GO:0022843 voltage-gated cation channel activity Gains GO:0005516 calmodulin binding Gains GO:0003779 actin binding Gains GO:0005245 voltage-gated calcium channel activity Gains GO:0046873 metal ion transmembrane transporter activity Gains GO:0005244 voltage-gated ion channel activity Gains GO:0022832 voltage-gated channel activity Gains GO:0008831 dTDP-4-dehydrorhamnose reductase activity Gains GO:0005262 calcium channel activity Gains GO:0005216 ion channel activity Gains GO:0022838 substrate-specific channel activity Gains GO:0005261 cation channel activity Gains GO:0097367 carbohydrate derivative binding Gains GO:0051020 GTPase binding Gains GO:0004519 endonuclease activity Gains GO:0004725 protein tyrosine phosphatase activity Gains GO:0005328 neurotransmitter:sodium symporter activity Gains GO:0015085 calcium ion transmembrane transporter activity Gains GO:0005085 guanyl-nucleotide exchange factor activity Gains GO:0022803 passive transmembrane transporter activity Gains GO:0015267 channel activity Gains GO:0052742 phosphatidylinositol kinase activity Gains GO:0005088 Ras guanyl-nucleotide exchange factor activity Gains GO:0004430 1-phosphatidylinositol 4-kinase activity Gains GO:0019198 transmembrane receptor protein phosphatase activity Gains GO:0005001 transmembrane receptor protein tyrosine phosphatase activity Gains GO:0005509 calcium ion binding Gains GO:0015294 solute:cation symporter activity Gains GO:0017016 Ras GTPase binding Gains GO:0030554 adenyl nucleotide binding Gains GO:0031267 small GTPase binding Gains GO:0005524 ATP binding Gains GO:0016849 phosphorus-oxygen lyase activity Gains GO:0003951 NAD+ kinase activity Gains GO:0032559 adenyl ribonucleotide binding Gains GO:0005326 neurotransmitter transporter activity Gains GO:0004568 chitinase activity Gains GO:0017076 purine nucleotide binding Gains GO:0019992 diacylglycerol binding Gains GO:0008332 low voltage-gated calcium channel activity Gains GO:0070300 phosphatidic acid binding Gains GO:0004363 glutathione synthase activity Gains GO:0051010 microtubule plus-end binding Gains GO:0072509 divalent inorganic cation transmembrane transporter activity Gains GO:0032553 ribonucleotide binding Gains GO:0003774 motor activity Gains GO:0032555 purine ribonucleotide binding Gains GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Gains GO:0016805 dipeptidase activity Gains GO:0035639 purine ribonucleoside triphosphate binding Gains GO:0008092 cytoskeletal protein binding Gains GO:0015370 solute:sodium symporter activity Gains GO:0022836 gated channel activity Gains GO:0005549 odorant binding Gains GO:0008061 chitin binding Gains GO:0004721 phosphoprotein phosphatase activity Gains GO:0030695 GTPase regulator activity Gains GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen Gains GO:0004143 diacylglycerol kinase activity Gains GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Gains GO:0004687 myosin light chain kinase activity Gains GO:0015293 symporter activity Gains GO:0005096 GTPase activator activity Gains GO:0038024 cargo receptor activity Gains GO:0008233 peptidase activity Gains GO:0070011 peptidase activity, acting on L-amino acid peptides Gains GO:0008324 cation transmembrane transporter activity Gains GO:0005089 Rho guanyl-nucleotide exchange factor activity Gains GO:0003964 RNA-directed DNA polymerase activity Losses GO:0034061 DNA polymerase activity Losses GO:0016779 nucleotidyltransferase activity Losses GO:0004190 aspartic-type endopeptidase activity Losses GO:0070001 aspartic-type peptidase activity Losses GO:0140097 catalytic activity, acting on DNA Losses GO:0003677 DNA binding Losses GO:0003676 nucleic acid binding Losses GO:1901363 heterocyclic compound binding Losses GO:0097159 organic cyclic compound binding Losses GO:0003899 DNA-directed 5'-3' RNA polymerase activity Losses GO:0004175 endopeptidase activity Losses GO:0008270 zinc ion binding Losses GO:0043565 sequence-specific DNA binding Losses GO:0004000 adenosine deaminase activity Losses GO:0097747 RNA polymerase activity Losses GO:0034062 5'-3' RNA polymerase activity Losses GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Losses GO:0046914 transition metal ion binding Losses GO:0016787 hydrolase activity Losses GO:0070011 peptidase activity, acting on L-amino acid peptides Losses GO:0003700 DNA binding transcription factor activity Losses GO:0003990 acetylcholinesterase activity Losses GO:0038023 signaling receptor activity Losses GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Losses GO:0000156 phosphorelay response regulator activity Losses GO:0008233 peptidase