF01485 0 1 0 0 0 0 PF01529 PF01207 1 0 0 0 0 0 PF01562 PF00090 1 0 0 0 0 0 PF01562 PF01421 1 0 7 0 0 0 PF01585 PF00035 1 0 0 0 0 0 PF01602 0 1 10 0 0 0 PF01699 PF16494 PF03160 PF01699 1 0 0 0 0 0 PF01728 PF07992 1 0 0 0 0 0 PF01749 0 1 0 0 0 0 PF01771 PF02902 1 0 0 0 0 0 PF01799 0 0 4 0 0 0 PF01852 0 1 0 0 0 0 PF02055 0 0 1 0 0 0 PF02135 0 0 8 0 0 0 PF02135 PF02172 0 0 6 0 0 0 PF02141 PF03455 PF02759 PF01477 PF02759 0 0 1 0 0 0 PF02171 0 1 0 0 0 0 PF02263 PF00514 1 0 0 0 0 0 PF02373 PF00035 1 0 0 0 0 0 PF02770 PF00441 0 1 0 0 0 0 PF02771 0 1 0 0 0 0 PF02781 0 1 0 0 0 0 PF02798 0 1 3 0 0 0 PF02801 0 0 1 0 0 0 PF02807 0 0 1 0 0 0 PF02828 PF00595 PF07653 PF00625 PF12796 1 0 0 0 0 0 PF02836 0 1 0 0 0 0 PF02837 PF00703 0 1 0 0 0 0 PF02872 0 1 0 0 0 0 PF02883 0 1 0 0 0 0 PF02892 PF04937 1 0 0 0 0 0 PF02892 PF04937 PF05699 1 0 0 0 0 0 PF02949 PF00858 1 0 0 0 0 0 PF02985 PF12372 1 0 0 0 0 0 PF02992 0 1 0 0 0 0 PF03104 PF00136 PF08996 0 0 1 0 0 0 PF03127 0 1 0 0 0 0 PF03175 PF02949 1 0 0 0 0 0 PF03175 PF09337 1 0 0 0 0 0 PF03208 PF16178 PF04547 1 0 0 0 0 0 PF03564 PF05585 PF05380 PF00665 1 0 0 0 0 0 PF03876 0 1 1 0 0 0 PF03949 0 0 1 0 0 0 PF04057 0 0 3 0 0 0 PF04063 0 0 1 0 0 0 PF04089 0 0 0 0 1 0 PF04158 0 1 0 0 0 0 PF04757 PF13923 1 0 0 0 0 0 PF04784 0 1 0 0 0 0 PF04821 PF05029 1 0 0 0 0 0 PF04825 0 0 1 0 0 0 PF04928 0 0 1 0 0 0 PF04930 0 0 0 0 1 0 PF04997 0 0 9 0 0 0 PF05250 0 0 0 0 1 0 PF05380 PF00665 1 0 0 0 0 0 PF05380 PF00928 1 0 0 0 0 0 PF05383 0 1 0 0 0 0 PF05729 0 1 0 0 0 0 PF06025 PF00627 PF02825 PF14377 PF00632 0 0 1 0 0 0 PF06087 0 1 0 0 0 0 PF06462 PF00337 PF06398 PF06462 0 0 1 0 0 0 PF06466 0 0 2 0 0 0 PF06743 0 1 0 0 0 0 PF06784 0 0 0 0 1 0 PF07443 0 1 0 0 0 0 PF07502 0 1 0 0 0 0 PF07648 PF00050 PF07648 1 0 0 0 0 0 PF07648 PF07679 1 0 0 0 0 0 PF07679 PF13927 PF00041 PF00102 1 0 0 0 0 0 PF07686 PF07679 PF13927 PF00041 1 0 0 0 0 0 PF07686 PF08205 PF13895 1 0 0 0 0 0 PF07714 0 1 0 0 0 0 PF07728 0 1 0 0 0 0 PF07732 0 1 0 0 0 0 PF07732 PF00394 1 0 1 0 0 