Domain arrangement Fusions Fissions Terminal losses Terminal emergences Single domain losses Single domain emergences PF00001 PF06113 1 0 0 0 0 0 PF00008 PF00059 1 0 0 0 0 0 PF00009 PF03144 PF14492 PF00679 1 0 0 0 0 0 PF00010 PF07527 PF05676 1 0 0 0 0 0 PF00010 PF14598 1 0 0 0 0 0 PF00013 0 1 0 0 0 0 PF00018 PF00620 1 0 0 0 0 0 PF00023 PF08344 PF00520 1 0 0 0 0 0 PF00023 PF12796 PF00520 1 0 0 0 0 0 PF00031 0 1 0 0 0 0 PF00036 PF13499 PF01794 PF08022 PF08030 0 1 0 0 0 0 PF00043 PF00647 0 1 0 0 0 0 PF00049 0 0 0 0 1 0 PF00057 PF13855 PF00001 1 0 0 0 0 0 PF00063 PF06017 0 1 0 0 0 0 PF00068 0 0 0 0 1 0 PF00069 PF00566 1 0 0 0 0 0 PF00069 PF10409 1 0 0 0 0 0 PF00071 PF06585 1 0 0 0 0 0 PF00076 PF00025 1 0 0 0 0 0 PF00084 PF00629 1 0 0 0 0 0 PF00090 PF00431 1 0 0 0 0 0 PF00096 PF12874 PF13894 PF12874 PF00096 1 0 0 0 0 0 PF00098 PF00270 PF00271 1 0 0 0 0 0 PF00109 PF02801 PF16197 PF00698 PF14765 PF00107 PF08659 PF00550 0 0 1 0 0 0 PF00130 PF00781 PF00609 PF00536 1 0 0 0 0 0 PF00149 PF13499 1 0 0 0 0 0 PF00151 PF00232 1 0 0 0 0 0 PF00160 PF07719 1 0 0 0 0 0 PF00168 PF00130 PF00069 PF00433 1 0 0 0 0 0 PF00169 PF00069 1 0 0 0 0 0 PF00169 PF00069 PF00433 1 0 0 0 0 0 PF00179 PF00627 1 0 0 0 0 0 PF00194 PF01253 1 0 0 0 0 0 PF00211 0 1 0 0 0 0 PF00226 0 1 0 0 0 0 PF00229 0 0 0 0 1 0 PF00240 PF07776 1 0 0 0 0 0 PF00246 PF13620 PF00246 PF13620 1 0 0 0 0 0 PF00249 PF03874 1 0 0 0 0 0 PF00254 PF13181 PF07719 1 0 0 0 0 0 PF00270 PF00271 PF00567 1 0 0 0 0 0 PF00270 PF00271 PF04408 PF07717 PF04146 1 0 0 0 0 0 PF00287 PF00036 1 0 0 0 0 0 PF00289 0 0 13 0 0 0 PF00307 PF00435 PF02187 1 0 0 0 0 0 PF00361 0 0 0 0 1 0 PF00390 PF03949 PF00390 PF03949 1 0 0 0 0 0 PF00400 0 1 0 0 0 0 PF00400 PF01839 1 0 0 0 0 0 PF00400 PF17034 1 0 0 0 0 0 PF00412 PF00788 1 0 0 0 0 0 PF00412 PF07714 1 0 0 0 0 0 PF00412 PF12130 1 0 0 0 0 0 PF00435 PF07679 1 0 0 0 0 0 PF00436 0 0 0 0 1 0 PF00462 PF07992 PF02852 1 0 0 0 0 0 PF00465 0 0 0 0 1 0 PF00467 0 0 4 0 0 0 PF00468 0 0 0 0 1 0 PF00484 0 0 0 0 1 0 PF00498 PF13920 1 0 0 0 0 0 PF00515 PF13181 1 0 0 0 0 0 PF00520 PF03493 1 0 0 0 0 0 PF00534 0 0 3 0 0 0 PF00538 PF01853 1 0 0 0 0 0 PF00554 0 1 0 0 0 0 PF00560 PF13855 PF13306 1 0 0 0 0 0 PF00567 PF06003 1 0 0 0 0 0 PF00575 PF00270 PF00271 PF04408 PF07717 1 0 0 0 0 0 PF00589 0 0 0 0 1 0 PF00595 PF00102 1 0 0 0 0 0 PF00595 PF00169 PF00620 1 0 0 0 0 0 PF00595 PF00536 1 0 0 0 0 0 PF00595 PF00620 1 0 0 0 0 0 PF00611 PF14604 1 0 0 0 0 0 PF00620 