activity Losses GO:0048027 mRNA 5'-UTR binding Losses GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Losses GO:0019239 deaminase activity Losses GO:0004104 cholinesterase activity Losses GO:0004523 RNA-DNA hybrid ribonuclease activity Losses GO:0022857 transmembrane transporter activity Losses GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Losses GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Losses GO:0060089 molecular transducer activity Losses GO:0097472 cyclin-dependent protein kinase activity Losses GO:0004693 cyclin-dependent protein serine/threonine kinase activity Losses GO:0052689 carboxylic ester hydrolase activity Losses GO:0004312 fatty acid synthase activity Losses GO:0042562 hormone binding Losses GO:0036081 extracellular ammonia-gated ion channel activity Losses GO:0008010 structural constituent of chitin-based larval cuticle Losses GO:0140110 transcription regulator activity Losses GO:0004888 transmembrane signaling receptor activity Losses GO:0004035 alkaline phosphatase activity Losses GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Losses GO:0016882 cyclo-ligase activity Losses GO:0017110 nucleoside-diphosphatase activity Losses GO:0045134 uridine-diphosphatase activity Losses GO:0008083 growth factor activity Losses GO:0004871 signal transducer activity Losses GO:0042302 structural constituent of cuticle Losses GO:0000155 phosphorelay sensor kinase activity Losses GO:0004673 protein histidine kinase activity Losses GO:0099600 transmembrane receptor activity Losses GO:0008514 organic anion transmembrane transporter activity Losses GO:0004364 glutathione transferase activity Losses GO:0003960 NADPH:quinone reductase activity Losses GO:0008187 poly-pyrimidine tract binding Losses GO:0016772 transferase activity, transferring phosphorus-containing groups Losses GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity Losses GO:0008329 signaling pattern recognition receptor activity Losses GO:0004046 aminoacylase activity Losses GO:0005384 manganese ion transmembrane transporter activity Losses GO:0008422 beta-glucosidase activity Losses GO:0016848 carbon-halide lyase activity Losses GO:0050308 sugar-phosphatase activity Losses GO:0005110 frizzled-2 binding Losses GO:0016630 protochlorophyllide reductase activity Losses GO:0008853 exodeoxyribonuclease III activity Losses GO:0038187 pattern recognition receptor activity Losses GO:0070883 pre-miRNA binding Losses GO:0004852 uroporphyrinogen-III synthase activity Losses GO:0015141 succinate transmembrane transporter activity Losses GO:0004501 ecdysone 20-monooxygenase activity Losses GO:0045505 dynein intermediate chain binding Losses GO:0018685 alkane 1-monooxygenase activity Losses GO:0005214 structural constituent of chitin-based cuticle Losses GO:0008509 anion transmembrane transporter activity Losses GO:0003676 nucleic acid binding Extinctions GO:0003677 DNA binding Extinctions GO:0004000 adenosine deaminase activity Extinctions GO:0000156 phosphorelay response regulator activity Extinctions GO:0016779 nucleotidyltransferase activity Extinctions GO:0003899 DNA-directed 5'-3' RNA polymerase activity Extinctions GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Extinctions GO:1901363 heterocyclic compound binding Extinctions GO:0004190 aspartic-type endopeptidase activity Extinctions GO:0070001 aspartic-type peptidase activity Extinctions GO:0097159 organic cyclic compound binding Extinctions GO:0034061 DNA polymerase activity Extinctions GO:0140097 catalytic activity, acting on DNA Extinctions GO:0043565 sequence-specific DNA binding Extinctions GO:0003964 RNA-directed DNA polymerase activity Extinctions GO:0097747 RNA polymerase activity Extinctions GO:0034062 5'-3' RNA polymerase activity Extinctions GO:0003700 DNA binding transcription factor activity Extinctions GO:0016882 cyclo-ligase activity Extinctions GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Extinctions GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity Extinctions GO:0008853 exodeoxyribonuclease III activity Extinctions GO:0015141 succinate transmembrane transporter activity Extinctions GO:0004165 dodecenoyl-CoA delta-isomerase activity Extinctions GO:0009008 DNA-methyltransferase activity Extinctions GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Extinctions GO:0036081 extracellular ammonia-gated ion channel activity Extinctions GO:0000155 phosphorelay sensor kinase activity Extinctions GO:0004673 protein histidine kinase activity Extinctions GO:0019239 deaminase activity Extinctions GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Extinctions