GO:0003964	RNA-directed DNA polymerase activity	Gains
GO:0034061	DNA polymerase activity	Gains
GO:0004984	olfactory receptor activity	Gains
GO:0005549	odorant binding	Gains
GO:0140097	catalytic activity, acting on DNA	Gains
GO:0038023	signaling receptor activity	Gains
GO:0004888	transmembrane signaling receptor activity	Gains
GO:0099600	transmembrane receptor activity	Gains
GO:0016779	nucleotidyltransferase activity	Gains
GO:0004872	receptor activity	Gains
GO:0060089	molecular transducer activity	Gains
GO:0004871	signal transducer activity	Gains
GO:0004930	G-protein coupled receptor activity	Gains
GO:0022824	transmitter-gated ion channel activity	Gains
GO:0022835	transmitter-gated channel activity	Gains
GO:0004970	ionotropic glutamate receptor activity	Gains
GO:0005234	extracellularly glutamate-gated ion channel activity	Gains
GO:0070001	aspartic-type peptidase activity	Gains
GO:0004190	aspartic-type endopeptidase activity	Gains
GO:0003676	nucleic acid binding	Gains
GO:0008066	glutamate receptor activity	Gains
GO:0005231	excitatory extracellular ligand-gated ion channel activity	Gains
GO:0008270	zinc ion binding	Gains
GO:0046914	transition metal ion binding	Gains
GO:0030594	neurotransmitter receptor activity	Gains
GO:0005230	extracellular ligand-gated ion channel activity	Gains
GO:0004519	endonuclease activity	Gains
GO:0004518	nuclease activity	Gains
GO:0022834	ligand-gated channel activity	Gains
GO:0015276	ligand-gated ion channel activity	Gains
GO:0004523	RNA-DNA hybrid ribonuclease activity	Gains
GO:0003723	RNA binding	Gains
GO:0016772	transferase activity, transferring phosphorus-containing groups	Gains
GO:0008233	peptidase activity	Gains
GO:0022836	gated channel activity	Gains
GO:0005216	ion channel activity	Gains
GO:0032450	maltose alpha-glucosidase activity	Gains
GO:0022838	substrate-specific channel activity	Gains
GO:0070011	peptidase activity, acting on L-amino acid peptides	Gains
GO:0008010	structural constituent of chitin-based larval cuticle	Gains
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	Gains
GO:0038187	pattern recognition receptor activity	Gains
GO:0008329	signaling pattern recognition receptor activity	Gains
GO:0022803	passive transmembrane transporter activity	Gains
GO:0015267	channel activity	Gains
GO:0003678	DNA helicase activity	Gains
GO:0046872	metal ion binding	Gains
GO:0043169	cation binding	Gains
GO:0090599	alpha-glucosidase activity	Gains
GO:0008527	taste receptor activity	Gains
GO:0036081	extracellular ammonia-gated ion channel activity	Gains
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Gains
GO:0005024	transforming growth factor beta-activated receptor activity	Gains
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Gains
GO:0004521	endoribonuclease activity	Gains
GO:0004175	endopeptidase activity	Gains
GO:0005214	structural constituent of chitin-based cuticle	Gains
GO:0015926	glucosidase activity	Gains
GO:0016788	hydrolase activity, acting on ester bonds	Gains
GO:0030414	peptidase inhibitor activity	Gains
GO:0016848	carbon-halide lyase activity	Gains
GO:0008011	structural constituent of pupal chitin-based cuticle	Gains
GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	Gains
GO:0004503	monophenol monooxygenase activity	Gains
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Gains
GO:0004033	aldo-keto reductase (NADP) activity	Gains
GO:0008447	L-ascorbate oxidase activity	Gains
GO:0008106	alcohol dehydrogenase (NADP+) activity	Gains
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	Gains
GO:0045735	nutrient reservoir activity	Gains
GO:0018685	alkane 1-monooxygenase activity	Gains
GO:0005212	structural constituent of eye lens	Gains
GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	Gains
GO:0042834	peptidoglycan binding	Gains
GO:0019955	cytokine binding	Gains
GO:0005488	binding	Gains
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	Gains
GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	Gains
GO:0004857	enzyme inhibitor activity	Gains
GO:0004867	serine-type endopeptidase inhibitor activity	Gains
GO:0042302	structural constituent of cuticle	Gains
GO:0016787	hydrolase activity	Gains
GO:0061134	peptidase regulator activity	Gains
GO:0005272	sodium channel activity	Gains
GO:0097159	organic cyclic compound binding	Gains
GO:0004386	helicase activity	Gains
GO:0004971	AMPA glutamate receptor activity	Gains
GO:0004463	leukotriene-A4 hydrolase activity	Gains
GO:0004185	serine-type carboxypeptidase activity	Gains
GO:1901363	heterocyclic compound binding	Gains
GO:0015299	solute:proton antiporter activity	Gains
GO:0005509	calcium ion binding	Losses
GO:0004683	calmodulin-dependent protein kinase activity	Losses
GO:0060072	large conductance calcium-activated potassium channel activity	Losses
GO:0017151	DEAD/H-box RNA helicase binding	Losses
GO:0097109	neuroligin family protein binding	Losses
GO:0015277	kainate selective glutamate receptor activity	Losses
GO:0008191	metalloendopeptidase inhibitor activity	Losses
GO:0032093	SAM domain binding	Losses
GO:0034185	apolipoprotein binding	Losses
GO:0004672	protein kinase activity	Losses
GO:0008201	heparin binding	Losses
GO:0004657	proline dehydrogenase activity	Losses
GO:0050220	prostaglandin-E synthase activity	Losses
GO:0050824	water binding	Losses
GO:0050825	ice binding	Losses
GO:0016162	cellulose 1,4-beta-cellobiosidase activity	Losses
GO:0004496	mevalonate kinase activity	Losses
GO:0016773	phosphotransferase activity, alcohol group as acceptor	Losses
GO:0005539	glycosaminoglycan binding	Losses
GO:0016776	phosphotransferase activity, phosphate group as acceptor	Losses
GO:0046873	metal ion transmembrane transporter activity	Losses
GO:0005488	binding	Losses
GO:0019198	transmembrane receptor protein phosphatase activity	Losses
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Losses
GO:0097157	pre-mRNA intronic binding	Losses
GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Losses
GO:0005432	calcium:sodium antiporter activity	Losses
GO:0004713	protein tyrosine kinase activity	Losses
GO:0001158	enhancer sequence-specific DNA binding	Losses
GO:0035326	enhancer binding	Losses
GO:0008191	metalloendopeptidase inhibitor activity	Extinctions
GO:0005509	calcium ion binding	Extinctions
GO:0004657	proline dehydrogenase activity	Extinctions
GO:0004496	mevalonate kinase activity	Extinctions
GO:0097157	pre-mRNA intronic binding	Extinctions
GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	Extinctions
GO:0001965	G-protein alpha-subunit binding	Extinctions
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	Extinctions
GO:0036002	pre-mRNA binding	Extinctions
GO:0005154	epidermal growth factor receptor binding	Extinctions