PF00788 1 0 0 0 0 0 PF00621 PF00620 1 0 0 0 0 0 PF00621 PF07679 1 0 0 0 0 0 PF00628 PF00439 PF00855 1 0 0 0 0 0 PF00628 PF00536 1 0 0 0 0 0 PF00628 PF00856 1 0 0 0 0 0 PF00636 PF00035 0 0 1 0 0 0 PF00646 PF01485 1 0 0 0 0 0 PF00648 PF01067 PF00168 1 0 0 0 0 0 PF00651 PF04500 1 0 0 0 0 0 PF00651 PF05649 PF01431 1 0 0 0 0 0 PF00653 PF00069 PF04212 1 0 0 0 0 0 PF00751 0 1 0 0 0 0 PF00763 PF02882 0 1 0 0 0 0 PF00787 PF00069 PF00433 1 0 0 0 0 0 PF00787 PF07714 1 0 0 0 0 0 PF00817 0 0 1 0 0 0 PF00839 0 0 0 0 1 0 PF01019 PF13883 1 0 0 0 0 0 PF01073 0 0 0 0 1 0 PF01088 PF00270 PF00271 1 0 0 0 0 0 PF01145 PF08923 1 0 0 0 0 0 PF01268 0 1 0 0 0 0 PF01281 0 0 0 0 1 0 PF01321 PF16189 0 0 2 0 0 0 PF01327 0 0 0 0 1 0 PF01390 PF07645 1 0 0 0 0 0 PF01392 PF00057 PF15494 PF00089 1 0 0 0 0 0 PF01408 0 0 0 0 1 0 PF01411 0 1 0 0 0 0 PF01421 PF00090 PF05986 PF00090 0 1 1 0 0 0 PF01428 0 1 0 0 0 0 PF01476 PF07534 1 0 0 0 0 0 PF01541 0 0 0 0 1 0 PF01553 PF13833 1 0 0 0 0 0 PF01562 0 1 0 0 0 0 PF01562 PF01421 PF00200 PF08516 PF07974 1 0 0 0 0 0 PF01594 0 0 0 0 1 0 PF01607 PF00057 PF01522 PF01607 PF00057 1 0 0 0 0 0 PF01612 PF00476 1 0 0 0 0 0 PF01663 0 1 0 0 0 0 PF01754 0 1 1 0 0 0 PF01851 PF13646 1 0 0 0 0 0 PF01931 0 0 0 0 1 0 PF02104 PF01423 1 0 0 0 0 0 PF02170 0 0 1 0 0 0 PF02197 0 0 0 0 1 0 PF02201 PF01253 1 0 0 0 0 0 PF02229 0 0 0 0 1 0 PF02269 PF01194 1 0 0 0 0 0 PF02436 PF00364 0 0 4 0 0 0 PF02759 PF00018 1 0 0 0 0 0 PF02759 PF00566 1 0 0 0 0 0 PF02798 0 1 0 0 0 0 PF02812 0 0 1 0 0 0 PF02825 PF13639 1 0 0 0 0 0 PF02828 PF00595 PF07653 1 0 0 0 0 0 PF02854 PF02020 1 0 0 0 0 0 PF02867 0 0 2 0 0 0 PF02891 0 1 0 0 0 0 PF02892 PF00651 1 0 0 0 0 0 PF02931 PF14845 PF00728 1 0 0 0 0 0 PF02933 PF00004 0 0 1 0 0 0 PF02937 0 0 0 0 1 0 PF02944 0 0 0 0 1 0 PF03055 0 0 0 0 1 0 PF03067 PF03351 1 0 0 0 0 0 PF03073 0 0 0 0 1 0 PF03098 0 1 0 0 0 0 PF03121 0 0 0 0 1 0 PF03171 0 0 0 0 1 0 PF03224 0 0 1 0 0 0 PF03465 0 0 2 0 0 0 PF03474 0 1 0 0 0 0 PF03485 PF00750 0 1 0 0 0 0 PF03670 PF01553 1 0 0 0 0 0 PF03731 0 0 2 0 0 0 PF03732 0 0 0 0 1 0 PF03810 0 1 0 0 0 0 PF03850 0 0 0 0 1 0 PF03876 PF00575 PF13771 PF05964 PF05965 PF00856 1 0 0 0 0 0 PF03879 0 0 0 0 1 0 PF03908 0 0 0 0 1 0 PF04003 0 1 0 0 0 0 PF04114 0 0 0 0 1 0 PF04117 PF00005 1 0 0 0 0 0 PF04148 0 0 0 0 1 0 PF04157 PF08265 1 0 0 0 0 0 PF04421 0 0 0 0 1 0 PF04438 PF00400 1 0 0 0 0 0 PF04506 0 0 0 0 1 0 PF04587 0 0 0 0 1 0 PF04696 0 0 1 0 0 0 PF04937 0 0 0 0 1 0 PF04987 0 