0 PF07766 PF00078 1 0 0 0 0 0 PF07776 PF12874 PF13912 1 0 0 0 0 0 PF07776 PF13909 1 0 0 0 0 0 PF07776 PF13912 PF00096 1 0 0 0 0 0 PF07776 PF13912 PF00096 PF12874 1 0 0 0 0 0 PF07776 PF13912 PF13894 PF13912 PF00096 1 0 0 0 0 0 PF07776 PF13912 PF13894 PF13912 PF12874 1 0 0 0 0 0 PF08069 0 1 0 0 0 0 PF08174 PF00169 1 0 1 0 0 0 PF08242 0 0 0 0 1 0 PF08245 0 0 0 0 1 0 PF08347 0 0 0 0 1 0 PF08368 0 1 0 0 0 0 PF08385 PF08393 PF12774 PF12775 PF12780 PF12777 PF12781 PF03028 1 0 0 0 0 0 PF08412 PF00520 PF00027 1 0 0 0 0 0 PF08424 0 0 0 0 1 0 PF08477 0 1 0 0 0 0 PF08572 PF06544 PF03098 1 0 0 0 0 0 PF08615 0 0 0 0 1 0 PF08777 0 1 2 0 0 0 PF08991 0 0 0 0 1 0 PF09000 0 0 0 0 0 1 PF09273 0 1 0 0 0 0 PF09437 0 0 0 0 0 1 PF09596 0 0 0 0 1 0 PF09763 0 0 1 0 0 0 PF09765 0 0 1 0 0 0 PF10161 0 0 0 0 1 0 PF10193 0 1 0 0 0 0 PF10213 0 0 0 0 1 0 PF10247 0 0 0 0 1 0 PF10283 0 1 0 0 0 0 PF10376 0 0 0 0 1 0 PF10409 PF00017 PF08416 1 0 0 0 0 0 PF10457 0 1 0 0 0 0 PF10551 PF00078 1 0 0 0 0 0 PF10551 PF04434 1 0 0 0 0 0 PF10584 0 1 0 0 0 0 PF10613 PF00060 PF10613 1 0 0 0 0 0 PF10757 0 0 0 0 0 1 PF11838 0 1 0 0 0 0 PF11942 0 0 3 0 0 0 PF12002 0 0 2 0 0 0 PF12004 0 1 0 0 0 0 PF12146 PF03959 1 0 0 0 0 0 PF12259 PF00665 1 0 0 0 0 0 PF12394 0 0 1 0 0 0 PF12624 0 1 0 0 0 0 PF12624 PF13329 PF16909 0 0 1 0 0 0 PF12701 PF09532 PF03853 1 0 0 0 0 0 PF12718 0 0 0 0 1 0 PF12796 PF00023 PF12796 PF13637 1 0 0 0 0 0 PF12796 PF00023 PF12796 PF13637 PF12796 1 0 0 0 0 0 PF12796 PF00023 PF12796 PF13857 PF00520 1 0 0 0 0 0 PF12796 PF00023 PF13637 1 0 0 0 0 0 PF12796 PF05186 1 0 0 0 0 0 PF12796 PF07647 PF00536 PF00640 1 0 0 0 0 0 PF12796 PF13606 PF00023 1 0 0 0 0 0 PF12796 PF13637 PF00023 PF12796 1 0 0 0 0 0 PF12796 PF13637 PF01529 1 0 0 0 0 0 PF12796 PF13637 PF01753 1 0 0 0 0 0 PF12796 PF13637 PF12796 PF00023 1 0 0 0 0 0 PF12796 PF13637 PF12796 PF13857 1 0 0 0 0 0 PF12796 PF13857 PF00520 1 0 0 0 0 0 PF12796 PF13857 PF07724 PF10431 1 0 0 0 0 0 PF12799 PF13855 PF00560 1 0 0 0 0 0 PF12872 0 1 3 0 0 0 PF12874 