1 0 0 0 0 PF05019 0 0 0 0 1 0 PF05050 0 0 0 0 1 0 PF05132 0 0 0 0 1 0 PF05207 0 1 0 0 0 0 PF05283 0 0 0 0 1 0 PF05428 0 0 0 0 1 0 PF05517 0 0 0 0 1 0 PF05699 0 0 0 0 1 0 PF05746 0 1 0 0 0 0 PF05773 PF00069 1 0 0 0 0 0 PF05970 0 0 0 0 1 0 PF06151 0 0 0 0 1 0 PF06220 PF00642 1 0 0 0 0 0 PF06237 0 0 0 0 1 0 PF06396 0 0 0 0 1 0 PF06662 0 0 0 0 1 0 PF06888 0 0 0 0 1 0 PF07522 0 0 0 0 1 0 PF07530 0 0 0 0 1 0 PF07572 0 0 0 0 1 0 PF07648 PF13927 PF07679 1 0 0 0 0 0 PF07653 PF00536 1 0 0 0 0 0 PF07679 PF00047 1 0 0 0 0 0 PF07679 PF01392 PF00051 PF07714 1 0 0 0 0 0 PF07679 PF13927 PF00041 PF00102 1 0 0 0 0 0 PF07679 PF13927 PF07679 PF07714 1 0 0 0 0 0 PF07679 PF13927 PF07679 PF13927 1 0 0 0 0 0 PF07679 PF13927 PF13895 PF13927 PF00041 1 0 0 0 0 0 PF07686 PF00047 1 0 0 0 0 0 PF07686 PF13927 PF00041 1 0 0 0 0 0 PF07686 PF13927 PF08205 PF13927 1 0 0 0 0 0 PF07690 PF12832 1 0 0 0 0 0 PF07701 0 1 0 0 0 0 PF07776 PF13894 PF00096 1 0 0 0 0 0 PF07776 PF13894 PF12874 1 0 0 0 0 0 PF07776 PF13894 PF12874 PF13912 1 0 0 0 0 0 PF07973 0 1 0 0 0 0 PF07974 PF15636 1 0 0 0 0 0 PF08122 0 0 0 0 1 0 PF08144 0 0 0 0 1 0 PF08205 PF13895 PF13927 1 0 0 0 0 0 PF08246 PF00112 0 1 0 0 0 0 PF08320 0 0 0 0 1 0 PF08366 PF00400 1 0 0 0 0 0 PF08389 PF08767 0 1 0 0 0 0 PF08477 PF01981 1 0 0 0 0 0 PF08515 PF00069 0 0 1 0 0 0 PF08524 0 0 0 0 1 0 PF08561 0 0 0 0 1 0 PF08574 0 0 0 0 1 0 PF08617 PF02517 1 0 0 0 0 0 PF08768 0 0 0 0 1 0 PF08953 PF00400 PF16300 PF08953 PF00400 PF16300 1 0 0 0 0 0 PF09279 PF00388 0 0 5 0 0 0 PF09302 0 0 0 0 1 0 PF09379 PF00373 PF09380 PF00621 PF00169 1 0 0 0 0 0 PF09412 0 0 0 0 1 0 PF09495 0 0 0 0 1 0 PF09588 0 0 0 0 1 0 PF09787 0 0 0 0 1 0 PF09803 0 0 0 0 1 0 PF09805 0 0 0 0 1 0 PF09817 0 0 0 0 1 0 PF10151 0 0 0 0 1 0 PF10163 0 0 0 0 1 0 PF10169 PF16881 PF04055 1 0 0 0 0 0 PF10188 0 0 0 0 1 0 PF10203 0 0 0 0 1 0 PF10217 0 0 0 0 1 0 PF10241 0 0 0 0 1 0 PF10269 PF04577 1 0 0 0 0 0 PF10373 PF13638 0 0 1 0 0 0 PF10396 PF12631 PF13532 1 0 0 0 0 0 PF10409 PF00017 PF08416 1 0 0 0 0 0 PF10469 0 1 0 0 0 0 PF10493 0 0 0 0 1 0 PF10500 0 0 0 0 1 0 PF10504 0 0 0 0 1 0 PF10505 0 0 0 0 1 0 PF10512 0 0 0 0 1 0 PF10520 0 0 0 0 1 0 PF10545 0 0 0 0 1 0 PF11029 0 0 0 0 1 0 PF11095 0 0 0 0 1 0 PF11502 0 0 0 0 1 0 PF11768 0 0 0 0 1 0 PF11788 0 0 0 0 1 0 PF11923 0 0 2 0 0 0 PF11968 0 0 0 0 1 0 PF12017 0 0 0 0 1 0 PF12146 PF03959 1 0 0 0 0 0 PF12510 0 0 0 0 1 0 PF12719 PF16029 1 0 0 0 0 0 PF12762 0 0 0 0 1 0 PF12796 PF00013 1 0 0 0 0 0 PF12796 PF00023 PF00520 1 0 0 0 0 0 PF12796 PF00023 PF07714 1 0 0 0 0 0 PF12796 PF01485 1 0 0 0 0 0 PF12796 PF07647 1 0 0 0 0 0 PF12799 PF14580 1 0 0 0 0 0 PF12836 0 0 0 0 1 0 PF12874 PF00096 PF13894 1 0 0 0 0 0 PF12874 PF00096 PF13912 PF12874 1 0 0 0 0 0 PF12874 PF13894 PF12874 1 0 0 0 0 0 PF12874 PF13894 PF12874 PF00096 1 0 0 0 0 0 PF12874 PF13912 PF00096 1 0 0 0 0 0 PF12895 PF13424 1 0 0 0 0 0 PF13086 PF13087 PF07145 1 0 0 0 0 0 PF13181 PF00638 1 0 0 0 0 0 PF13181 PF13414 1 0 0 0 0 0 PF13202 PF13499 PF00153 1 0 0 0 0 0 PF13306 PF07679 1 0 0 0 0 0 PF13347 PF07690 1 0 0 0 0 0 PF13358 0 0 0 0 1 0 PF13359 0 0 0 0 1 0 PF13414 PF13432 1 0 0 0 0 0 PF13426 PF00233 1 0 0 0 0 0 PF13426 PF00520 1 0 0 0 0 0 PF13426 PF00520 PF00027 1 0 0 0 0 0 PF13499 PF00153 1 0 0 0 0 0 PF13513 PF02985 1 0 0 0 0 0 PF13593 0 0 0 0 1 0 PF13621 PF02373 1 0 0 0 0 0 PF13637 PF00788 1 0 0 0 0 0 PF13637 PF01753 1 0 0 0 0 0 PF13637 PF13920 1 0 0 0 0 0 PF13716 PF00621 PF00169 1 0 0 0 0 0 PF13815 0 0 0 0 1 0 PF13855 PF00041 1 0 0 0 0 0 PF13855 PF00307 1 0 0 0 0 0 PF13855 PF07679 PF00002 1 0 0 0 0 0 PF13855 PF13306 PF07679 1 0 0 0 0 0 PF13855 PF13516 1 0 0 0 0 0 PF13857 PF00069 1 0 0 0 0 0 PF13873 0 0 0 0 1 0 PF13893 PF00076 1 0 0 0 0 0 PF13894 PF13912 PF00096 1 0 0 0 0 0 PF13894 PF13912 PF13894 PF13912 1 0 0 0 0 0 PF13909 PF00096 1 0 0 0 0 0 PF13909 PF12874 1 0 0 0 0 0 PF13909 PF13912 1 0 0 0 0 0 PF13912 PF00096 PF13912 PF00096 PF13912 1 0 0 0 0 0 PF13912 PF00096 PF13912 PF12874 PF13894 1 0 0 0 0 0 PF13912 PF13894 PF12874 1 0 0 0 0 0 PF13927 PF00656 1 0 0 0 0 0 PF13927 PF07679 PF13927 PF07679 PF13927 PF00041 1 0 0 0 0 0 PF13927 PF13895 1 0 0 0 0 0 PF14214 0 0 0 0 1 0 PF14223 0 0 0 0 1 0 PF14291 0 0 0 0 1 0 PF14324 0 1 0 0 0 0 PF14555 PF00240 1 0 0 0 0 0 PF14555 PF02338 1 0 0 0 0 0 PF14604 0 1 0 0 0 0 PF14604 PF08824 PF12026 1 0 0 0 0 0 PF14634 PF00642 1 0 0 0 0 0 PF14661 0 0 0 0 1 0 PF14705 0 0 0 0 1 0 PF14716 PF10391 PF14792 0 0 1 0 0 0 PF14783 PF14782 0 0 1 0 0 0 PF14813 0 0 0 0 1 0 PF14839 0 0 0 0 1 0 PF14857 0 0 0 0 1 0 PF14909 0 0 0 0 1 0 PF14952 0 0 0 0 1 0 PF15004 0 0 0 0 1 0 PF15009 0 0 0 0 1 0 PF15072 0 0 0 0 1 0 PF15243 0 0 0 0 1 0 PF15328 0 0 0 0 1 0 PF15346 0 0 0 0 1 0 PF15353 PF16002 1 0 0 0 0 0 PF15388 0 0 0 0 1 0 PF15663 PF00642 1 0 0 0 0 0 PF15868 0 0 0 0 1 0 PF15886 0 0 0 0 1 0 PF15936 PF00412 1 0 0 0 0 0 PF16013 0 0 0 0 1 0 PF16087 0 0 0 0 1 0 PF16179 0 1 0 0 0 0 PF16503 0 0 1 0 0 0 PF16975 0 0 0 0 1 0