PF00096 PF13912 1 0 0 0 0 0 PF12874 PF13912 PF00096 1 0 0 0 0 0 PF12884 0 0 0 0 1 0 PF12938 0 1 0 0 0 0 PF13054 0 0 0 0 0 1 PF13174 0 1 0 0 0 0 PF13181 PF00515 1 0 1 0 0 0 PF13181 PF02373 1 0 0 0 0 0 PF13181 PF07719 1 0 0 0 0 0 PF13202 PF00857 1 0 0 0 0 0 PF13271 0 1 0 0 0 0 PF13281 PF00069 PF07647 1 0 0 0 0 0 PF13344 0 0 1 0 0 0 PF13358 PF05536 1 0 0 0 0 0 PF13359 PF00078 1 0 0 0 0 0 PF13476 0 0 0 0 1 0 PF13499 PF00153 1 0 0 0 0 0 PF13589 0 0 7 0 0 0 PF13606 PF12796 PF00536 1 0 0 0 0 0 PF13637 PF00520 1 0 0 0 0 0 PF13637 PF12796 PF00023 PF12796 1 0 0 0 0 0 PF13637 PF12796 PF13637 1 0 0 0 0 0 PF13688 0 1 0 0 0 0 PF13833 PF13202 1 0 0 0 0 0 PF13855 PF00560 PF13855 PF00560 1 0 0 0 0 0 PF13855 PF03372 1 0 0 0 0 0 PF13857 PF12796 1 0 0 0 0 0 PF13872 0 0 1 0 0 0 PF13873 PF13923 1 0 0 0 0 0 PF13879 PF00160 1 0 0 0 0 0 PF13894 PF00096 PF13912 PF12874 1 0 0 0 0 0 PF13894 PF12874 PF13894 1 0 0 0 0 0 PF13894 PF13909 1 0 0 0 0 0 PF13894 PF13912 PF13894 1 0 0 0 0 0 PF13905 PF01436 1 0 0 0 0 0 PF13913 PF00096 PF13894 1 0 0 0 0 0 PF13913 PF00890 PF02910 1 0 0 0 0 0 PF13927 PF08205 PF13927 PF00041 1 0 0 0 0 0 PF13960 0 1 0 0 0 0 PF13975 PF00078 1 0 0 0 0 0 PF13976 PF00665 PF07727 1 0 0 0 0 0 PF13976 PF07727 1 0 0 0 0 0 PF14050 PF16273 PF04969 1 0 0 0 0 0 PF14223 PF00098 PF00665 1 0 0 0 0 0 PF14223 PF00098 PF13976 PF00665 PF07727 1 0 0 0 0 0 PF14429 PF06920 0 1 3 0 0 0 PF14559 0 1 0 0 0 0 PF14604 PF00621 PF00169 1 0 0 0 0 0 PF14604 PF07679 1 0 0 0 0 0 PF14633 0 0 6 0 0 0 PF14634 PF00643 PF01436 1 0 0 0 0 0 PF14844 PF02138 PF00400 PF01363 1 0 0 0 0 0 PF14892 0 0 0 0 1 0 PF15785 0 1 0 0 0 0 PF15795 0 0 0 0 1 0 PF15949 PF00412 1 0 0 0 0 0 PF16012 PF00078 1 0 0 0 0 0 PF16012 PF00078 PF00075 1 0 0 0 0 0 PF16012 PF14529 1 0 0 0 0 0 PF16172 0 1 0 0 0 0 PF16183 PF00498 0 1 0 0 0 0 PF16203 0 0 2 0 0 0 PF16470 0 0 2 0 0 0 PF16486 PF08699 PF02170 PF16488 0 1 0 0 0 0 PF16678 0 1 0 0 0 0 PF16808 PF00027 PF00069 1 0 0 0 0 0 PF16908 PF16910 PF06650 PF16909 0 1 0 0 0 0 PF17219 0 1 0 0 0 0